BIOLOGICAL CONTROL
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2026
·
IF 4
Ge Zhang,Kuo Huang,Changwen Ye,Qingchang Li,Chen He,Mengmeng Liu,Wei Ding,Qingyuan Hu
Postharvest mold contamination poses a significant threat to the quality and economic value of cigar tobacco leaves. This study evaluated the efficacy of the biocontrol yeast Pichia terricola N-4 (N-4) at different concentrations (10 6 , 10 7 , and 10 8 CFU/mL, designated JK1, JK2, and JK3) for inhibiting mold. The impact of N-4 on volatile organic compounds (VOCs) and the fungal community of cigar tobacco leaves was investigated using gas chromatography-ion mobility spectrometry (GC-IMS) and high-throughput sequencing (HTS). Results indicated that JK2 and JK3 treatments significantly inhibited mold growth. Importantly, olfactory sensory evaluation confirmed that the effective JK2 treatment successfully controlled mold without introducing off-odors. Furthermore, a double-dish assay demonstrated that N-4 completely inhibited mold outbreaks on cigar tobacco leaves via a gaseous fumigation effect, without requiring direct physical contact. GC-IMS identified 74 VOCs, with 17 exhibiting significant differences ( P < 0.05) among treatments. The relative contents of 2-methyl-1-butanol and 2-methyl-1-propanol were significantly elevated in N-4 treated samples and showed strong positive correlations with the genus Pichia . Fungal community analysis revealed a decrease in α-diversity in all treated samples (MB7, JK1, JK2, JK3) compared to MB0. Although Aspergillus remained the dominant genus natively, the relative abundance of Pichia increased significantly in the high-concentration N-4 treatment (JK3). Spearman correlation analysis revealed strong positive associations between Pichia and key VOCs. This study clarified the inhibitory effects of N-4 and provided systematic guidance for its safe, eco-friendly application in cigar tobacco mold prevention.
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Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Wenjun Gong,Yating Pang,Chenyu Wang,Wenming Wang,Hong-Fei Wang
The dinitrosyl iron complex (DNIC) is a ubiquitous functional brick often used as a vehicle for the NO radical and chelatable iron pool, with a key role in chemical and biomedical applications. In this work, four DNICs modified with different thiolate bridging ligands (–SL) were synthesized. These complexes were characterized by 1H-NMR, electrospray ionization mass spectrometry, and X-ray crystal diffraction. Photoinduced NO release from the complexes in solution was further explored by time-resolved infrared and time-resolved electron paramagnetic resonance (EPR) spectra. The cluster complexes showed relatively lower cytotoxicity against the normal human liver cell line HL-7702 and higher cytotoxicity against human cervical cancer cells, with a selectivity index of 2.4–4.8. The cluster complexes with different L groups had different rates of NO release and protein binding constants. Moreover, NO released upon photoirradiation entered living cells, which were successfully imaged using an NO-selective fluorescent probe. The ferritin complex adducts further enhanced the cytotoxicity and cellular fluorescent intensity of NO, and the crystal structure revealed the coordination of the Fe(SL)2 unit with Cys102 of ferritin. This study provides insight into the photodynamic mechanism of nitrosyl iron−sulfur clusters to understand their physiological activity.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2025
·
IF 2.2
Min Zheng,Ali Farajtabar,Abolghasem Jouyban,William E. Acree,Hongkun Zhao
