Journal of Coatings Technology and Research
·
2025
·
IF 2.8
He Chengtian,Chen Rongrong,Liu Xin,Wang Chao,Liu Qi,Liu Jingyuan,Liu Peili,Wang Jun
Marine biofouling has caused huge economic and energy losses, and the application of marine antifouling coatings is one of the effective solutions to this problem. Sily-acrylate based self-polishing coatings are favored because of excellent antifouling performance. However, weak static antifouling performance restricts the development of sily-acrylate based antifouling coatings. To solve this problem, an eugenol ester-based sily-acrylate polymer (EMSPs) is synthesised, which showed both self-polishing and antifouling performance. The highest content of eugenol (EMSP-16) inhibits Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) up to 62.2% and 76.3%, respectively, and inhibits the adhesion of Halamphora sp. and Nitzschia closterium (N. closterium) up to 85.1% and 90.8%, respectively. Mussel adhesion experiments show that mussels tend to avoid coatings with high eugenol content. The eugenol ester-based sily-acrylate polymer provides a new way to develop new environmentally friendly marine antifouling coatings and alleviate heavy metal pollution in the marine environment.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2024
·
IF 1.5
Lei Miao,Zhang Jun,Liu Chang,Guo Junpeng,Li Ye
Herein, S-nZVI was synthesized to remove U(VI) from seawater. At a S/Fe ratio of 0.18 and pH of 5, adsorption of U(VI) reached equilibrium after 20 min with the removal rate of 97.93%. And the maximum adsorption capacity obtained by Langmuir isothermal model was 1177.09 mg/g. Moreover, S-nZVI exhibited selectivity in the presence of interfering ions, regeneration performance in 5 reuse cycles, and high removal efficiency in actual seawater. Mechanism investigations showed that UO 2 2+ uniformly adsorbed on S-nZVI surface was irreversibly reduced and generated UO 2 precipitates due to the electrons provided by S 2− , S 2 2− and Fe(II).
✓ 已验证
产品关联
DOI
高影响因子
Tungsten
·
2025
·
IF 11.2
Shi Xue-Chao,Wang Yi-Mei,Hou Shu-Xian,Yang Guo-Qiang,Liu Xin-Xin,Ge Jun,Gui Lin,Zhang Wei-Wei,Kaoutar Chaldi,Li Shu-Jie,Wang Jun,Ge Fei
Waterborne microbial contamination represents a significant global environmental challenge. Microorganisms can induce water pollution, precipitating infectious disease outbreaks and posing a substantial threat to human health. Currently, the excessive use of conventional antibiotics has resulted in the emergence of bacterial resistance, posing a challenge to the design and development of antimicrobial agents with high antibacterial efficacy in diverse water such as rivers, lakes, and wastewater from microbiology laboratories. Bimetallic nanomaterials, that amalgamate the distinctive characteristics of diverse metals, are garnering attention due to their synergistic properties. In this study, PVP-FeMo 2 S 3 (PVP: Polyvinylpyrrolidone) and PVP-ZnMo 2 S 3 nanocrystals were synthesized by a high-temperature reaction. The prepared nanocrystals exhibited excellent biocompatibility, regular morphology, long-term stability, and remarkable antibacterial effects. The bacterial biofilms could be eradicated by the combination of photothermal (PTT) and photodynamic synergistic effects of PVP-FeMo 2 S 3 and PVP-ZnMo 2 S 3 nanocrystals. PVP-ZnMo 2 S 3 nanocrystals exhibited enhanced PTT conversion efficiency for water treatment. Remarkably, even after 20 cycles of recycling, PVP-ZnMo 2 S 3 retained substantial antibacterial efficacy. The excellent biosafety of PVP-ZnMo 2 S 3 further guarantees the safety of water quality post-treatment. Thus, PVP-ZnMo 2 S 3 bimetallic nanocrystals can serve as a novel antimicrobial agent for the treatment of microbial contamination in water. This study offers a potential strategy to mitigate secondary water pollution and prevent the development of drug resistance among pathogenic microorganisms.
