Bioactive Materials
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2022
·
IF 16.874
Yihao Liu,Haoyi Niu,Chengwei Wang,Xiaoxiao Yang,Wentao Li,Yuxin Zhang,Xiaojun Ma,Yuanjing Xu,Pengfei Zheng,Jinwu Wang,Kerong Dai
Uncontrolled hemorrhage and wound infection are crucial causes of trauma-associated death in both the military and the clinic. Therefore, developing an efficient and rapid hemostatic method with biocompatibility, easy degradation, and wound healing is of great importance and desirability. Inspired by spontaneous blood cell plug formation in the hemostasis process, an adenosine 5′-diphosphate modified pro-coagulation hyaluronic acid (HA-ADP) coordinated with enhanced antibacterial activity of undecanal-modified chitosan (UCS) was fabricated through physical electrostatic cross-linking and freeze-drying. The as-prepared hydrogel sponges showed a porous structure suitable for blood cell adhesion. In particular, the hydrogel exhibited excellent antibacterial ability and promoted the adhesion of platelets and red blood cells, thus inducing a prominent pro-coagulation ability via platelet activation, which exhibits a shorter hemostasis time (58.94% of control) in vitro . Compared with commercially available CELOX and gelatin sponge (GS), HA-ADP/UCS accelerates hemostasis and reduces blood loss in both rat tail amputation and rat artery injury models. Furthermore, all the samples exhibited superior cytocompatibility and biodegradability. Due to these performances, HA-ADP/UCS promoted full-thickness skin defect healing significantly in vivo . All the properties of HA-ADP/UCS suggest that it has great potential for translation as a clinical application material for hemostatic and wound healing.
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PubMed
高影响因子
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
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2022
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IF 4.52
Long Zhu,Mingrong Wang,Shuo Fu,Kaiqi Li,Jialin Liu,Zaizhao Wang
Bisphenol A (BPA) is a widely used endocrine disruptor , which has attracted much attention due to its harmful effects on male reproduction. To investigate the interference of BPA on steroid synthesis in males, male rare minnows ( Gobiocypris rarus ) were exposed to 15 μg L −1 BPA for 7, 14 and 21 d. Meanwhile, a positive control group was performed with 25 ng L −1 17α-ethynyl estradiol (EE2). Results showed that BPA exposure induced lower testosterone (T) levels, while affecting the transcripts of steroidogenic gene StAR . Moreover, BPA induced abnormal germ cells proliferation in the testis in rare minnow. Transcriptome analysis showed that 354 transcripts significantly differentially expressed after BPA exposure for 14 d, several of them were enriched in the signaling pathways of cell cycle process, PPAR signaling pathway, the steroid synthesis pathway and estrogen signaling pathway. BPA significantly increased estrogen receptor (ER) levels and induced abnormal protein levels of PPARγ. BPA disrupted the StAR expression by interfering ER enrichments within StAR 5′ flanking region . Additionally, our study also revealed that BPA and EE2 might have different mechanisms for interfering with steroid hormone levels and germ cells proliferation in the testis.
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PubMed
高影响因子
Biomass Conversion and Biorefinery
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2022
·Vol. 13
·期 5
·4305-4315
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IF 4.05
Yan Lishi,Li Liangzhi,Zhou Yuanzhuo,Hu Cuiying,Lu Chenxi,Shen Xin
Kinetic model is an important approach for quantitative expression of the mechanism of polysaccharide degradation to value-added products. This study conducted a mechanistic kinetic comparison for acidic degradation of terrestrial biomass-derived cellulose and marine algae-derived agarose to monosaccharides and 5-hydroxymethylfurfural (5-HMF). A pseudo-homogeneous first-order reaction kinetic model with Arrhenius-type temperature dependence was applied to interpret acidic degradation process of cellulose and agarose. The subsequent sensitivity analysis of the impact of rate constants on the production of monosaccharides and 5-HMF predicted in the kinetic model was performed. Results showed that rate constant of polysaccharide hydrolysis (k 1 ) exceeded rate constants of monosaccharide dehydration (k 2 ) and 5-HMF degradation (k 3 ) during agarose decomposition process, but was opposite in cellulose depolymerization process. The corresponding activation energy of agarose hydrolysis (64.5 kJ mol −1 ) was much lower than that of cellulose hydrolysis (121.4 kJ mol −1 ). Agarose was demonstrated to be superior to cellulose for producing monosaccharides and 5-HMF. The desired yields of monosaccharides and 5-HMF from agarose were obtained 58.5% and 27.5%, respectively. Subsequent sensitivity analysis revealed that rate constants k 1 and k 3 were the key factors controlling production of monosaccharides and 5-HMF from agarose, respectively.