At 298.15 Kelvin, the method of isothermal dissolution was utilized in this current work at 101.0 kPa to obtain the experimental solubility data for the quaternary terephthalic acid (TA), p -toluic acid ( p -TLA) + 4-carboxybenzaldehyde (4-CBA) + N -methylpyrrolidone (NMP) system. Generation of the quaternary phase diagram was made through the Jãneck approach, which was based on the mutual solubility that was determined. Three zones of neat solid crystallization, one invariant point, along with three co-saturated curves, were included in the quaternary phase diagram. The three solids that were validated by Schreinemaker approach of wet residue were pure p -TLA, pure 4-CBA, and pure TAˑ2NMP, an adduct of TA with NMP with a mole ratio of 1:2. The area where TAˑ2NMP crystallizes is larger compared to that for p -TLA and 4-CBA. In addition, the model of NRTL was used to mathematically correlate and calculate the quaternary solid-liquid phase diagram. The experimental quaternary phase diagram was found to be in good agreement with the computed one obtained from the NRTL model as evidenced by a root-mean-square deviation of 0.14632 and a relative average deviation of 5.01 %. Separating TA from its mixtures by solvent adduct crystallization might be fundamentally supported by the quaternary phase diagram and thermodynamic models. Considering the investigation on the independent gradient model based on Hirshfeld partitions, as well as the 2D fingerprint plot and difference map of electron density, density difference and difference map of ELF analysis, the van der Waals forces are viewed as favorable weak interactions during the process of forming the adduct of TAˑ2NMP.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qianqian Yu,Xiaohan Sun,Meiying Wu,Zejun Pan,Jing Chen,Zhaolin Yang,Xin Li,Yudong Li,Dexiu Min,Xiaodong Li,Chengyu Wang
With the advancement of technology, the production of domestic sewage and industrial wastewater containing dyes are increasing steadily. In the evolutionary process of catalytic reduction wastewater, recyclability and homogenization are still puzzles. Herein, a wood-derived cellulose catalytic system with hierarchical pore structure was proposed based on chlorite-alkali method for efficient catalytic reduction on 4-nitrophenol (4-NP). The chlorite-alkali hydrolysis process played a significant role in enhancing channel connectivity and hydrophilicity of balsa (BS, O. pyramidale ) when removing lignin and hemicellulose. The results of cumulative complete intrusion and extrusion showed that the porosity of BS increased from 76.07 % to 92.58 % after removing components. A universal in-situ constructed tactic of PdNPs supported on a dehemicellulose BS (DHBS) without external reducing agent. Additionally, the superhydrophilic hierarchical porous wood-derived cellulose structure had a synergistic effect with plasmonic enhancement of PdNPs on the catalytic reduction of 4-NP, resulting in reducing 4-NP rapidly, which achieving a reduction efficiency of 90 % in the 90 s with the rate constant of 1.51 min −1 . The approach addressed the issue of low catalytic metal particle load and hider catalytic activity resulting from the limited thickness and porosity, and has a good application prospect in wastewater treatment.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jiahui Li,Zhongrui Chen,Jianhua Zhang,Ziping Song,Hongjin Yan,Haoyu Zhan,Qijia Han,Yunbo Zheng,Xiaojia Zheng,Hao Zhang,Quan Kang,Chunrui Wu
Exploring novel aqueous monomers to construct loose nanofiltration (LNF) membranes with excellent permeability and dye/salt selectivity is still needed for recovering resources in textile wastewater. In this study, a novel strategy for exploiting the differential N-site reactivities in 4-aminobenzoylhydrazine (4ABH) was proposed to precisely modulate the structure of the polyamide (PA) layer, thereby fabricating unique LNF membranes. The nucleophilic reactivities of 4ABH monomer and their effect on the PA layer formation were studied via density functional theory (DFT) and molecular dynamics simulation (MDS), which provided theoretical guidance for understanding the formation mechanism of LNF membranes. Based on the differential nucleophilic reactivities of N-sites in 4ABH (-NH₂ > -NH 2 of -NH-NH₂ > -NH- of -NH-NH₂), the proportion of large cavities within the PA cross-linked networks