✓ 已验证
产品关联
DOI
高影响因子
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
·
2024
·
IF 2.6
Li Fen,Yu Xuemin,Xu Jicai,Di Mohan,Song Hongzan,Run Mingtao
In order to prepare white fluorescent emitting materials, poly(ethylene glycol succinate- co -2,5-furandicarboxylic acid ethylene glycol ester) (PESF) blue fluorescent copolyester was prepared by melt polycondensation, and an orange fluorescent copolyester was prepared by introducing 1,6,7,12-tetrachloro-3,4,9,10-perylene tetracarboxylic acid dianhydride, as one of the fluorescent units, into the molecular chain of poly(butylene glycol isophthalate- co -butylene glycol terephthalate)(PBIT). 4,4-dicyclohexylmethane diisocyanate (HMDI) was used as a chain extender for linking PESF and PBIT to obtain the white fluorescent copolyester. The results showed that introducing 2,5-furandicarboxylic acid (FDCA) into the molecular chain of aliphatic polyesters can significantly enhance the blue fluorescence intensity of the PESF copolyesters, and white-light emission with CIE coordinates of (0.31, 0.35) and (0.30, 0.34) was achieved for the copolyester by varying the content of in the PESF and the copolymerization ratio of PESF and PBIT. In addition, by adjusting the magnitude of the excitation wavelength, it is possible to achieve the fine-tuning of the light color of the white copolyester in a certain region, e.g., the CIE coordinates at 350 nm excitation are (0.32, 0.35). The white copolyester displayed high thermal decomposition temperature about 350 o C, remarkably increased elongation at break above 300%, relatively high tensile strength up to 33.2 MPa; therefore, these performance advantages make enhance their potential for applications.
✓ 已验证
产品关联
DOI
高影响因子
Parasites & Vectors
·
2024
·Vol. 17
·期 1
·1-11
·
IF 3
Li Xin,Jiang Ning,Li Qilong,Zheng Kexin,Zhang Yiwei,Sang Xiaoyu,Feng Ying,Chen Ran,Chen Qijun
Background Artemisinin (ART) is a frontline drug for the treatment of malaria; however, the emergence of ART-resistant Plasmodium strains necessitates increasing ART sensitivity. Given that taurine (TAU) has been shown to have immunomodulatory activity, we investigated the effects of TAU as an adjunct therapy to ART in mice infected with Plasmodium berghei . Methods Mice infected with P. berghei ANKA strain ( P. berghei ANKA) were treated with TAU alone, ART alone or a combination of TAU and ART (TAU + ART), and their survival time and parasitaemia were recorded. The cytotoxic effects of TAU and ART were subsequently assessed. The expression levels of inflammasome-related genes and inflammatory factors in mice infected with P. berghei ANKA were analysed in relation to those in mice treated with TAU alone, ART alone or the TAU + ART combination. The therapeutic effects were further evaluated by histological analysis and measurement of the spleen index. Results Compared with the control mice, P. berghei ANKA-infected mice treated with ART in combination with TAU presented significantly lower parasitaemia and prolonged survival. The combined treatment resulted in significant reductions in the expression levels of inflammasome-related genes in the spleen, including absent in melanoma 2 ( AIM2 ), caspase-1, NOD-, LRR- and pyrin domain-containing protein 3 ( Nlrp3 ), Nlrp1b , Nlrp1b , NLR family CARD domain containing 4 ( Nlrc4 ), Nlrp6 , nucleotide binding oligomerization domain containing 1 ( NOD1 ) and NOD2 , and decreases in the levels of inflammatory cytokines in the serum, including interleukin (IL)-12p70, tumour necrosis factor-alpha, monocyte chemoattractant protein-1, IL-10 and IL-6. Histopathological analysis confirmed that TAU + ART combination treatment reduced spleen pathology caused by P. berghei ANKA infection. Conclusions The findings indicate that TAU potentiates ART efficacy by modulating the immune response in P. berghei -infected mice. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Translational Medicine
·
2025
·Vol. 23
·期 1
·1-19
·
IF 7.5
Hu Songliu,Zhan Ning,Li Jian,Wang Liqun,Liu Yiyan,Jin Ke,Wang Yixuan,Zhang Juxuan,Chen Yiyang,Bai Yang,Wang Yichong,Qi Lishuang,Liu Shilong
