Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
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IF 15.7
Zhi Yinglin,Shao Yan,Xia Rui,Lin Weikun,Cai Daohang,Zhao Fuxing,Dong Jiufeng,Li Qingxian,Wang Zihao,Li Lixuan,Gu Long,Tian Peng,He Zhen,Wang Jinlong,Ning Guiling,Li Baowen,Yang Canhui,Wang Hong,Yu Shuhong,Yu Yanhao
Oxide/elastomer composites combine the functional attributes of metal oxides with the mechanical deformability of elastomers, but face the challenge of balancing oxide loading and stretchability as ceramic fillers decrease the entropic elasticity of polymer networks. Here, we report an interfacial composite design that enables high oxide fraction and large stretchability by minimizing the contact area yet maximizing the binding strength between the oxide and elastomer. The elongation at break for an interfacial composite with 80 vol% of oxides reaches 500%, whereas that of a regular bulk composite with the same oxide fraction is 20%. These composites are synthesized based on a Marangoni co-assembly process with tuned interfacial tension and reaction at the water-oil interface. The assembly chemistry is nearly independent of oxides’ sizes, compositions, geometries, and functions, making this interfacial structure broadly applicable to optical, electric, magnetic, and thermal-conducting oxides. Compared to bulk composites, the interfacial composites deliver larger magnetic actuation, lower thermal resistance, and higher conformability with nonplanar surfaces, providing rich implications for designing intelligent and electronic systems.
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POLYMER BULLETIN
·
2024
·
IF 3.1
Xiao Qinglin,Ai Xiujuan,Chen Zhiyuan,Chen Piaoyi,Chen Lingling,Liu Ou,Ma Yongyan,Huang Yugang,Li Xufeng,Ye Guodong
Transcatheter arterial embolization is one of the important tools in the interventional treatment of hepatocellular carcinoma. However, the existing embolic agents cannot achieve long-term visualization effectiveness. Therefore, we developed a radiopaque embolic microsphere (PTADE@Ta) capable of long-term imaging. PTADE@Ta was successfully prepared by dispersing tantalum nanoparticles in a poly (diallyl terephthalate) via photopolymerization. The microspheres were characterized by SEM observation and thermogravimetric analysis. The in vitro biocompatibility was assessed by determining the cell metabolic activity of human umbilical vein endothelial cells, and the in vivo biocompatibility was assessed by observing tissue sections from New Zealand white rabbits. Their non-degradability was verified by their degradability in lysozyme solution. The radiopaque effect was verified by X-ray and CT imaging capability. The results showed that the embolic product has good dispersibility, thermal stability, biocompatibility and long-term imaging. Graphical abstract
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Bioresources and Bioprocessing
·
2024
·Vol. 11
·期 1
·1-11
·
IF 4.3
Duan Suyang,Zhang Zhirong,Wang Xiaoli,Sun Yaqin,Dong Yuesheng,Ren Lina,Geng Lili,Xiu Zhilong
As an alternative to antibiotics in response to antimicrobial-resistant infections, bacteriophages (phages) are garnering renewed interest in recent years. However, the massive preparation of phage is restricted using traditional pathogens as host cells, which incurs additional costs and contamination. In this study, an opportunistic pathogen, Klebsiella pneumoniae used to convert glycerol to 1,3-propanediol (1,3-PDO), was reused to prepare phage after fermentation. The phage infection showed that the fed-batch fermentation broth containing 71.6 g/L 1,3-PDO can be directly used for preparation of phage with a titer of 1 × 10 8 pfu/mL. Then, the two-step salting-out extraction was adopted to remove most impurities, e.g. acetic acid (93.5%), ethanol (91.5%) and cells (99.4%) at the first step, and obtain 1,3-PDO (56.6%) in the top phase as well as phage (97.4%) in the middle phase at the second step. This integrated process provides a cheap and environment-friendly manner for coproduction of 1,3-PDO and phage. Graphical abstract
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RARE METALS
·
2024
·
IF 9.6
Li Qun-Yin,Li Ze-Yu,Ben Miao,Kang San-Ning,Yang Min-Jian,Wu Si-Yu,Xiong Yi-Fei,Li Lin,Zeng Rong,Mao Jian-Feng,Liu Jian-Wen
