ChemistrySelect
·
2026
·Vol. 11
·期 14
·e05177
·
IF 2.3
Yin Wang,Kai Chen,Chao Lv,Dong Ju Zhou,Ya Wei Chen,Hui Yun Zhou,Hyun Jin Park
In this study, Ser-β-CD was synthesized, and BBH/Ser-β-CD IC was prepared by the freeze-drying method and characterized by FTIR, 1 H NMR, phase solubility, and SEM. Then, the BBH/Ser-β-CD IC@CS hydrogel was prepared by the BBH/Ser-β-CD IC and CS with GP as the crosslinking agent. The effect on hydrogel properties was investigated by altering (CS+BBH/Ser-β-CD IC) % (w/v), CS/(BBH/Ser-β-CD IC) (w/w), and (CS+BBH/Ser-β-CD IC)/GP (v/v). The FTIR results proved the interaction between hydrogel molecules. The SEM results confirmed the porous structure of the hydrogel. Meanwhile, hydrogels have been proven to have good swelling properties. The in vitro release results indicated that the hydrogel had a sustained-release effect, and the release mechanism of BBH from the hydrogel conformed to the first-order kinetic model. The DPPH scavenging capacity of hydrogels was comparable to that of Vc. The hemolysis test confirmed that the hydrogel had good biocompatibility. The antibacterial investigation proved that the hydrogel had an inhibitory effect on E. coli or S. aureus . Therefore, BBH/Ser-β-CD IC@CS hydrogel has broad prospects in the research and development of drug sustained-release and antibacterial materials. Graphical Ser-β-CD was synthesized, and BBH/Ser-β-CD IC was prepared by the freeze-drying method. BBH/Ser-β-CD IC@CS hydrogel was prepared using BBH/Ser-β-CD IC and CS with GP as a crosslinking agent. The BBH/Ser-β-CD IC@CS hydrogel had antioxidant properties, sustained-release performance, and antibacterial activity against E. coli and S. aureus .
✓ 已验证
DOI
高影响因子
MOLECULAR IMMUNOLOGY
·
2026
·
IF 3.7
Zeyu Tao,Jingwei Gao,Hongbo Huang,Tao Xu,Tianqi Zhang,Jingtang Liang,Longkai Bao,Shaoping Liao,Long Mo,Jinyi Chi,Limin Li,Li Xie
Human Immunodeficiency Virus (HIV) infection is characterized by the depletion of human CD4 + T cells, in which ferroptosis has been identified as a contributing mechanism. Dysregulation of the canonical Wnt/β-catenin signaling pathway is strongly associated with HIV infection. Our findings demonstrate that Wnt7a activates this pathway. Subsequently, β-catenin translocates to the nucleus, where it interacts with the transcription factor 4 (TCF4) to regulate ferroptosis in T lymphocytes from HIV-infected individuals. Analysis of peripheral blood mononuclear cells (PBMCs) from HIV-infected individuals revealed significantly decreased expression levels of Wnt7a, along with key Wnt/β-catenin pathway components (β-catenin, TCF4) and the ferroptosis regulator GPX4, compared to healthy controls. Concurrently, PBMCs from HIV-infected individuals exhibited elevated levels of ferroptosis. We established an in vitro HIV-infected T lymphocyte model by expanding patient-derived PBMCs using a CD3/CD28/CD2 T cell activator and IL-2. Lentiviral transduction was used to stably overexpress Wnt7a in this model. Wnt7a overexpression successfully activated the Wnt/β-catenin pathway and significantly reduced ferroptosis levels. Furthermore, pharmacological manipulation of ferroptosis modulated Wnt7a expression: treatment with the ferroptosis inhibitor Liproxstatin-1 and Ferrostatin-1 increased Wnt7a expression, while exposure to the ferroptosis inducer RSL-3 decreased it. Flow cytometry analysis confirmed that overexpressing Wnt7a significantly increased the number of CD4 + T cells compared to the control. In summary, Wnt7a activates the Wnt/β-catenin signaling pathway to reduce ferroptosis in T lymphocytes from HIV-infected individuals, likely by targeting GPX4, suggesting a potential new strategy for treating HIV infection by restoring the T lymphocyte population.
