Biomaterials Science
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2020
·Vol. 8
·期 17
·4757-4766
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IF 6.183
Jing Zhang,Dan Liu,Jiale Liu,Yanfeng Han,Haiyan Xu,Xigang Leng,Deling Kong,Lanxia Liu
Combined blockades of CTLA-4 and PD-1 can yield better overall complementary clinical outcomes than individual blockades, but the response rates are still relatively low. To investigate the anti-tumor effects of various combined strategies, we designed various spherical nucleotide nanoparticles (SNPs) loaded with CTLA-4 aptamer (cSNPs), PD-1 siRNA (pSNPs) or both (hybrid SNPs, or hSNPs). The results demonstrated that hSNPs could promote significantly stronger anti-tumor immune responses in a nonredundant fashion than the mixture of pSNPs and cSNPs (pSNPs & cSNPs). We reasoned that this is because all individual immune cells could receive both CTLA-4 and PD-1 blockades when they engulfed hSNPs, but it is much less likely that individual immune cells could receive both CTLA-4 and PD-1 blockades as many of them may not take both pSNPs and cSNPS from pSNPs & cSNPs. Further results revealed that the synergistic immune stimulatory effects of CTLA-4 and PD-1 blockades in the form of hSNPs were at least partly through regulating the immune suppressive function of both Tregs and TIM3+ exhausted-like CD8 T cells and allowing effector T cells to expand. This mechanism is not identical to earlier reported mechanisms of CTLA-4 and PD-1 blockades.
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Advanced Electronic Materials
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2024
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IF 5.3
Wei Wang,Yujun Deng,Shuai Sun,Massimiliano Galluzzi,Yang Jiao,Paul K. Chu,Zeren Li,Jia Li,Jianquan Yao
Visible-blind ultraviolet (VBUV) photodetectors are designed for UV detection without responding to visible light, thus having many applications in communications, flame detection, environment monitoring, and astronomy. Herein, an organic device concept based on the bulk heterojunction (BHJ) photodiode is presented for high-performance VBUV photodetection and imaging. The BHJ, comprised of an organic electron donor, 2,7-dioctyl[1]benzothieno[3,2-b][1]benzothiophene (C8-BTBT), and an electron acceptor, indene-C 60 bisadduct (ICBA), shows efficient generation and transport of free charges upon UV irradiation. The organic photodiode (OPD) delivers exceptional VBUV photodetection performance. At a low voltage of −0.5 V, the device exhibits a wide linear dynamic range of 98.15 dB. Furthermore, the OPD can detect ultra-low light intensities down to 0.58 µW cm −2 with a high photoresponsivity of 0.12 A W −1 and specific detectivity of 2.75 × 10 12 Jones. More importantly, by integrating the OPD with a readout integrated circuit, the pixel-array organic VBUV imager is demonstrated to have high-quality imaging capability. The results reveal a novel strategy to design VBUV photodetectors and imagers with balanced performance, cost, area, flexibility, and power consumption.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Feng Ye,Shuanshi Fan,Xuemei Lang,Yanhong Wang,Gang Li
Silicalite-1 zeolite membranes were successfully activated at 300–350 °C in a hydrogen atmosphere. FTIR, TGA, and N 2 adsorption-desorption characterizations confirmed that the amount of the organic structure directing agent (OSDA) residue in silicalite-1 zeolite channels was tunable. The H 2 -calcined membrane showed a lower gas permeance than that of the air-calcined membrane due to the partial pore blockage by the OSDA residue. The permeance of H 2 and CO 2 increased with increasing temperature, showing an activated diffusion-like mechanism. The activation energies for the permeation of H 2 and CO 2 were in the range of 1.63–4.15 and 0.76–5.90 kJ mol −1 , respectively, which confirmed the reduced average membrane pore size and different pore surface chemistry due to the presence of the OSDA residue in the membrane. Significant interactions between CO 2 molecules and OSDA residues confined in the membrane resulted in a notably lower CO 2 permeance compared to N 2 and CH 4 , despite CO 2 having a smaller kinetic diameter. Enhanced H 2 /CO 2 selectivity in the silicalite-1 zeolite membrane, featuring confined OSDA residue, was attributed to the reduction in membrane pore size and the fine-tuning of pore surface chemistry.
