FOOD CHEMISTRY
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2021
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IF 7.514
Chao Zou,Ling Huang,Donghui Li,Yu Ma,Yixiang Liu,Yanbo Wang,Min-Jie Cao,Guang-Ming Liu,Lechang Sun
In this work, an enteric soluble alginate was proposed to improve the absorption efficiency of cyanidin-3-O-glucoside (C3G) through molecular self-assembly. Under the optimized conditions, the obtained low-viscosity alginate (LVA) was released completely during the simulated gastrointestinal digestion and an LVA–C3G complex with 84.2% binding efficiency was acquired. Fourier transform infrared spectroscopy displayed that the characteristic spectrum of C3G had disappeared after the LVA conjugation. Furthermore, based on the analysis of scanning electron microscopy and differential scanning calorimetry, a porous network structure and the shifted endothermic peak in the thermograms were observed, further confirming the formation of a complex between LVA and C3G. The results of simulated gastrointestinal digestion reveal that the LVA assembly significantly ( p < 0.05) improved the bioaccessibility of C3G. Correspondingly, the C3G level in mouse plasma was increased by 27.4% in the C3G-LVA group. This suggests the suitability of LVA as an oral delivery vehicle for dietary anthocyanins.
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JOURNAL OF CHROMATOGRAPHY A
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2021
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IF 4.759
Xue Zhao,Xiaoying Fu,Xinyi Yuan,Aerduosi Shayiranbieke,Ru Xu,Fang Cao,Jianping Ren,Qi Liang,Xinfeng Zhao
The pursuit of new ligands binding to muscarinic-3 acetylcholine receptor (M 3 R) is viewed as challenging due to the lack of screening methods with high efficiency. To address such challenges, this work developed and characterized an approach to the rapid discovery of M 3 R ligands using the immobilized receptor as the chromatographic stationary phase. We fused haloalkane dehalogenase (Halo) as a tag at the C-terminus of M 3 R. The fusion M 3 R was immobilized on 6-chlorocaproic acid-activated ammino-microspheres by the specific covalent reaction between the Halo-tag and the linker. Comprehensive characterizations of the immobilized M 3 R were performed by scanning electron microscope, X-ray photoelectron spectroscopy, and the investigation on the binding of three specific ligands to the receptor. The feasibility of the immobilized M 3 R in complex matrices was tested by screening the bioactive compounds in Zhisou oral liquid, assessing the interaction between the screened compounds and the receptor using zonal elution, and evaluating the in vivo activity of the targeted compounds. The results evidenced that the immobilized M 3 R has high specificity, good stability, and the capacity to separate M 3 R ligands from complex matrices. These allowed us to identify naringin, hesperidin, liquiritigenin, platycodin D, and glycyrrhizic acid as the potential ligands of M 3 R. The association constants of the five compounds to M 3 R were 4.44 × 10 4 , 1.11 × 10 4 , 7.20 × 10 4 , 4.15 × 10 4 , and 3.36 × 10 4 M −1 . The synergistic application of the five compounds exhibited an equivalent expectorant activity to the original formula. We reasoned that the current method is possible to provide a highly efficient strategy for the discovery of receptor ligands.
