BIOMEDICAL MICRODEVICES
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2026
·Vol. 28
·期 1
·3
·
IF 3.3
Yang Chun-Guang,Han Yi,Zhang Jing-Jing,Xu Li-Wen,Li Jin
The expression levels of miRNAs in cells or biological fluids are closely associated with the onset and progression of many diseases, making the detection of miRNAs in serum and plasma increasingly important. However, due to the low levels of miRNAs in biological fluids and the complexity of their surrounding environment, their analysis faces challenges related to accuracy and reproducibility. We developed a duplex-specific nuclease (DSN)-mediated detection method for the direct detection of miRNA-21 in real samples. This method eliminates the need for total RNA extraction from real samples using commercial kits, a key advantage over traditional methods requiring pre-treatment. As verified by performance evaluation, this method exhibits a linear range of 5.00 fmol·L − 1 to 500 pmol·L − 1 and a limit of detection (LOD) of 2.66 fmol·L − 1 for miRNA-21. Direct detection of miRNA-21 in real samples yielded favorable results. These findings confirm that the method holds great application potential for the direct detection of miRNA-21 in real biological samples and exhibits promising prospects in clinical cancer diagnosis and drug screening.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 3.9
Wang Rong,Tian Xiao-Li,Li Jin,Chen Jia-Jia,Hu Yue,Zhang Ji
Ferroptosis is a non-apoptotic form of cell death that offers unique advantages in various cancer therapies. Gene therapy, on the other hand, involves transferring therapeutic genes into cancer cells to regulate related proteins and exert therapeutic effects. Nanomaterials that combine the ability to induce ferroptosis in cancer cells with gene delivery functionality hold great potential for tumor therapy. Herein, we designed and synthesized a series of ferrocene-containing (Fc) cationic lipids (NFC-1~4) based on the Ugi reaction. Fc, as a typical Fenton reaction catalyst, can effectively trigger ferroptosis in cancer cells. The results showed that NFC-1~3 lipoplexes could be efficiently taken up by A549 cells and exhibit excellent gene transfection capabilities, with the best transfection efficiency surpassing that of Lipofectamine 2000. Reactive oxygen species (ROS) detection experiments revealed that NFC-2 possesses Fenton characteristics, enabling it to induce the Fenton reaction and produce ROS. In vitro antitumor experiments demonstrated that NFC-2 LNPs could inhibit tumor cell growth to some extent, with its efficacy significantly enhanced after DNA encapsulation. Mechanistic studies indicated that the Fenton reaction mediated by NFC-2@DNA lipoplexes converted endogenous H 2 O 2 into highly toxic ·OH, leading to increased intracellular ROS levels, glutathione (GSH) depletion, and inactivation of glutathione peroxidase 4 (GPX4). The disruption of the cellular redox balance caused excessive accumulation of lipid peroxides (LPOs), ultimately inducing ferroptosis. NFC-2 holds promise as an efficient ferroptosis agent and a dual-function lipid for co-delivering DNA, offering potential for combined gene therapy and ferroptosis-based cancer treatment. Graphical abstract
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.7
Panpan Huo,Linghuan Guo,Haifeng Zhang,Shiwei Guan,Shun Xing,Sicong Chen,Haobo Pan,Lidan Liu,Xuanyong Liu
Cutaneous melanoma is highly metastatic and deadly, with conventional therapies often proving ineffective while causing significant side effects. Cerium-based metal-organic frameworks (Ce-MOFs) and their derivatives have recently attracted attention in antitumor therapy due to their unique physicochemical properties and multi-enzyme-mimicking activities. However, their catalytic efficiency remains suboptimal because of challenges such as ambiguous active sites and low utilization efficiency of metal ions. Their therapeutic efficacy is also frequently hampered by inefficient delivery systems. Here, a microneedle (MN) patch-assisted transdermal delivery system of oxygen vacancy-rich cerium‑iron bimetallic organic framework (CeFe-MOFs) derivatives (CeFeO x ) is constructed for synergistic chemodynamic (CDT) and starvation therapy against melanoma. Compared with Ce-MOFs derivatives (CeO x ), CeFeO x exhibits superior peroxidase-like (POD-like) activity, which may be attributed to Fe doping increasing the Ce 3+ /Ce 4+ ratio and, consequently, the concentration of oxygen vacancies. Through theoretical calculations, the catalytic pathway of CeFeO x toward H 2 O 2 and the mechanism by which Fe doping enhances the POD-like activity of CeO x are further