✓ 已验证
DOI
PubMed
高影响因子
PHYTOMEDICINE
·
2026
·
IF 11.3
Guoguo Zhi,Haiyu Shen,Zihao Li,Manju Che,Lin Cheng,Zhirui Du,Xueqiao Yan,Shaoyang Zhang,Ruichen Yang,Xiuying Ma,Huijuan Liu,Funeng Geng,Baojie Li
Background Cutaneous wound repair is a complex biological process that restores the integrity of the skin. Forsythia suspensa (LQ) is a traditional Chinese medicinal herb known for its anti-inflammatory and antimicrobial properties; however, its role and molecular mechanisms in promoting cutaneous tissue regeneration remain unclear. Objective This study aimed to evaluate the pharmacological efficacy of LQ and its bioactive compounds in treating acute skin injuries and to elucidate the underlying molecular mechanisms. Method Two distinct animal models, a full-thickness thermal injury wound (complex inflammatory damage) and a full-thickness excisional wound (mechanical trauma), were established to evaluate the therapeutic potential of LQ. Therapeutic effects were assessed by histopathological examination and immunofluorescence analysis of skin lesions. RNA sequencing and pathway-specific inhibitors were used to investigate and validate the molecular mechanisms involved. Active compounds were identified by UPLC-MS/MS, and their mechanisms of action were explored using molecular docking, molecular dynamics simulation, and experimental validation. Results LQ significantly accelerates cutaneous wound healing in both models. Mechanistically, LQ promotes tissue regeneration by suppressing neutrophil extracellular trap (NET) formation and activating Wnt/β-catenin signaling to drive epidermal cell proliferation, and these effects are reversed by the NET inhibitor GSK484 and the Wnt pathway inhibitor IWP2. Forsythoside A, an active component of LQ, similarly enhances wound closure, re-epithelialization, and cell proliferation, indicating that it is likely the key mediator. We further show that inhibition of NETs increases Wnt ligand production and β-catenin signaling, linking inflammatory responses to regenerative signaling. Conclusion LQ and forsythoside A promote skin wound healing by coordinately regulating NET-mediated inflammation and Wnt/β-catenin signaling–mediated cell proliferation, thereby highlighting their potential as therapeutic agents in regenerative medicine.
✓ 已验证
DOI
PubMed
高影响因子
American Journal of Cancer Research
·
2026
·Vol. 16
·期 3
·1115
·
IF 3.1
Nan Liu,Mingyue Zhao,Lei Xu,Yeting Cui,Yu Tian,Juan Li,Xiaoyu Hu,Tongcun Zhang,Haining Zhen,Yanyang Tu
Glioma is the most aggressive tumor of the central nervous system and is associated with poor prognosis, especially in patients with high-grade gliomas. In this study, we investigated the biological role of inhibitor of kappa B kinase interacting protein (IKBIP) in promoting the progression of glioma. Analysis of the TCGA and GTEx databases revealed that IKBIP is upregulated in both lower-grade gliomas (LGG) and glioblastomas (GBM) compared with normal brain tissues. Kaplan-Meier survival analysis demonstrated that IKBIP upregulation is associated with shorter overall survival (OS) and disease-specific survival (DSS) in patients with LGG. Pan-cancer analysis indicated that IKBIP is aberrantly expressed in various malignant tumors, including gliomas. IKBIP knockdown inhibited the proliferation of glioma cells both in vitro and in vivo . Additionally, IKBIP knockdown in U251 and U87 glioma cell lines significantly suppressed their invasive capacity. Furthermore, IKBIP knockdown resulted in decreased expression of proteins associated with Wnt/β-catenin/epithelial-mesenchymal transition (EMT) pathway, including β-catenin, ZEB1, ZEB2, N-cadherin, whereas the expression of E-cadherin was increased. Conversely, IKBIP overexpression reduced the level of phosphorylated β-catenin (p-β-catenin) while increasing the expression of total β-catenin in glioma cells. Furthermore, we identified that transcription factor SP1 (Specificity Protein 1), which is also upregulated in glioma tissues and cell lines and is associated with the malignant phenotype of glioma, can bind to the promoter region of IKBIP. Upregulation of SPI in glioma cells significantly increased the expression level of IKBIP, while inhibiting the phosphorylation of β-catenin. These findings collectively suggest that upregulation of IKBIP promotes the proliferation and invasive behaviors of glioma cells by activating the Wnt/β-catenin/EMT pathway. Overall, our findings suggest that SP1-IKBIP axis facilitates the proliferation and invasion of glioma through Wnt/β-catenin-associated EMT, and SP1-IKBIP axis may represent a promising target for the clinical diagnosis and treatment of glioma.
