Advanced Healthcare Materials
·
2026
·
IF 11
Jiajia Jia,Zhitong Guan,Jiaxin Wang,Ting Fang,Jiajun Sun,Aiyang Tong,Yingzhen Fan,Ming Zhao,Dongkai Wang,Zheran Wang,Ji Li
Although cGAS-STING immunotherapy holds immense potential, its efficacy is severely compromised by pathway evasion. To overcome this, we engineered a core-shell bilayer nanobomb (M/ZIF/MnO 2 @DBCO) via a template-assisted approach, integrating MSC1094308 into ZIF-8 cores followed by MnO 2 shell deposition and DBCO functionalization. In a simulated tumor microenvironment, ZIF-8 loading accelerated Mn 2+ release from MnO 2 , increasing the cumulative release by nearly 30% within 8 h compared to pristine MnO 2 . Cellular assays demonstrated rapid bio-orthogonal targeting of azide-modified tumors, achieving lysosomal escape within 6 h postuptake. Subsequently, MnO 2 -mediated glutathione (GSH) depletion and hydroxyl radical (·OH) generation, combined with Zn 2+ induced mitochondrial oxidative stress, produced cytotoxic reactive oxygen species (ROS) that triggered immunogenic cell death. Furthermore, Mn 2+ , Zn 2+ , and dsDNA released from damaged mitochondria cooperatively activated the cGAS-STING pathway. Concurrently, MSC1094308 inhibited ESCRT-mediated negative regulation, as evidenced by a ∼0.2 decrease in the p-STING/VPS4B-RFP colocalization coefficient, confirming the blockade of cGAS-STING evasion. In vivo studies revealed that the nanoplatform profoundly stimulated antitumor immunity, increasing tumor-infiltrating cytotoxic T lymphocytes approximately 8-fold versus untreated controls after 21 days. This work establishes an integrated strategy harnessing Zn 2+ /Mn 2+ synergy, nanobomb reactivity, and ESCRT inhibition to circumvent cGAS-STING evasion, offering a promising paradigm for cancer immunotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2026
·
IF 8.7
Qing Zhang,Chenguang Liu,Sirui Wu,Nan Zhong,Junfeng Qiu,Wei Fu,Xujun You
Purpose: Prostate cancer (PCa) remains a leading cause of cancer-related mortality in men, with current treatments often limited by drug resistance and systemic toxicity. Although traditional Chinese medicine components such as Astragaloside IV and polypeptide extract from scorpion venom (PESV) have demonstrated promising antitumor activity, their clinical translation is hampered by poor bioavailability and lack of tumor specificity. To address these limitations, we engineered an E3 aptamer-modified T cell-derived exosomal nanoplatform (EAPE) for the targeted co-delivery of Astragaloside IV and PESV in prostate cancer therapy.Methods: EAPE was constructed and characterized, and its targeting capability, biosafety, and therapeutic performance were evaluated in vitro and in vivo. In vitro, the antitumor efficacy was assessed by proliferation, migration and apoptosis assays, while the immunomodulatory effects were investigated using a co-culture system of LNCaP cells and T lymphocytes. In vivo, the antitumor efficacy and immune activation were examined in prostate cancer xenograft mouse model, with tumor growth inhibition, apoptosis and immune responses measured.Results: EAPE demonstrated efficient tumor-targeting capability and favorable biosafety profiles both in vitro and in vivo. EAPE demonstrated superior therapeutic efficacy against PCa by inhibiting proliferation and migration of prostate cancer cells and inducing apoptosis, while suppressing immunosuppression and activating antitumor immune response.Conclusion: This study presents a biologically derived, targeted nanodelivery system that improves the delivery efficiency and therapeutic efficacy of Astragaloside IV and PESV. These findings support the potential of exosome-based nanoplatforms as promising strategies for enhancing the translational application of traditional Chinese medicine-derived therapeutics in prostate cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Research
·
2026
·
IF 12.9
Jian-Xuan Sun,Ye An,Si-Han Zhang,Jin-Zhou Xu,Abudureyimu Maimaiti,Jing-Yu Xu,Yi-Fan Huang,Yu-Xuan yang,Mei-Cheng Liu,Shao-Gang wang,Qi-Dong Xia