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高影响因子
Biomass Conversion and Biorefinery
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2022
·
IF 4.05
Zhang Yameng,Shen Xinming,Hu Lei,Wu Zhen,Wang Xiaoyu,Jiang Yetao
The Meerwein-Ponndorf-Verley (MPV) reduction is an extremely attractive strategy for the selective hydrogenation of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-bis(hydroxymethyl)furan (BHMF) in which constructing a low-cost and high-efficiency catalyst is very essential and crucial. In this work, the enzymatic hydrolysis lignin (EL), which is a waste residue in the production process of lignocellulosic ethanol, was firstly and directly adopted as the cheap organic ligand to prepare a new zirconium-lignin hybrid catalyst (Zr-EL) by a simple solvothermal self-assembly method. Amazingly, Zr-EL displayed superior catalytic activity for the MPV reduction of HMF to BHMF, providing 98.9% yield with a high turnover frequency (TOF) of 10.86 h -1 in 2-propanol ( i PrOH) at 140 °C for 4 h. Intensive characterization and analysis results indicated that this superior catalytic activity of Zr-EL was principally attributed to the cooperative effects of Lewis acid-base sites (Zr 4+ -O 2− ) under the assistance of good hydrophilicity. Additionally, Zr-EL showed excellent catalytic stability, and when it was recovered and reused for five successive reaction cycles, an apparent loss in the yield of BHMF was not observed. More meaningfully, Zr-EL also exhibited outstanding applicability, allowing it to convert various ketone and aldehyde compounds to the corresponding alcohol products with satisfactory yields in i PrOH via MPV reduction. Conclusively, this work presents a newfangled idea to utilize the low-rank biorefinery residues and construct more practical zirconium-based catalysts for the selective synthesis of high-value chemicals. Graphical abstract
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高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 4
·2257-2272
·
IF 6.123
Shi Ning,Zhu Yuju,Qin Bangzhi,Liu Ying,Zhang Hongyan,Huang Hongsheng,Liu Yunhua
A simple and efficient biphasic system comprising H 2 O, tetrahydrofuran (THF), cyclohexane (CHX) and Al 2 (SO 4 ) 3 was employed to convert cellulose into 5-hydroxymethylfurfural (HMF). The volume ratio of the organic phase to the aqueous phase (V org /V aque ), concentration of Al 2 (SO 4 ) 3 in the aqueous phase (C[Al 2 (SO 4 ) 3 ] aque ) and concentration of Al 2 (SO 4 ) 3 in the organic phase (C[Al 2 (SO 4 ) 3 ] org ) of the biphasic system played critical roles in the conversion of cellulose into HMF. In the biphasic systems with H 2 O/THF/Al 2 (SO 4 ) 3 of 4/18/0.4 and H 2 O/THF/CHX/Al 2 (SO 4 ) 3 of 3/16/3/0.4, > 80% of the added H 2 O was dissolved in the organic phase, whereas most of the added Al 2 (SO 4 ) 3 remained in the aqueous phase under the reaction temperature, jointly leading to high V org /V aque , high C[Al 2 (SO 4 ) 3 ] aque and low C[Al 2 (SO 4 ) 3 ] org in the biphasic system. All of these results yield the excellent performance of these biphasic systems in the conversion of cellulose into HMF. The addition of CHX into the biphasic system can decrease the solubility of Al 2 (SO 4 ) 3 in the organic phase, thus improving the stability of HMF in the reaction system. The influences of catalyst usage, reaction temperature and time, and cellulose/solvent ratio were all explored, and a high HMF yield of 71.2% was obtained in the H 2 O–THF–CHX biphasic system with an H 2 O/THF/CHX volume ratio of 3/16/3 under optimized conditions. Graphical abstract
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Cell Death Discovery
·
2022
·Vol. 8
·期 1
·1-10
·
IF 7.109
Wang Jingyu,Wang Yaqing,Liu Yi,Cai Xintian,Huang Xin,Fu Wenjing,Wang Lei,Qiu Lihua,Li Junying,Sun Li
Ferroptosis is a non-traditional form of regulated cell death, characterized by iron overload and lipid peroxidation. Exploration of ferroptosis in chronic kidney disease (CKD) has been extremely limited to date. In this study, we established a rat model of CKD by 5/6 nephrectomy, treated CKD rats with the ferroptosis inducer, cisplatin (CDDP), and the ferroptosis inhibitor, deferoxamine mesylate (DFO), and observed the resulting pathologic changes (injury markers and fibrosis) and ferroptotic biochemical indices. Kidney iron deposition, lipid peroxidation, mitochondrial defects, ferroptosis marker induction, and TUNEL staining positivity were detected in CKD group rats. Further, treatment with CDDP or DFO influenced renal injury and fibrosis by affecting ferroptosis, rather than apoptosis, and ferroptosis occurs in the remnant kidney due to disordered iron metabolism. In conclusion, our study shows for the first time that 5/6 nephrectomy induces ferroptosis in the remnant kidney and clarifies the underlying pathogenesis. Moreover, we demonstrate that ferroptosis is involved in CKD progression and represents a therapeutic target in chronic kidney injury and renal fibrosis.