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ELECTROCHIMICA ACTA
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2021
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IF 6.901
Wenhao Ren,Yun Huang,Saisai Li,Junyuan Gan,Jun Yang,Xing Li,Mingshan Wang,Haijun Cao
Lithium metal has been considered as a potential replacement for the commercialized graphite anode to further boost the energy density of Li-ion batteries. However, Li dendrite growth during Li plating/stripping causes safety concern and poor lifespan of Li metal batteries (LMBs). In addition, the deploy of Ni-rich high-loading LiNi x Co y Mn 1-x-y O 2 (NCM, 0.6 ≤ x ≤ 0.95) is also an efficient way for boosting energy density. However, the dissolution of transition metal ion and structure evolution during cell operation can leave an adverse effect on cell performances. Herein, dual-functional 3-thiopheneboronic acid (TB) additive is used to form a lithium borate-rich solid electrolyte interphase (SEI) on Li anode and an improved cathode electrolyte interphase (CEI) on Ni-rich cathode. The TB-induced SEI layer is conductive and stable, and thus beneficial to improving kinetic limitation of Li nucleation and obtain a uniform morphology of Li deposition. When the TB-protected Li metal anode matches the high-loading LiNi 0.6 Co 0.2 Mn 0.2 O 2 (NMC622) cathode (13.65 mg cm −2 ), high initial capacities of 163.78 mAh g −1 (2.23 mAh cm −2 ) at 0.2 C and 164.82 mAh g −1 (2.25 mAh cm −2 ) at 0.5 C after activation are obtained, attributing to the effective SEI and stable CEI induced by TB. This strategy of introducing additives into LMB system with Ni-rich high-loading NMC cathode affords an emerging energy storage system to demonstrates the material engineering of batteries with very high energy density.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2021
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IF 5.302
Wei Xie,Qiangang Fu,Chunyu Cheng,Pei Zhang,Ningning Yan
The medium-entropy oxide (Y 1/3 Yb 1/3 Lu 1/3 ) 2 O 3 with a body-centered cubic structure was successfully synthesized by solid-state reaction process, and then it was introduced into SiC ceramic to study its effect on the oxidation behavior of SiC ceramic at 1700 °C. The (Y 1/3 Yb 1/3 Lu 1/3 ) 2 O 3 -modified SiC ceramic exhibited better oxidation resistance than its individual oxides (Y 2 O 3 , Yb 2 O 3 , and Lu 2 O 3 ) modified SiC ceramic. The experimental and calculated results all indicate that the rare-earth atoms had the tendency to diffuse into the SiO 2 structure and occupy the interstitial positions within SiO 2 structure. The introduction of medium-entropy oxide (Y 1/3 Yb 1/3 Lu 1/3 ) 2 O 3 reduced the initial oxidation rate of the ceramic samples (1−3 h), and enhanced the stability of SiO 2 structure, thus resulting in a better oxidation resistance at 1700 °C.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Jin Xu,Yanfei Chen,Yuanfang Tian,Zhaojie Yang,Zhixin Zhao,Wenhao Du,Xi Zhang
As a promising biodegradable resin, poly (butylene succinate) (PBS) is often blended with starch to reduce the cost. In this paper, 1-buyl-3-methylimidazolium halide pre-plasticized corn starch (CS) was blended with PBS to prepare PBS/corn starch blend material modified by ionic liquid (PBS/CS-IL). Ionic liquid (IL) acted as plasticizer and compatibilizer, and the effects of 1-butyl-3-methylimidazolium halide with different halogen anion on PBS/Starch blends were explored. The effects of IL on the structure and tensile property of PBS/Starch blends were evaluated by FTIR, SEM, DSC , TGA and XRD, respectively. Test results showed that the addition of IL significantly reduced the crystallinity of PBS/Starch blends, and the size of starch particles in the PBS matrix was also effectively reduced. IL also acted as a compatibilizer of starch and PBS, and induced the morphology of the blends to change from “sea-island” structure to homogeneous phase. The results of the tensile test showed that compared with the PBS/Starch blend without IL, the elongation at break of PBS/CS-IL increased from 22% to 93%. This study provided a simple and feasible method for the preparation of low-cost PBS bio-composite materials, and provided theoretical support for future industrial production.
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ACS Sustainable Chemistry & Engineering
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2020
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IF 7.632
Dan Zhao,Shi-Rui Zhang,Yan-Ping Fan,Bao-Zhong Liu,Ya-Nan Li,Lin-Ying Shi,Shao-Jie Dai
Developing broad-band-emitting phosphors is very important to light-emitting diode (LED) lighting and displays. We introduced Eu2+ to solid solutions K2YZr1–yHfy(PO4)3 with a langbeinite-type structure to prepare a series of new phosphors. In this structure, two K+ sites could be occupied by Eu2+ cations to provide two different kinds of coordination environments, leading to broad emitting bands in the range of 390–700 nm. The coordination circumstance of Eu2+ was analyzed by Gaussian fitting and time-resolved emission spectra. Furthermore, the emitting intensity and thermal stability can be improved by modulating the crystalline field via substituting Zr4+ by Hf4+. When the Zr4+ was fully substituted by Hf4+, the external quantum efficiency increased by 53.75%, giving a bright cyan emission. Finally, an archetype white-LED lamp was made using cyan phosphor K2YHf(PO4)3:0.04Eu, red phosphor CaAlSiN3:Eu2+, and a 365 nm LED chip, which realized an applicable color rendering index (Ra = 81) and a correlated color temperature (CCT = 3792 K).
