Journal of Physical Chemistry C
·
2021
·
IF 4.126
Meng Zhang,Yanan Wang,Xu Wang,Bing Zhao,Weidong Ruan
Surface-enhanced Raman scattering (SERS) substrates have shown rapid development in recent years, but the use of transparent conductive oxides (TCOs) in SERS is still limited. Here, a series of In-doped CdO (ICO) NPs with different In3+ doping contents x (x = 0, 0.025, 0.050, 0.075, 0.100, 0.125, 0.150, and 0.200) were synthesized by a hydrothermal method and first employed as a SERS platform. The structures and properties of the ICO NPs influenced by dopant concentration of In3+ ions were characterized by powder X-ray diffraction (XRD), inductively coupled plasma (ICP) analysis, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared (FTIR) spectroscopy. Furthermore, the SERS spectra of ICO-MPY were investigated. Interestingly, the enhancement was dominated by the charge-transfer (CT) contribution through the free electrons in conduction bands (CBs). The changes in electronic distributions in energy levels of ICO NPs at different doping contents were explored, and the corresponding effect on SERS was discussed by employing 633 and 785 nm excitation lines, respectively. The CT route was found to be the excitation of electrons from CBs of semiconductor to the LUMO of molecule, which provides a new perspective in understanding SERS mechanisms. The present work provides a new approach to develop potential semiconductive SERS substrates.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Yi Xu,Md Mehedi Hassan,Afang Zhu,Huanhuan Li,Quansheng Chen
A new dual-mode optical-nano-sensor was designed to effectively isolate, discriminate and inactivate multiple foodborne pathogens through the combined effort of magnetic SERS tags and functionalized upconversion nanoparticles. The positively charged quaternary ammonium salt (QAS) functionalized upconversion nanoparticles (UCNPs@QAS) were used as a fluorescent probe for the analysis of total bacteria count and inactivation of bacteria, and 4-mercaptophenylboronic acid (4-MPBA) modified magnetic Au@Ag NPs (MAu@Ag@MPBA) were applied as a SERS tag for isolation and classification of bacteria. Various types of bacteria can be captured by UCNPs@QAS through electrostatic interactions and by MAu@Ag@MPBA via the reversible recognition interaction of a boronic acid group of 4-MPBA and peptidoglycan from bacteria simultaneously. And then the formed complex structural assemblies were isolated rapidly from the sample matrix by employing the magnetic force for fast and simple dual-model optical detection. In addition, the novel biosensor was successfully applied to discriminate and detect Escherichia coli , Salmonella , Staphylococcus aureus, and their mixture in contaminated milk with the classification rate of 97.2–100 %. The proposed multi-functional nano-platform was able to sensitively capture, detect, and kill foodborne pathogens in a complex system, which could be deployed successfully towards the monitoring of food safety.
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ANALYTICAL CHEMISTRY
·
2020
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IF 6.785
Yan Zhou,Jia Liu,Tingting Zheng,Yang Tian
The aggregation of Aβ has been reported to closely correlate with Alzheimer’s disease (AD). However, clear monitoring of the entire aggregation process of Aβ from monomer to fibril has been scarcely reported until now. Herein, we developed a label-free ratiometric surface enhanced Raman spectroscopic (SERS) platform for real-time monitoring of the entire process of Aβ aggregation in neurons and brain tissues. Different gold nanoparticles, generated in situ with Aβ monomer and fibril as templates separately, were served as effective SERS substrates to achieve a high sensitivity with a limit of detection (LOD) down to 70 ± 4 pM and 3.0 ± 0.5 pM for Aβ40 monomer and fibrils, respectively. Besides, the introduction of ratiometric determination of Aβ monomer and fibril (I1244/I1268) realized real-time monitoring of the entire aggregation process of Aβ monomer with high accuracy and selectivity against other proteins and amino acids. The significant analytical performance of the developed platform, together with good biocompatibility, long-term stability, and remarkable spatial resolution, enabled the present SERS platform imaging and real-time monitoring and imaging of Aβ aggregation influenced by different metal ions (Cu2+, Zn2+, and Fe3+) in neurons and brain tissues at the single cell level. Our results suggested that Cu2+ and Zn2+ ion of low concentration (10 μM) promoted fibril formation, while Fe3+ and Zn2+ of high concentration (100 μM) showed inhibition of fibrosis.