Anodes based on silicon@carbon (Si@C) composites are expected to be used in the next generation of commercial lithium-ion batteries due to their high specific capacity and high element abundance. However, particle pulverization and falling off, caused by volume expansion and repeated rupture and formation of SEI on electrode surface, still hinder its industrialization. Herein, a three-dimensional hydrogen-bonding network and porous film structure are constructed from chitosan (CS), polyvinyl alcohol and polyvinylpyrrolidone to enable high-performance Si@C anode in this work. The formed hydrogen-bonding network can significantly improve the electrical conductivity. The unique porous film structure, owing to a high specific surface area, can increase the contact between the material and the electrolyte and effectively accommodate the expansion effect of the electrode during the cycle. After 800 cycles at the current density of 500 mA·g −1 , the reversible specific capacity remains at 945.8 mAh·g −1 . When testing rate performance, the specific capacity can still reach 522 mAh·g −1 under the current density of 2000 mA·g −1 and returns to 1126 mAh·g −1 at 100 mA·g −1 . The porous film material proposed in this work has a simple preparation method and excellent properties, which will provide useful provision for the industrial application of Si@C materials in the future. Graphical Abstract
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FIBERS AND POLYMERS
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2024
·Vol. 25
·期 6
·2107-2116
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IF 2.2
Zhao Gege,Jin Zhehai,Zhang Xinya,Li Chengcheng,Su Xing,Geng Qiuju,Zhao Yaping
The formation of a metallic layer on fiber substrates has aroused great interest in recent years due to the application of metal-deposited fiber composite materials in many fields, such as microelectronics, aerospace, and military materials. To achieve sustained high conductivity throughout the entire service life of conductive fibers, it is an essential step to modify the surface of substrates to improve the adhesion between the fiber substrate and the conductive structure. Herein, a practical and feasible two-step approach consisting of mixed solution etching and dopamine self-polymerization was proposed to enhance electroless silver deposition on para-aramid fabrics. The hydrophilicity, surface morphology, infrared spectroscopy, and tensile strength of the fibers after etching in different solutions were compared. The modification conditions of etched fibers with polydopamine before electroless silver deposition were explored by comparing the square resistance and washing resistance of the conductive fabrics. With the assistance of the metal-binding ability of polydopamine, a homogeneous and compact silver layer was obtained on para-aramid fabrics by palladium-free activation electroless plating. The composite fabrics exhibited a low electrical resistivity of 0.052 Ω/sq and satisfactory resistance stability under high/low-temperature, ice, and flame environments, as well as in acids, alkalis, and organic solutions.
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EUROPEAN JOURNAL OF PLANT PATHOLOGY
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2025
·
IF 1.9
Huang Zhixing,He Zhenrui,Ding Jiexin,Zhu Yiming,Zhou Erxun
Soybean root rot, caused by Fusarium neocosmosporiellum , poses a significant threat to soybean productivity. Although chemical fungicides are widely used, their environmental risk necessitate sustainable alternatives. This study proposes an integrated control strategy combining the biocontrol bacterium Pseudomonas aeruginosa E1 - 23 with prochloraz. Initial screening of seven candidate bacterial strains identified E1 - 23 as the most potent antagonist, exhibiting 64.1% inhibition against F. neocosmosporiellum in dual-culture assays. Concurrent fungicide evaluation revealed prochloraz as the optimal agent (EC 50 = 0.1646 μg/mL). Compatibility analysis demonstrated E1 - 23's robust tolerance to prochloraz concentrations at ≤ 50 μg/mL. In vitro combination of prochloraz (0.25 μg/mL) and E1 - 23 (1 × 10 6 CFU/mL) achieved 91.86% pathogen suppression, surpassing individual treatments by > 10% and theoretical additive effects. Greenhouse trials confirmed enhanced efficacy, with integrated application increasing disease control efficacy by 34.35%—significantly outperforming standalone bacterial (18.96%) or fungicide (20.52%) controls. The qRT-PCR analysis revealed that the combination application of E1 - 23 and prochloraz up-regulated the expression of some defense genes of soybean plants 5 days post-inoculation (dpi), but the induced plant disease resistance was low. This study highlights the potential of E1 - 23-prochloraz as an eco-friendly approach to mitigate soybean root rot while reducing fungicide dependency.