revealed. The results indicate that the enhanced POD-like activity of CeFeO x originates from local changes in the electronic structure of the cerium lattice induced by Fe doping, which reduces the activation energy of key reaction steps. Meanwhile, Fe doping promotes the adenosine triphosphate (ATP) hydrolysis ability of CeO x , which is attributed to the strong binding affinity between Fe 3+ and ATP. The MN patch penetrates the stratum corneum, enabling efficient delivery of CeFeO x to intratumoral regions and thereby inducing melanoma cell death. Taken together, the MN-assisted cutaneous delivery system of CeFeO x provides a reasonable strategy for treating melanoma with highly enhanced catalytic activity.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Qiuyu Yang,Xiuxiu Wang,Yuanxin Tang,Shaopeng Lin,Yachen Gao,Hong Meng,Yifan He,Chensha Li
To promote the development of precise photo control of liquid crystal elastomer (LCE) actuators with ease of stimulating operations, a study on the wavelength-selective actuation of LCE actuators using light-absorbing dyes with special optical waveband absorption properties is performed. LCE materials doped by visible light-absorbing dyes of different absorption bands demonstrated good functionality for selective actuation through the modulation of visible light wavelength bands, and the selective actuation of four wavebands on dye-doped LCE actuators was achieved for the first time. On the basis of the dye-doped LCE actuators, a crawling soft robot was constructed, capable of achieving excellent performance in terms of four-directional photo-actuated motion by filtering light irradiation from the same quasi-daylight source into four different wavelength bands. It could move to any destination through the appropriate combinations of these four directional movements or parts of these four directional movements. Our work further developed technologies for the selective photo actuation of LCE actuators and expanded the potential of quasi-daylight and even natural sunlight for precise and convenient photo control of LCE actuators.
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BIOSENSORS & BIOELECTRONICS
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2026
·
IF 10.5
Qi Feng,Jiaying Wang,Zileng Yu,Zhipeng Zhang,Huizi Zheng,Jiao Qu,Xiaolin Zhu
To address the growing environmental risks associated with emerging contaminants and limited rapid toxicity assessment tools, we developed a mediator-free microbial electrochemical biosensor using Escherichia coli nucleotide metabolism. This biosensor enables the direct detection of electroactive metabolites without exogenous mediators by utilizing the oxidation peak current as a sensitive toxicity indicator. An electrode was modified with a nanocomposite of carboxylated multi-walled carbon nanotubes and zinc oxide (MWCNT-COOH/ZnO), which significantly enhanced the electrochemical signals. Mechanistic studies revealed that the detection signal originated from the oxidation of guanine and xanthine. The biosensor was used to detect four bisphenol analogues and two per-/polyfluoroalkyl substances. The toxicity followed the order of bisphenol AF > bisphenol A > bisphenol F > bisphenol S, suggesting that bisphenol AF posed a higher toxicity risk than bisphenol A. The half-maximal inhibitory concentration (IC 50 ) for perfluorooctanesulfonic acid was 1011.13 μM, and its substitute, 6:2 fluorotelomer sulfonic acid, exhibited significantly lower toxicity at equivalent concentrations. The biosensor was further applied to actual water samples from the Yitong River, revealing generally low toxicity (inhibition rate <30 %) with higher inhibition rates observed at densely populated urban sites. This biosensor is characterized by simple operation, fast response, low cost, and independence from water turbidity or color, thereby offering an efficient and sensitive analytical platform for both toxicity assessment of emerging contaminants and safety evaluation of real water samples.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Chen Ma,Jinshuo Duan,Furong Liang,Jiawei Liu,Haowen Deng,Wanxin Zhi,Fan Xiao,Wanjing Zhang,Baojie Zhang
