COLLOIDS AND SURFACES B-BIOINTERFACES
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2018
·
IF 3.997
Miao Zhao,Ying Chen,Rongcheng Han,Dan Luo,Libo Du,Qiang Zheng,Lijun Wang,Yuankai Hong,Yang Liu,Yinlin Sha
We here report a facile synthesis of chitosan shelled quantum dot (QD/fGC) that holds essential properties requisite for biological applications, such as excellent water solubility, super colloidal stability, and low nonspecific adsorption as well as ease of functionalization. In this method, the amphiphilic glycol chitosan fragment (MW 1.0–1.7 kDa) was assembled on the top of CdSeS/ZnS nanocrystal through hydrophobic interaction in aqueous solution, without displacing the native coordinating ligands, which result in a higher quantum yield of about 0.26, 46% of the uncoated CdSeS/ZnS QDs in chloroform (0.57). In addition, the prepared QD/fGC composes an individual semiconductor core and presents an extremely small size of about 6.03 ± 1.50 nm (n = 399) in diameter. By conjugation with bioactive amines via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-based hydroxyl activation approach, the functionalized QD/fGC presented excellent recognition of specific cells in fluorescent imaging. Our work provides a new general method of chitosan modification of hydrophobic nanoparticles for biomedical applications.
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Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Hang Yin,Qiuqiu Xiong,Miao Zhang,Bowen Wang,Fenge Zhang
In this study, magnetic composite microspheres (SCFP) were prepared by cross-linking chitosan (CS), sodium alginate (SA), poly(vinyl alcohol) (PVA), and ferric tetraoxide (Fe 3 O 4 ) in a CaCl 2 solution. CS and Fe 3 O 4 were encapsulated in gel spheres formed by cross-linking SA with Ca(II), while PVA facilitated the dispersion of CS in SA. SCFP was utilized as an adsorbent to remove Cu(II) from water. The effects of the initial pH of the solution, SCFP dosage, and initial Cu(II) concentration on the adsorption efficiency were investigated through batch experiments. The results demonstrated that the adsorption capacity reached 58.260 mg/g (removal rate = 97.1%) after 100 min of adsorption at a pH of 5. The removal rate remained above 90% even after 6 cycles of the cycling experiment. The incorporation of CS with other functional materials allowed SCFP to compensate for its inherent drawbacks such as low mechanical strength, poor acid resistance, and short service life. The pseudo-first-order kinetic model and Freundlich adsorption isotherm provided better descriptions of the adsorption process. A comprehensive analysis was conducted on the structure and adsorption mechanism of SCFP using characterization techniques such as SEM-EDS, FTIR , BET, XRD , etc. In summary, SCFP has the potential to be an excellent environmentally friendly material for the removal of Cu(II).
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Qianyu Sun,Tianzhong Yuan,Gang Yang,Daliang Guo,Lizheng Sha,Rendang Yang
The solubility of cyclodextrin metal-organic frameworks (CD-MOFs) in aqueous media making it not suitable as sustained-release drug carrier. Here, curcumin-loaded CD-MOFs (CD-MOFs-Cur) was embedded in chitosan- graft -poly(lactic acid) (CS-LA) via a solid-in-oil-in-oil (s/o/o) emulsifying solvent evaporation method forming the sustained-release composite microspheres . At CS-LA concentration of 20 mg/mL, the composite microspheres showed good sphericity. The average particle size of CS-LA/CD-MOFs-Cur (2:1), CS-LA/CD-MOFs-Cur (4:1) and CS-LA/CD-MOFs-Cur (6:1) composite microspheres was about 9.3, 12.3 and 13.5 μm, respectively. The above composite microspheres exhibited various degradation rates and curcumin release rates. Treating in HCl solution (pH 1.2) for 120 min, the average particle size of above microspheres reduced 28.19 %, 24.34 % and 6.19 %, and curcumin released 86.23 %, 78.37 % and 52.57 %, respectively. Treating in PBS (pH 7.4) for 12 h, the average particle size of above microspheres reduced 30.56 %, 26.56 % and 10.66 %, and curcumin released 68.54 %, 54.32 % and 31.25 %, respectively. Moreover, the composite microspheres had a favorable cytocompatibility, with cell viability of higher than 90 %. These composite microspheres open novel opportunity for sustained drug release of CD-MOFs.