increased, and then the compact cross-linked structure emerged as the monomer concentration increased. The experimental result demonstrated that the optimized 4ABH/TMC LNF membrane exhibited a high water permeability of 45.03 L·m -2 ·h -1 ·bar -1 , while maintaining excellent rejection for methyl blue (MB) (95.18%), eriochrome black T (EBT) (99.24%) and congo red (CR) (99.64%) with a low salt rejection for Na₂SO₄ (24.37%), MgSO 4 (7.03%), NaCl (6.79%), and MgCl 2 (3.29%). Moreover, the membrane achieved a selectivity factor of 239.00 for CR/NaCl in dye/salt mixture solutions and showed robust stability and fouling resistance in continuous filtration tests. The strategy explored in this work provided a new insight into selecting suitable aqueous monomers for preparing the unique LNF membranes with excellent permeability and dye/salt selectivity.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
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IF 2.714
Baoyong Liu,Mei Yang,Hongguang Li
In this paper, an effective approach was successfully developed to synthesize gold nanoflowers (GNFs) using a hydrocarbon/fluorocarbon (CH-CF) hybrid surfactant ( 1 ). Upon mixing with aqueous solution of 1 in presense of AgNO 3 , HAuCl 4 could be reduced into GNFs by ascorbic acid (AA). Influences of aging time, concentration of HAuCl 4 , AgNO 3 , AA and 1 as well as temperature were investigated in detail. GNFs could not be obtained at the absence of AgNO 3 and 1 , indicating that both of them play important roles in the formation of these anisotropic gold structures. Influences of AA and temperature are relatively less pronounced, and well-defined GNFs can be synthesized in a wide range of the concentration of AA (1×10 −3 mol·L −1 to 6 × 10 −3 mol·L −1 ) and temperature (25–50 °C). The GNFs have inhomogenous cores, indicating that they are formed by the aggregation of gold crystals of smaller sizes. A two-stage growth pathway was thus proposed to explain the mechanism of the formation of GNFs. With a large surface-to-volume ratio, GNFs show surface-enhanced Raman scattering for solid R6G with enhancement factors up to a magnitude of 10 6 . They can also be used as efficient catalysts for the reduction of 4-nitroaniline by KBH 4 . The strategy demonstrated here is a facile, rapid, and contrallable one-pot method for the synthesis of GNFs in aqueous solution, which will bring out a wide range of applications.
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DESALINATION
·
2022
·
IF 11.211
Junqiang Zhang,Jiliang Ma,Gaojie Jiao,Kangning Liu,Rui Cui,Shangru Zhai,Runcang Sun
Designing an adsorbent with excellent practical application on uranium extraction from seawater is extremely difficult but urgent. Here, the poly(amidoxime) (PAO)/polyvinyl alcohol (PVA)/methyl 4-hydroxybenzoate (MeP) hydrogel (named as PP@MeP-H) was prepared using a simple and controllable ultralow temperature-solvent exchange two step strategy. With assistance of solvent exchange, MeP nanospheres anchored on the hydrogel network showed excellent antibacterial activity during the uranium adsorption from seawater. Furthermore, the hydrogel with 3D network porous structure allows uranium to easily and rapidly spread into its interior owing to its abundant porous and anti-biological pollution ion channels, which ensures maximum utilization of the effective adsorption sites on this adsorbent. The superior uranium extraction capacity achieved 162.64 mg g −1 , and the sample shows excellent stability and reusability . Interestingly, when the pH close to natural seawater , PP@MeP-H showed the highest uranium adsorption activity (153.30 mg g −1 ), and for 500 L of natural seawater, the uranium adsorption capacity achieved 3.12 mg g −1 after 21 days. Furthermore, experimental results showed that the O and N atoms of amidoxime group act as main bonding sites for uranium adsorption. As the discussed above, PP@MeP-H has excellent potential of uranium adsorption from natural seawater.