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高影响因子
Catalysts
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2022
·Vol. 12
·期 3
·351
·
IF 4.501
Peng Wang,Xia Xiao,Yutong Pan,Zhen Zhao,Guiyuan Jiang,Zhongdong Zhang,Fanfang Meng,Yuming Li,Xiaoqiang Fan,Lian Kong,Zean Xie
The development of an effective strategy for synthesizing two-dimensional MFI zeolites has attracted more and more attention. Herein, nanosheet-stacked hierarchical ZSM-5 zeolite was obtained by a seed-assisted hydrothermal synthesis route using a small amount of [C18H37-N+(CH3)2-C6H12-N+(CH3)2-C6H12]Br2(C18-6-6Br2) as a zeolite structure-directing agent and triethylamine (TEA) as a zeolite growth modifier. By varying the molar ratio of C18-6-6Br2/TEA from 2.5/0 to 2.5/40, the morphologies and textural properties of the resultant HZ5-2.5/x catalysts were finely modulated. By increasing x from 5 to 40, the morphology of the HZ5-2.5/x changed from unilamellar assembly with narrowa–cplane to intertwined nanosheets with widea–cplane and multilamellar nanosheets with house-of-cards morphology. The thickness of these nanosheets was almost 8–10 nm. In addition, selectivity to light olefins reached 70.7% for the HZ5-2.5/10 catalyst, which was 6.6% higher than that for CZSM-5 (64.1%). Furthermore, the MFI zeolite nanosheets exhibited better anticoking stability within the 60 h reaction time compared to conventional ZSM-5 zeolite, which could be attributed to the short diffusion path and hierarchical porosity. This work will provide valuable insights into the rational design of novel zeolite catalysts for the efficient cracking of hydrocarbons.Keywords:ZSM-5;nanosheets;zeolite growth modifiers;catalytic cracking of n-octane;light olefins
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高影响因子
Engineering
·
2022
·
IF 12.834
Youwen Shuai,Xue Huang,Benyin Zhang,Lu Xiang,Hao Xu,Qian Ye,Jinfeng Lu,Jing Zhang
The heterogeneous catalytic activation of peroxymonosulfate (PMS) for wastewater treatment is attracting increased research interest. Therefore, it is essential to find a sustainable, economical, and effective activated material for wastewater treatment. In this study, metal–organic framework (MOF)-5 was used as the precursor, and a stable and recyclable material ZnO@Ni 3 ZnC 0.7 that exhibited good adsorption and catalytic properties, was obtained by the addition of nickel and subsequent calcination. To investigate and optimize the practical application conditions, the elimination of rhodamine B (RhB) in water was selected as the model process. This study demonstrated that the degradation of organic matter in the system involved a coupling of the adsorption and degradation processes. Based on this, the mechanism of the entire process was proposed. The results of scanning electron microscopy, infrared spectrum analysis, and theoretical analysis confirmed that the van der Waals forces, electrostatic attraction, and hydrogen bonding influenced the adsorption process. Electron paramagnetic resonance analysis, masking experiments, and electrochemical tests conducted during the oxidative degradation process confirmed that the degradation mechanism of RhB included both radical and non-free radical pathways, and that the surface hydroxyl group was the key active site. The degradation of the adsorbed substrates enabled the regeneration of the active sites. The material regenerated using a simple method exhibited good efficiency for the removal of organic compounds in four-cycle tests. Moreover, this material can effectively remove a variety of organic pollutants, and can be easily recovered owing to its magnetic properties. The results demonstrated that the use of heterogeneous catalytic materials with good adsorption capacity could be an economical and beneficial strategy.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Yuanyuan Peng,Xinjing Du,Daolian Zhu,Yu Nie,Shengbin Shi,Jinfeng Xing
Drug-loaded nanogels have attracted extensive research interest and shown great potential for many biomedical applications. A facile preparation method for drug-loaded nanogels is desirable to be developed. In this study, a range of nanogels were prepared by combining thiol-ene click reaction and photopolymerization at 532 nm for in situ loading 5-Fluorouracil (NG-S). The drug loading amount was improved by introducing mercaptosuccinic acid (MCA) to trigger thiol-ene click reaction. The drug loading capacity and swelling ratio characteristics of NG-S could be tuned by changing the proportion of PEGDA/MCA and the initial dose of drug. Especially, the drug release performance of the NG-S showed that 5-Fluorouracil presented the relatively excellent behavior of controlled release with a sustained release time up to 20 h in PBS (pH 7.4) at 37 °C. The fitting results of NG-S based on R 2 were consistent with the First order, Weibull and Biexponential kinetic models .
