JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 34
·2170
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IF 2.8
Wang Yan,Su Congxue,Tao Wenlong,Chen Zelong,Fan Jun,Cheng Min,Chen Beiyi,Zhou Huanfu,Sun Yuan
In light of advancements in 5G/6G technologies, current research on microwave dielectric ceramics is focused on the development of materials characterized by low sintering temperatures and low permittivity, in order to satisfy the requirements of high-frequency low-temperature co-fired ceramic (LTCC) applications. Novel monoclinic structure GdBaK(MoO 4 ) 3 and YBaK(MoO 4 ) 3 ceramics, with C2 / c space group, were synthesized using a conventional solid-state method. GdBaK(MoO 4 ) 3 and YBaK(MoO 4 ) 3 ceramics were sintered at 830 °C and 850 °C, exhibited ε r ~ 8.54 and 8.77, τ f ~ − 51.1 ppm/°C and − 45.8 ppm/°C, Q × f ~ 23, 240 GHz and 59, 277 GHz, respectively. The compression from Ba 2+ and K + cations was identified as the main reason for the higher theoretical ε theo compared to the corrected ε corr . The dielectric loss of both ceramics is mainly affected by the density and packing fraction. The full width at half maximum (FWHM) values of the vibrational peak at 932 cm −1 , corresponding to the symmetric stretching modes of MoO 4 2− , exhibits a negative correlation with the Q × f values. Based on the P–V–L theory, the lattice energy and bond energy associated with the Mo–O bond played a substantial role in influencing the Q × f and τ f . Moreover, YBaK(MoO 4 ) 3 showed good chemical compatibility with Ag, indicating its potential for LTCC applications.
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JOURNAL OF MATERIALS RESEARCH
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2025
·
IF 2.9
Dong Ningning,Guan Jinwei,Zhang Yuan,Liu Lu,Guo Li,Chao Liuxin,Sun Zhengming,Ying Guobing
In this work, bionic structure design was introduced to optimize the mechanical properties of ceramics using Si 3 N 4 fibers and BN interfaces. It was shown that Si 3 N 4 f /BN i fibrous monolithic ceramic possessed outstanding fracture toughness with the K IC value of 13.06 MPa·m 1/2 while retaining the flexural strength of 603.59 MPa. This indicated that the BN interfaces extended the crack propagation path and improved the fracture toughness of ceramics. Meanwhile, the densification of ceramics was efficiently promoted by the constant application of pressure starting from room temperature during the sintering process, with a density of up to 3.18 g/cm 3 . An innovative fiber inclusion model was first established to calculate the residual stress, and predict the flexural strength considering residual stress. This work offers new prospects for the synchronous realization of high strength and toughness in Si 3 N 4 ceramics and for predicting the strength of fibrous monolithic ceramics. Graphical abstract
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Nature Communications
·
2025
·
IF 15.7
Zhu Yuxin,Guo Zhengyang,Zeng Jian,Zhao Jinfu,Li Hongguan,Gao Guangying,Di Shuanlong,Wang Shulan,Li Li
Manganese-rich layered transition-metal oxides are of great interests as positive electrodes for sodium-ion batteries considering their high specific capacity and operating voltage. However, it remains challenging to synthesize layered transition-metal oxides with high stability and rapid ion-migration kinetics. Herein, we develop a straightforward and universal synthesis approach for P2-type layered transition-metal oxides by simply updating the conventional solid-state reaction with only additional dicyandiamide introduced. We reveal the ammonia released successfully restrains the irreversible oxygen redox for stabilizing cationic migration and decreases the crystallization temperature for high-quality structure formation. The effectively suppressed Jahn-Teller distortion and facilitated Na + transport kinetics therefore endow Na 1/2 MnO 2 with overall performance enhancement, including a 6.7-fold improvement in rate capability and enhanced cycling stability. Similar performance enhancements are also found in other manganese-based layered transition-metal oxides, presenting great strategy universality. This work marks a key step forward in the synthesis-by-design of high-performance sodium-ion batteries electrode materials.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·
IF 12.6
Hu Zhihao,Li Hongji,Gan Kai,Li Yu,Jiang Yao,Zhang Keying,Li Zhengxuan,Zhou Yike,Lu Tong,Xu Chao,Liu Shaojie,He Limin,Yang Fa,Jiang Jun,Song Hongtao,Wang Ying,Guo Li,Shi Changhong,Wen Weihong,Han Donghui,Qin Weijun
