INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Wenwen Li,Gege Cheng,Shuangju Wang,Yan Jiang,Xiuyu Liu,Qin Huang
Lignocellulose nanofibers (LCNF) obtained from agricultural waste are potential candidates for enhancing composite materials because of their excellent mechanical properties, abundant groups and high biocompatibility. However, the application of LCNF has received limited attention to date from researchers in the healthcare field. Herein, based on the bifunctional group (carboxyl and aldehyde groups) modified LCNF (DCLCNF) and chitosan (CS), we developed a multifunctional bio-based hydrogel (CS-DCLCNF). The addition of lignin-containing DCLCNF strengthened the internal crosslinking and the intermolecular interaction of hydrogels, and the presence of lignin and carboxyl groups increased the mechanical strength of the hydrogel and the adsorption of aromatic drugs. Results revealed that the hydrogels exhibited self-healing, injectable, and high swelling rates. The hydrogels had favorable mechanical strength (G' max of ~16.60 kPa), and the maximum compressive stress was 24 kPa. Moreover, the entire tetracycline hydrochloride (TH) release process was slow and pH-responsive, because of the rich noncovalent and π–π interactions between DCLCNF and TH. The hydrogels also exhibited excellent biocompatibility and antibacterial properties . Notably, the wound healing experiment showed that the hydrogels were beneficial in accelerating wounds healing, which could heal completely in 13 days. Therefore, CS-DCLCNF hydrogels may have promising applications in drug delivery for wound healing.
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高影响因子
ACS Applied Nano Materials
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2024
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IF 5.3
Fanqi Meng,Lei Chen,Haoran Chen,Meili Shen,Guangyi Wang,Yulei Chang
Combined phototherapy with other therapeutic strategies can improve the therapeutic outcomes of tumors and reduce the side effects. However, shaping multiple modalities for combination therapy remains challenging. Herein, multiple stimuli-responsive drug-loaded micelles are presented, which are self-assembled from cypate-conjugated pH-sensitive poly(ethylene glycol)–poly(2-(diisopropylamino) ethyl methacrylate)–poly(2-aminoethyl methacrylate hydrochloride) and redox-responsive poly(glycidyl methacrylate)–poly(propylene sulfide) copolymer and loaded with chemo agents doxorubicin (DOX) and sorafenib (SRF, also a ferroptosis inducer) for enhanced tumor therapy. The DOX and SRF chemo drugs were encapsulated into the hydrophobic core of PPS and PDPA to enable multiple stimuli-responsive controlled drug delivery. In vivo and in vitro experiments are carried out to investigate the potential application for controlled drug release and systemic chemo-phototherapy. This study highlights the rational design of cypate-based drug-loaded micelles, offering multiple stimuli-responsive drug releases and synergistic photo-, ferro-, and chemotherapy in colorectal cancer.
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ENVIRONMENT INTERNATIONAL
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2024
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IF 10.3
Wenchao Zhan,Chenxu Wang,Xiyu Yang,Hongtao Li,Sicheng Xiong,Xiaoyang Li
A pH-responsive colorimetric method based on dual-enzyme catalysis for rapid and facile detection and quantification of nanoPET at environment-dependent concentration is proposed. The nanoPET was hydrolyzed by the synergistic catalysis of cutinase and lipase to terephthalic acid which can be sensitive detected using bromocresol purple as the indicator. The color changed from purple to bright yellow as the nanoPET detection concentration increased from 0 mg/mL to 2 mg/mL which can be detected by UV–Vis. This naked-eye method has a high sensitivity for nanoPET detection with the visual detection cutoff of 31.00 μg/mL, and has a good linearity in the range of 0 ∼ 1 mg/mL with LOD of 22.84 μg/mL. The reliability of this method is verified in the detection of nanoPET in lake water and beer samples, with an average recovery of 87.1 %. The as-developed dual-enzyme colorimetric chemosensor holds promising potential as a robust and effective platform for the sensitive detection of nanoPET.