Precision theranostics for castration-resistant prostate cancer remain a major challenge because of tumor heterogeneity, drug toxicity, and resistance to conventional therapies. Here, we report a multifunctional theranostic nanoplatform that integrates multimodal imaging guidance, dual-targeted delivery, photothermal therapy, and immune activation for the precision treatment of prostate cancer. By encapsulating aggregation-induced emission luminogens and magnetic nanoparticles, this system achieves superior second near-infrared fluorescence and magnetic resonance imaging fusion for deep-tissue visualization. The dual-targeting strategy, which integrates magnetic navigation with simultaneous engagement of six-transmembrane epithelial antigen of the prostate 1 and prostate specific membrane antigen (PSMA), effectively addresses tumor heterogeneity by enabling externally guided and biologically specific delivery to both PSMA+ and PSMA− prostate cancer cells. Upon targeted delivery, the synergistic combination of photothermal therapy and chemotherapy achieves potent tumor growth inhibition, activates CD8+ T cells and macrophages to promote robust antitumor immune responses, and elicits durable immunological memory to prevent tumor recurrence. In vitro and in vivo studies demonstrate superior tumor targeting specificity, enhanced imaging contrast, and minimal off-target toxicity. This study provides novel insights into the construction of a multifunctional theranostic nanoplatform in precision oncology, with promising translational potential for clinical management of castration-resistant prostate cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2026
·
IF 8.2
Ajing Wu,Wenxuan Wang,Rui Liu,Huifang Hao,Xiaochun Zheng,Mingxin Zhao,Haonan Chen,Yanchun Ma,Weiwei Kang,Ziliang Zheng
A synergistic nanoprobe enables precise, safe, non-radiative skeletal imaging. • Multi-targeting enables precise enrichment throughout the skeleton. • AA@TFN provides a versatile platform for bone disease diagnosis and monitoring. Early diagnosis of bone-related diseases remains a critical clinical challenge, attributable to persistent limitations in imaging accuracy and safety. While near-infrared Region II fluorescence (NIR-II FL) imaging confers substantial advantages for deep-tissue visualization, its clinical translation is hampered by the inadequate targeting specificity of conventional contrast agents. Here, we developed Au-Ag@Apo-Tf/-N 3 (AA@TFN), a synergistic targeting gold–silver nanocluster probe engineered with glutathione and azide functionalities, which achieved bone-specific enrichment via a hierarchical multi-targeting mechanism. AA@TFN first anchored to hydroxyapatite in the bone matrix through glutathione carboxyl-mediated chelation, then targeted transferrin receptors highly expressed in bone marrow, and finally endured macrophage-mediated uptake facilitated by azide-enhanced bone affinity. A synergistic targeting strategy enabled real-time, high-resolution NIR-II FL imaging across the complete skeleton, with enhanced probe enrichment at lesion sites driven by microenvironmental changes. AA@TFN enabled visualization of synovial inflammation in rheumatoid arthritis models and millimeter‑scale microlesions in multiple myeloma models. Furthermore, the probe exhibited excellent biocompatibility and favorable safety profiles, underscoring its strong translational potential. A versatile platform was established for the diagnosis of bone diseases and non-invasive monitoring of therapeutic efficacy. Download: Download high-res image (129KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Siyuan Meng,Fangnan Lv,Jieqing Chen,Linlin Tao,Hao Guo,Danhui Wang,Jie Sun,Jian Li,Ning Liu,Wei Xu,Meirong Huo