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Communications Biology
·
2025
·Vol. 8
·期 1
·1-15
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IF 5.1
Fan Zhan,Xu Yilun,Lu Yafang,Li Xinlin,Xu Mengli,Liu Jinxin,Cai Zhenzhen,Liu Jiayang,Su Jingping,Wang Jialu,Luo Qingming,Zhang Zhihong,Liu Zheng
The excessive accumulation of neutrophils within the epidermis is a significant hallmark of cutaneous diseases; however, the mechanisms governing neutrophil transepidermal migration (NTEM) remain inadequately understood. In this study, we develop trichromatic-fluorescence-labeled chimeric mice by utilizing Cx3cr1 GFP/+ Lyz2 RFP/+ mice as bone marrow donors and Krt14 YFP/+ mice as recipients. This approach enables us to visualize the process of NTEM and the crosstalk between neutrophils and monocytes in a murine model of irritant contact dermatitis (ICD). Intravital imaging reveals a preferential transmigration of neutrophils through hair follicle (HF), where dermal neutrophils exhibit limited mobility and interact with dermal monocytes. Notably, 18 h following hapten exposure, dermal neutrophils continuously migrate toward HF regions and form clusters within 3 h. Importantly, MMP-9 is identified as essential for the NTEM process; the depletion of dermal monocytes results in a significant reduction of MMP-9 expression in the skin and inhibits the NTEM process in ICD. Mechanistically, dermal monocytes are found to be a crucial source of the cytokines TNF-α and CXCL2, which promote the upregulation of MMP-9 in neutrophils. Therefore, our results highlight HF regions as crucial gateways for dermal monocyte-modulated NTEM and provide visual insights into the crosstalk between neutrophils and monocytes in inflammatory skin disorders.
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Virology Journal
·
2025
·Vol. 22
·期 1
·1-14
·
IF 3.8
Liu Xianglan,Hu Jiaming,Wu Jiarui,Tian Yiru,Wang Jinbo,Wu Chunyan,Chen Qingfeng,Krall Leonard,He Yanping,Lu Qun
Background Human norovirus (HNV) is the predominant pathogen causing outbreaks of acute gastroenteritis globally. Despite significant efforts to combat norovirus infections, there is currently no FDA approved vaccine or antiviral drug available. Consequently, the development of effective antiviral agents is of critical importance. Methods and results In this study, a series of 41 5-cyano-2-thiacetyl aromatic pyrimidinone compounds were designed and synthesized. A cell viability-based screening for anti-murine norovirus (MNV) compounds was conducted, revealing that compound 29 (hereafter used as Co-29) exhibited antiviral activity against MNV. Co-29 demonstrated effective inhibition of MNV CW3 RNA replication, exhibiting an EC 50 of 58.22 μM. An RdRp enzyme activity assay indicated that Co-29 directly inhibits RdRp activity to both MNV and HNV. Molecular docking studies suggested that Co-29 interacts with the palm region of RdRp via hydrogen bonding with specific residues, which are conserved in RdRps across MNV and HNV norovirus variants. Conclusions In conclusion, our study suggests that the newly synthesized Co-29 may serve as a potential antiviral candidate or lead compound for future studies.
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RARE METALS
·
2025
·
IF 11
Mao Pu,Sun Jie,Feng Hui-Min,Liu Zhi-Yong,Guo Kun,Xie Bing,Wang Ting,He Li-Qiang,Gao Jing-Hui
Copper calcium titanate (CaCu 3 Ti 4 O 12 , CCTO) ceramics with colossal permittivity have gained widespread concern because of their potential application in modern electronic devices with miniaturization and integration. However, the extent of grain and grain boundary contribution to the colossal permittivity of CCTO-based ceramics based on the internal barrier layer capacitor (IBLC) model is still in debate. This affects their electrical performance optimization and real-world applications. In this study, a series of novel lead-free colossal permittivity ceramics, x LiCuNb 3 O 9 –(1– x )CaCu 3 Ti 4 O 12 (LCNO-CCTO), were designed and prepared using a solid-phase reaction approach. The colossal permittivity response mechanism of LCNO-CCTO ceramics was further explored by performing the complex impedance spectrum and analyzing the activation energy from the grain and grain boundary contribution viewpoint. As a result, the LCNO-CCTO ceramics present the cubic perovskite structure with the space groups of \(Im \overline{3}\) . All the LCNO-CCTO ceramics exhibit the significantly enhanced colossal permittivity (10 5 ) response, and the ceramic with x = 0.15 shows the highest permittivity of about 4.64 × 10 5 (20 Hz, room temperature) accompanied by a lower grain resistance of 9.61 Ω and larger grain activation energy of 0.21 eV. The enhanced colossal permittivity response is primarily attributed to the great electrical response inside grains of LCNO-CCTO ceramics, resulting from a smaller grain resistance. Also importantly, the high-frequency dielectric relaxation characteristics are improved by incorporating the LCNO into CCTO ceramics as an ion form. Accordingly, the LCNO-CCTO ceramics show a suppressed high-frequency dielectric loss. These results can provide a thorough knowledge and useful optimization strategy for developing high-performance colossal permittivity materials. Graphical
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 5