Radioresistance and off-target toxicity remain major challenges in prostate cancer (PCa) radiotherapy. Here, we report a biomimetic nanoplatform (Au/MOF-FIN@M-gy1) that synergistically enhances radiation deposition and ferroptosis for precision radiosensitization. By engineering macrophage membranes with prostate-specific membrane antigen (PSMA)-targeting nanobodies (gy1), we achieve tumor-selective delivery of Au/MOF nanoparticles preloaded with ferroptosis inducers (FINs). Upon lysosomal release, FINs disrupt redox homeostasis via GPX4 suppression, while Au/MOF amplifies radiation-induced reactive oxygen species (ROS), collectively triggering lethal lipid peroxidation cascades. This dual mechanism is further demonstrated to elicit radiosensitizing effects in both bone-metastatic and radio-refractory PCa models without requiring radiation dose escalation, thereby improving the therapeutic index. Our study demonstrates a nanoparticle-enabled strategy to enhance tumor-specific radiotherapy by dual-targeting metabolic vulnerabilities.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Ji Mingbo,He Jiexian,Yang Dacan,Cui Yiqun,Zhang Wenxue,Liu Xiaolong,Ma Fuqiu,Feng Haining,Wang Guixiang
The growing demand for high-specific-activity 177 Lu necessitates efficient Yb/Lu separation. This study synthesized and characterized novel phosphorus-containing levextrel resins. HEH(EHP)-based resin achieved over 99% Lu adsorption under low acidity with a separation factor ( SF Yb/Lu ) exceeding 3, while HDEHP-based resin showed faster kinetics. Using the optimized HDEHP/HEH(EHP)-XAD-7 resin, a three-cycle process yielded 94.98% Lu recovery, and a secondary separation achieved 83.37% Yb removal. These findings demonstrate the resin’s high efficacy for producing high-purity 177 Lu. Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·10533
·
IF 15.7
Han Gaojie,Cheng Hongli,Feng Yuezhan,Zhang Shiliang,Dong Jingwen,Zhou Bing,Liu Xianhu,Liu Chuntai,Tao Guangming,Shen Changyu
Layered film-based thermal management materials with high in-plane thermal conductivity can effectively diffuse point heat sources and prevent local overheating. However, their low through-plane thermal conductivity limits its overall heat dissipation. Here, we introduce a honeycomb-gel densification strategy that forms zigzag yet continuous interlayer phonon bridges within the layered structure. This design establishes bi-directional thermal pathways, boosting both in-plane and through-plane thermal conductivity by 488.9% and 503.3% of the aramid nanofiber/boron nitride nanosheet, respectively, compared to random-gel densified films. Also, the aramid nanofiber/boron nitride nanosheet film exhibits high solar reflectivity, infrared emissivity, and thermal radiation, enabling efficient subambient cooling (17.2 °C at 100 mW/cm²) for heat-generating devices.
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JOURNAL OF NANOBIOTECHNOLOGY
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2025
·
IF 12.6
Leye Yan,Xinyan Hu,Jianan He,Hairun Gan,Yang Shi,Luting Li,Siyu Li,Kunpeng Wei,Jiaxing Wei,Jianxun Cai,Bing Li,Pengfei Pang
Atherosclerosis is a chronic inflammatory disease affecting arterial walls and remains a leading cause of morbidity and mortality worldwide. While anti-inflammatory therapy is widely recognized as a critical component in the management of atherosclerosis, current treatments are often limited by adverse effects and suboptimal efficacy. Membrane-derived nanovesicles have demonstrated excellent biocompatibility and prolonged circulation times, making them effective drug delivery carriers. However, their targeting capabilities remain limited, as only a small fraction of transmembrane proteins possesses intrinsic targeting functions. To overcome these limitations and leverage the targeting capability of folate in inflammatory disease, we designed biomimetic nanovesicles modified with folate by covalently conjugating folate-C 6 -PEG 4 -NHS to nanovesicles under physiological conditions enabling efficient drug delivery to atherosclerotic plaques. Meanwhile we also identified the PU.1 inhibitor DB1976 as an anti-inflammatory target for the treatment of atherosclerosis. Mechanistically, DB1976 suppresses inflammation by inhibiting the IL-1β/NF-κB signaling pathway, reducing reactive oxygen species (ROS) levels, and decreasing apoptosis rates. Folate-modified biomimetic nanovesicles loaded with DB1976 achieved promising therapeutic outcomes. In summary, folate-modified macrophage biomimetic nanovesicles loaded with a PU.1 inhibitor effectively alleviate atherosclerosis by targeting inflammation in atherosclerotic plaques, highlighting their potential as a promising therapeutic strategy for atherosclerosis treatment.