Multifunctional materials offering high-temperature thermal insulation and electromagnetic wave (EMW) absorption have become a research focus in recent years. Mullite offers excellent thermal insulation; however, it exhibits high infrared transmittance and lacks EMW absorption capability. Silicon carbide (SiC) exhibits infrared-shielding and EMW absorption capabilities but suffers from insufficient stability under long-term high-temperature oxidative exposure. Here, this research designed and fabricated a composite structure by embedding hollow SiC spheres (HSSs) into mullite fibers, aiming to synergistically combine the advantages of both materials. Compared to pure mullite nanofibers, the composite with an HSS content of 30% exhibited 24.4% and 29.3% lower thermal conductivity values at 25 °C and 1000 °C, respectively. The infrared transmittance in the 2.5–8 μm wavelength range decreased from 90% to 32%. Furthermore, at a thickness of 2.0 mm, the composite achieved a minimum reflection loss of −45.37 dB and an effective absorption bandwidth of 4.32 GHz. These improvements originate from synergistic mechanisms enabled by the HSSs. The intrinsic infrared shielding and dielectric loss properties of SiC provide a fundamental performance baseline. Meanwhile, the hollow structure not only hinders solid-phase heat conduction but also enhances infrared attenuation via multiple reflection, scattering, and absorption. Moreover, the introduced heterogeneous interfaces promote interfacial polarization and multiple relaxation processes, which optimize impedance matching and loss capacity, leading to significantly enhanced EMW absorption performance. Overall, this research offers a new approach for designing materials with thermal protection and electromagnetic stealth performance.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
·
IF 9
Diwen Xiao,Jiahao Cao,Hongjie Wang,Wenyi Dong,Fang Ma
Fluoride-containing wastewater pollution poses a serious threat to the global environment. Adsorption represents the most widely employed defluoridation process. Among various adsorbents, metal-organic frameworks (MOFs) demonstrate considerable potential. However, current zirconium-based MOFs for fluoride removal face challenges such as high cost, low adsorption capacity, insufficient mechanistic understanding, and difficulties in reuse due to the lack of stable immobilization methods. Herein, a zirconium‑cerium MOF (denoted as Zr/Ce-M) was prepared by doping MOF-801 with the low-cost metal cerium. At an initial F − concentration of 26 mg/L, its actual adsorption capacity reached 213 mg/g. This represents a 326% improvement compared to conventional MOF-801 and is 66% higher than the adsorbent with the highest known adsorption capacity.Further, zirconium/cerium MOF-based sponge (Zr/Ce-MS) was prepared via a simple method. Zr/Ce-MS exhibited exceptional loading stability under mechanical stress and solvent corrosion. Regeneration tests confirmed effective fluoride removal after eight cycles. Computational results revealed an upward shift in the d-band center of metals and enhanced electron-donating capability after Ce doping. Monodentate coordination (Zr F and Ce F) proved more stable than μ₂- or μ₃-bridging configurations. Strong hybridization occurred between Zr d/Ce d and F p orbitals, with Ce doping strengthening electron transfer from Zr to F − . The defluoridation mechanism of Zr/Ce-MS involves ion exchange, electrostatic interactions, hydrogen bonding, and Lewis acid–base complexation.This work provides new insights for developing fluoride adsorbents and mechanistic analysis.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Zhuojun Wu,Wenwen Gong,Xiao Wang,Yuhan Zhang,Wei Zhou,Shixiong Yi,Hong Yang,Guilong Peng
The selective oxidation of methyl phenyl sulfoxide (PMSO) to methyl phenyl sulfone (PMSO 2 ) is widely used to probe high-valent metal-oxo species in advanced oxidation processes (AOPs). However, its specificity remains uncertain. This study systematically investigates PMSO oxidation by sodium hypochlorite (NaClO), sodium periodate (PI), and peroxymonosulfate (PMS) under acidic (pH = 3.0 ± 0.2), neutral (pH = 7.2 ± 0.2), and alkaline (pH = 9.2 ± 0.2) conditions. Batch experiments and kinetic simulations using Kintecus V6.80 revealed that NaClO exhibited the highest reactivity across all pH values, with second-order rate constants of 125, 25, and 2.15 M −1 s −1 under acidic, neutral, and alkaline conditions, respectively. PI was reactive only in acidic media (7.5 M −1 s −1 ), while PMS showed comparable oxidation rates under acidic and alkaline conditions (1.25 and 1.28 M −1 s −1 ), but negligible activity at neutral pH. H 2 18 O labeling confirmed 18 O incorporation into PMSO 2 even without metal catalysts, supporting oxygen atom transfer (OAT) as the dominant mechanism. These results demonstrate that PMSO oxidation and 18 O labeling are not exclusive indicators of high-valent metal species and should therefore be interpreted with caution. The study underscores the need for more selective and reliable approaches to identify transition-metal-based oxidants in AOPs.