·1-15
·
IF 2.4
Liu Tao,Zhou Guangming,Yu Bingyan,Fu Lihu,Yu Simiao,Xu Zhenjie,Lu Gang
To address the problem of dye wastewater pollution, hierarchical porous alumina ceramics (HPAC) were prepared as carriers in this study by using digital light processing (DLP) 3D printing combined with the freeze-drying method. The results showed that the hierarchical porous alumina ceramics with a porogenic agent content of 33 wt% exhibited the highest porosity of 34.20% ± 1.22% and a pore size of 2–5 nm. An efficient photocatalytic system was constructed by loading nickel oxide nanoparticles (n-NiO) via the sol-gel method. The prepared photocatalytic carriers and photocatalysts were characterized for structural and morphological analysis using X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) surface area analyzer, and energy-dispersive X-ray fluorescence spectroscopy (EDS). The results indicated that n-NiO/HPAC with 15.43% NiO loading achieved optimal performance in methylene blue (MB) degradation experiments, with the MB degradation rate reaching 94.51%. This study provides a theoretical basis and technical support for the practical application of porous-material-loaded n-NiO photocatalysts in dye wastewater treatment. Graphical abstract
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Stem Cell Research & Therapy
·
2025
·Vol. 16
·期 1
·1-21
·
IF 7.3
Zhu Yanlin,Yang Yuhan,Lan Yuyan,Yang Zun,Gao Xiang,Zhou Jie
Background Diabetes mellitus (DM) and periodontitis have a bidirectional relationship, with each being a high-risk factor for the other. Prolonged hyperglycemia exacerbates periodontal inflammation and disrupts bone homeostasis. Pyruvate kinase M2 (PKM2), a key enzyme in glycolysis, is involved in metabolic reprogramming, but its role in osteogenesis under high-glucose (HG) inflammatory conditions remains largely unknown. This study aimed to investigate the effects of HG and inflammation on bone marrow mesenchymal stem cells (BMSCs) under indirect co-culture conditions and to explore how PKM2 regulates metabolism and mitochondrial function during osteogenic differentiation in HG inflammatory environments, elucidating its role in diabetic periodontitis (DP).Methods Expose BMSCs to conditioned medium (CM) collected from RAW264.7 cells stimulated with HG and/or lipopolysaccharide (LPS). BMSCs functionality was assessed using CCK8, EdU, Annexin V-PI apoptosis assay, alkaline phosphatase (ALP), and Alizarin Red S (ARS) staining. Metabolic characteristics were evaluated through Seahorse assays, lactate production, glucose uptake, and ATP measurements. Mitochondrial function was assessed via JC-1, and ROS staining, Mito-Tracker staining, and transmission electron microscopy (TEM). Gene and protein expression were analyzed by quantitative real-time PCR and western blotting. In vivo therapeutic effects of shikonin were validated via micro-CT and histological staining in a diabetic periodontitis mouse model.Results In vitro experiments demonstrated that HG inflammatory conditions impaired the survival of BMSCs, suppressed osteogenic differentiation, and induced metabolic reprogramming. This reprogramming was characterized by enhanced glycolysis, impaired oxidative phosphorylation (OXPHOS), abnormal upregulation of PKM2 expression, and mitochondrial dysfunction accompanied by morphological alterations. Shikonin effectively reversed these adverse effects by inhibiting PKM2 tetramerization, rescuing the loss of osteogenic function in BMSCs. The therapeutic potential of shikonin was confirmed in the diabetic periodontitis mouse model.Conclusion PKM2 impairs the osteogenesis of BMSCs by affecting metabolism and mitochondrial function, suggesting it as a potential therapeutic target for diabetic periodontitis.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Chen Jian-Hua,Li Wan-Ting,Cai Kun-Yu,Tu Hui-Jie,Long Zi-Tong,Akhtar Shoaib,Liu Lin-Dong
Decentralized water treatment technologies, designed to align with the specific characteristics of the water source and the requirements of the user, are gaining prominence due to their cost and energy-saving advantages over traditional centralized systems. The application of chemical water treatment via heterogeneous advanced oxidation processes using peroxide (O–O) represents a potentially attractive treatment option. These processes serve to initiate redox processes at the solid-water interface. Nevertheless, the oxidation mechanism exemplified by the typical Fenton-like persulfate-based heterogeneous oxidation, in which electron transfer dominates, is almost universally accepted. Here, we present experimental results that challenge this view. At the solid-liquid interface, it is demonstrated that protons are thermodynamically coupled to electrons. In situ quantitative titration provides direct experimental evidence that the coupling ratio of protons to transferred electrons is almost 1:1. Comprehensive thermodynamic analyses further demonstrate that a net proton-coupled electron transfer occurs, with both protons and electrons entering the redox cycle. These findings will inform future developments in O–O activation technologies, enabling more efficient redox activity via the tight coupling of protons and electrons.
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