✓ 已验证
DOI
PubMed
高影响因子
ENERGY & FUELS
·
2026
·
IF 6
Shaocong Pang,Jingyi Yu,Tianle Li,Liangliang Yan,Yuxiu An
Extreme high-temperature and high-salinity environments pose severe challenges for the field application of water-based drilling fluids. The thermal degradation of conventional polymer loss control agents is a key factor limiting their performance. The incorporation of nanomaterials offers a novel approach to enhance the high-temperature resistance of polymer loss control agents, making it a research hotspot in this field. In this study, a novel composite additive (DANT/HCM) was developed by physically blending β-cyclodextrin (β-CD) hydrothermal carbon microspheres (HCMs) with a comb-like polymer (DANT). Thermogravimetric analysis showed that DANT/HCM has excellent thermal stability. Structural characterization results reveal that oxygen-containing functional groups on the HCM surface form stable interfacial interactions with polymer segments via hydrogen bonding, conferring unique structural synergistic effects to the system. Scanning electron microscopy images showed that the HCM maintained an intact spherical structure after compositing. Performance tests showed that after aging at 240 °C, the filtration loss of the base mud with 1.5 wt % DANT/HCM was only 9.0 mL, significantly lower than the 20.8 mL of DANT alone. Additionally, this composite material exhibits excellent salt resistance, maintaining a filtration volume of 27 mL even in 30 wt % NaCl drilling fluid. Combined with the zeta potential, particle size distribution, and SEM analyses, the performance enhancement was mainly due to the enhanced thermal stability of the composite system, improved particle dispersion, and the formation of a dense, uniform filter cake structure. This study achieves highly efficient filtration loss reduction by introducing thermally stable, nanosized, water-based, thermally carbonized microspheres and combining them with long-chain comb polymers, thereby forming a unique synergistic loss reduction mechanism. It provides a theoretical basis and practical reference for the development of high-performance, high-temperature-resistant filtration loss reduction additives suitable for ultradeep wells and high-temperature environments and has a good prospect for engineering applications.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2026
·
IF 7.3
Taoran Wang,Long Tian,Jiangmin Zeng,Ziyao Ning,Li Zhang,Chunhui Zhao,Shuyuan Jiang,Chunlan Zeng,Jiaqi Han,Liang Luan,Weifeng Ye,Qingbin Meng
The rational design of proteolytically stable antimicrobial peptides (AMPs) is crucial for combating antibiotic resistance. Although cyclization has been extensively applied to stabilize α-helical and random-coiled AMPs, its impact on the structure–activity relationship of β-turn AMPs remains underexplored. Here, we engineered cyclized derivatives of P-07─a linear β-turn AMP developed by our group─via disulfide/lactam bond cyclization and d-amino acid substitution. The lead candidate, PT-17, exhibited remarkably enhanced stability, retaining potent broad-spectrum activity against MDR pathogens and a high therapeutic index. Additionally, PT-17 exhibited rapid membrane disruption ability, low potential to induce bacterial resistance, and synergy with conventional antibiotics. In a murine infection model, PT-17 achieved a significant reduction of Escherichia coli (MDR) loads in the main organs with undetectable toxicity. This study provides comprehensive evidence that cyclization and d-amino acid substitution confer synergistic stability to β-turn AMPs without compromising activity, offering a viable strategy for developing novel AMPs with clinical potential.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
·
2026
·
IF 4
Zhewen Deng,Mengyuan Zhang,Senqiang Zhu,Yunlong Zhang,Haitao Liao,Jiaqi Li,Peiyu Yan,Qi Zhang,Rui Liu,Bo Ma
Osteosarcoma (OS), a highly aggressive bone cancer with a dismal prognosis in the metastatic setting, urgently demands novel therapeutic modalities. While phototherapy offers a promising, minimally invasive strategy, its clinical efficacy is often hampered by the poor aqueous solubility of photosensitizers and the development of multidrug resistance. In response, we constructed the dual-modal nanoplatform BDP-NPs by leveraging a multifunctional F127/TPGS mixed micelle to encapsulate a cationic BODIPY photosensitizer, thereby creating a system engineered for enhanced tumor accumulation and to overcome multidrug resistance. Benefiting from their uniform size, colloidal stability, and hypoxia-responsive properties, the BDP-NPs demonstrate potent reactive oxygen species generation and high photothermal conversion efficiency