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高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
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2022
·
IF 3.428
Hao Guo,Songjie Fan,Jianhua Liu,Yumei Wang
The synergistic effect of leucovorin calcium (LVCa) on 5-fluorouracil (5-FU) has been widely confirmed, but as far as we know, there is no effective way to simultaneously deliver LVCa and 5-FU to tumor sites. In this paper we innovatively established a dual-pH sensitive drug release system based on ZIF-8 frameworks decorated with hyaluronic acid-LVCa bioconjugates linked with an acid-cleavable hydrazone bond to achieve the combinatorial delivery and on-demand drug release of 5-fluorouracil (5-FU) and leucovorin calcium (LVCa) at the acidic pH conditions of the tumor sites. The as-obtained HA-LVCa/5-FU@ZIF-8 nanoplatforms load 0.35 g of 5-FU and 0.048 g of LVCa per gram and exhibited high inhibiting colon cells growth performance in vitro.
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高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 13
·3348-3358
·
IF 7.779
He Han,Hong Yang,Anfeng Zhang,Limin Ren,Xiaowa Nie,Chaoqiu Chen,Min Liu,Chuan Shi,Chunshan Song,Xinwen Guo
This work aims to achieve high para-selectivity while maintaining catalytic stability for the alkylation of toluene with methanol to para-xylene over ZSM-5 catalysts under demanding reaction conditions. A high para-selectivity of greater than 97% is achieved by applying consecutive SiO2–P2O5–MgO (SPM) and SiO2 surface coatings on the surface of pristine ZSM-5. This surface modification passivates the external acid sites and at the same time narrows the pore openings of the ZSM-5 particles, which are both beneficial for the high para-selectivity. The catalytic stability of the surface modified catalysts is achieved by loading with metals including Pt, Ni and (Pt + Ni). This study shows that catalysts co-loaded with (Pt + Ni) exhibit superior catalytic stability, not only in pure H2 but also in a carrier gas containing a very low H2 fraction of 5% H2 and 95% Ar. This is because the co-existence of Pt and Ni effectively inhibits the formation of low-carbon olefins (the coke precursors) via the dehydrogenation of methanol to carbon oxides and the hydrogenation of olefins to paraffins. By studying the different locations of metal loading on the catalysts, this work also confirms that the most effective location of metal loading is on the external surface of the modified catalysts.
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高影响因子
FUEL
·
2022
·
IF 8.035
Qiaozhi Ma,Mingzhao Guan,Di Fan,Enchen Jiang
5-hydroxymethylfurfural (5-HMF) is a crucial biomss-derived fuel precursor with versatile conversion pathways to advanced fuels. However, direct production of 5-HMF from crystalline cellulose is critical challenging due to the inefficient deconstruction of recalcitrant cellulose structure. Molten salt hydrates (MSHs) are unique in cellulose deconstruction and dissolution. In this work, a biphasic system of LiBr hydrate/acetone was established. It was found that 93.4% yield of 5-HMF can be efficiently converted from fructose without any catalysts. With the addition of AlCl 3 to adjust Lewis acidity, an enhanced 5-HMF yield of 75.1% together with 13.7% of glucose were directly produced from cellulose, showing a promising carbon balance of 88.8%. A proposed mechanism for cellulose conversion was studied by density functional theory (DFT) calculations, demonstrating that the isomerization of glucose to fructose rather than crystalline cellulose hydrolysis was the rate-determining step. After reaction, the formed 5-HMF can be efficiently recycled from solvent via hyper-cross-linked polymer adsorption and the reaction system can be recycled for more than 5 times without reducing 5-HMF selectivity.
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高影响因子
危险品化学品经营许可证（带存储）