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Materials Advances
·
2023
·Vol. 4
·期 4
·1135-1145
·
IF 5
Dongcang Sun,Changtong Song,Xianhong Zhang,Dong Chen,Yuhong Ma,Wantai Yang
An ultrafiltration (UF) membrane was prepared using a blend of poly(vinyl chloride) (PVC) and low molecular weight poly(vinyl chloride-co-maleic acid monoamide) (PVMA), demonstrating a significantly improved filtration flux. For example, the water flux of the membrane fabricated with PVMA/PVC (50/50 wt%/wt%) was boosted to 691.67 L m−2 h−1vs. 64.66 L m−2 h−1 for the pure PVC membrane, while the porosity of the UF membranes was 88.6% vs. 74.7%, respectively. Employing immobilized palladium nanoparticles as a catalyst, the Pd-PVMA/PVC membrane offered an efficiency as high as 99.0%, which remained greater than 97.0% over three cycles at a filtration flux of 208.75 L m−2 h−1 for the degradation of 4-nitrophenol (4-NP). The catalytic reaction exhibited first-order kinetics and the apparent kinetic reaction constant was as high as 2.65 × 10−3 s−1 at a relatively low Pd nanoparticle loading. In this study, we developed a simple method to prepare PVC UF membranes with high water flux and efficiency for the removal of 4-NP by coupling the catalytic and separation processes.
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Yuhang Liu,Yi Zhang,Pran Gopal Karmaker,Yuting Tang,Lilei Zhang,Feng Huo,Ya Wang,Xiupei Yang
The misuse of organic pollutants such as nitrofuran antibiotics (NFAs) and 2,6-dichloro-4-nitroaniline (DCN) has become a hot topic of global concern, and developing rapid, efficient, and accurate techniques for detecting NFAs and pesticides in water is a major challenge. Here, we designed a novel lead-based anion 2D metal–organic framework (MOF){[(CH3)2NH2]2[Pb(TCBPE)(H2O)2]}n (F3) with interlocking structures, in which TCBPE stands for 1,1,2,2-tetra(4-carboxylbiphenyl)ethylene. Powder X-ray diffraction and thermogravimetric analysis revealed that F3 has excellent chemical and solvent stability. It is worth noting that F3 has a grinding discoloration effect. The solvent-protected grinding approach achieved F3B with a high quantum yield (QY = 73.77%) and blue fluorescence, while the direct grinding method produced F3Y with a high quantum yield (QY = 37.27%) and yellow–green fluorescence. Importantly, F3B can detect NFAs in water rapidly and sensitively while remaining unaffected by other antibiotics. F3Y can identify DCN in water quickly and selectively while remaining unchanged by other pesticides. F3B demonstrated high selectivity and rapid response to NFAs at a limit of detection (LOD) as low as 0.26 μM, while F3Y indicated high selectivity and responded quickly to DCN in water at an LOD as low as 0.14 μM. The method was successfully applied to detect NFAs in actual water samples of the fish tanks and ponds as well as the pesticide DCN in soil samples. The recovery rates were 97.0–105.15% and 102.2–106.48%, and the relative standard deviations were 0.63–1.45% and 0.29–1.69%, respectively. In addition, F3B and F3Y can be made into fluorescent test papers for the visual detection of NFAs and DCN, respectively. Combined with experiments and density functional theory calculations, the mechanism of fluorescence quenching of MOFs by target analytes was also revealed.
