Nature Communications
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2025
·Vol. 16
·期 1
·1-11
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IF 15.7
Zhang Yue,Ming Zechang,Zhou Zijie,Wei Xiaojie,Huang Jingjing,Zhang Yufan,Li Weikang,Zhu Liming,Wang Shuang,Wu Mengjie,Lu Zeren,Zhou Xinran,Xiong Jiaqing
Temperature-adaptive elastic conductive fibers (ECFs) are crucial for seamlessly integrating electronic textiles, promoting the development of wearables, soft robotics, and high/low-temperature electronics. Realizing ECFs with balanced elasticity, conductivity, and temperature adaptivity remains challenging due to the difficulty of coupling the mechano-electrical-thermal properties at a microscale fiber. We design a wet-spun ECF consisting of thermoplastic polyurethane (TPU), silver flakes (AgFKs) and liquid metal microspheres (LMMSs) with regularly arranged filler architecture, revealing a cold/thermal stretching activated tricomponent-dynamic-coordination mechanism for autonomously-enhanced electrical conductivity (from ~1070 S cm −1 at 25 °C to 1160 S cm −1 at −30 °C and 3020 S cm −1 at 180 °C) and improved electrical stability to sustain 1000 stretching cycles (60% strain at 80 °C). The fiber exhibits scalability and favorable knittability, demonstrating e-textiles such as biomedical electrodes, high/low-temperature near-field communication gloves, and intelligent firefighting suits. The autonomous mechano-thermo-electrical coupling strategy can inspire high-performance and environment-adaptive ECFs for extreme applications.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Fan Yun,Yan Yunhui,An Qizheng,Xia Zhongcheng,Pan Yuping,Lu Yuxuan,Zhu Zhonghuan,Wang Ruiqi,Liu Qinghua,Zou Yuqin,Li Yongjun,Wang Shuangyin
The use of renewable electricity to drive the electrocatalytic coupling of CO with nitrogen-containing organics offers a promising strategy for producing high-value chemicals. In this work, we conduct a systematic investigation of the coordination effect between iodide and copper oxide to generate Cu δ+ active sites. These Cu δ+ sites enable the electrosynthesis of dimethylacetamide from CO and dimethylamine. Through precise regulation of the electrode surface microenvironment, a dimethylacetamide Faradaic efficiency of 45.6% is achieved at a partial current density of 182.4 mA·cm -2 , with a production rate of 435.9 mmol·g cat. −1 ·h -1 and selectivity approaching 70%. Mechanistic studies reveal that specific adsorption of I - forms an iodide-enriched Cu 0 /Cu + interface that synergistically promotes dimethylacetamide formation by enhancing adsorption of ketene intermediates (*CCO) and facilitating C–N bonds formation. This anion-coordination interfacial engineering strategy demonstrates broad applicability for synthesizing various acetamide derivatives from CO 2 /CO and amine, providing a foundational framework for electrocatalytic C-N coupling in acetamide synthesis.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
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2024
·Vol. 130
·期 11
·1-17
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IF 2.5
Xu Dian,Yang Mingxin,Luo Zhengwei,Lian Zhouyang,Zhou Yongzhang,Geng Wenhua,Kong Weifeng,Li Jiaojiao
It is well known that zinc oxide (ZnO) is recognized as a highly effective and stable inorganic antibacterial material. The dispersibility and microstructure of ZnO play crucial roles in determining its antibacterial activity. In this investigation, we successfully synthesized ZnO nanoparticles with exceptional dispersibility and potent antibacterial properties through ultrasonic sonication, utilizing sodium hexametaphosphate, sodium dodecyl benzene sulfonate, and sodium polyacrylate as effective dispersants. To comprehensively assess the impact of these dispersants on the structure and morphology of the ZnO nanoparticles, various characterization techniques, including X-ray diffraction analysis, transmission electron microscopy imaging, Fourier transform infrared spectroscopy, thermogravimetric analysis, UV‒Vis absorption spectroscopy, X-ray photoelectron spectroscopy, and zeta potential analysis, were employed. The average particle sizes calculated for ZnO-SHMP, ZnO-SDBS, and ZnO-PAAS are approximately 300 nm. The zeta potential of ZnO-SHMP, ZnO-SDBS, and ZnO-PAAS are − 18.67, -12.77, and − 16.77 mV, which is significantly lower than that of the pristine ZnO (-2.01 mV). Our findings demonstrate that the addition of dispersants significantly enhances the dispersibility of ZnO nanoparticles while also improving their antibacterial efficacy against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) by achieving an antibacterial rate exceeding 99%. It’s observed that the introduction of dispersants led to morphological changes in the ZnO particles, contributing