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International Journal of Nanomedicine
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2023
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IF 8
Nan Zhang,Yang Tan,Liwei Yan,Chunyang Zhang,Ming Xu,Huanling Guo,Bowen Zhuang,Luyao Zhou,Xiaoyan Xie
Background and Purpose Sonodynamic therapy (SDT) has been widely used for the noninvasive treatment of solid tumors, but the hypoxic tumor microenvironment limits its therapeutic effect. The current methods of reoxygenation to enhance SDT have limitations, prompting reconsideration of the design of therapeutic approaches. Here, we developed a tumor microenvironment-responsive nanoplatform by reducing oxygen consumption to overcome hypoxia-induced resistance to cancer therapy.Methods A pH-responsive drug-loaded liposome (MI-PEOz-lip) was prepared and used to reduce oxygen consumption, attenuating hypoxia-induced resistance to SDT and thereby improving therapeutic efficiency. Photoacoustic imaging (PAI) and fluorescence imaging (FI) of MI-PEOz-lip were evaluated in vitro and in breast xenograft tumor models. The pH-sensitive functionality of MI-PEOz-lip was applied for pH-triggered cargo release, and its capacity was evaluated. The MI-PEOz-lip-mediated SDT effect was compared with other treatments in vivo.Results MI-PEOz-lip was demonstrated to specifically accumulate in tumors. Metformin molecules in liposomes selectively accumulate in tumors by pH-responsive drug release to inhibit the mitochondrial respiratory chain while releasing IR780 to the tumor area. These pH-responsive liposomes demonstrated PAI and FI imaging capabilities in vitro and in vivo, providing potential for treatment guidance and monitoring. In particular, the prepared MI-PEOz-lip combined with ultrasound irradiation effectively inhibited breast tumors by producing toxic reactive singlet oxygen species (ROS), while the introduction of metformin inhibited mitochondrial respiration and reduced tumor oxygen consumption, resulting in excellent sonodynamic therapy performance compared with other treatments.Conclusion In this study, we present a novel strategy to achieve high therapeutic efficacy of SDT by the rational design of multifunctional nanoplatforms. This work provides a new strategy that can solve the current problems of inefficient oxygen delivery strategies and weaken resistance to various oxygen-dependent therapies.
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高影响因子
CELLULOSE
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2024
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IF 4.9
Zhang Yu-Ping,Zhao Chang-Hua,Yuan Pei,Wan Li
Materials with stimulus-responsive wettability are attracting increasing attention because of their potential applications in oil/water separation and oil spill remediation. Herein, a pH-responsive filter paper was rapidly fabricated by initially forming a complex between TiO 2 and octadecylamine, followed by immersion in an ethanolic solution of SiO 2 nanoparticles. The resultant filter paper exhibited superhydrophobicity and superoleophilicity in air when the solution pH was greater than 6.0, whereas it became superhydrophilic and superoleophobic when the solution pH was less than 2.0. The treated filter paper was used for the controllable separation of complex oil/water/oil ternary mixtures, demonstrating its strong response to pH changes. The pH-responsive filter paper effectively separated both immiscible oil/water mixtures and different kinds of oil-in-water emulsions with separation efficiencies exceeding 99%. The durability of the pH-responsive filter paper was demonstrated by its ability to maintain a separation efficiency of around 99%, even after 25 cycles of separating a typical emulsion of tetrachloromethane in water. The developed approach has the potential to provide innovative smart materials for the treatment of oil-contaminated wastewater. Graphical abstract
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ACS Applied Nano Materials
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2024
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IF 5.3
Yunpeng Zhou,Jing Wang,Jiawei Yang,Long-Hui Duan,Hai-Bo Liu,Junfei Wu,Lina Gao
SBA-15@MOF-525 composites were constructed by in situ self-assembly of a metal–organic framework (MOF-525) with mesoporous SBA-15 silica. MOF-525 crystals were confined inside the mesopores as well as grown on the outside surface of SBA-15, under the impact of the structure-directing role of SBA-15, and the composites exhibited both microporous and mesoporous characteristics. In general, the adsorption of tetracycline (TC) on MOF-525 was affected by pH. The adsorption capacity of MOF-525 decreased rapidly, especially in an alkaline environment, due to the collapse of the MOF-525 skeleton. By contrast, incorporating MOF-525 into SBA-15 improved the stability of MOF-525. The adsorption of TC on SBA-15@MOF-525 was almost unaffected by pH. High and stable adsorption capacity over a wide pH range was maintained under acidic, neutral, and alkaline environments. The composites were used effectively for TC adsorption. The maximum adsorption capacity of TC on SBA-15@MOF-525 was 690 mg/g, which is higher than that of most of the reported adsorbents. The great potential of SBA-15@MOF-525 in practical applications was demonstrated by investigating the adsorption of TC in lake water samples.