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Analytical Methods
·
2024
·Vol. 16
·期 35
·5959-5970
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IF 2.7
Zhang Jingru,Chu Hongtao,Chen Jiaqi,Wang Qian,Qin Shili,Gao Lidi,Ma Wenhui,Li Jun,Zhao Ming,Zhang Weibing
In this study, three different materials were prepared: dendritic fiber-type silica (KCC-1), zeolitic imidazolate framework-8 (ZIF-8), and a new composite material called KCC-1@ZIF-8. These materials were synthesized using microemulsion, stirring, and coating methods, respectively. The properties of the materials were characterized using various techniques such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), TGA and X-ray diffraction (XRD). The results showed that KCC-1@ZIF-8 exhibited a significant increase in the BET surface area and pore size compared to the individual components KCC-1 and ZIF-8. These improved properties of the composite material were beneficial for enhancing the adsorption capacity. The effects of initial concentrations, solution pH and reaction time on the adsorption capacity were investigated. The adsorption kinetics and isothermal data of ZIF-8 and KCC-1@ZIF-8 fitted well with pseudo-second-order and Langmuir isotherm models. The results of adsorption thermodynamics show that the adsorption process is spontaneous and endothermic. KCC-1@ZIF-8 exhibited a very high adsorption capacity (751.46 mg g−1) at an initial TC hydrochloride concentration of 80 mg L−1 in an aqueous solution at 301.15 K, and the value was higher than that of ZIF-8 (549.80 mg g−1) under the same conditions. KCC-1 exhibited a relatively lower capacity (37.860 mg g−1). Based on these findings, KCC-1@ZIF-8 was considered a promising adsorbent for the treatment of wastewater contaminated with TC hydrochloride. Additionally, the composite material, when combined with high-performance liquid chromatography (HPLC), could be used as a solid-phase extraction adsorbent for the adsorption of TC hydrochloride in animal foodstuff samples. The calibration curves showed a linear range of 20–500 μg L−1, and the recovery rate ranged from 85.216% to 90.717%. No one has made adsorbents with this new structure before, and KCC-1@ZIF-8 possessed excellent adsorption properties, which make it a potential candidate for environmental remediation and analytical applications involving TC hydrochloride.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Tengfei Liu,Yuanshuang Liu,Dingrong Qu,Shougang Chen,Wenwu Chen,Lei Han,Zhigang Qiu,Linqi Zhu,Mindong Chen
COF LZU-1 has the characteristics of a porous structure, a large specific surface area , and good chemical stability. In recent decades, extensive research has been conducted on its use as a nanomaterial for drug loading and separation. Here, we report a new corrosion inhibitor encapsulated nanostructure (LZU-1 @BTA). We synthesized LZU-1 via a hydrothermal method and loaded benzotriazole (BTA) corrosion inhibitor into LZU-1. The results show that loaded BTA can achieve effective pH-responsive release under acidic and alkaline conditions. The amino group present in the LZU-1 molecule can cross-link with epoxy resin , and its compatibility allows for good dispersion in epoxy resin without any further modification. The LZU-1 @BTA modified epoxy coating has shown remarkable anti-corrosion properties and excellent self-healing capabilities, which have been evaluated through various techniques such as potentiodynamic polarization curves, electrochemical impedance spectroscopy (EIS), local electrochemical impedance spectroscopy (LEIS), scanning Kelvin probe (SKP) and salt spray testing. The high-quality dispersion of LZU-1 @BTA in the resin, the high cross-linking density, and the pH-responsive release of BTA in the epoxy resin are some of the key factors that contribute to the excellent anti-corrosion performance of the epoxy resin composite coating . This research has opened up new possibilities for designing anti-corrosion coatings with significantly better corrosion resistance .
