Nature Catalysis
·
2025
·
IF 44.6
Huang Liang,Gao Ge,Zhao Jiwu,Roberts William L.,Lu Xu
Electrochemical upcycling of captured CO 2 under high pressure holds significant potential to bridge between CO 2 emissions and hydrocarbon commodities, yet it remains underexplored. Here we convert gas-phase high-pressure captured CO 2 into ethylene (C 2 H 4 ) using a high-pressure membrane electrode assembly equipped with In/Cu catalysts, affording up to 85% Faradaic efficiency and 750 mA cm −2 partial current density under 20 bar. Theoretical calculations and operando studies link enhanced C–C coupling to the pressure-modulated *CO adsorption configuration and elevated CO 2 coverage. High pressure also mitigates salt precipitation by relocating bicarbonate formation to the catalyst–membrane interface, enabling stable electrolysis for over 1,500 h at 600 mA cm −2 . As a proof of concept, by recapturing residual CO 2 , the system delivers industrial-grade 99.9% purity C 2 H 4 , creating an opportunity to turn the otherwise costly CO 2 capture into a profit. Energy analysis suggests that directly valorizing high-pressure captured CO 2 , instead of depressurizing and repressurizing, is essential to minimize energy consumption.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-17
·
IF 12.6
Xu Jia,Deng Cheng,Gao Tang,He Mengrong,Fu Wenpei,Zhang Xin,Bai Yin,Qiu Jiani,Wang Rui,Chen Yihan,Jin Qiaofeng,Zhang Li,Lv Qing,Xie Mingxing,Wu Wenqian
Chronic rejection (CR) remains the leading cause of morbidity and mortality in heart transplantation survivors. The primary pathological features of CR encompass cardiac allograft vasculopathy and myocardial fibrosis. Currently, its diagnosis heavily relies on invasive procedures, underscoring the pressing need for non-invasive evaluation methods. This study introduces a novel approach utilizing mannose-modified microbubbles (MBman) targeting CD206 (mannose receptor) positive M2 macrophages for early CR detection. In vitro experiments demonstrate substantial adhesion of MBman to M2 macrophages compared to common microbubbles (MBcon). In a CR rat model, MBman and MBcon are administered at three distinct time points (2 weeks, 4 weeks, and 6 weeks), followed by contrast-enhanced ultrasound images and quantitative analysis using the ultrasound destruction-supplementation method. Starting at 2 weeks and continuing through 6 weeks, MBman demonstrates significantly higher signal intensity than MBcon in allograft rats. However, this difference is not observed in isograft rats at any of the indicated time points. These findings suggest an increase in M2 macrophage infiltration in allografts compared to isografts. Furthermore, the signal intensity of MBman positively correlates with the percentage of CD206 in allograft rats. This study proposes a promising approach, simultaneous noninvasive ultrasound molecular imaging, for the early-stage evaluation of CR.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CURRENT MICROBIOLOGY
·
2025
·Vol. 82
·期 9
·1-14
·
IF 2.6
Xiao Mengzhu,Wu Yujia,Li Wanzhen,Wang Jun,Zhang Weiwei,Gui Lin,Ge Fei
Antibiotics, a milestone invention in modern medicine, have significantly improved human quality of life and serve as a primary weapon against bacterial infections. However, antibiotic abuse has led to the emergence and worsening of bacterial resistance, now a major global public health challenge. Therefore, the efficient use of nanoscale antimicrobial peptides (APs) as therapeutic and diagnostic agents offers a novel strategy to replace conventional antibiotics. In this study, we innovatively combined AP with manganese dioxide (MnO 2 ) and zeolitic imidazolate framework-8 (ZIF-8) to develop a novel composite: ZIF-8-encapsulated and AP-loaded MnO 2 (AP-MnO 2 @ZIF-8). This composite exhibited superior properties, including enhanced biocompatibility, excellent aqueous stability, and increased antibacterial activity. Both in vitro and in vivo AP-MnO 2 @ZIF-8 demonstrated potent efficacy against multidrug-resistant (MDR) Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Its minimum inhibitory concentrations (MICs) were 20 μg/ml for E. coli and 39 μg/ml for S. aureus . Furthermore, colony-forming unit (CFU) assays showed that 150-μg/ml AP-MnO 2 @ZIF-8 reduced bacterial survival below 5%, indicating effective growth inhibition. Crucially, it significantly suppressed bacterial activity in S. aureus -infected mouse wound models. Compared to free AP or MnO 2 alone, AP-MnO 2 @ZIF-8 showed significantly enhanced water solubility, bioavailability, and antibacterial activity. This work provides a foundation for developing AP-based antimicrobial strategies and offers a novel nanomaterial approach to combat the increasingly severe antibiotic resistance crisis. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL PAPERS