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Journal of Materials Chemistry A
·
2026
·
IF 9.5
Xi Chen,Hang Luo,Guanghu He,Deng Hu,Fan Wang,Xiaona Li,Zhongna Yan,Dou Zhang
Electrostatic capacitors are considered the preferred candidates for high-power energy storage. The demand for electrostatic capacitors operating at high temperatures (>150 °C) has been driven by applications in electric vehicles, aerospace systems, etc. Herein, we propose a strategy of using a B–N coordination supramolecular network to construct crosslinked polymer dielectrics for improved energy storage performance at elevated temperatures and electric fields. Specifically, by incorporating 2,7-diboronic ester-9,9′-spirobifluorene (DBASBF) into the polyetherimide (PEI) matrix, B–N coordination bonds are formed between the nitrogen atoms in PEI and the boron atoms in DBASBF, leading to the formation of a supramolecular coordination network. Theoretical calculations and experimental results confirm that the formation of this supramolecular network effectively enhances mechanical robustness and suppresses charge migration. As a result, the fully organic PEI/DBASBF-0.5% composite dielectric achieves a discharged energy density of 4.52 J cm−3 at 200 °C with an energy efficiency exceeding 90%, which is increased by 139% compared with the PEI matrix and surpasses many of the currently reported polymer dielectrics. Moreover, the composite also exhibits outstanding flexibility, along with remarkable long-term reliability. This work offers a design paradigm for developing high-performance polymer dielectrics suitable for harsh environments.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Cheng Zuo,Xin-Yi Hui,Pin-An Xin,Hao-Nan Qi,Xiaojun Shen,Jia-Long Wen,Tong-Qi Yuan
The sustainable biorefinery of lignocellulosic biomass (LCB) is pivotal for a circular bioeconomy, yet conventional fractionation often requires harsh conditions that compromise lignin functionality and carbohydrate integrity. Here we report an integrated strategy for dual valorization of industrial xylose residue (XR) by combining a mild alkaline hydrogen peroxide (AHP) pretreatment with pH-dependent lignin fractionation. Under 2 wt% AHP (pH 11.5, 60 °C, 1 h), the pretreatment achieved 90.04% delignification while producing a cellulose-rich residue that delivered a glucose yield of 98.12% at 5 wt% solids (10 FPU/g, 100 mg/g and 48 h), corresponding to a glucose concentration of approximately 45.90 g/L (16.98 and 78.52 g/L at 2 and 10 wt% solids, respectively). Crucially, the recovered lignin fractions retained key near-native, non-condensed structure and possesses reactive functionalities, enabling versatile lignin valorization including lignin nanoparticles, antioxidant performance, and a fully lignin-based adhesive formulated by water-only adjustment (25 wt% solids) that exhibited excellent dry and wet bonding strengths of 2.69 MPa and 1.24 MPa, respectively, exceeding the Chinese national standard. In summary, this work establishes an integrated and sustainable biorefinery paradigm for the valorization of agricultural and forestry wastes into fermentable sugars and high-performance fully lignin-based adhesive.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Hui Duan,XiaoQian Yao,Rana R. Neiber,Xingbo Jie,XiuJie Cheng,Jiayu Xin,Qing Zhou,Yi Li,Junli Xu,Dongxia Yan,Yu Zhang,Xingmei Lu