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
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2020
·Vol. 56
·期 4
·1788-1800
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IF 2.773
Huanhuan Dong,Xin Yin,Wusigale,Hao Cheng,Narangerel Choijilsuren,Xing Chen,Li Liang
Summary Ligand-binding proteins were proposed as ideal carriers for the co-encapsulation of bioactive compounds. Multiple compounds co-encapsulated in food formulation may give rise to different effects on bioactivity and stability. The protein effect on the interplay between bioactive compounds was investigated for selecting suitable co-encapsulation strategy. α-Tocopherol, resveratrol and epigallocatechin-3-gallate (EGCG), as model compounds, interacted with bovine serum albumin (BSA) to form tri-ligand complexes when added in the sequence. For ferric-reducing antioxidant power, the mixtures of α-tocopherol and resveratrol,α-tocopherol and EGCG, resveratrol and EGCG were respectively additive, antagonistic and synergistic, while their ternary mixture were antagonistic. For ABTS+ scavenging capacity, all pairs were antagonistic. BSA improved FRAP of α-tocopherol, resveratrol and EGCG mixture but decreased their ABTS inhibition. Although structural stability and antioxidant activity of resveratrol decreased when alone interacted with BSA, they were improved when α-tocopherol and EGCG were co-presented. Mixing the antioxidants improved their stability and the complexation with BSA can further stabilise them. BSA could thus be a suitable carrier for co-encapsulation/protection of α-tocopherol, resveratrol and EGCG in functional foods.
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BIOELECTROCHEMISTRY
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2020
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IF 4.722
Guiyin Li,Huafu Feng,Xiaohang Shi,Min Chen,Jintao Liang,Zhide Zhou
Glypican-3 (GPC3) is a highly specific tumor marker for hepatocellular carcinoma (HCC), and plays an important role in reflecting the existence, therapeutic evaluation, monitoring and prognosis of HCC. Herein, an electrochemical aptasensor was designed for GPC3 detection with the reduced graphene oxide-hemin nanocomposites (RGO-Hemin) modified on the screen-printed electrode surface as the sensing platform and GPC3 aptamer as recognize molecule. In the existence of GPC3, the aptamer can specifically bind with the target GPC3 and form GPC3-aptamer conjugations on the sensing surface, which would increase the resistance of the electron transfer on the electrode and make the decrease of electrochemical signals of Hemin in RGO-Hemin nanocomposites. The electrochemical current change was recorded by differential pulse voltammetry (DPV). Scanning electron microscopy (SEM), Raman microscope (RM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to characterize the GPC3 electrochemical aptasensor. Under the optimum conditions, the current response of the electrochemical aptasensor is linearly correlated with the concentration of GPC3 (0.001–10.0 μg/mL) with the detection limit of 2.86 ng/mL (S/N = 3) and the sensitivity of 0.134 μA/μM/cm 2 . In addition, the aptasensor was applied to the determination of GPC3 in spiked human plasma and the recoveries fluctuated from 102.68% to 117.29%. All these results show that the aptasensor has good specificity, sensitivity, stability and reproducibility for GPC3 detection.
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FOOD RESEARCH INTERNATIONAL
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2020
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IF 4.972
Shujie Wang,Guoqin Liu,Weiwei Cheng
3-Monochloropropanediol esters (3-MCPDEs) and glycidyl esters (GEs) with high toxicity have drawn global concerns due to their widespread occurrence in refined oils and oil-based foods . The effect mechanisms of organic chlorine compound lindane, inorganic chlorine compounds tetra- n -butylammonium chloride (TBAC) and sodium chloride (NaCl) on the formation of 3-MCPDEs and GEs were investigated in model oils and chemical models at 240 °C. Results showed that 3-MCPDEs contents increased with the addition of lindane and TBAC, whereas, surprisingly, GEs presented the same tendency as the results of 3-MCPDEs. This suggested that although chlorine compounds were not involved in the formation reaction of GEs, they could also promote GEs formation. Chemical model experiments confirmed that the presence of chlorine compounds led to the transformation of GEs to 3-MCPDEs and conversely 3-MCPDEs could also transform to GEs. The latter transformation rate from 3-MCPDEs to GEs was higher than the former, which might account for the fact that chlorine compounds promoted GEs formation. Additionally, it was also observed that solid NaCl did not induce the increase of 3-MCPDEs and GEs levels in chemical models, suggesting that the chlorine in NaCl, different from lindane and TBAC, was not available for 3-MCPDEs formation. The present findings give novel insights into the interactions between 3-MCPDEs and GEs formation mechanisms, which offer the theoretical basis for efficient and simultaneous inhibition of 3-MCPDEs and GEs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