under 525 nm laser irradiation. This dual-modal action induces severe mitochondrial dysfunction, thereby triggering apoptosis in both 3D tumor spheroids and tumor tissues. The synergistic phototherapy elicited profound mitochondrial-targeted cytotoxicity, inhibited clonogenic survival, and significantly suppressed tumor growth in human osteosarcoma models, all while maintaining a favorable biosafety profile. Mechanistic analyses revealed that this synergistic phototherapy plays a pivotal role in suppressing the YAP1/β-catenin axis, thereby reversing the epithelial-mesenchymal transition (EMT) program and consequently inhibiting OS cell proliferation, migration and invasion. This study not only establishes BDP-NPs as a potent and biocompatible nanotherapeutic for OS but also presents a groundbreaking phototherapeutic strategy to disrupt the YAP1/β-catenin axis-a key signaling network driving tumorigenesis and malignant progression. This approach provides a robust conceptual foundation for devising next-generation phototherapeutics that precisely target oncogenic signaling in aggressive cancers.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Yuxuan Liang,Xiangwei Li,Yuzheng Zhou,Yuchao Wang,Zhe Wang
Mixed matrix membranes (MMMs) offer a promising route to high-performance gas separation by integrating the benefits of fillers and polymer matrices. However, Polymers of Intrinsic Microporosity (PIM-1) suffers from poor interfacial compatibility with fillers and is constrained by the Robeson upper bound. As a result, the selectivity of MMMs remains less than ideal. This study proposes a cross-scale coordination strategy that adjusts the molar ratio of β -cyclodextrin ( β -CD) to the oligomer KH560-M2070 during the synthesis of porous liquids (PLs). This cross-scale coordination boosts MMM performance at both macro and micro levels. Grafting more oligomers increases the porous liquid's fluidity at the macroscopic scale. This effect arises from fewer hydrophilic hydroxyl groups on β -CD and the “like dissolves like” nature of the oligomers. As a result, the filler loading increases from 2 wt% to 10 wt%. KH560-M2070 and β -CD are covalently linked at both ends, creating a graded pore structure (0.41–0.8 nm) at the microscopic level. Our experimental data show that the β -CD PLs (1:0.7)/PIM-1 MMM achieves a CO 2 /N 2 selectivity of 65.68 ± 2.16 at 30 °C, well above the 2019 Robeson upper bound. This cross-scale strategy thus offers a new route for applying porous liquids in gas separation.
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 4
·123295
·
IF 7.5
Yik Tung Sham,Min Pan,Steven Jing-Liang Xu,Tsz Wai Ng,Jennie Yan Ning Yu,Qiuxiang Xu,Zhangna Wang
Aquaculture operations generate substantial volumes of wastewater containing pathogenic bacteria that threaten cultured species and surrounding ecosystems. Conventional treatment methods face limitations in efficiency, cost, and environmental protection, necessitating sustainable and innovative disinfection technologies for on-site treatment. This study constructed photocatalytic self-Fenton systems (PSFs) using β-ketoenamine covalent organic frameworks (COFs) for aquaculture wastewater disinfection. Two β-ketoenamine-linked COFs, TpBpy and TaTp, with the irreversible keto-enamine transformation providing chemical stability in aquatic environments. Photocatalytic H 2 O 2 production under visible light revealed that TpBpy achieved a yield of 3852.6 μmol/g over 90 min, outperforming TaTp of 1349.6 μmol/g. This higher efficiency of TpBpy may be attributed to its stronger O 2 adsorption and greater electron transfer capacity. Kinetic analysis demonstrated minimal H 2 O 2 decomposition, suggesting system stability for continuous oxidant supply. Coupling β-ketoenamine COFs with Fe(II) created PSFs that effectively eliminated key aquaculture pathogens, achieving 7-log removal of V. parahaemolyticus and A. hydrophila within 10 min, while P. aeruginosa and E. coli required 30–50 min. Mechanical study confirmed sustained hydroxyl radical (•OH) production, with TpBpy-PSF exhibiting higher efficiency due to enhanced Fe 2 + binding. Field validation in fish tanks and river water demonstrated 99% disinfection within 30 min against native microorganisms, confirming real-world viability. To the best of our knowledge, this is the first report of β-ketoenamine COF-based PSFs designed for aquaculture wastewater treatment, systematically evaluated against key aquaculture pathogens and the native microbial community. These findings highlight PSFs as an innovative and sustainable approach to aquaculture wastewater disinfection with potential for broader water treatment applications.