A biomimetic antigen outpost is engineered to sustainably co-deliver tumor antigens, siSOCS1, and Mn 2+ adjuvant. • Plasma gel recruits DCs to the injection site, while CRT on nanovaccines acts as an "eat-me" signal to enhance antigen uptake. • SOCS1 silencing and PD-L1 blockade synergistically empower DCs to more effectively prime and activate cytotoxic T lymphocytes (CTLs). • PD-L1 blockade further protects activated CTLs from tumor cell-mediated exhaustion, enabling sustained tumor killing and potent antitumor immunity in TNBC models. Tumor vaccines represent a promising immunotherapy approach but are challenged by rapid systemic clearance, low immunogenicity, and various immunosuppressive mechanisms. To overcome these issues, we created a biomimetic antigen outpost system to enhance vaccine delivery and immune activation. This system uses cationic 1,2-dihydroxybenzene-modified poly- l -lysine to co-load small interfering RNA targeting cytokine-suppressing factor 1 (siSOCS1) and immunoadjuvant (Mn 2+ ) as the core. This core is further coated with calreticulin (CRT)-enriched tumor cell membranes to form a nanovaccine (CRTM/PBM siSOCS1 ), which is ultimately encapsulated in a plasma gel (PG@CRTM/PBM siSOCS1 ). This design prolongs the vaccine's in vivo retention, recruits dendritic cells (DCs) by simulating subcutaneous hemorrhage signals, and enhances effective antigen uptake through CRT-mediated “eat me” signals. Upon DC internalization, the nanovaccine undergoes non-lysosomal trafficking, avoiding siSOCS1 degradation. The efficient SOCS1 silencing alleviates intracellular immunosuppressive feedback and, together with synergistic DC activation by antigens and Mn 2+ , further promotes DC maturation and antigen cross-presentation. In a triple-negative breast cancer model, the combination with anti-PD-L1 antibody simultaneously blocked PD-L1 on both mature DCs and tumor cells, significantly enhancing cytotoxic T lymphocyte function at both the immune priming and effector stages, and demonstrating potent antitumor efficacy. This multi-level intervention strategy provides a promising platform for enhancing cancer immunotherapy. Download: Download high-res image (112KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
CANCER LETTERS
·
2026
·
IF 11.8
Jie Wang,Huihao Ma,Baozhi Feng,Yan Fu,Chunlin Lu,Mingyang Fei,Yuxin Zhang,Bin Dong,Ying Li,Jing Liu
Aldo-keto reductase family 1 member C3 (AKR1C3) is a pivotal metabolic enzyme involved in arachidonic acid (AA) metabolism and cancer metabolic reprogramming, which plays a critical role in the initiation and progression of glioblastoma (GBM). We integrated single-cell and transcriptome data to characterize AA metabolism features in GBM and identify the key gene AKR1C3. Using CCK8 assays, wound-healing assays, transwell assays, and mouse tumor formation experiments, we elucidated the effects of AKR1C3. Dual-luciferase reporter assays and ChIP-PCR experiments were performed to investigate the regulation of transcription factor JUN on AKR1C3 expression. RNA-seq analysis, combined with rescue experiments, demonstrated that AKR1C3 significantly regulates the RhoA/ROCK pathway. Arachidonic acid metabolism is closely associated with clinical outcomes in glioma, with AKR1C3 identified as a key gene within this pathway. AKR1C3 knockdown enhanced tumor cell proliferation, migration, and invasion, whereas AKR1C3 overexpression suppressed these malignant behaviors. In vivo experiments further confirmed the inhibitory effect of AKR1C3 on glioma progression. Dual-luciferase reporter and ChIP-PCR assays demonstrated that JUN acts as an upstream regulator of AKR1C3. ELISA results indicated that AKR1C3 overexpression reduced cellular PGD2 levels. RNA-seq analysis suggested that the RhoA/ROCK pathway was a downstream effector of AKR1C3, and exogenous PGD2 supplementation could reverse AKR1C3-mediated regulation of this pathway. We identified curcumin, a natural product with anti-cancer metabolic regulatory activity, as an upstream modulator that suppresses JUN expression, thereby activating the JUN/AKR1C3 axis and inhibiting malignant phenotypes in GBM cells. JUN/AKR1C3 axis influences glioma progression via modulating PGD2-mediated RhoA/ROCK Signaling.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Hao-Yu Chen,Wu-Dan Yang,Jie-Yang Dong,Ling-Bao Wu,Dan-Dan She,Ze-Kuan Zhang,Tian-Jun Gong,Qi Zhang,Yao Fu