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BIOORGANIC CHEMISTRY
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2024
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IF 4.5
Yi Chen,Shasha Song,Yongfang Wang,Lili Wu,Jianbing Wu,Zhengmeng Jiang,Xinyu Li
Psoriasis (PSO) is a common inflammatory skin disease caused by multiple factors. Magnolia officinalis is an important medicinal plant in China, with various values such as ecology, medicine, food, and daily chemicals. However, its diverse application potential has not been fully explored. Magnolol (MGO) is the main active compound of Magnolia officinalis with significant anti-inflammatory effect. To investigate the application potential of MGO in inflammatory skin disease, the effects and underlying mechanisms of topical MGO treating psoriasis were explored in this study. Network pharmacology and molecular docking firstly predicted that topical MGO may treat psoriasis by regulating pyroptosis pathway and acting on caspase-1 (CASP1). In vitro experiments then demonstrated that MGO could inhibit the level of inflammatory cytokines and the key protein expression of NOD-like receptor protein 3 (NLRP3)/Caspase-1 pathway in lipopolysaccharide (LPS)-stimulated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 cells. Meanwhile, MGO could inhibit CuSO 4 -induced neutrophils migration in Tg (mpx:EGFP) zebrafish by suppressing inflammation and pyroptosis. This study further indicated that topical application of MGO ameliorated imiquimod (IMQ)-induced psoriasis-like dermatitis by reducing the release of inflammatory factors and decreasing the key protein expression of pyroptosis-related NLRP3/Caspase-1 pathway. Metabolomics analysis revealed that topical application of MGO could significantly regulate tryptophan metabolism and affect the level of tryptophan in skin lesions. Tryptophan could also regulate inflammation-related genes and inhibit pyroptosis-related NLRP3/Caspase-1 pathway in LPS-stimulated PMA-differentiated THP-1 cells. In conclusion, this study suggested that topical MGO may ameliorate psoriasis-like dermatitis by inhibiting NLRP3/Caspase-1 pathway and regulating tryptophan metabolism.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Weijie Zhang,Xiaofei Wang,Peng Wang,Qingdong Li,Yankun Zhang,Xiaoshuo Meng,Geng Tian,Jianmin Xiao,Guilong Zhang
Cisplatin (CDDP), a first-line chemotherapeutic agent, faces significant challenges in the treatment of non-small-cell lung cancer (NSCLC) due to the rapid emergence of drug resistance. In this study, a glucose transporter protein 1-targeted nanodrug (RCPM) was developed by coordinating rutin with polymetallic ions, including Fe, V , and Pt. RCPM selectively targeted CDDP-resistant A549 (A549R) cells, efficiently accumulating within tumors. Exhibiting exceptional photothermal (PT) properties, RCPM facilitated PT-induced tumor ablation. Within the tumor microenvironment, RCPM underwent degradation, releasing high concentrations of V , Fe, and CDDP. The liberated V and Fe ions catalyzed the Fenton reaction, generating reactive oxygen species (ROS) and inducing ferroptosis. Simultaneously, these metal ions synergistically suppressed the expression of excision repair cross-complementing 1 (ERCC1), glutathione (GSH), and adenosine triphosphate (ATP), effectively disrupting DNA repair pathways, preventing CDDP inactivation, and enhancing its cytotoxicity against A549R tumors. Furthermore, RCPM demonstrated complete and rapid renal clearance, ensuring excellent biosafety and strong clinical translational potential. In vivo studies revealed that a single administration of RCPM, combined with PT therapy, significantly inhibited NSCLC progression. These findings highlight RCPM as a promising nanodrug for overcoming CDDP resistance and enhancing NSCLC treatment efficacy.