·
2025
·
IF 2.5
Chen De Xing,Long Yun Fei
In this paper, a novel copper nanoclusters (ARG-CuNCs) has been synthesized by Acid red G stabilized. The optimal excitation wavelength of the synthesized ARG-CuNCs is 330 nm, and a corresponding emission peak is 426 nm. Notably, the fluorescence intensity of ARG-CuNCs could be stablized over six months, and it exhibits minimal variation within the pH range of 2.21–11.58, indicating exceptional stability of the synthesized copper nanoclusters. It was observed that tetracycline (TC) effectively quenches the fluorescence intensity of ARG-CuNCs, and the relative fluorescence intensity change ( Q = F 0 /F) exhibiting a linear relationship with the concentration of TC in the range of 1.0–110.0 µmol/L, and the detection limit (LOD) is 0.33 µmol/L. Thus, a fluorescence-based analytical method for determining TC concentration has been developed based on the relationship of the Q value with the concentration of TC. Furthermore, leveraging a smartphone and colorimetric analysis software, a novel visual quantitative detection method for TC detection has been established based on the image of the mixture solution (TC and ARG-CuNCs) under the 365 nm ultraviolet lamp irradiation, and using ARG-CuNCs as a fluorescence probe. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
FIBERS AND POLYMERS
·
2025
·
IF 2.3
Zhang Lele,Sun Yi,Yang Haiwei,Sun Wanlin,Kuai Long,Wang Zongqian
Polyethylene terephthalate (PET) textile waste, which is resistant to degradation, contributes significantly to environmental pollution. Currently, traditional methods, such as high-temperature and high-pressure treatments, microwave heating, etc. exhibit low initial degradation rates for polyester fibers while also facing challenges such as high energy consumption, complex degradation products, and difficulties in subsequent reuse. Thus, research on efficient recycling and sustainable development of PET waste has become imperative. Here, we report a novel method to degrade PET fibers completely at low temperatures within 1 h. A synergistic hydrolysis system consisting of a deep eutectic solvent (ChCl–EG DES) composed of choline chloride and ethylene glycol, along with sodium hydroxide (NaOH) was used to facilitate the highly efficient and complete degradation of polyester fibers under mild conditions. The degradation process can be conducted at temperature below 100 °C, achieving a degradation rate of up to 100%, with the degradation product being sodium terephthalate, which exhibits a high purity of 99.85% and can be directly reused as a raw material without complex treatments and purification steps. The degradation kinetic of polyester fibers fits first-order reaction, with an activation energy of 108.59 kJ/mol. Overall, this study provides a green, low-cost, and energy-saving strategy with practical application value for efficient degradation and recycling of polyester fibers.
✓ 已验证
产品关联
DOI
高影响因子
Communications Biology
·
2025
·Vol. 8
·期 1
·1-15
·
IF 5.1
Wang Yue,Wang Yang,Tong Fei,Gao Qianqian,Li Baoxuan,Zhao Yan
Preeclampsia is one of the most common pregnancy disorders, and characterized by insufficient trophoblast invasion and placental inflammation. Our RNA sequencing results showed that OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) was downregulated in placenta from preeclampsia patients, compared with the healthy control. Clinical and experimental data demonstrated that OTUB2 was expressed in macrophages. Gain- and loss-of-function experiments revealed that OTUB2 overexpression blocked M1 polarization of macrophages, and attenuated macrophages-induced apoptosis, and impaired migration and invasion of trophoblasts. Moreover, OTUB2 alleviated LPS-induced preeclampsia-like symptoms in rats, including hypertension, proteinuria, inflammation in placenta and insufficient infiltration of trophoblasts. Additionally, OTUB2 mediated deubiquitination of nuclear receptor subfamily 4 group A member 1 (NR4A1) and suppressed its degradation, and the Cys51 is crucial for catalytic activity of OTUB2. The effects of OTUB2 were partially reversed by shNR4A1. In conclusion, OTUB2 suppressed macrophage M1 polarization, macrophages-induced trophoblast damage, and restrained experimental preeclampsia in rodents by mediating deubiquitination of NR4A1. These findings may provide novel insight for clinical prevention and diagnosis of preeclampsia.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIODEGRADATION
·
2025
·Vol. 36
·期 4
·1-15
·
IF 3.2
Shao Pengfei,Yao Jun,Li Miaomiao,Min Ning