to their enhanced antibacterial activity. Compared with dark conditions, particularly under fluorescent lamp irradiation, superior antibacterial effects were achieved. Mechanistically, our findings suggest that the synergistic effect of the ZnO-bacteria interaction, along with soluble Zn 2+ ions and the generation of reactive oxygen species, accounts for the observed antibacterial efficacy. The average contents of ZnO-PAAS released Zn 2+ in the liquid culture media of E. coli and S. aureus were 27.5 mg/L and 41.1 mg/L, respectively, higher than that of the pristine ZnO. The incorporation of ZnO, which is prepared with a dispersant, into waterborne paint yields a pronounced antibacterial effect, rendering it highly promising for practical applications such as antibacterial coatings.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-17
·
IF 14.7
Huang Yanli,Wan Xufeng,Su Qiang,Zhao Chunlin,Cao Jian,Yue Yan,Li Shuoyuan,Chen Xiaoting,Yin Jie,Deng Yi,Zhang Xianzeng,Wu Tianmin,Zhou Zongke,Wang Duan
Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis to amplify the efficacy of sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine and copper, the ultrasound-activated piezo-hot carriers transfer easily to copper by polydopamine. It boosts reactive oxygen species production by piezoelectrics, and facilitates the interconversion between Cu2 + and Cu + to promote hydroxyl radical generation via Cu + -catalyzed chemodynamic reactions. Finally, the elevated reactive oxygen species cause bacterial membrane structure loosening and DNA damage. Transcriptomics and metabolomics analysis reveal that intracellular copper overload restricts the tricarboxylic acid cycle, promoting bacterial cuproptosis-like death. Therefore, the polyetherketoneketone scaffold engineered with the designed nanoreactor shows excellent antibacterial performance with ultrasound stimulation and promotes angiogenesis and osteogenesis on-demand in vivo.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-17
·
IF 14.7
Lin Lin,Ba Zhaojing,Tian Hao,Qin Haoxiang,Chen Xi,Zhou Xin,Zhao Shanlan,Li Lang,Xue Fangchao,Li Hong,He Lang,Li Xiaochen,Du Jiahui,Zhou Zhenhua,Zeng Wen
There is no effective and noninvasive solution for thrombolysis because the mechanism by which certain thrombi become tissue plasminogen activator (tPA)-resistant remains obscure. Endovascular thrombectomy is the last option for these tPA-resistant thrombi, thus a new noninvasive strategy is urgently needed. Through an examination of thrombi retrieved from stroke patients, we found that neutrophil extracellular traps (NETs), ε-(γ-glutamyl) lysine isopeptide bonds and fibrin scaffolds jointly comprise the key chain in tPA resistance. A theranostic platform is designed to combine sonodynamic and mechanical thrombolysis under the guidance of ultrasonic imaging. Breakdown of the key chain leads to a recanalization rate of more than 90% in male rat tPA-resistant occlusion model. Vascular reconstruction is observed one month after recanalization, during which there was no thrombosis recurrence. The system also demonstrates noninvasive theranostic capabilities in managing pigs’ long thrombi (>8 mm) and in revascularizing thrombosis-susceptible tissue-engineered vascular grafts, indicating its potential for clinical application. Overall, this noninvasive theranostic platform provides a new strategy for treating tPA-resistant thrombi.
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Nature Nanotechnology
·
2025
·
IF 34.9
Wang Dong,Ji Lei,Li You,Xu Meng,Wang Hao,Brovelli Sergio,Qiao Zeng-Ying,Zhang Jiatao,Li Yadong
Chemodynamic therapy and sonodynamic therapy are two promising tumour therapeutic strategies. However, lack of highly effective sonosensitizers and control over chemodynamic therapy limit their application. Here we synthesize silver-doped zinc selenide quantum dots with atomically dispersed superficial Fe and show that they act as efficient sonosensitizers, catalysers and immunoreagents. Surface modification with an in situ self-assembly peptide drives accumulation in tumours. Superficial Fe III remains stable and converts to Fe II only under ultrasonic processing, reverting to Fe III upon ultrasound cessation. Under ultrasound stimulation, superficial Fe undergoes valence change with concomitant amelioration of the hypoxic tumour microenvironment and production of sonodynamic therapy-beneficial hydroxyl radicals. Furthermore, silver doping suppressed nonradiative recombination of excitons, leading to improved production of singlet oxygen. Meanwhile, selenium promotes robust systemic immune responses for the inhibition of tumour metastases. This nano-platform allows control of valence switching of atomically dispersed catalysts, representing an effective tool for chemodynamic/sonodynamic/immunotherapy.