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CELLULOSE
·
2023
·Vol. 30
·期 18
·11875-11887
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IF 5.7
Chen Kunlin,Ni Yezhou,Shi Xuan,Jia Zhenhua,Qiu Hua,Portale Giuseppe
The growing interest in green synthesis and multifunctional application of microcapsules is due to their eco-friendly nature, health benefits, safety advantages, controlled release capabilities, and enhanced protection and stability. In this study, chitosan microcapsules were synthesized using a green double emulsion-simple coacervation method. The shell and core materials are derived from plants and are environmentally friendly, while the preparation process does not require volatile organic solvents. Both water-soluble vitamin C (VC) and oil-soluble lemon essential oil (LEO) were loaded as active substances in the chitosan microcapsules. The prepared microcapsules are about 3 μm in size and exhibit good thermal stability. Further modified microcapsules with UV crosslinked monomers could be coated on the fabric to form a functional fabric coating as well as UV crossing linkers. The obtained functional fabric based on chitosan microcapsules has the slow-release property of VC and LEO. The sustained-release VC exhibits a skincare effect and is beneficial to human health. Furthermore, this coated fabric has durable antibacterial properties due to the synergistic effect of LEO and chitosan. This method offers a sustainable solution for creating innovative microcapsules with diverse applications such as medical textiles, home textiles, cosmetics, and more. Graphical abstract
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Foods
·
2023
·Vol. 12
·期 20
·3807
·
IF 5.2
Yixi Li,Yulong Qiu,Hongman Hou,Gongliang Zhang,Hongshun Hao,Jingran Bi
In this paper, amino-carboxymethyl chitosan (ACC) was prepared through amino carboxymethylation, which introduces -COOH and -NH2groups to the chitosan (CS) chains. Meanwhile, dialdehyde starch (DAS) was produced by oxidizing corn starch using sodium periodate. To attain the optimal loading and long-time release of ε-polylysine (ε-PL), the ACC/DAS hydrogels were synthesized through the Schiff base reaction between the amino group on ACC and the aldehyde group in DAS. The molecular structure, microcosmic properties, loading capacity, and bacteriostatic properties of the four types of hydrogels containing different mass concentrations of ACC were investigated. The results showed that the dynamic imine bond C=N existed in the ACC/DAS hydrogels, which proved that the hydrogels were formed by the cross-linking of the Schiff base reaction. With the increasing mass concentration of the ACC, the cross-sectional morphology of the hydrogel became smoother, the thermal stability increased, and the swelling behavior was gradually enhanced. The tight network structure improved the ε-PL loading efficiency, with the highest value of 99.2%. Moreover, the loading of ε-PL gave the hydrogel good antibacterial properties. These results indicate that ACC/DAS hydrogel is potential in food preservation.Keywords:hydrogel;amino-carboxymethyl chitosan;dialdehyde starch;antimicrobial peptide;bacterial inhibition
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Hao Guo,Haifeng Shen,Juping Ma,Penghui Wang,Zheng Yao,Wenjie Zhang,Xiaoyan Tan,Bo Chi
Iatrogenic ulcers resulting from endoscopic submucosal dissection surgery remain a significant clinical concern due to the risk of uncontrolled bleeding. Herein, we have developed an injectable shear-thinning hydrogel cross-linked through electrostatic interactions and hydrogen bonding. The hydrogel underwent comprehensive characterization, focusing on rheological behavior, injectability, microstructure, film-forming capability, adhesion, swelling behavior, degradation kinetics, antibacterial efficacy, hemostatic performance, and biocompatibility. The incorporation of poly(vinyl alcohol) notably enhanced the internal structural stability and injection pressure, while the Laponite content influenced self-healing ability, modulus, and viscosity. Additionally, the hydrogel exhibited pH sensitivity, appropriate degradation, and swelling rates and displayed favorable film-forming and adhesion properties. Notably, it demonstrated excellent resistance against Escherichia coli and Staphylococcus aureus, highlighting its potential to create an optimal wound environment. In vivo studies further confirmed the hydrogel’s exceptional hemostatic performance, positioning it as an optimal material for endoscopic submucosal dissection (ESD) surgery. Moreover, cell experiments and hemolysis tests revealed high biocompatibility, supporting their potential to facilitate the healing of iatrogenic ulcers post-ESD surgery. In conclusion, our hydrogels hold great promise as endoscopic treatment materials for ESD-induced ulcers given their outstanding properties.