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SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Lingnan Kong,Quanhua Xie,Yuanyuan He,Shiyu Dong,Yang Liu,Wenliang Fan,Haiyan Yao,Mingfu Zhao,Nianbing Zhong
This paper proposes a polyvinyl alcohol/AlFFIVE-1-Ni (PVA/KAUST-8)-coated long-period fiber grating (LPFG) SO 2 concentration sensor to accurately monitor SO 2 concentrations online. To enhance the adhesion strength between the fiber and a SO 2 -sensitive film, the etched LPFG surface was silanized using 3-aminopropyltriethoxysilane, and then coated with a PVA/KAUST-8 SO 2 -sensitive sol using the doctor blading method. A fluorosilane hydrophobic coating was deposited on the SO 2 -sensitive membrane surface and integrated with a LPFG temperature sensor, thereby effectively eliminating measurement interference caused by ambient temperature and humidity fluctuations during SO 2 concentration detection. The morphology and composition of the SO 2 -sensitive films were characterized using optical microscopy, field-emission scanning electron microscopy, X-ray diffraction analysis, and X-ray photoelectron spectroscopy. Furthermore, the working principle of the sensors for the detection of SO 2 was established. Under optimized parameters (LPFG diameter: 60 μm; PVA doping in PVA/KAUST-8: 12 wt%; SO 2 -sensitive film: 45 μm; fluorosilane composite layers: 12) within a humidity range of 0–60 % RH and a temperature range of 25–45 °C, the sensor demonstrated a good selective SO 2 detection with 2.79 pm/ppm sensitivity, 1.07 ppm detection limit, 390 s response time, and 8.89 % maximum relative error.
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BRITISH JOURNAL OF PHARMACOLOGY
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2025
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IF 7.7
Hui Ma,Yue Chen,Yi-Mo Zhang,Yue Zhang,Xiao-Juan Hou,Hai-Long Li,Yi-Xin Yang,Qian Long,Xin Qiao,Yun-Feng Li
Background and Purpose Ischaemic stroke is one of the most critical causes of death and disability worldwide, but its pharmacotherapies are currently lacking. This study aimed to investigate the effects of the sigma non-opioid intracellular receptor 1 agonist hypidone hydrochloride (YL-0919) on ischaemic stroke as well as the underlying mechanisms. Experimental Approach Male mice were subjected to a middle cerebral artery occlusion (MCAO)/reperfusion (R) model to mimic ischaemic stroke injury. Neurological and cognitive functions were evaluated, and neuroinflammatory pathways in the medial prefrontal cortex and hippocampus were detected. Key Results Mice subjected to MCAO exhibited obvious neurological and motor deficits, increased infarct volume and neuronal death in the acute phase, and severe cognitive impairment in the chronic phase. Administration of YL-0919 for seven consecutive days beginning within 7 h after MCAO significantly ameliorated the pathological changes described above. Further studies demonstrated that YL-0919 exerted its effect by suppressing absent in melanoma 2 (AIM2)-related inflammatory signals in MCAO mice and alleviated the neuronal deficits in the medial prefrontal cortex and hippocampus, thereby ameliorating chronic post-stroke cognitive impairment. This effect was eliminated by AIM2 overexpression in the medial prefrontal cortex and hippocampus. Conclusions and Implications This study highlights the extended therapeutic window for sigma non-opioid intracellular receptor 1 agonist administration during the acute phase of ischaemic stroke and further demonstrates that targeted inhibition of AIM2-mediated neuroinflammatory pathways may promote sustained cognitive rehabilitation in post-stroke survivors. Graphical
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REPRODUCTIVE TOXICOLOGY
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2025
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IF 2.8
Cheng Cheng,Yanfan Cui,Yujie Wang,Jingfeng Huang,Jiale Ma,Tao Luo,Wen Chen