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MARINE BIOTECHNOLOGY
·
2025
·Vol. 27
·期 6
·155
·
IF 2.8
Xiang Jionghua,Wu Qiming,Xu Kai,Liu Qun,Nie Yusen,Weng Wuyin,Zhang Yucang,Wang Haiqi
At present, shells have been used to incubate Pyropia haitanensis ( P. haitanensis ) shell-boring conchocelis. To develop a more convenient substrate for P. haitanensis conchocelis cultivation, a novel P. haitanensis shell-boring conchocelis culture substrate (CaCO 3 /LPE/CA) was developed from calcite, low-density polyethylene, and calcium alginate. The mechanical properties and stability of CaCO 3 /LPE/CA, including implanting density (ID) and Yield per unit area, were tested. The results showed that the CaCO 3 /LPE/CA met practical P. haitanensis shell-boring conchocelis breeding application requirements. P. haitanensis was successfully cultured on CaCO 3 /LPE/CA, and its life cycle was observed through biomicroscopy and scanning electron microscopy (SEM). After conchospores was succrssfully reseased from P. haitanensis conchosporangial branch, the movement and germination of conchospores were also observed. The yield of conchospores per unit area of optimized CaCO 3 /LPE/CA reached 369.6 × 10 3 conchospores/cm 2 , making it a suitable candidate for P. haitanensis shell-boring conchocelis cultivation. Overall, CaCO 3 /LPE/CA exhibits great potential as a marine bioactive material, and the process and cost of P. haitanensis culture breeding could be simplified due to its comprehensive characteristics.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2025
·
IF 0
Wu Guizhi,Duan Xuebin,Xu Hongqing,Han Chunyu,Liu Jing,Yan Boyin,Li Jincheng,Wang Jianming,Wang Songxue
The UV/SPC process was employed for the removal of rhodamine B (RhB), and the influences of reaction parameters and natural water components on the degradation of RhB were systematically studied. The results demonstrate that RhB can be efficiently eliminated in the UV/SPC system compared to using UV photolysis or SPC oxidation alone, with •OH and CO 3 •− being the main radicals to degrade RhB. The degradation efficiency of RhB was enhanced with increasing SPC concentration but decreased with increasing initial RhB concentration. Moreover, the degradation efficiency of RhB decreased with the increasing initial pH. When pH increased from 3 to 11, the degradation efficiency of RhB declined from nearly 100 to 81.93% within 20 min. Natural organic matter (NOM) and anions (Cl − and HCO 3 − ) exhibited an inhibitory effect on the degradation of RhB in the UV/SPC system, and the inhibitory effect was aggravated with the increase of NOM and anion concentrations. Consequently, there was a decrease in the degradation efficiency of RhB in the UV/SPC system in real water compared to pure water. The byproducts generated during the degradation of RhB were attributed to hydroxylation, N -deethylation, and C-O bond cleavage. Some intermediate products from RhB degradation still pose relatively high environmental risks, while most have low environmental hazards.
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Journal of Environmental Health Science and Engineering
·
2025
·Vol. 23
·期 2
·40
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IF 2.8
Suanon Fidèle,Kanhounnon Wilfried G.,Hounfodji Jean Wilfried,Kiki Claude,Zeng Qiaoting,Kpotin Gaston,Yete Pelagie,Tometin Lyde Arsène Sewedo,Atohoun Yacolé Guy Sylvain,Yu Chang-Ping,Mama Daouda,Qian Sun
Mitigating the pollution of water by emerging contaminants (ECs) presents a critical environmental challenge that demands innovative, effective, cost-efficient, and sustainable strategies. In this study, the potential of TiO₂-modified activated carbon (AC) for the sequestration of ECs from water was evaluated through a combined experimental and in silico approach, using molecular modeling based on density functional theory (DFT). Unmodified AC removed 67.76–82.09% of ECs such as carbamazepine, flumequine, clarithromycin, azithromycin, and roxithromycin, and 44.54–52.27% of sulfamerazine, sulfamethoxazole, sulfamonomethoxine, trimethoprim, and levofloxacin. Incorporating TiO₂ and utilizing sunlight improved removal efficiencies to 93.09–99.91%. The hydrophobicity of contaminants significantly influenced adsorption. Kinetic and isotherm analyses indicated chemical interaction-driven, monolayer adsorption, with the Langmuir model fitting best (R² = 0.9856–0.9975). Textural analysis of TiO₂–AC (10% TiO₂) revealed a surface area of 557.72 m²·g⁻¹ and a pore volume of 0.317 cm³·g⁻¹, supporting its high adsorption potential. Fourier transform infrared spectroscopy and molecular modeling identified functional groups facilitating adsorption, while DFT provided insights into energetic and non-covalent interactions (NC-interaction) including hydrogen bonding, van der Waals forces (VDW-forces), and charge transfer that occur during the process. TiO₂-modified AC demonstrates high efficiency for pharmaceutical removal from water, highlighting great promise as a sustainable and advanced adsorbent material, offering practical solutions for tackling diverse water pollution challenges.
