BMC Complementary Medicine and Therapies
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2020
·Vol. 20
·期 1
·1-17
·
IF 0
Wang Le,Tan Nana,Wang Huan,Hu Jingbo,Diwu Wenbo,Wang Xiaoling
Background Flavonoids from plant medicines are supposed to be viable alternatives for the treatment of type 2 diabetes (T2D) as less toxicity and side effects. Radix scutellariae ( RS ) is a widely used traditional medicine in Asia. It has shown great potential in the research of T2D. However, the pharmacological actions remain obscured due to the complex chemical nature of plant medicines. Methods In the present study, a systematic method combining ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology was developed to screen α -glucosidase inhibitors from flavonoids of RS , and explore the underlying mechanism for the treatment of T2D. Results The n -butanol part of ethanol extract from RS showed a strong α -glucosidase inhibition activity (90.55%, IC 50 0.551 mg/mL) against positive control acarbose (90.59%, IC 50 1.079 mg/mL). A total of 32 kinds of flavonoids were identified from the extract, and their ESI-MS/MS behaviors were elucidated. Thirteen compounds were screened as α -glucosidase inhibitors, including viscidulin III, 2′,3,5,6′,7-pentahydroxyflavanone, and so on. A compound-target-pathway (CTP) network was constructed by integrating these α -glucosidase inhibitors, target proteins, and related pathways. This network exhibited an uneven distribution and approximate scale-free property. Chrysin ( k = 87), 5,8,2′-trihydroxy-7-methoxyflavone ( k = 21) and wogonin ( k = 20) were selected as the main active constituents with much higher degree values. A protein-protein interaction (PPI) weighted network was built for target proteins of these α -glucosidase inhibitors and drug targets of T2D. PPARG ( C d = 0.165, C b = 0.232, C c = 0.401), ACACB ( C d = 0.155, C b = 0.184, C c = 0.318), NFKB1 ( C d = 0.233, C b = 0.161, C c = 0.431), and PGH2 ( C d = 0.194, C b = 0.157, C c = 0.427) exhibited as key targets with the highest scores of centrality indices. Furthermore, a core subnetwork was extracted from the CTP and PPI weighted network. Type II diabetes mellitus (hsa04930) and PPAR signaling pathway (hsa03320) were confirmed as the critical pathways. Conclusions These results improved current understanding of natural flavonoids on the treatment of T2D. The combination of ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology provides a novel strategy for the research of plant medicines and complex diseases.
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JOURNAL OF ORGANIC CHEMISTRY
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2021
·
IF 4.354
Qi Xia,Xiang Li,Xi Fu,Yaxuan Zhou,Yanqing Peng,Jiayi Wang,Gonghua Song
A novel three-component reaction of α-ketoaldehydes, 1,3-dicarbonyl compounds, and organic boronic acids catalyzed by CuO in water has been developed to give a wide range of products containing 1,3/1,4-diketones. The method has some advantages such as the use of readily available starting materials, wide substrate scopes, excellent yields, gram-scale synthesis, and mild reaction conditions.
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Molecular Catalysis
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2021
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IF 5.062
Junyi Liu,Xianxiang Liu,Qiong Xu,Dulin Yin
A series of highly active and ortho -position selective catalysts based on (α-Fe 2 O 3 ) 1- x (V 2 O 5 ) x catalysts were proposed for the C -methylation of phenol with methanol. The (α-Fe 2 O 3 ) 1- x (V 2 O 5 ) x catalysts were synthesized by coprecipitation method of Fe and V elements and microwave drying. The chemical composition, material structure, acid-base properties, and structure-activity relationship of (α-Fe 2 O 3 ) 1- x (V 2 O 5 ) x catalysts were systematically analyzed by the techniques of XRD, XPS, TEM, N 2 adsorption-desorption, Raman, UV-Vis, ESR, NH 3 /CO 2 -TPD and Pyridine-IR. The (α-Fe 2 O 3 ) 1- x (V 2 O 5 ) x catalysts have the double advantages of high activity and high stability for the methylation of phenol due to the high BET surface area, large total pore volume, dispersive active sites and enhanced acid-base property. o -cresol and 2,6-xylenol were the main products, and nearly 100% selectivity to the ortho -position of phenol and 90% selectivity to o -cresol were obtained. Furthermore, the (α-Fe 2 O 3 ) 1- x (V 2 O 5 ) x catalysts possess long lifetime over 2500 h and high activity at a weight hourly space velocity of 1.6 h −1 compared with the microwave-dried α-Fe 2 O 3 catalyst. The doping of vanadium improves the activity and stability of α-Fe 2 O 3 catalyst, which attributes to the modification of catalyst structure, especially the improvement of acid-base centers and oxygen vacancy. Recently the (α-Fe 2 O 3 ) 1- x (V 2 O 5 ) x catalysts have been stably and efficiently applied in industry for the methylation of phenol.