A dual-regulation strategy integrating O V engineering and AuCu bimetallic synergy is developed for ZnO photocatalysts. • The optimal Cu 2 Au 2.6 /O V -ZnO delivers a coupling yield of 2625.0 μmol·g −1 ·h −1 , 4.0 and 11 times that of Cu/ZnO and Au/ZnO. • Heterogeneous photocatalysis enables flexible C(sp 3 )–C(sp 3 )-bridged bifuran synthesis, breaking long-standing bottlenecks. • The synergistic mechanism is clarified, and the bifuran monomers are directly applicable for bio-based polyester fabrication. The photocatalytic C C coupling of furanic platform molecules represents a green and sustainable route to valorization of biomass into high-value chemicals. Nevertheless, this process is frequently plagued by low efficiency owing to rapid charge recombination and insufficient catalytic activity. Herein, we report a highly efficient photocatalyst, Cu Au bimetal supported on oxygen vacancy-rich ZnO (Cu 2 Au 2.6 /O V -ZnO), for the light-driven coupling of furfuryl chloride derivatives into a bifuran monomers. A combination of oxygen vacancy (O V ) engineering and bimetallic synergy was employed to optimize the performance of the catalyst. Systematic characterization, including SEM/TEM, XPS, UV–vis, EPR, PL/TRPL, and KPFM, revealed that O V sites enhance visible light absorption and serve as electron traps, whereas the Cu Au bimetallic system forms a Schottky heterojunction, collectively promoting the separation and migration of photogenerated electron-hole pairs. The optimized Cu 2 Au 2.6 /O V -ZnO catalyst achieved an exceptional yield of 2625.0 μmol·g −1 ·h −1 , which is approximately 4.0 and 11.0 times greater than those of the monometallic Cu 2 /ZnO and Au 2 /ZnO catalysts, respectively. Mechanistic studies confirmed the crucial roles of both photogenerated electrons and holes, with photogenerated electrons facilitating the critical reductive steps. This work provides a strategic design of multifunctional photocatalysts through defect and interface engineering for efficient biomass conversion to high-value monomers. Download: Download high-res image (179KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2026
·
IF 6
Yueyang Shang,Tianyu Gao,Haoran Zhu,Xiulin Sun,Jing Wang,Xinmiao Lan,Di Zhao,Peijian Feng
Electrical stimulation serves as a fundamental tool for neuromodulation. Piezoelectric nanomaterials have become a central focus in wireless, battery-free electrical stimulation, which holds great promise for modulating neural circuits and treating neurological disorders. However, ultrasound-activated piezoelectric stimulation remains limited by off-target effects, low spatial precision, and inefficient energy transfer. Here, we developed a cell-targeting neuromodulation strategy using L-Dopa-coated barium titanate nanoparticles (BT-Dopa NPs). The biomimetic L-Dopa coating significantly enhances nanoparticle dispersibility and improves neuronal targeting efficiency. Under ultrasound excitation, these BT-Dopa NPs generate localized electrical currents that effectively stimulate Ca2+ influx and trigger the release of key catecholamine neurotransmitters, including dopamine and norepinephrine, from PC 12 cells. This on-demand stimulation was achieved without inducing significant cytotoxicity, providing a minimally invasive platform for precise neural circuit modulation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LUMINESCENCE
·
2026
·Vol. 41
·期 7
·e70567
·
IF 2.8
Fenqiang Luo,Liyan Zheng
Novel multifunctional metal–organic frameworks prepared by encapsulating luminol, hemin, and glucose oxidase within UiO-66 have been employed for the chemiluminescent determination of glucose via a one-step method. Benefitting from the encapsulating cascade catalyst with luminescent reagent in UiO-66, the as-prepared material can be utilized to fabricate practical glucose sensors with a wide response range, a low detection limit, and a short detection time. This promising sensing material is anticipated to have widespread applications in biotechnology and demonstrates significant potential for the green, selective, and sensitive detection of target analytes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2026
·
IF 17.3
Yating Zhan,Hao Xing,Minchao Liu,Yufang Kou,Zuyang He,Yixiang Wang,Enyun Xing,Yang Song,Mohamed F. Mady,Wei Li,Fan Zhang,Dongyuan Zhao,Tiancong Zhao,Xiaomin Li