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MOLECULAR PHARMACEUTICS
·
2022
·
IF 5.364
Huan Huang,Yuling Chen,Na Yin,Gaojie Li,Shanshan Ye,Ling Guo,Min Feng
Regulating non-apoptotic cell death of cancer cells provides a promising strategy to overcome apoptosis resistance during cancer treatment. Lipids are essential components to exacerbate several non-apoptotic cell death pathways. In the present study, unsaturated fatty acid (UFA) liposomes prepared with linoleic acid, oleic acid, or α-linolenic acid have the potential to affect lipid metabolism. Notably, UFA liposomes markedly increased cellular reactive oxygen species (ROS) and down-regulated the expression of glutathione peroxidase 4 (GPX4) in tumor cells, resulting in lipid peroxidation, which in turn caused rapid membrane rupture and induced non-apoptotic cell death of tumor cells. Concomitantly, UFA liposomes induced ROS-mediated tumor-associated macrophages toward a tumoricidal phenotype to reverse the immunosuppressive tumor microenvironment. Consequently, UFA liposomes substantially inhibited tumor growth in a melanoma model by promoting lipid peroxidation, inducing non-apoptotic cell death of tumor cells, and increasing infiltration of anti-tumor immune cells at tumor sites. Therefore, UFA liposomes regulate GXP4 to exacerbate lipid peroxidation and provide a versatile liposome platform for enhancing anti-tumor therapy which could be readily extended to the delivery of anticancer agents.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Sheng Liu,Yujuan Guo,Shunmin Yi,Shijing Yan,Chaoliu Ouyang,Fei Deng,Chunxue Li,Guangfu Liao,Qing Li
Supported noble metal heterogeneous catalysts have been proven to be effective for the treatment of toxic organic pollutants. Herein, ultrafine Ag nanoparticles (NPs) with an average size of approximately 4.37 nm was decorated on the surface of pure silicon zeolite nanoparticle (PSZN) and confined in pore channels through a low-cost and environmentally friendly in-situ reduction strategy. The prepared Ag/PSZN nanocomposites showed ultrahigh catalytic activity for the reduction of 4-nitrophenol (4-NP) (∼200 s, 17.29 × 10 -3 s −1 ) and methylene blue (MB) (∼4 min, 76.53 × 10 -2 min −1 ), which outperforms the majority of the previously reported Ag-based catalysts. The excellent catalytic performance is due to the large loading amount (W t = 16.8 %) and ultrasmall size of Ag NPs, which provides abundant active sites. Moreover, it showed outstanding recyclability of 93 % and 86 % removal of 4-NP and MB, respectively, after 10 cycle reactions, and stability after 300 days of storage at room temperature. This work offers new insights into the fabrication of Ag-based catalysts for efficiently removing organic pollutants from aqueous solutions.
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MOLECULES
·
2022
·Vol. 27
·期 22
·7857
·
IF 4.927
Rong Tian,Haiyan Zhu,Yan Lu,Xunlong Shi,Peng Tu,Hong Li,Hai Huang,Daofeng Chen
Qingdai-Mabo (QM), a traditional Chinese herbal formula composed of medicinal herb and fungus, has been used for treatment of cough and viral pneumonia. However, the underlying mechanism and bioactive components against anti-influenza A virus remain unclear. In the present study, ethyl acetate (EA) extract of QM decoctions was tested for its biological activity against acute lung injury (ALI) and its main components were identified using UPLC−MS/MS. In total, 18 bioactive components were identified, including 2-Methylquinaozlin-4(3H)-one (C1), which showed significant antiviral activity in vitro with an IC50of 23.8 μg/mL. Furthermore, we validated the efficacy of C1 in ameliorating ALI lesions and inflammation in influenza A virus-infected mice. The results showed that C1 significantly reduced the lung index, downregulated neuraminidase (NA) and nucleoprotein (NP), and decreased the expression of pro-inflammatory molecules IFN-α, TNF-α, MCP-1, IL-6, and IL-8; however, they enhanced levels of IL-10 and IFN-γ in lung homogenate from mice infected by influenza A virus. In addition, C1 inhibited the recruitment of macrophages. These in vitro and in vivo studies suggested that the significant anti-influenza A virus activity contributed to its curative effect on lesions and inflammation of viral pneumonia in mice. Given its potential antiviral activity against influenza A virus, C1 is determined to be a main active component in the EA extract of QM. Taken together, the antiviral activity of C1 suggests its potential as an effective treatment against viral pneumonia via the inhibition of virus replication, but the mechanism C1 on antiviral research needs to be explored further.Keywords:influenza A virus;2-Methylquinazolin-4(3H)-one;antiviral activity;acute lung injury;viral pneumonia;Qingdai-Mabo
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