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ACS Omega
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2024
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IF 3.7
Di Zhang,Wanyu Wei,Tianxiang Xie,Xue Zhou,Xu He,Jie Qiao,Rui Guo,Gang Jin,Ningbo Li
In this study, the mesoporous Fe3O4 nanodrug carriers containing disulfide bonds (CHO-SMNPs) were successfully synthesized and characterized. Doxorubicin (DOX) was loaded onto the CHO-SMNPs as a model drug and gatekeeper through the formation of imine bonds with the aldehyde groups on the surface of the mesoporous materials. This drug carrier demonstrates effective drug release triggered by pH, glutathione (GSH), and near-infrared (NIR) light, along with satisfactory photothermal conversion efficiency under NIR irradiation at 808 nm. Furthermore, CHO-SMNPs exhibit excellent blood compatibility and biodegradability. They also show good biocompatibility and efficient cellular uptake in HeLa and MCF-7 cancer cells. Most importantly, the CHO-SMNPs/DOX has shown significant effectiveness in killing both HeLa and MCF-7 cancer cells. Consequently, CHO-SMNPs/DOX presents substantial potential as a magnetic-targeted, pH/GSH/NIR triple-triggered drug delivery system for synergistic chemo-photothermal therapy in tumor treatment.
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高影响因子
NANOTECHNOLOGY
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2024
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IF 2.9
Yuhai He,Chen Wang,Qiuhua Wu,Guolin Zhang
In this paper, a new Janus-structured nano drug delivery carrier Fe3O4@TiO2&mSiO2 was designed and synthesized, which consisted of a spherical head and a closely connected rod. The head was a nanocomposite of core/shell structure with magnetic spinel ferric tetraoxide core and anatase titanium dioxide shell (Fe3O4@TiO2), and the rod was ordered mesoporous silica (mSiO2). The nanocarriers showed excellent magnetic targeting capability (saturation magnetization, 25.18 emu g-1). The core/shell heads endowed the carriers with fine microwave responsiveness. The pore volume of mesoporous nanocarriers was 0.101 cm3 g-1, and the specific surface area was 489.0 m2 g-1. Anticancer drug doxorubicin could be loaded in the mesoporous of the carriers to form Fe3O4@TiO2&mSiO2-DOX. The drug loading capacity was 10.4%. Fe3O4@TiO2&mSiO2-DOX exhibited acid-sensitive and microwavesensitive release properties along with good bio-compatibility. Fe3O4@TiO2&mSiO2 Janus nanoparticles are expected to be ideal drug carriers.
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FOOD CHEMISTRY
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2025
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IF 9.8
Junting Wang,Jiaxuan Liu,Zhiqiang Li,Qun Li
Barrier films are essential for food packaging, but conventional solutions hinder the circular economy. This study introduces hemicellulose-based antioxidant crosslinked composite films as a sustainable alternative. We develop pH-responsive films (K-B/PVA/OA) using polyvinyl alcohol (PVA), silanized hemicellulose (KHC), blueberry anthocyanin (BA) as a pH indicator, and oxalic acid (OA) as a crosslinker. The films exhibit excellent oxygen and water vapor barrier properties and can be easily fabricated via solution casting with food-safe dispersions. The oxygen permeability ( OP ) decreases from 13.22 ± 0.65 × 10 −14 to 3.24 ± 0.98 × 10 −14 cm 3 ·μm/(m 2 ·d·Pa), and the water vapor permeability coefficient ( Pv ) drops from 15.43 ± 0.85 × 10 −13 to 7.27 ± 0.46 × 10 −13 g·cm/(cm 2 ·s·Pa). Tensile strength and modulus increase from 32.63 MPa and 765.80 MPa to 41.24 MPa and 1281.39 MPa. Esterification between PVA and hemicellulose raises surface energy, increasing the contact angle from 39.4° to 78.34°. Strawberries packaged in these films maintain their structure and exhibit a visible color change after 7 days, offering sustainable, real-time monitoring packaging.