Disruption of calcium ion (Ca2+) homeostasis has emerged as a promising strategy for tumor therapy. However, the intricate regulation of Ca2+ signaling and the limitations of single-dimensional modulation often hinder therapeutic efficacy. Here, we developed a Janus nanomotor platform that orchestrates mechanochemically coupled multidimensional modulation of Ca2+ overload for enhanced tumor therapy. Utilizing a liquid–nano–liquid interface-mediated anisotropic encapsulation strategy, amorphous calcium carbonate (ACC) nanoparticles were asymmetrically coated with mesoporous polydopamine (mPDA) and subsequently functionalized with l-arginine (l-Arg) and hyaluronic acid (HA), forming the Janus ACC@SiO2&mPDA-Arg-HA nanomotors that combine structural asymmetry, NO-driven propulsion, and tumor-targeting capability. Within the tumor microenvironment (TME), degradation of the ACC provided a sustained exogenous Ca2+ reservoir. Simultaneously, the endogenous catalytic conversion of l-Arg into NO triggered self-propulsion, mechanically stimulating the cell membrane to activate Piezo1 channels and promote extracellular Ca2+ influx. In parallel, NO acted as a gaseous chemical messenger to trigger ryanodine receptors (RyRs)-mediated Ca2+ release from the endoplasmic reticulum (ER). The mechanically and chemically coupled regulation induces persistent Ca2+ overload, leading to mitochondrial dysfunction and apoptosis. Our study presents a paradigm of mechanochemical coupling for multidimensional signal modulation, offering a framework for engineering nanomachines that reprogram intracellular signaling in cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2026
·Vol. 16
·期 7
·613
·
IF 4.5
Xin Wang,Yunkai Zhou,Qingsong Wang,Dongxue Liang,Wenjia Li,Zhou Zhang,Mingqiang Zhu,Jia Wang
Hydrolysis of cellulose to produce ethanol has become an effective way to utilize biological resources, but its large-scale industrial application has been limited. In this study, a one-pot catalytic conversion process for transforming cellulose into ethanol was developed. Meanwhile, multifunctional Mo/Pt/WOx/Al2O3catalysts were prepared by loading nano-alumina (Nano-Al2O3) via a stepwise impregnation method. The influence of catalysts with varying metal ratios on the types of products generated during the cellulose hydrolysis process to ethanol was examined. The catalyst with 0.1% Mo, 2% Pt, and 7.5% W loadings showed the best selectivity. With an ethanol yield of 45.3% after heating at 5 MPa H2and 518 K for 2 h. Nano-Al2O3can provide suitable active sites. The addition of W5+and Mo0increased the surface oxygen vacancy density and enhanced the hydrodeoxidation and metal anchoring capacity of the catalyst. The solid solution structure facilitates electron transfer from W and Mo atoms to Pt atoms, forming electron-rich Ptδ-species, promoting the hydrolysis of cellulose and the formation of ethanol.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 8
·522
·
IF 5.4
Qiao Yuchun,Wu Yiying,He Jiahui,Chen Wen,Fan Jiaqi,Zhang Zhicong,Shen Jialu,Su Mengping,Wang Qidong,Li Shuai,Shen Yingjie,Shang Jizhen,Wang Hua
Glucose is a vital energy source, and its accurate monitoring is crucial for the diagnosis and management of metabolic diseases. Herein, we report a simple colorimetric sensing platform for glucose detection based on MnO 2 /Au-Ag nanozymes, glucose oxidase (GOx), and 3,3′,5,5′-tetramethylbenzidine (TMB). In this cascade system, GOx catalyzes the oxidation of glucose to generate H 2 O 2 , which is subsequently decomposed by MnO 2 /Au-Ag to produce reactive species that oxidize TMB, yielding a visible blue signal. The incorporation of Au-Ag nanoparticles provides additional catalytic sites and promotes interfacial electron transfer, thereby enhancing the catalytic performance of MnO 2 . The platform exhibits a linear response over 0.025-0.20 mM with a detection limit of 0.012 mM. It enables reliable glucose detection in artificial sweat and 80-fold diluted serum samples. In addition, portable nitrocellulose test strips were developed for visual and smartphone-assisted glucose detection. This strategy provides a simple and portable approach for low-concentration glucose analysis and offers potential for point-of-care applications after further validation. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）