Phthalate esters (PAEs) are widely used as plasticizers and beneficiation flotation agents in ore smelters, which are ubiquitously distributed emerging contaminants in the environment. The biodegradation of PAEs by degrading microbes is a promising method for their remediation. In this study, we isolated a novel PAE-degrading bacteria, Sinomonas sp. S2, from a contaminated area of a metal(loid) smelter in Guangxi Zhuang Autonomous Region, China. Strain S2 is capable of degrading short-chain PAEs, including dimethyl phthalate (DMP), diethyl phthalate (DEP), di-iso-butyl phthalate (DIBP) and di-n-butyl phthalate (DBP). Sinomonas sp. S2 can completely degrade DBP at concentrations of 400 mg·L −1 within 24 h. The degradation kinetics of PAEs followed the modified Gompertz model. Strain S2 demonstrated good environmental adaptability thriving at pH ranging from 5 to 9 and temperatures between 20 and 40 °C, indicated by its growth on DBP. The optimal pH and temperature for degradation were found to be 7 and 40 °C, respectively. Additionally, several metabolites of DBP were identified, including phthalic acid (PA), butyl acetate, ethyl propionate and methyl 2-methylbutyrate. The reconstructed degradation pathway of DBP may involve protocatechuic acid, β-carboxy-cis, cis-mucronate and γ-carboxy muconolactone, ultimately leading to the tricarboxylic acid (TCA). In a bioaugmentation experiment involving soil artificially contaminated with DBP, strain S2 could promote the degradation of DBP in soil. The results indicate that strain S2 had high degradation capacity and environmental tolerance, which had the potential to be applied in the bioremediation of DBP-contaminated environments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Coatings Technology and Research
·
2025
·
IF 2.8
Tang Baoling,He Ziyu
The commonly used dispersants for graphene dispersions reduce the conductivity of the composite. In this work, a dispersant with an amphiphilic structure, CA-g-PANI, has been designed and synthesized. The dispersant grafts citric acid (CA) onto polyaniline via an amide reaction, which gives CA-g-PANI the hydrophilic groups (carboxyl groups) and the benzene ring structures that can be π–π conjugated with graphene, and it can improve the dispersion properties of graphene; CA-g-PANI contains the polyaniline structure, which is electrically conductive and enhances the electrical conductivity of graphene dispersions. The molecular structure and properties of the dispersant were systematically characterized through FTIR spectra, UV absorption spectra, and other methods. The graphene-based composites were prepared by screen printing method, and the dispersibility and resistivity of CA-g-PANI were compared with gum arabic and alkali lignin (natural dispersants). Graphene concentration reached up to 30 mg/mL in the presence of CA-g-PANI at the weight ratio of 1:0.03 (CA-g-PANI: graphene). CA-g-PANI also exhibited good performance for stabilizing graphene (stable for 6 days), with an electrical conductivity of up to 917.43 S/m. In the study, it was shown that CA-g-PANI as a graphene dispersant improved the conductivity of graphene dispersions while enhancing the dispersing properties of graphene.
✓ 已验证
产品关联
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2025
·
IF 2.8
Zhu Guanglai,Xu Chao,Xu Ziyi,Yu Yitao,Sun Cuicui,Zhuang Haihua,Ma Baichang,Hou Yantao,Li Bing,Wang Zhenhua,Dai Caifeng
Phthalonitrile (PN) resins are high-performance thermosetting polymers recognized for their exceptional thermal stability and flame resistance, making them attractive candidates for aerospace, electronics, and high-temperature structural applications. However, their broader adoption is hindered by two primary challenges: the high melting point of PN precursors and the volatility of conventional curing agents, which complicate processing and raise safety concerns. Despite ongoing research, effective strategies that simultaneously address these issues while enhancing the overall performance of PN resins remain limited. In this study, we introduce a novel self-catalyzing curing agent, 4-(7-amino-1-naphthoxy) phthalonitrile (ANP), which functions both as a precursor and curing agent. The presence of amino and naphthoxy groups promotes efficient curing without the need for external catalysts, thereby expanding the processing window. Additionally, amino and cyano groups act as reactive sites and flexibilizers, enhancing the properties of bisphenol A-based PN (AFPN) resin systems. Thermal analysis revealed that the ANP-modified resin exhibits outstanding thermal and thermo-oxidative stability, with a 5% weight loss temperature ( T 5% ) exceeding 450 °C and a glass transition temperature ( T g ) above 439 °C. Vector network analysis further demonstrated excellent dielectric properties, with a dielectric constant ( D k ) of 3.15 and a dissipation factor ( D f ) of 0.017 at 9.05 GHz. These findings indicate that ANP effectively overcomes key limitations of conventional PN resins. As a multifunctional curing agent, ANP shows significant potential for the development of advanced PN-based composites in aerospace, electronic packaging, and microelectronic applications. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