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Zicong Guo,Jiawei Cao,Jincheng Zhang,Chengjie Ren,Wentao Xu,Yongqiang Cheng,Zhigang Jiang,Jiangtao Zhou,Dejian Huang,Ju Qiu
Avenanthramide-C (AVN) is a unique ingredient in oats with various bioactivities, but its low gastrointestinal stability limits its application. The AVN was encapsulated with curdlan (CD), oat (OG), and yeast (YG) β-glucans by alkali-neutralization (AN) in this study. Both CD and YG exhibited more ordered aggregation than OG based on Congo red result, possibly contributing to differences in their interaction with AVN. OG-AVN exhibited a higher binding degree (86.57%) than CD-AVN (71.61%) and YG-AVN (81.44%), indicating that the more AVN was retained, the higher solubility and antioxidant capacity of β-glucans-AVN complexes during in vitro digestion. Lower viscoelasticity of OG-AVN and YG-AVN than CD-AVN suggested that the different glycosidic bonds within linear backbone of OG or branches within the triple helix of YG perhaps weakened the tight entanglement, thus providing sufficient regions for AVN binding. Differences in hydrogen bonding structure among β-glucans contributed to their noncovalent interactions with AVN, supported by FTIR (O–H stretching band shift of β-glucans vs. AN-treated ones), XRD (lower relative crystallinity of AVN than complexes), and ITC (higher binding affinity of OG-AVN than YG-AVN and CD-AVN). AFM results supported the change in linear backbone from long to short, which promoted the AVN loading into OG. The binding regions might be located at the OH-7 of AVN with the H-3 of OG or YG, but not CD-AVN, as evidenced by NMR analyses. It demonstrated that the short chains of OG and the branches of YG potentially interacted more easily with AVN, while OG-AVN achieved even better performance.
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Zhang Kairui,Li Jie,Liu Jianchao,Tang Qiong,Liu Lei,Dong Jinxiang
Cumene,
produced via the alkylation of benzene with propene, is
a crucial intermediate for phenol and acetone. The catalytic performance
depends on framework architecture, crystal size, and the acid properties
of zeolites. Co-Al-LDO-β was synthesized by anchoring nanosized
β zeolite onto cobalt-aluminum layered double hydroxide (Co-Al-LDH)
via an in situ strategy, where Co-Al-LDH served as both an aluminum
source and support. The uniform dispersion of β zeolites on
the LDH allowed for tuning of the polymorph A/B ratio. The influence
of polymorph distribution on pore architecture and acid site distribution
was investigated by XRD, HRTEM, NMR, and pyridine-FTIR. The results
show that polymorph B enriches framework aluminum at T2 sites, forming
accessible Brønsted acid sites. Polymorph A induces aluminum
migration to constrained T7 and T5+T6 sites and extraframework aluminum,
increasing Lewis acidity. The B-type dominant β zeolite has
a favorable pore structure and acid site distribution, leading to
superior catalytic performance in benzene–propene alkylation.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
·
2026
·
IF 5.7
Xiaowen Huang,Lu Chen,Huajian Ou,Yanyan Huang,Zhiyun Peng,Langhong Wang,Konglong Feng,Qiaohui Zeng,Jing Jing Wang
A novel photodynamic ice glaze with high antibacterial ability based on curcumin (Cur)/β-cyclodextrin (β-CD) inclusion complex was developed, and its active cold-chain preservation efficiency for Pacific white shrimp was investigated. Results showed that β-CD/Cur inclusion complex significantly enhanced the aqueous solubility and photostability of curcumin by facilitating the formation of a novel crystalline phase, which enabled efficient reactive oxygen species (ROS) generation in its frozen aqueous state. Under blue LED irradiation during frozen storage, the photodynamic ice exhibited broad-spectrum antibacterial ability against foodborne pathogens, notably with a reduction of >5.98 Log CFU/mL for Gram-positive Staphylococcus aureus and an undetectable level for Gram-negative Vibrio parahaemolyticus . Mechanistic studies confirmed that the generated ROS disrupted cellular structural integrity, and inflicted severe oxidative damage to bacterial DNA and proteins. During 15 days of frozen storage of shrimp, the photodynamic ice glaze slowed microbial proliferation (<5.20 Log CFU/g), inactivated endogenous proteases, retarded water migration, and maintained muscle quality. Therefore, the photodynamic ice glaze is a green and feasible strategy for improving the microbial safety and quality of aquatic products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）