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IF 6.953
Ling Ding,Shen Song,Lele Chen,Jipeng Shi,Baotang Zhao,Guixiang Teng,Ji Zhang
In this work, an innovative composite hydrogel composed of curdlan (CD)/polyvinyl alcohol (PVA) hydrogels with a 3-d network structure was successfully prepared by freeze-thaw processing. The presence of interactions, changes in crystallinity, and thermal behaviour were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and thermogravimetry (TGA and DTG), respectively. The morphology of the hydrogels was investigated by scanning electron microscopy (SEM). With the increase of PVA concentration, the composite hydrogel had a greater mechanical strength while remaining remarkably ductile as evinced by tensile test results. PVA content affects the swelling and water retention of CD/PVA hydrogels. The results of CCK-8 assay showed that CD/PVA hydrogels have no cytotoxic effect on the mouse fibroblast L929 cells. The AO/EB double-staining experiment further proved that the cells in the composite hydrogels had good cytocompatibility. The porous biohydrogels developed in the present work can provide an ideal cell growth environment as a scaffold. CD/PVA hydrogels highlight the value of this system for cell adhesion and proliferation, and further soft tissue engineering application.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2021
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IF 19.503
Xiaoyun Chen,Huizhi Sun,Dong-Hau Kuo,Adugna Boke Abdeta,Osman Ahmed Zelekew,Yuanbo Guo,Jubin Zhang,Zhanhui Yuan,Jinguo Lin
Photocatalytic H 2 O splitting by sulfide-based materials is a great challenge, because of the poor resilience of such materials against hole oxidation. Although sulfide ion of catalyst negatively shifts the valence band-edge relative to its oxide ion, the instability of sulfide ions during H 2 O oxidation is a critical obstacle to simultaneous evolution of H 2 and O 2 . Here, active, stable, and spherical nanoflower-like bimetal (Mo,Ni)(S,O) 3- x sulfo-oxide catalysts with a band gap of ∼2.1 eV and different concentrations of oxygen vacancy defects were synthesized for H 2 O splitting. (Mo,Ni)(S,O) 3- x of 25 mg with a suitable amount of oxygen vacancy defects could evolve 587.5 μmol/h H 2 under visible-light irradiation. This work demonstrated an example of converting an oxidation photocatalyst into a reduction one. Microstructure analysis showed that surface oxygen vacancy defects and the multiple-valence charges in Ni and Mo not only promoted effective separation, interface transfer, and reactions of photo-carriers but also reduced the charge build-up to avoid photo-corrosion during photocatalytic water decomposition.
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COMPOSITES PART B-ENGINEERING
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2021
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IF 9.078
Hafezeh Nabipour,Xin Wang,Lei Song,Yuan Hu
Organic-inorganic hybrid flame retardant technology integrates independent ingredients into a whole, thus showing advantage of simultaneous improvement in flame retardant, smoke suppressant and mechanical properties of polymers over traditional flame retardants. In this work, a novel organic-inorganic hybrid flame retardant denoted as IR-MOF-3-Mel was synthesized by covalent hybridization of isoreticular metal-organic framework-3 (IR-MOF-3) with melamine. A relatively low amount of IR-MOF-3-Mel nanoparticles dramatically decreased the fire risk of epoxy resin (EP). Specifically, the EP with only 2.0 wt% of IR-MOF-3-Mel achieved a limiting oxygen index (LOI) of 30.5% as well as a UL-94 V-0 classification, whereas its counterpart with 2.0 wt% of IR-MOF-3 showed a LOI of 25.0% and no classification in UL-94 test. Furthermore, the peak heat release rate , total heat release and smoke production rate of the EP with 2.0 wt% of IR-MOF-3-Mel was declined by 74.0%, 71.4% and 35.6%, respectively, compared to neat EP. Additionally, the glass transition temperature , the tensile strength , and the young's modulus were 11 °C, 38%, and 27% higher than those of neat EP, respectively. The flame retardant mechanism analysis clarified that IR-MOF-3-Mel contributed to formation of a char layer with a high level of thermal resistance and graphitization which accounted for significantly reduced fire risks.
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