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FOOD CHEMISTRY
·
2020
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IF 6.306
Leilei Wu,Hongbin Pu,Lunjie Huang,Da-Wen Sun
Synthetic dyes have been widely applied to food processing, but abuse of colourants in food may pose risks to human health. To analyze new coccine (NC) and orange II (OII) in food, a versatile surface-enhanced Raman scattering (SERS) platform was proposed. A metal-organic framework (MOF, UiO-66(NH 2 )) with octahedral crystal structure was synthesized and gold nanoparticles were grown on the MOF surface to fabricate UiO-66(NH 2 )@Au versatile SERS platform. The UiO-66(NH 2 )@Au displayed much better SERS performance than gold nanoparticles with high R 2 of 0.9684 for NC and 0.9912 for OII and low LOD of 0.4015 mg/L for NC and 0.0546 mg/L for OII. The recoveries of NC and OII in Mirinda soft drink and paprika ranged from 82.92 to 109.63%. This study provided a sensitive and rapid method for determination of NC and OII through UiO-66(NH 2 )@Au, and the proposed SERS platform revealed great potential for analyzing synthetic colourants in food samples.
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NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 44
·期 38
·16384-16389
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IF 3.288
Ru-Yi Tang,Zhang Lei,Yi-Jin Weng,Xue-Min Xia,Xia Zhang
Surface Enhanced Raman Scattering (SERS), with good reproducibility and stability, is an analytical testing technique that uses metals or metal nanoparticles as detection substrates, and it can also be used to characterize the information from molecular vibration. In this paper, we first report a facile one-step approach that allows the fabrication of assembled Ag NPs induced by polyaniline (PANI). Ag@PANI nanocomposites have the dual functions of saccharide-oxidase-like and peroxidase-like activities. Therefore, they can be used as a tandem enzyme to produce hydrogen peroxide from saccharides and catalyze the oxidation of TMB. At the same time, they can be considered as a SERS substrate to obtain the characteristic peaks of TMBox. In addition, on the basis of SERS, the effects of the Ag+ concentration, temperature and pH on the activity of Ag@PANI nanocomposites as the tandem enzyme are further explored. Under the optimal conditions, the common saccharides (sucrose, fructose, glucose and lactose) were detected with linear correlation (R2) in different concentration ranges, and ultra-sensitive detection of various saccharides under label-free conditions was achieved.
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Nanomaterials
·
2020
·Vol. 10
·期 5
·826
·
IF 4.324
Lingzi Zhang,Jun Liu,Guowei Zhou,Zhiliang Zhang
In this work, a series of highly flexible and sensitive surface-enhanced Raman scattering (SERS) substrates were fabricated by the in-situ growth of silver nanoparticles (AgNPs) on polydopamine (PDA) templated filter papers (FPs), based on mussel-inspired surface chemistry. The obtained FP@PDA@AgNPs strips exhibited high sensitivity and reproducibility with Rhodamine 6G (R6G) probe molecules, with a calculated detection limit of approximately 10−10M. More critically, these FP@PDA@AgNPs strips could be used as outstanding flexible SERS sensors to quickly collect and detect malachite green (MG) residues on fish scales, crab shells and shrimp skins by a swabbing extraction method. The detection limits for MG residues were calculated to be approximately as low as 0.04635 pg/cm2, 0.06952 pg/cm2and 0.09270 pg/cm2, respectively. This facile and efficient strategy could to be utilized as a universal approach to fabricating a variety of flexible, cheap and portable SERS sensors for surface contamination analysis, and has great potential in the environmental scientific analysis and food safety monitoring fields.Keywords:surface-enhanced Raman scattering;silver nanoparticles;polydopamine;filter paper;malachite green
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CHEMICAL ENGINEERING JOURNAL
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2020
·
IF 10.652
Yuan-Yuan Yang,Yuan-Ting Li,Xue-Jian Li,Lei Zhang,Essy Kouadio Fodjo,Sheng Han