Microplastics and nanoplastics (MNPs) are widespread in the environment and have male reproductive toxicity. However, toxic interventions involving MNPs have not been extensively examined. In this investigation, we explored the elimination capacity of magnetic nano-Fe 3 O 4 on polystyrene microplastics and nanoplastics (PS-MNPs) of different sizes. This study also investigated whether magnetic nano-Fe 3 O 4 could alleviate the toxicity of PS-MNPs in spermatogonial GC-1 cells. After coprecipitation by magnetic nano-Fe 3 O 4 in ddH 2 O, the removal rates of polystyrene microplastics (PS-MPs, 4 and 10 μm) are much higher than those of PS-NPs (25 nm, 100 nm, and 500 nm). The removal rate of the PS-NPs dramatically enhanced in the salt ion solutions. In addition, 25-nm, 100-nm, 500-nm, and 4-µm PS-MNPs penetrated GC-1 cells. Nevertheless, exclusively 25-nm PS-NPs decreased cell viability, elevated reactive oxygen species, disrupted the mitochondrial membrane potential, and induced apoptosis and inflammation through the P38/MAPK and Nrf2/HO-1 signaling pathways in GC-1 cells. Interestingly, magnetic nano-Fe 3 O 4 alleviated these harmful impacts of the 25-nm PS-NPs on the GC-1 cells. In conclusion, we demonstrated the toxicity of PS-NPs in GC-1 cells and provided a viable way to alleviate their toxicity.
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INORGANIC CHEMISTRY COMMUNICATIONS
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2025
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IF 5.4
Fengxing Long,Yanjia Zhou,Xiaodong Tang,Zheng Wang,Zhedan Yang,Liping Feng
For lithium extraction processes from liquid lithium resources, surmounting the interference of coexisting ions on the selective extraction of Li + − especially the selective separation of Mg 2+ and Li + − presents a challenging task. UIO-66 and HKUST-1, both metal-organic frameworks (MOFs), are synthesized using organic ligands with benzene ring groups. To boost the Li + adsorption and recognition capabilities of these two materials, LiNO 3 was introduced as a template, which not only constructs a Li + -size-adapted microenvironment within the adsorbent framework but also functions as a mineralizer, facilitating the formation of more uniformly sized crystals. The modified Li/UIO-66 and Li/HKUST-1 achieved maximum Li + adsorption capacities ( Q ) of 35.57 and 26.33 mg/g, respectively, reaching adsorption equilibrium within approximately 3 h. Li/UIO-66 showcases excellent Mg 2+ /Li + separation performance and maintains certain separation factor even in mixed solutions containing multiple interfering ions. Although Li/HKUST-1 demonstrates a stronger tendency for selective adsorption of higher-valent ions, it holds promise for the removal of interfering ions from solutions, thereby contributing to the overall optimization of lithium extraction processes.
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APPLIED CATALYSIS A-GENERAL
·
2025
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IF 4.8
Huimin Li,Bin Wu,Zhimin Zhu,Chenyang Li,Zhihan Liu,Fuweng Zhang,Huidong Zheng,Longfei Yan
Ethylene sulfate (DTD) is a new type of solid electrolyte interphase (SEI) film-forming additive for lithium-ion batteries. DTD was typically synthesized in the industry by oxidation of ethylene sulfite (ES) with NaClO via a RuCl 3 -catalyzed reaction. However, this route generates significant amount of Cl-containing wastes, and the recovery of RuCl 3 is costly and technically challenging. Herein, we present a green and heterogeneous route for synthesizing DTD from ES, utilizing the Titanium Silicalite-1 (TS-1) and H 2 O 2 as catalysts and green oxidants, respectively. Our research reveals that the tetra-coordination framework of Ti in TS-1 serves as the main active site for the oxidation of ES, achieving a remarkable yield of DTD up to 92 % under optimized reaction conditions. Additionally, we developed a continuous green oxidation process for synthesizing DTD from ES, which is the first of its kind and has been successfully operated continuously for over 300 h. This work provides a cost-effective, green, and efficient route for synthesizing DTD from ES.
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