The transformation of waste polyethylene terephthalate (PET) into high-value functional materials remains a key challenge for sustainable polymer circularity. Here, we report a sustainable PET-derived zwitterionic gel in which phosphonium-based ionic liquids modulate the network through ion-dipole and ion-ion interactions, while the PET-based polyurethane functions as a structural regulator providing additional hydrogen-bond anchoring. The deep-eutectic betaine/Zn(OAc) 2 solvent serves as an efficient catalyst for PET glycolysis, enabling sustainable conversion of PET into polyurethane precursors. The ionic liquids act as dynamic cross-linking centres that densify chain packing, enhance charge transport, and facilitate stress delocalization throughout the dual network structure. When combined with the PET-PU-derived hydrogen-bond framework and MXene fillers, the gel preserves high conductivity and integrity in the presence of large deformation. The optimized gel exhibits a high toughness (486.9 kJ m −3 ), 856% elongation, ultralow modulus (0.078 MPa), and a high adhesion (245.8 kPa), which is similar to, or even higher than, human skin. The gel can be used as a flexible electronic-skin sensor that has a wide strain range (0–856%), high sensitivity (maximum gauge factor of 4.24 in the high-strain region), a detection limit of 0.5%, and stability of more than 1000 cycles. This work highlights ionic-liquid-induced dynamic cross-linking as a key mechanism governing mechanical and electrical performance, establishing a sustainable PET upcycling strategy for next-generation soft bioelectronic materials.
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ChemistrySelect
·
2026
·Vol. 11
·期 1
·e05258
·
IF 2
Qiong-Ru Wu,Meng-Ge Mao,Cheng-Yang Jiao,Jian-Bo Yang,Xin-Yu Li,Hua Mei,Yan Xu
Methanol steam reforming for hydrogen production is a promising hydrogen production technology that can meet the process or operation of hydrogen preparation, storage, transportation, and downstream utilization, contributing to the achievement of carbon neutrality. In this study, copper-based catalysts Cu x /MCM-41/HCOOH (x = 0.10, 0.15, 0.25) and Cu 0.15 X 0.01 /MCM-41/HCOOH (X = Y, Ga, Zr) were prepared by the modified impregnation method using MCM-41 as the carrier. In addition, the catalysts were comprehensively characterized using a variety of test methods, and the effects of copper content and type of additives on catalyst performance were investigated. Among the six catalysts, the Cu 0.15 Y 0.01 /MCM-41/HCOOH catalyst exhibited the lowest reduction temperature for CuO, the most effective dispersion of active metal, and the formation of more Cu 0 /Cu + species, demonstrating outstanding catalytic performance. Specifically, the methanol conversion rate achieved 99.85% with a H 2 selectivity of up to 99.91% and CO selectivity and CO 2 selectivity of 1.55% and 98.45%, respectively, at optimal reaction conditions of 250°C, the S/C molar ratio of 3:2, and the weight hourly space velocity (WHSV) of 0.16 h −1 . Graphical The Cu 0.15 Y 0.01 /MCM-41/HCOOH catalyst was prepared via a modified impregnation method for methanol steam reforming. At a reaction pressure of 1 MPa, a reaction temperature of 250°C, a steam-to-carbon ratio of 1.5, and a weight hourly space velocity of 0.16 h −1 , the catalyst exhibited a methanol conversion of 99.85%, a H 2 selectivity of 99.91%, and a CO selectivity of 1.55%. The catalyst demonstrated good stability, with no significant deactivation observed during the 110-h stability test.
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