Background Radiotherapy is commonly used for locoregionally advanced NSCLC, but radioresistance is a clinical challenge. The long non-coding RNA CBR3-AS1 mediates radioresistance in NSCLC, yet the underlying molecular mechanism is unclear. This study aims to explore whether and how N6-methyladenosine (m6A) modification regulates CBR3-AS1 expression and promotes NSCLC radioresistance. Methods Integrative bioinformatics analyses were used to investigate the m6A methyltransferases that were associated with CBR3-AS1 expression and radioresistance of patients using data from The Cancer Genome Atlas of lung adenocarcinoma and squamous cell carcinoma. Clinical samples of 133 patients with NSCLC was collected to validate the correlation of the methyltransferase with radioresistance. The functional role and molecular mechanism of the methyltransferase in radioresistance was investigated through a series of in vitro experiments including m6A MeRIP-PCR, lentivirus transfection, RNA immunoprecipitation, Luciferase reporter, Colony formation, Transwell invasion, Flow cytometry, ELISA and TUNEL assay and in vivo experiments. Results The methyltransferase RNA binding motif protein 15 (RBM15) was identified as it was significantly positively correlated with CBR3-AS1 expression and overall survival of NSCLC patients receiving radiotherapy. The clinical samples demonstrated that the high protein expression of RBM15 was significantly enriched in patients with radioresistance as well as associated with poor prognosis of patients receiving radiotherapy. In vitro, RBM15 silencing enhanced the effects of radiation on the growth and invasion inhibition, and apoptosis induction of NSCLC cells; RBM15 overexpression had the opposite effects. Mechanistically, RBM15 induced CBR3-AS1 upregulation via an m6A-IGF2BP3-dependent mechanism, inducing CXCL1 expression by sponging miR-409-3p to recruit myeloid-derived suppressor cells (MDSCs) and inhibit T cell activity. In vivo, RBM15 silencing suppressed MDSC invasiveness and enhanced CD8 + and CD4 + T cell infiltration, causing NSCLC cells to overcome radioresistance. Conclusion Our study identifies methyltransferase RBM15 as a potential therapeutic target for NSCLC radioresistance whose inhibition reverses resistance through limiting MDSC recruitment via the m6A-IGF2BP3-CBR3-AS1/miR-409-3p/CXCL1 axis. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Probiotics and Antimicrobial Proteins
·
2024
·
IF 4.4
Wang Fei,Li Xiang,Wang Qi,Jin Qian,Xu Shujie,Tang Li,Zeng Zihan,Fu Aikun,Zhu Jinhui,Zhang Qiao,Yang Rongchang,Xiao Yingping,Li Weifen
Suanshui is a traditional fermented vegetable food in the southwest of China that is a rich source of probiotics. This study aimed to screen probiotics from Suanshui that have a protective effect against liver injury using in vivo and in vitro experiments. Eleven strains were isolated according to acid-producing capacity and probiotic properties, including antibacterial activity against pathogenic bacteria, tolerance to artificial gastrointestinal fluid and bile salts, heat resistance, antioxidant capacity, hydrophobicity, autoaggregation capacity, and adhesion capacity. Three probiotic strains, LAB36 ( Lacticaseibacillus paracasei , ( L . paracasei )), LAB19 ( Lactiplantibacillus plantarum ( L . plantarum )), and LAB51 ( Limosilactobacillus fermentum ( L . fermentum )), were obtained by the TOPSIS comprehensive evaluation. Furthermore, in an in vitro model of inflammation induced by LPS treatment of AML12, metabolites derived from the intestinal contents of mice treated with the three strains significantly decreased the gene expression of IL-1β , TNF-α , and Caspase 3 in the LAB (19, 36, 51) + LPS group ( P < 0.05) and significantly increased the gene expression of Bcl-2 compared with those in the untreated LPS group ( P < 0.05). In addition, the LAB36 + LPS group also exhibited significantly decreased gene expression of TLR4 and Bax ( P < 0.05). In vivo experiments, LAB36 pretreatment significantly decreased the levels of ALT, AST, and inflammatory factors (IL-1β and IL-6) in the serum, improved the antioxidant capacity, and reduced apoptosis in the livers of the model mice (liver injury induced by D-GalN/LPS). In summary, LAB36 isolated from Suanshui has a protective effect on liver injury.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Environmental Science and Technology
·
2024
·
IF 3
Dou W.,Song Y.,Zhang Y.,Liu T.,Kong L.,Hu X.,Li D.