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APPLIED SURFACE SCIENCE
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2019
·
IF 5.155
Yangqing He,Zhengrui Huang,Zhanying Ma,Binghua Yao,Haiyang Liu,Linlin Hu,Qing Zhao,Qian Yang,Dongjie Liu,Deguo Du
In this study, zinc (II) 1, 8(11),15(18),22(25) - tetrakis (4-carboxylphenoxy) phthalocyanine (α-ZnTcPc) was synthesized as sensitizer to construct a novel photocatalyst α-ZnTcPc/g-C 3 N 4 by a polycondensation strategy. The FT-IR and XPS spectra demonstrated that the α-ZnTcPc molecules were covalently coupled on g-C 3 N 4 . The 10%α-ZnTcPc/g-C 3 N 4 composites exhibit excellent extended spectral response with intense broad near-infrared absorption at 695 nm and with significantly fascinated charge carrier separation. As expected, the 10%α-ZnTcPc/g-C 3 N 4 displayed a remarkable improved photocatalytic performance in decomposition of methylene blue (MB) and antibiotic tetracycline with degradation rates of 94.49% and 91.43% under visible light irradiation, respectively. The hydroxyl radicals (·OH) were observed as the main reactive oxidizing species in tetracycline decomposition. Moreover, the possible mechanism for enhanced visible light photocatalytic capability might be ascribed to the synergetic effect between α-ZnTcPc and g-C 3 N 4 , which creates large surface areas, decreases the recombination rate of photogenerated charge carries, as well as improves the visible light harvesting significantly. This work not only presents a practical method to conquer the drawback of pure g-C 3 N 4 , but also provides useful insights to construct other g-C 3 N 4 -based composites to take full advantage of solar light towards practical applications for eliminating recalcitrant organic pollutants.
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ACS Omega
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2019
·
IF 2.584
Bo Cao,Chunhua Luo,Jie Lao,Hanqing Chen,Ruijuan Qi,Hechun Lin,Hui Peng
Layered cobalt hydroxides are cost-efficient electrocatalysts for oxygen evolution reaction (OER) in the field of energy conversion. Herein, we developed a facile synthesis method of 3d transition-metal-doped α-Co(OH)2 nanomaterials mediated with ammonia in water–methanol at room temperature. The doping of Cu2+ and Ni2+ leads to flower-like nanostructures similar to pure α-Co(OH)2, whereas the doping of Fe2+ produces nanoparticles with more than 2 times larger surface area in comparison with the Cu2+- and Ni2+-doped nanoflowers. The obtained dispersion with the addition of Nafion can be used directly as an electrocatalyst for OER with excellent catalytic activity, especially that the overpotential of Fe2+ doped is as low as 290 mV at 10 mA cm–2 and the turnover frequency is improved by 3 times as compared with that of α-Co(OH)2. Furthermore, the catalyst can be loaded onto foam nickel, which presents excellent durability with the current density unchanged under continuous chronoamperometry reaction for as long as 12 h and almost quantitative faradaic efficiency. The superior electrocatalytic properties combined with the simple synthesis without the tedious purification procedure is very promising for OER.
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CHEMICAL ENGINEERING JOURNAL
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2019
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IF 8.355
Ruiyang Zhang,Tao Ran,Yuehan Cao,Liqun Ye,Fan Dong,Qian Zhang,Lizhi Yuan,Ying Zhou
Photocatalytic NO x removal is regarded as a promising technique for air purification in recent years. However, NO x removal process usually accompanies with toxic NO 2 generation, leading to serious secondary pollutant and limiting its practical application. Herein, a noble-metal-free g-C 3 N 4 /α-Ni(OH) 2 photocatalyst was fabricated through hydrothermal method. The introduction of α-Ni(OH) 2 microspheres combines with g-C 3 N 4 , resulting in an enlarged surface area from 35 to 95 m 2 /g, while the unique structure of α-Ni(OH) 2 broadens visible-light response range and accelerates photogenerated charge carriers transfer. More importantly, the H atoms of α-Ni(OH) 2 improve the adsorption and activation of O 2 and oxygen atoms to promote NO and NO 2 oxidized to nitrate. Consequently, g-C 3 N 4 /α-Ni(OH) 2 shows enhanced NO removal ratio of 51.3% without any toxic NO 2 generation, indicating its great potential for air purification. Our results provide fresh insight into the design of highly efficient and safe photocatalyst for toxic byproduct control in the application of environmental remediation.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2019
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IF 2.298
Zisheng Zhang,Xianyi Wang,Jun Ma,Renzhou Bian,Hong Sui,Lin He,Xingang Li
The solubility of calcium formate (form α) in four different binary solvent mixtures (methanol + water, ethanol + water, n-propanol + water, and acetone + water) from 283.15 to 323.15 K was measured by a static equilibrium method under atmospheric pressure. Results indicated that the solubility increased with the increasing temperature and water content in binary mixed solvents. The modified Apelblat equation, the combined nearly ideal binary solvent/Redlich-Kister equation, and the Jouyban–Acree equation were applied for the correlation of experimental solubility, among which the modified Apelblat equation was found to be the best fitting model for the crystallization of calcium formate (form α). This experimental data can be a fundamental guide to choose a suitable crystallization process for calcium formate in industry.