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Journal of Materials Chemistry B
·
2023
·
IF 7
Xiaoxue Dong,Zongwei Zhu,Qian Sun,Hongqian Zhang,Chuanxu Yang
The development of a theranostic platform that integrates both diagnostic and therapeutic capabilities is in great need for precise and personalized medicine. Here, we present a novel nanoplatform (AuNS@CS-hpDNA) formulated by chitosan functionalized gold nanostar composites and further complexed with fluorescent hairpin DNA (hpDNA) probes for tumor-related miRNA imaging and photothermal therapy (PTT). The optimized AuNS@CS-hpDNA nanoplatform mediated efficient hpDNA probe loading and intracellular delivery. Subsequently, the cytosol transfer of the hpDNA probe enabled specific hybridization using the targeted miRNA, which triggered the recovery of fluorescence for the precise detection of biomarker miR21 in living cells and realized the distinguishing cancer cell line MCF-7 and normal cells. Meanwhile, the AuNS@CS-hpDNA nanoplatform exhibited excellent photothermal conversion properties, which induced efficient cancer cell killing under laser irradiation. Thus, the developed AuNS@CS-hpDNA nanoplatform could simultaneously realize the precise detection of cancer cells and accurately initiate efficient PTT, which represents a promising strategy for precise cancer therapy.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Meiyan Wu,Pai Zhang,Mei Li,Rui Xu,Xin Zheng,Qiu Cui,Ruitao Cha,Bin Li
Surgical threads are of great importance to prevent wound infection and accelerate tissue healing in surgical treatment. Cellulose nanofibrils (CNF) and chitosan (CS) are attracting increasing attention to be employed as biomedicine materials due to their nontoxicity, cytocompatibility, and biodegradability. However, a robust and absorbable cellulose-based surgical thread has not been explored. Therefore, in this work, a bioinspired CNF/CS composite thread containing 5% cationic polyacrylamide (CPAM) by the mass of CS was prepared, and the obtained CNF/CS-5C thread exhibited excellent mechanical properties and low swelling ratio in water due to the high cross-link degree. Especially, the tensile strength (1877 ± 107 MPa) of this thread was much higher than that of most reported CNF-based threads. Meanwhile, compared with commercial silk and Vicryl surgical threads, the CNF/CS-5C thread exhibited better in vitro cytocompatibility toward endothelial and fibroblast cells and lower inflammatory response in vivo to subcutaneous tissues of rats. In addition, the obtained thread could be regarded as a promising absorbable suture, which exhibited excellent wound healing performances in vivo. Therefore, the prepared absorbable thread will open a new window to prepare novel and advanced cellulose-based threads for medical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xin Pan,Pei Liu,Ye-jun Zhang,Hao-kuang Zhang,Hao Wei,Jing-yi Jiang,Hui-Yan,Er-xin Shang,Wei-wen Li,Yiwei Wang,Jin-ao Duan
Carboxymethyl chitosan and resistant starch exhibit good performance in diabetes regulation. We prepared carboxymethyl chitosan - resistant starch complex. Test the properties of composite resistant starch by using X-ray diffraction, water contact angle, infrared spectroscopy, and scanning electron microscopy, interactions with intestinal microbiota and mouse experiments were also conducted. The results indicated that the composite resistant starch had a good effect on promoting the proliferation of probiotics on Bifidobacterium and a significant inhibitory effect on Escherichia coli than resistant starch ( P < 0.05). After administration, the water intake and weight of diabetic mice were significantly reduced. The blood glucose of diabetic mice was also reduced, and oral glucose tolerance showed that the glucose degradation rates of composite resistant starch were significantly improved compared to model mice. Cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein were significantly lower than those in the diabetes group ( P < 0.05). The diversity of the gut microbiota was also proven.