Removal of chloride (Cl(− I)) and fluoride (F(− I)) ions is a major issue in metallurgical waste acid recycling. This study explored the synchronous and two-step precipitation approaches using bismuth oxide (Bi 2 O 3 ) to remove Cl(− I) and F(− I). Under the mole ratio of Bi 2 O 3 and halide ions at respectively 0.3 and 0.7 for the first and second steps, residual concentrations of Cl(− I) and F(− I) below 100 and 50 mg/L, respectively, were obtained, where the removal proportions of Cl(− I) and F(− I) in the first and second steps were respectively 1:1.1 and 1:3.3. During the treatment, Bi 2 O 3 was dissolved to produce Bi 3+ , which reacted with Cl(− I) first and then F(− I), leading to the precipitation of bismuth oxychloride and bismuth oxyfluoride. After the removal of Cl(− I) and F(− I), residual Bi 3+ was removed to a final concentration of 1.3 mg/L through introduction of hydrogen sulfide (H 2 S) and recovered as bismuth sulfide (Bi 2 S 3 ). In this method, approximately 97.6% of Bi 2 O 3 was regenerated, additionally, Cl(− I) and F(− I) were transferred to a NaOH/NaCl/NaF concentrate with minimal volume. This two-step approach for the removal of Cl(− I) and F(− I) using Bi 2 O 3 exhibited excellent performance in terms of high efficiency, high reagent recovery rate and low secondary pollution risk.
✓ 已验证
产品关联
DOI
高影响因子
Biomass Conversion and Biorefinery
·
2024
·
IF 3.5
Zhang Wenrui,Huang Jintian
The non-biodegradability and microtoxicity of harmful anions in water, especially hexavalent chromium, have caused serious damage to the environment and human health. Therefore, research on efficient and environmentally friendly adsorbents for the removal of Cr(VI) becomes essential. In this paper, we propose for the first time to effectively remove Cr(VI) anion by aminated graphene oxide/cellulose oxide nanocellulose/sodium alginate porous materials (NH 2 -GO/NOC/SA) prepared by cross-linking aminated graphene oxide with biomass materials (oxidized nanocellulose and sodium alginate) via epichlorohydrin. The porous materials were characterized using tools such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), electroluminescence (EDS), Brunauer Emmett Teller (BET), and X-ray photoelectron spectroscopy (XPS) analysis. The optimum adsorption performance of the porous material was obtained by varying the initial concentration (from 100 to 500 mg/L), pH (from 1 to 8), and adsorption time (from 15 min to 72 h) of the Cr(VI) solution. The analysis of the adsorption data showed that the adsorption process was more in line with the pseudo-second-order kinetic equation and Langmuir isotherm model, and the equilibrium adsorption amount reached 394.1 mg/g. The adsorption of Cr(VI) on the NH 2 -GO/NOC/SA porous material was achieved by electrostatic interactions, Schiff base chemical bonding energy, ion exchange, protonation, precipitation, and hydrogen bonding. In conclusion, the experimental results show that the biomass adsorbent NH2-GO/NOC/SA can be consistently applied to remove Cr(VI) from wastewater. Graphical
✓ 已验证
产品关联
DOI
高影响因子
Discover Oncology
·
2024
·Vol. 15
·期 1
·1-10
·
IF 2.8
Fan Ruizhi,Xu Teng,Kuang Yuting
Background Colorectal cancer, which originates from the human colon or rectum, is one of the leading causes of death worldwide. Timely diagnosis and interventional therapy can significantly improve the prognostic survival of colorectal cancer patients, making regular screening and early detection essential. Aim To investigate the regulatory function of lncRNA CTBP1-DT (CTBP1-DT) on colorectal cancer cells and to assess its diagnostic significance. Methods A total of 102 patients with colorectal cancer and 92 healthy individuals were selected. The levels of CTBP1-DT and microRNA-30a-5p (miR-30a-5p) in serum and cell samples of the above subjects were compared by RT-qPCR. The effects of CTBP1-DT and miR-30a-5p dysregulation on the biological functions of colorectal cancer cells were analyzed via CCK-8, flow cytometry and Transwell assays. In addition, the