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Alzheimers Research & Therapy
·
2025
·Vol. 17
·期 1
·253
·
IF 7.6
Liu Li-Rong,Li Li,Lu Li-Li,Fan Shu-Juan,Liu Li-Zhe,He Ruo-Bing,Li He,Xian Xiao-Hui,Li Wen-Bin
Background Mitochondrial dysfunction and dysregulated calcium homeostasis contribute to Alzheimer’s disease (AD) pathogenesis. The extrasynaptic N-methyl-D-aspartic acid (NMDA) receptor (eNMDAR) plays a crucial role in calcium influx and subsequent signaling cascades. In individuals with AD, the reduced expression and function of glutamate transporter-1 (GLT-1) result in glutamate spillover from the synaptic clefts to the extrasynaptic region, thereby activating eNMDAR and inducing mitochondrial damage. Ceftriaxone (Cef) has been reported to ameliorate cognitive deficits in APPswe/PS1dE9 (APP/PS1) mice by upregulating GLT-1. This study aimed to explore whether Cef alleviates mitochondrial dysfunction to improve cognitive impairment and the roles of GLT-1 and eNMDAR, particularly the participation of eNMDAR-induced intracellular calcium signaling in this process. Methods C57BL/6J, APP/PS1, and GLT-1-knockdown APP/PS1 mice were used. NMDA (1 mM, 2 µL per ventricle) was injected cerebroventricularly into APP/PS1 mice once to activate eNMDAR. Cef (200 mg/kg) was intraperitoneally administered for 14 days. Cognitive function was evaluated by novel object recognition, novel location recognition and Morris water maze tests. Hippocampal mitochondrial ultrastructure was observed using transmission electron microscopy. Hippocampal mitochondrial membrane potential (MMP) was detected using JC-1 staining. The expression of eNMDAR and proteins related to mitochondrial biogenesis and dynamics was evaluated by western blot. A neuron‒astrocyte coculture derived from the cerebral cortex of embryonic mice was used to evaluate the effects of Cef on eNMDAR-induced neuronal calcium influx, mitochondrial calcium accumulation and MMP loss using live-cell imaging. Results Cef treatment attenuated hippocampal mitochondrial dysfunction, including ultrastructural damage, reduced aspect ratio, dysregulation of MMP, impaired biogenesis and dynamics, and cognitive deficits, and prevented the upregulation of eNMDAR expression in APP/PS1 mice in a GLT-1-dependent manner. These protective effects on hippocampal mitochondrial dysfunction and cognitive deficits were counteracted by eNMDAR activation. Furthermore, Cef incubation inhibited eNMDAR-mediated calcium influx in a GLT-1-dependent way and reduced MMP in primary cortical neurons. Notably, Cef incubation significantly suppressed mitochondrial calcium overload, which was mechanistically linked to the observed decline in MMP. Conclusions Cef treatment prevented the upregulation of eNMDAR expression and the subsequent extracellular calcium influx in a GLT-1-dependent manner, thereby reducing mitochondrial calcium loading and ultimately mitigating mitochondrial damage and cognitive deficits in APP/PS1 mice.
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Neuroscience Bulletin
·
2025
·
IF 5.8
Zhang Haifeng,Su Tiantian,Wu Xiaoke,Shi Mengmeng
There is a vicious cycle between brain metabolism and epileptic seizures that compounds the deleterious consequences of seizures. Human epilepsy samples implicate cholesterol 25-hydroxylase (CH25H) in linking lipid metabolism and immunity. CH25H expression increased in microglia after status epilepticus, with its product 25-hydroxycholesterol (25-HC) accumulating in the hippocampus and blood. Thus, we generated microglia-specific CH25H knockdown mice to study the role of CH25H specifically in epilepsy. CH25H knockdown inhibited the assembly and activation of NLRP3 inflammasome and restrained the loss of neurons in the hippocampal area in epileptic mice. More importantly, CH25H knockdown reduced the number of recurrent seizures and time in seizure by electroencephalogram recording, which was partly reversed after 25-HC treatment. Untargeted metabolomics showed that another lipid metabolite, arachidonic acid, might be a potential biomarker of CH25H-mediated epilepsy. These findings suggest that microglial CH25H regulated the status epilepticus in a hydroxylase-dependent mechanism.
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