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RSC Advances
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2018
·Vol. 8
·期 25
·13728-13738
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IF 2.936
Yongxian Zhou,Wei Chen,Pengfei Wang,Yimin Zhang
The low contact efficiency, large mass transfer resistance and high operational cost of traditional 13X molecular sieve particle adsorbents (MSPs) have greatly limited their application in deep purification of trace oxygenated compounds from gaseous olefins. Herein, we successfully fabricated dense and thin 13X molecular sieve membranes on a porous α-Al2O3 tube (MSCMs) by a combination of 3-aminopropyl triethoxy silane (APTES) surface modification and vacuum pre-coating sol technology for purifying the above impurities. By a solid–solution transformation process, 13X molecular sieve membranes on MSCMs that were continuous and integral without any cracks, pinholes or other defects, and mainly composed of 1–1.5 μm regular 13X crystals with a thickness of 5–6 μm have been achieved. The purification performance of the MSPs, non-APTES functionalized MSCMs (nMSCMs) and MSCMs was evaluated by dynamic adsorption of N2 or C2H4 feed flow containing dimethyl ether, methanol and propanal impurities at room temperature. The results demonstrated that both the nMSCMs and MSCMs could deeply purify the trace amounts of the three oxygenated compounds to below 1 × 10−6 (mol mol−1) from gaseous olefins at an initial concentration of 20 × 10−6 (mol mol−1), exhibiting much more excellent purification performance than that of MSPs. In particular, the breakthrough times of MSCMs for dimethyl ether, methanol and propanal were 7 h, 32 h and 51 h in a N2 system, and 12.1 h, 53 h and 90 h in a C2H4 system. The cumulative adsorption amounts of MSCMs for dimethyl ether, methanol and propanal were 12.108 mg g−1, 35.812 mg g−1 and 103.129 mg g−1 in a N2 system, and 25.88 mg g−1, 94.19 mg g−1 and 256.26 mg g−1 in a C2H4 system, respectively. The regeneration experiment also indicated that the MSCMs had a more stable structure and a longer lifetime. The excellent purification performance of MSCMs could be attributed to the continuous 13X molecular sieve layers without non-adsorption interfacial voids. Hence, the MSCMs have great potential for future industrial application of trace oxygenated compound removal from gaseous olefins.
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CARBOHYDRATE POLYMERS
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2018
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IF 5.158
Abishek Jung Poudel,Feng He,Lixia Huang,Lin Xiao,Guang Yang
A supramolecular hydrogel system was prepared by the host-guest interaction between the α-cyclodextrin (α-CD) and poly (ethylene glycol) (PEG) chains of the poly (ethylene glycol)- block -poly (lactic acid) (PEG- b -PLA) micelles. The formation of inclusion complex (IC) crystals between α-CD and the PEG chains of the micelles was verified by different techniques. Rheological studies indicated that the gelation kinetics and the mechanical strength of the hydrogels could be modulated by the α-CD concentration. Also, the shear-thinning and self-healing properties of the hydrogels were confirmed. Doxorubicin (DOX) could be encapsulated into the hydrogels via the micelles and be released from the hydrogels sustainably, with the release rate dependent on the α-CD concentration. The released DOX showed higher inhibition efficacy against HeLa cells compared with the free drug. These attractive features, together with the superior biocompatibility, make the present hydrogels an potential injectable drug delivery system for tumour treatment.