ability of CTBP1-DT and miR-30a-5p to early identify colorectal cancer patients was determined through ROC curve. Results Serum CTBP1-DT was elevated in patients with colorectal cancer, which was obviously higher than in healthy controls. The expression of serum miR-30a-5p was downregulated in colorectal cancer. Both CTBP1-DT and miR-30a-5p have the value of distinguishing colorectal cancer, and the combined diagnostic ability is higher. Knockdown of CTBP1-DT directly targeted miR-30a-5p to repress cell activity and metastatic ability, whereas deregulation of miR-30a-5p eliminated the above inhibitory effects. Conclusion Overexpression of CTBP1-DT has a certain application potential in the diagnosis of colorectal cancer and may be a therapeutic target for colorectal cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 11
·1-13
·
IF 2.8
Wu Yunjian,Cai Fujin,Xu Kaidong,Liu Ying,Zhang Xiaoxing
The power grounding grid is a critical apparatus for ensuring the safe operation of electrical networks. However, the long-term burial of grounding grids underground makes them susceptible to soil corrosion, undermining their grounding effectiveness and posing threats to personnel and equipment safety. This paper developed silicone rubber with excellent mechanical properties, outstanding corrosion resistance, and high electrical conductivity to mitigate the corrosion rate of grounding electrodes and extend the lifespan of grounding grids. The effects of graphite and carbon nanotubes mixed conductive fillers on silicone rubber’s electrical, thermal, mechanical, and corrosion resistance were investigated. The results show that when the addition amount of carbon nanotubes and graphite mixed conductive filler is less than 4%, the content of conductive filler increases with the increase of the content of conductive filler. The electrical conductivity, tensile strength, thermal conductivity, and thermal stability of conductive silicone rubber gradually increase, and its corrosion resistance and adhesion are unaffected. With a filler loading of only 4 wt%, the silicone rubber achieves an electrical conductivity of 0.41 s/cm, a tensile strength of 4.08 MPa, and a fracture elongation of 113%. These results confirm that the corrosion resistance, heat resistance, and adhesion meet the requirements of grounding electrodes. The outcomes of this research provide robust support for the advancement of green electrical equipment.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2024
·
IF 2.9
Niu Jichao,You Tingting,Wang Xin,Ya Hanqin,Liang Shanshan,Zhao Ruobing,Ma Yongqiang
Lutein has high nutritional value and plays a variety of physiological functions, particularly in terms of eye protection. It presents potential value for the development of functional foods. However, different environmental factors can significantly influence the properties of lutein. In this study, we utilized whey protein isolate (WPI), sodium alginate (SA), and tea polyphenols (TP) as ternary solid particles to fabricate Pickering emulsions that encapsulate lutein through non-covalent interactions. We examined the retention rate of lutein, microstructure, and rheological properties. The light stability, thermal stability, and storage stability were determined. Additionally, an in vitro digestion model was established. These results demonstrated that WPI-SA-TP composite particles encapsulated lutein Pickering emulsions showed a uniform droplet distribution and possessed an elastic gel structure. The retention rate of lutein remained high after exposure to UV irradiation, heat, and storage for 30 days. During in vitro simulated digestion experiments under gastrointestinal conditions, the bioaccessibility and free fatty acid release rate of lutein were determined to be 14.6% and 13.55%, respectively. Therefore, the mentioned Pickering emulsions efficiently deliver lutein while providing potential insights for the development of other functional nutrient delivery systems. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）