A bio-inspired polydopamine (PDA) molecularly imprinted substrate is fabricated by one-step oxidative self-polymerization of dopamine and template molecules in weakly alkaline medium on screen-printed electrode (SPE). Through the catechol and amine groups on PDA surface, Au nanoparticles (AuNPs) can be easily anchored and growth on PDA-MIP coating, thereby forming a three-dimensional (3D) architecture. By adjusting the reaction conditions, the particle size and distribution of PDA and AuNPs can be well controlled. Benefiting from the “hot spots” generated by AuNPs and recognition sites produced by MIP, the AuNP/PDA-MIP nanocomposite can serve as excellent SERS substrate enabling selective enrichment and identification of phthalate plasticizers (PAEs). Using this substrate, an enhancement factor (EF) up to 1.70 × 10 7 for dimethyl phthalate (DMP) is achieved with a detection limit as low as 1.0 × 10 −10 M. Furthermore, the rebinding kinetics study demonstrates that the portable MIP-based SERS substrate can promptly reach the adsorption equilibrium within 10 min. Thanks to its highly selectivity, the substrate exhibits low SERS interference for structural analogues benzyl butyl phthalate (BBP) and di(2-ethylhexyl) phthalate (DEHP). Besides, the straightforward SERS recognition of DMP in surface water, commercial bottled water and liquor samples are successfully realized using this substrate. This green and environmental-friendly fabrication method is promising for synthesis of highly performance sensing substrate, adsorbent or catalysts. Combining with portable Raman spectrometer, the fabricated MIP-based SERS substrate has exhibited a great potential as on-site device for environmental monitoring, food safety and homeland security.
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SENSORS AND ACTUATORS B-CHEMICAL
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2020
·
IF 7.1
Chundong Liu,Maosen Yang,Jing Yu,Fengcai Lei,Yisheng Wei,Qianqian Peng,Chonghui Li,Zhen Li,Chao Zhang,Baoyuan Man
Surface-enhanced Raman spectroscopy (SERS) is widely used in chemical analysis, with very promising application prospects in daily life. However, there are still lots of problems in actual operation, for instance, pollutant detection from sewage, in which the analyte is often dispersed in nonhomogeneous solutions, leading to inaccurate Raman signal collection. Adjusting surface wettability to realize selective self-separation of multiphase liquids in situ on SERS substrate is an effective and challenging approach. In this work, a complex of CuO@Ag nanowires on Cu mesh modified by different wettability, converting from hydrophilic to hydrophobic by simple infrared illumination, is prepared as a multifunctional SERS substrate. Benefitting from the controllable wettability of the substrate, the multiphase solution can be self-separated and adsorbed at the two opposite terminals of it, and the 10 −9 M of malachite green and 10 −5 M of thiram used as two kinds of probe molecules can be separately detected at these two terminals. In addition, after fully hydrophobic modification, the substrate can be also used to extract the organic phase in the ‘water/oil’ mixture and perform in situ detection of the probe molecules in the ‘oil’.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 12
·1-9
·
IF 5.479
Feng Jun,Li Xuan,Cheng Hao,Huang Wenyi,Kong Hongxing,Li Yanqing,Li Lijun
An antibody-free immunoassay that makes use of a boronate affinity molecularly imprinted polymer (MIP) and surface enhanced Raman scattering (SERS) tags is described. It was applied to the specific determination of the carcinoembryonic antigen (CEA) in human serum. For the preparation of the boronate affinity array, a polymer capable of adsorbing glycoproteins was first synthesized on the surface of a glass slide with four spots using 4-vinylbenzeneboronic acid (VPBA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent, and ethylene glycol and cyclohexanol as porogens. The surface of the VPBA-Co-EGDMA can bind target glycoproteins. After specific capture of the glycoprotein, a “MIP-target glycoprotein-SERS tag” sandwich structure was formed by covalent interaction between the SERS nanotag (consisting of gold nanoparticles and 4-mercaptophenylboronic acid [MPBA]). CEA can be quantified in spiked serum with a detection limit of 0.1 ng·mL −1 via the specific Raman band at 1098 cm −1 .