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高影响因子
FOOD HYDROCOLLOIDS
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2024
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IF 11
Xuedi Ma,Zheng Zhang,Zhao Li,Zhengzong Wu,Lu Lu,Katsuyoshi Nishinari,Meng Zhao,Bo Cui
The impact of phase separation behavior on the performance of hydrogels has always been the research focus. This study explored the relationship of “pH-microstructure-hydrogel properties” of phase-separated hydrogels composed of type-A gelatin (GE, 5 wt%) and hydroxypropyl starch (HPS, 3 wt%). The results revealed that changes in the microstructure of the hydrogel at different pHs significantly impacted the gel properties. At pH 4.00 and 11.00, phase separation occurred in the GE/HPS gel with a microstructure of HPS-in-GE. In particular, at pH 5.00, 6.00, 7.00, and 9.00, severe phase separation resulted in the separation of substantial aggregates of HPS and GE, resulting in a continuous phase structure. At pH 2.00 and 3.00, phase separation was suppressed, resulting in a homogeneous microstructure. Compared to the phase-separated gels at pH 4.00–11.00, the homogeneous systems at pH 2.00 and 3.00 displayed a synergistic effect with higher gel strength. Analysis of intermolecular forces in the GE/HPS gel indicated that hydrogen bonding was the primary interaction force. Furthermore, the addition of GE/HPS into hawthorn jelly at about pH 3.00 effectively preserved the structural appearance and exhibited higher levels of hardness, thus improving the sensory properties of hawthorn jelly. In summary, phase separation decreased the storage modulus of GE/HPS gel, but the compatibility of GE/HPS macromolecules exhibited synergistic effects at 2.00 and 3.00 and improved the hydrogel mechanical properties. This work provides some new insights for GE/HPS-based gel foods.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Kainan Guo,Kangkang Ou,Md All Amin Newton,Jun Zhang,Hui Xu,Jinyi Li,Binjie Xin,Yinjun Huang
Chronic wounds often produce a significant volume of exudate, posing a substantial obstacle to healing. Consequently, there is a pressing demand for a versatile dressing capable of effectively managing exudate in chronic wounds. In this context, a Janus smart dressing is proposed, featuring unidirectional water transport and a pH-responsive color-changing for exudate management and wound monitoring. The dressing’s mechanisms for unidirectional water transport and color changing are elucidated. The Janus dressing consists of a polyacrylonitrile (PAN)/sodium polyacrylate (SPA)/anthocyanin (An) hydrophilic layer with antioxidant and pH-sensitive functions and a poly (3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) hydrophobic layer, enabling unidirectional exudate drainage without reverse osmosis. Studies indicate that the Janus dressing exhibits excellent air permeability, moisture permeability, mechanical properties, cytocompatibility, and antioxidant performance while promptly responding to color variations in solutions of varying pH levels. In vivo studies demonstrated the excellent wound healing ability of Janus PHBV-PAN/SPA/An membrane. Consequently, this study provides a promising solution to develop wound dressings that can effectively manage excessive wound exudate and dressing changes.
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高影响因子
Wood Material Science & Engineering
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2024
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IF 2.2
Li Jin,Xin Ren,Fei Wang,Zhiwei Fan,Shuaibo Han,Yan Zhang,Hui Wang,Xinxing Wu,Fangli Sun
Disodium octoborate tetrahydrate (DOT) is a well-received and eco-friendly preservative. However, it is prone to leaching from wood in humid conditions or rainy seasons, causing problems such as decreased efficiency in resisting fungi and poor surface performance in surface finishing. To obtain enhanced leaching resistance and simultaneously achieve controlled release of DOT, a pH and temperature dual responsive poly (2-hydroxyethyl methacrylate/2-(Dimethylamino) ethyl methacrylate) (PDH) was prepared and optimized for in situ construction of DOT-loaded PDH (PDHD) in wood. Results showed that PDH displayed obvious pH and temperature-responsive swelling, and when loaded with DOT, the PDHD consequently released DOT in a pH and temperature-responsive way. Fourier transform infrared spectroscopy, Solid-13C NMR analysis and Dynamic mechanical analysis confirmed the copolymerization of 2-Hydroxyethyl methacrylate (HEMA) and 2-(Dimethylamino) ethyl methacrylate (DMAEMA), as well as the presence of crosslinked structure formed from hydrogen bond between the hydroxyl group of HEMA and the N,N-dimethylamino groups of DMAEMA. After that, the PDHD was in situ constructed in wood for controlled release of boron. During the water leaching test, the modified wood exhibited a boron fixation rate of 49.05% compared with 0.72% of the neat DOT-treated wood. Besides, it presented controlled release activity in response to pH and temperature. This work provides new approaches to the fixation of boron preservatives and notably realizes responsive releasing of boron compounds for long-term wood preservation.
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高影响因子
危险品化学品经营许可证（带存储）