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Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Yimin Huang,Xueyan Li,Yan Peng,Hua Zhang,Anxian Shi,Xiujun Deng,Baoling Wang,Yingtang Zhou,Bing Wang,Guangzhi Hu
The discharge of hexavalent chromium [Cr(VI)] in industrial wastewater into the natural environment can seriously cause harm to the environment and human health. We modified chitosan (CS) with Co and polydopamine (PDA) to synthesize a spherical adsorbent (CS–Co/PDA HCl ) for Cr(VI) removal from wastewater. Co doping can help CS–Co/PDA HCl maintain a high adsorption capacity (666.7 mg g -1 ) for Cr (VI) while retaining a complete bead shape after multiple recycling. In addition, CS–Co/PDA HCl can maintain 96% of its initial adsorption capacity after five adsorption cycles, demonstrating a strong regeneration ability. Under competitive conditions, the adsorption capacity of CS–Co/PDA HCl for Cr(VI) greatly exceed its adsorption capacity for Ni (II) and Mn (II). Because of the high selectivity of CS–Co/PDA HCl for Cr(VI), 1 kg of CS–Co/PDA HCl (cost approximately $31) could reduce the concentration of Cr(VI) in 87 m 3 of secondary electroplating wastewater containing various complex components to the drinking water standard. Owing to the high selective adsorption capacity of CS–Co/PDA HCl for Cr(VI) and its good regeneration ability and expected economic feasibility, CS–Co/PDA HCl can find potential applications in removing Cr(VI) from real wastewater .
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Weiyang Shen,Yongxin Wang,Yali Li,Zongyao Cui,Yitong Yang,Honglu Shi,Chenfeng Xu,Tingjie Yin
Bacterial infections would cause pathological inflammation and even generate chronic wound. Herein, a ciprofloxacin (Cip)-loaded mild acid-responsive electrospinning nanofiber membrane (NFM) containing 3-diethylaminopropyl isothiocyanate material grafted glycol chitosan (GC-DEAP) was fabricated to prevent bacterial infection against hemostatic and inflammatory phases of wounds. The presence of Cip and GC-DEAP in the objective NFM (PCL/GC-DEAP/Cip) was confirmed through XRD and FTIR. Meanwhile, PCL/GC-DEAP/Cip NFM exhibited high mechanical profiles, suitable water absorption and water vapour transmission ratio. The non-protonated amphiphilic GC-DEAP under pH 7.4 facilitated the formation of uniform and smooth nanofibers with polycaprolactone (PCL) and Cip. However, the GC-DEAP was demonstrated to sharply respond to the mild-acid environment of the wound and effectively be protonated, and thus improved the swelling ability of NFM and triggered burst release of Cip. Due to the combination between protonated GC-DEAP and Cip, PCL/GC-DEAP/Cip NFM achieved attractive antibacterial activity in the mild-acid environment in vitro , and induced more efficient prevention of wound infection and faster wound healing compared with the commercial chitosan dressing. The designed NFM is expected to be a potential smart wound dressing against hemostatic and inflammatory phases with mild-acid specifically strengthened antibacterial features and satisfactory biocompatibility.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Kaiping Wang,Wangtianzi Teng,Nire Wu,SaiSai Gu,Tao Zhou,Yu Zhang
In this study, a porous sponge material was formed by physically mixing chitosan (CS) and Angelica sinensis polysaccharide (ASP). After removing the water by freeze-drying, the CS/ASP sponge was obtained. The prepared sponges exhibited excellent swelling properties, thermal stability and biocompatibility as well as improvements over the insufficient mechanical properties of pure chitosan sponges. Notably, the ASP released from the CS/ASP sponge could be effectively absorbed by the liver, which endowed the CS/ASP sponge with effective liver-protective effects against CCl 4 -induced acute liver injury; these protective effects surpassed those of both blank CS and CS/Dextran sponges. The underlying protective mechanism may involve the activation of the Nrf2-mediated antioxidant signaling pathway and the inhibition of hepatocyte apoptosis. Understanding CS/ASP sponges may provide new insights and inspire new methods for the clinical application of ASP. At the same time, we hope to suggest future directions for the development of polysaccharide preparations.
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