Schematic representation of the boronate affinity molecularly imprinted polymer (MIPs) array-based SERS sensor for rapid and sensitive detection of the carcinoembryonic antigen (CEA) from human serum. The boronate affinity MIPs array are used as capture probes, and MPBA@AuNPs are used as SERS tags.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 9
·1-8
·
IF 5.479
Wang Ailin,Guan Ce,Shan Guiye,Chen Yanwei,Wang Chunliang,Liu Yichun
Silver-carbon dots (Ag-CDs) nanocomposites with excellent peroxidase-like and surface-enhanced Raman scattering (SERS) activities were fabricated by reducing silver ion with carbon dots. The formation of the core-shell structure was demonstrated by transmission electron microscopy. The Ag-CD nanocomposite catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H 2 O 2 to form oxidized TMB (oxTMB) that has a blue color with an absorption maximum at 652 nm. The catalytic activity originates from the fact that the electrons of CDs are transferred to H 2 O 2 and decompose H 2 O 2 into hydroxy radicals. The nanocomposites can be used for uric acid (UA) detection because UA can reduce oxTMB to form colorless TMB. The absorbance drops as the concentration of UA increases from 1 to 500 μM. The SERS signal of oxTMB can be detected (at 1605 cm −1 ) using the Ag-CD nanocomposites as SERS substrate. The intensity of the SERS signal decreases when the concentration of UA ranges from 0.01 to 500 μM.
Schematic representation of the fabrication of silver-carbon dots (Ag-CDs). The Ag-CDs catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H 2 O 2 to form blue-colored oxidized TMB (oxTMB). UA reduces oxTMB to form colorless TMB. This process is monitored by surface-enhanced Raman scattering (SERS) spectra for UA detection.
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Food Science and Human Wellness
·
2023
·
IF 7
Chen Chen,Yingfang Zhang,Ximo Wang,Xuguang Qiao,Geoffrey I.N. Waterhouse,Zhixiang Xu
Herein, a novel interference-free surface-enhanced Raman spectroscopy (SERS) strategy based on magnetic nanoparticles (MNPs) and aptamer-driven assemblies was proposed for the ultrasensitive detection of histamine. A core-satellite SERS aptasensor was constructed by combining aptamer-decorated Fe 3 O 4 @Au MNPs (as the recognize probe for histamine) and complementary DNA-modified silver nanoparticles carrying 4-mercaptobenzonitrile (4-MBN) (Ag@4-MBN@Ag-c-DNA) as the SERS signal probe for the indirect detection of histamine. Under an applied magnetic field in the absence of histamine, the assembly gave an intense Raman signal at “Raman biological-silent” region due to 4-MBN. In the presence of histamine, the Ag@4-MBN@Ag-c-DNA SERS-tag was released from the Fe 3 O 4 @Au MNPs, thus decreasing the SERS signal. Under optimal conditions, an ultra-low limit of detection of 0.65 × 10 -3 ng/mL and a linear range 10 -2 –10 5 ng/mL on the SERS aptasensor were obtained. The histamine content in four food samples were analyzed using the SERS aptasensor, with the results consistent with those determined by high performance liquid chromatography. The present work highlights the merits of indirect strategies for the ultrasensitive and highly selective SERS detection of small biological molecules in complex matrices.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Chucheng Wang,Junshan Han,Danni Xue,Chenjie Gu,Shuwen Zeng,Junhui Jiang,Tao Jiang,Xing Li,Kerong Wu
Surface-enhanced Raman scattering (SERS) technique with high sensitivity, reliable specificity, and rapid recognition ability exhibits attractive promise for the effective fast-monitoring of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, a novel SERS-active immunoassay kit for SARS-CoV-2 nucleocapsid (N) protein was prepared by in-situ growing gold (Au) nanowire forests (NFs) onto Ti 3 C 2 T x , which was then modified onto polymethyl methacrylate (PMMA) matrix and encapsulated into kit. It was noted that the Au nanowires with fibrous structures which vertically anchored on Ti 3 C 2 T x served as perfect channels to promote photo-induced charge transfer. The synergistic action of electromagnetic and chemical effects resulted in an enhancement factor (EF) of 1.27 × 10 7 . Furthermore, the unreliable fluctuation of the enhanced signal was eliminated by using the intrinsic Raman signal of the flexible PMMA platform, achieving an improved correlation coefficient (R 2 ) value from 0.950 to 0.990. Moreover, the as-designed immunoassay kit with both high sensitivity and remedied quantitative ability rendered by the Ti 3 C 2 T x @Au NFs-PMMA composite exhibited a powerful performance in the practical detection of N-protein with concentration low to 5.0 × 10 −8 mg/mL.
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