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Advanced Fiber Materials
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2025
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IF 21.3
Dong Xiang,Ma Yan,Zhang Shidai,Rong Caiyu,Jiang Xiaoyu,Li Yan,Nie Shibin,Tian Konghu
Smart firefighting clothing is in urgent need of rigorous fire resistance. Here, a novel 2D nanomaterial, silver nanoparticle@polydopamine@M(OH)(OCH 3 ) (M=Co, Ni) (AgNP@PDA@M(OH)(OCH 3 )), was utilized to construct self-assembled nano-coated aramid fiber (NCANF). Through phase interface catalysis and high-temperature reduction, NCANF forms a distinctive “metal–carbon–air” honeycomb-like buffer that enables NCANF to withstand the butane flame (1300 °C) for at least 60 s, exceeding the performance of firefighting uniform (FU, Nomex) in service. In this process, the back temperature of NCANF decreased by more than 50% compared to FU, with a maximum difference of 236.1 °C. NCANF offers a rapid fire alarm response under 3 s with a maximum resistance change rate of 15%, and supports the graded indication using arithmetic amplifier circuit. NCANF maintained a maximum resistance change rate of approximately 63% during 50 repeated bends of the manipulator joint. Leveraging the relationship between the joint bending angle and resistance change rate, an “attitude code” system can be established as the initial parameter matrix of a neural network and can enable the recognition of the firefighters’ body language. NCANF well solves the problem of current smart firefighting clothing that lacks rigorous fireproofing and is promising to establish a linked rescue mode based on real-time on-site information collection. Graphical
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Advanced Fiber Materials
·
2025
·
IF 21.3
Feng Yuhao,Hai Guangtong,Sun Guoxu,Chen Keke,Wang Xiyao,Zhao Jindi,Li Yang,Chen Xiao
The rapid development of miniaturized and high-power electronics urgently demands multifunctional materials that simultaneously mitigate thermal shock and electromagnetic interference (EMI). While phase change materials (PCMs) offer thermal buffering capabilities, their limited thermal conductivity and inability to address EMI restrict applications in integrated electronic systems. Herein, we develop multi-interfacial engineered composite PCMs (PW–MXene/CNFs@MoS 2 ) that synergistically integrate thermal management and electromagnetic wave (EMW) absorption. Through hierarchical assembly of 2D MXene and MoS 2 nanosheets on a 3D carbon nanofiber (CNF) network, composite PCMs achieve synergistic dual functionality. The architecture establishes an efficient phonon conductive framework for rapid thermal dissipation, while maintaining remarkable heat storage capacity of 121.8 J/g. Additionally, polarization-enhanced heterointerfaces enable excellent EMW absorption (− 64.1 dB reflection loss across 4.28 GHz bandwidth below 2.1 mm). The composite PCMs also exhibit outstanding cyclic stability, retaining 97% of their phase change enthalpy after 300 thermal cycles, while maintaining superior leakage resistance under combined thermal and mechanical stresses. Practical validation reveals its dual functionality: a 6.4 °C thermal buffer under 1200 W/m 2 thermal shock and effective Bluetooth signal shielding. This work provides an innovative solution for the synergistic management of thermal shock and electromagnetic interference issues, showing viable potential for applications in advanced electronic systems. Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Zhang Jie,Liu Yong,Dittrich Thomas,Wang Zhuan,Ji Pengxiang,Li Mingrun,Ta Na,Zhang Hongyan,Zhen Chao,Xu Yanjun,Li Dongfeng,Feng Zhendong,Li Zheng,Luo Yaling,Cui Junhao,Su Dong,Weng Yuxiang,Liu Gang,Wang Xiuli,Fan Fengtao,Li Can
Charge separation is a critical process for achieving high photocatalytic efficiency, and ferroelectrics hold significant potential for facilitating effective charge separation. However, few studies have demonstrated substantial photocatalytic activity in these materials. In this study, we demonstrate that in ferroelectric PbTiO 3 , surface Ti vacancy defects near the positively polarized facets impede photocatalytic performance by trapping electrons and inducing their recombination. To tackle this issue, we selectively grew SrTiO 3 nanolayers on the polarized facets PbTiO 3 , effectively mitigating interface Ti defects. This modification establishes a efficient electron transfer pathway at the interface between the positively polarized facets and the cocatalyst, extending the electron lifetime from 50 microseconds to the millisecond scale and significantly increasing electron participation in water-splitting reactions. Consequently, the apparent quantum yield for overall water splitting achieves the highest values reported to date for ferroelectric photocatalytic materials. This work provides an effective strategy for designing advanced ferroelectric photocatalytic systems.