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Asian Journal of Pharmaceutical Sciences
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2018
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IF 4.56
Shu Han,Ruiyang Sun,Hong Su,Jing Lv,Huan Xu,Di Zhang,Yuanshan Fu
This study aimed to investigate the ability of the novel materials D -α-tocopheryl poly(2-ethyl-2-oxazoline) succinate (TPOS) to construct pH-sensitive liposomes. TPOS was initially synthesized and characterized by TLC, FTIR, and 1 H-NMR. The buffering capacity of polyethylene glycol- distearoyl phosphatidylethanolamine (PEG-DSPE) and TPOS was determined by acid-base titration, and TPOS displayed a slower downtrend and gentler slope of titration curve than PEG-DSPE within pH 7.4–5.0. Studies on the in vitro drug release demonstrated that TPOS modified docetaxel (DOC) liposomes (TPOS-DOC-L) had a slower drug-release rate at pH 7.4 similar to PEGylated-DOC liposomes (PEG-DOC-L), whereas the release rate reached approximately 86.92% ± 1.69% at pH 6.4. In vitro cellular uptake assays by microplate reader, and flow cytometry revealed that TPOS modified coumarin 6 liposomes (TPOS-C6-L) had stronger cellular uptake at pH 6.4 than that at pH 7.4 ( P < 0.01). Conversely, for PEGylated C6 liposomes (PEG-C6-L) and conventional C6 liposomes (C6-L), very similar cellular uptakes were exhibited at different pH values. Confocal laser scanning microscopy images showed that PEG-C6-L and C6-L were mainly located in lysosomes. By contrast, TPOS-C6-L showed broader cytoplasmic release and distribution at 4 h. MTT assay showed that the cytotoxicity of TPOS-DOC-L was similar to that of PEG-DOC-L and conventional DOC liposomes (DOC-L) at the same DOC concentration and at pH 7.4, but was much lower than those at pH 6.4 after 48 h of incubation. The apoptosis of PEG-DOC-L and DOC-L had no remarkable improvement with decreased pH from 7.4 to 6.4. Meanwhile, TPOS-DOC-L significantly induced the apoptosis of HeLa cells with decreased pH. Therefore, TPOS can be a biomaterial for the construction of a pH-sensitive drug delivery system.
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INORGANICA CHIMICA ACTA
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2018
·
IF 2.264
Feng He,Dan Wang,Baiyu Jiang,Zhen Zhang,Zhenmei Cheng,Zhisheng Fu,Qisheng Zhang,Zhiqiang Fan
A novel α-diimine nickel pre-catalyst Cat.1 with two electron-donating methyl substituents on the ligand backbone was synthesized and investigated for ethylene polymerization using methylaluminoxane as cocatalyst. Cat.1 exhibited higher polymerization activity and produced highly branched polyethylene with slightly higher molecular weight than that of the typical Brookhart catalyst ( B-Cat ) at elevated temperature. By tracing the changes of active center number in the polymerization process, Cat.1 was found to have higher ratio of activated nickel ([C ∗ ]/[Ni]), longer catalyst lifetime and larger chain propagation rate constant ( k p ) as compared with B-Cat . The computational studies demonstrated the electron-donating methyl substituents can make a more electron-rich ligand to influence the catalytic properties of Cat.1 . Stronger interactions between the electron-rich ligand and the nickel center should be the main reasons for longer catalyst lifetime and enhanced thermal stability of Cat.1 . The production of polyethylene with higher molecular weight by Cat.1 can be explained by its larger k p value and more stable transition state for ethylene insertion than for chain transfer reaction due to the electron-donating ligand. Overall, the results of this work clearly support the importance of ligand electronic effects on the thermal stability and intrinsic reactivity of active centers in α-diimine Ni(II) catalysts.
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MATERIALS CHEMISTRY AND PHYSICS
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2015
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IF 2.259
Ying Pan,Haifeng Pan,Bihe Yuan,Ningning Hong,Jing Zhan,Bibo Wang,Lei Song,Yuan Hu
Nano-architecture on the flexible polyurethane foam (FPUF) was built by layer by layer (LbL) self-assembling of α-zirconium phosphate (α-ZrP) and two biopolymers . Through electrostatic attraction and hydrogen bonding between α-ZrP, chitosan and alginate , the nano-coatings were successfully deposited on the substrate. The LbL self-assembly coatings were characterized by X-ray diffraction, UV–vis absorption spectroscopy , attenuated total reflection Fourier transform infrared spectroscopy and scanning electron microscopy. This loaded nano-coating endowed FPUF with excellent flame retardancy. Compared with pure FPUF, the reduction in the peak heat release rate of the modified foam with 12.3 wt% weight gain was achieved 71%, and the melt-dripping during combustion disappeared. Meanwhile, the thermal degradation of coated FPUF under nitrogen atmosphere was obviously retarded compared with pure FPUF. Additionally, the mechanical properties of the treated FPUFs were investigated. After loaded with 12.3 wt% nano-coating, the tensile and tear strength were enhanced by 13% and 54%, respectively. These investigations indicated that the study has great potential to add new dimensions in the fire retardancy modification of FPUF.
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危险品化学品经营许可证（带存储）