Science China-Chemistry
·
2025
·
IF 9.7
Kang Kai,Wang Qiuxiang,Huang Hongpu,Zhuang Xinxin,Cai Junlin,Wang Tao,Wang Xue,Xie Zhaoxiong,Xie Shuifen
Despite utilization of state-of-the-art Cu-based catalysts, achieving high selectivity and stability in multicarbon (C 2+ ) compounds production through electrocatalytic CO 2 reduction reaction (CO 2 RR) remains a critical and challenging objective. Here we employ lattice chlorine-doped Cu 2 O nanocubes (Cl d -Cu 2 O NCs) with well-defined {100} facets as a model catalyst to demonstrate that halogen doping can serve as a versatile and effective strategy for modulating surface charge distribution, thereby enhancing asymmetric C–C coupling toward high-selectivity C 2+ products in CO 2 RR. Compared to Cl-free Cu 2 O NCs, Cl d -Cu 2 O NCs exhibit a greatly enhanced C 2+ Faraday efficiency, i.e., ∼85% at −1.1 V (versus the reversible hydrogen electrode). Additionally, the Cl d -Cu 2 O NCs demonstrate significantly enhanced long-term durability, attributed to better preservation of the cubic morphology and more stable Cu δ + states. In-situ electrochemical studies reveal that Cl d -Cu 2 O NCs facilitate the formation of the key asymmetric *COH and *OCCOH intermediates, ultimately leading to higher C 2+ products. Density functional theory (DFT) calculations confirm that the introduced Cl-dopants disrupt the charge balance of the Cu 2 O(100) surface, enriching the Cl-adjacent Cu atoms with more electrons compared to those near O atoms. This unbalanced charge distribution significantly reduces the free energy of the rate-determining step for asymmetric C–C coupling from the *CO to *OCCOH on Cl-doped Cu 2 O (100) surface, requiring only 1.04 eV, in contrast to 1.50 eV on pristine Cu 2 O(100) surface. This study provides valuable insights into the surface charge modulation of Cu 2 O catalysts via halogen doping for enhancing asymmetric C–C coupling and C 2+ production in CO 2 RR.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 4
·1-18
·
IF 21.8
Peng Yanzhi,Xu Zunyan,Fu Li,Liu Liyuan,Gao Peng,Lu Qiong,You Xin,Yi Jianhong,Li Caiju
Achieving a uniform intragranular dispersion of nano-reinforcements in the powder metallurgy preparation of metal matrix composites (MMCs) is still a challenging problem. In order to alleviate this problem, the repeated deformation ball milling (RDBM) process is proposed, which can effectively inhibit the cold-welding phenomenon of composite powder, restart the plastic deformation process of composite powder, and improve the uniformity of reinforcements. The results show that the SiC nanoparticles (SiC p ) reinforced M142 composites prepared by the RDBM process show a uniform distribution of intragranular SiC p within matrix. Therefore, compared with conventional ball milled SiC p /M142 composites, the ultimate tensile strength and ductility of RDBMed SiC p /M142 composites are increased by 22% and 26%, respectively. The results show that RDBM process is an effective dispersion strategy. This work provides a new idea into the preparation of high strength and high ductility MMCs processed by powder metallurgy.
✓ 已验证
产品关联
DOI
高影响因子
npj Science of Food
·
2025
·Vol. 9
·期 1
·1-8
·
IF 7.8
Pan Hui,Zhang Wei,Jin Meng,Zhang Fang,Chen Xuelei,Meng Xiao,Shao Hua,Song Liqun,Zhang Zhihu,Wang Cuijuan
Concerns over health risks associated with mixed pesticide residues have led to a demand for rapid analytical methods. We present a portable surface-enhanced Raman spectroscopy (SERS) device specifically designed for real-time monitoring of indoxacarb (INDX) and chlorfenapyr (CFP) in vegetable juice. This point-of-use sensor integrates silver nanoparticles with a metal-organic framework (Ag/MOF-808(Zr)) and employs a 19-well quartz plate alongside a portable Raman spectroscopy instrument, facilitating simultaneous adsorption, separation, and detection. Detection limits for INDX and CFP in ginger and spinach juices were 0.26–0.76 ppb. Notably, results closely matched those from liquid chromatography, and in-situ detection was achieved within 2 min without pre-treatment, significantly enhancing efficiency over conventional chromatographic methods. This innovative approach demonstrates substantial potential for detecting pesticide mixtures in non-laboratory settings, presenting a valuable option for point-of-use applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）