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Neuroscience Bulletin
·
2025
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IF 5.8
He Junqiu,Sun Shan,Wang Hongfeng,Ying Zheng,Tam Kin Yip
Alzheimer’s disease (AD) poses one of the most urgent medical challenges in the 21st century as it affects millions of people. Unfortunately, the etiopathogenesis of AD is not yet fully understood and the current pharmacotherapy options are somewhat limited. Here, we report a novel inhibitor, Compound 44, for targeting cholinesterases, amyloid-β (Aβ) aggregation, and glycogen synthase kinase 3β (GSK-3β) simultaneously with the aim of achieving symptomatic relief and disease modification in AD therapy. We found that Compound 44 had good inhibitory effects on all intended targets with IC 50 s of submicromolar or better, significant neuroprotective effects in cell models, and beneficial improvement of cognitive deficits in the triple transgenic AD (3 × Tg AD) mouse model. Moreover, we showed that Compound 44 acts as an autophagy regulator by inducing nuclear translocation of transcription factor EB through GSK-3β inhibition, enhancing the biogenesis of lysosomes and elevating autophagic flux, thus ameliorating the amyloid burden and tauopathy, as well as mitigating the disease phenotype. Our results suggest that triple-target inhibition via Compound 44 could be a promising strategy that may lead to the development of effective therapeutic approaches for AD.
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-14
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IF 10.6
Shen Wenqi,Li Yecheng,Yang Ziyi,Li Wenjing,Cao Yi,Liu Yilin,Wang Zheng,Pei Renjun,Xing Chungen
The combination of immune checkpoint inhibitors and immunogenic cell death (ICD) inducers has become a promising strategy for the treatment of various cancers. However, its efficacy remains unmet because of the dense stroma and defective vasculatures in the tumor microenvironment (TME) that restricts the intratumoral infiltration of cytotoxic T lymphocytes (CTLs). Herein, cancer-associated fibroblasts (CAFs)-targeted nanoemulsions are tailored to combine the ICD induction and the TME reprogramming to sensitize checkpoint blockade immunotherapy. Melittin, as an ICD inducer and an antifibrotic agent, is efficiently encapsulated into the nanoemulsion accompanied by a nitric oxide donor to improve its bioavailability and tumor targeting. The nanoemulsions exhibited dual functionality by directly inducing direct cancer cell death and enhancing the tumoral immunogenicity, while also synergistically reprogramming the TME through reversing the activated CAFs, decreasing collagen deposition and restoring tumor vessels. Consequently, these nanemulsions successfully facilitated the CTLs infiltration and suppressing the recruitment of immunosuppressive cells. A combination of AE-MGNPs and anti-CTLA-4 antibody greatly elicited a striking level of antitumor T-cell response to suppress tumor growth in CAFs-rich colorectal tumor models. Our work emphasized the integration of the ICD induction with simultaneous modulation of the TME to enhance the sensitivity of patients to checkpoint blockade immunotherapy.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-14
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IF 10.6
Sun Xiaodong,Li Yujie,Liu Xiaowan,Cui Dandan,Shi Yujiao,Huang Guojia
Background Properly designed second near-infrared (NIR-II) nanoplatform that is responsive tumor microenvironment can intelligently distinguish between normal and cancerous tissues to achieve better targeting efficiency. Conventional photoacoustic nanoprobes are always “on”, and tumor microenvironment-responsive nanoprobe can minimize the influence of endogenous chromophore background signals. Therefore, the development of nanoprobe that can respond to internal tumor microenvironment and external stimulus shows great application potential for the photoacoustic diagnosis of tumor. Results In this work, a low-pH-triggered thermal-responsive volume phase transition nanogel gold nanorod@poly(n-isopropylacrylamide)-vinyl acetic acid (AuNR@PNIPAM-VAA) was constructed for photoacoustic detection of tumor. Via an external near-infrared photothermal switch, the absorption of AuNR@PNIPAM-VAA nanogel in the tumor microenvironment can be dynamically regulated, so that AuNR@PNIPAM-VAA nanogel produces switchable photoacoustic signals in the NIR-II window for tumor-specific enhanced photoacoustic imaging. In vitro results show that at pH 5.8, the absorption and photoacoustic signal amplitude of AuNR@PNIPAM-VAA nanogel in NIR-II increases up obviously after photothermal modulating, while they remain slightly change at pH 7.4. Quantitative calculation presents that photoacoustic signal amplitude of AuNR@PNIPAM-VAA nanogel at 1064 nm has ~ 1.6 folds enhancement as temperature increases from 37.5 °C to 45 °C in simulative tumor microenvironment. In vivo results show that the prepared AuNR@PNIPAM-VAA nanogel can achieve enhanced NIR-II photoacoustic imaging for selective tumor detection through dynamically responding to thermal field, which can be precisely controlled by external light. Conclusions This work will offer a viable strategy for the tumor-specific photoacoustic imaging using NIR light to regulate the thermal field and target the low pH tumor microenvironment, which is expected to realize accurate and dynamic monitoring of tumor diagnosis and treatment.
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