Translational Neurodegeneration
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2025
·Vol. 14
·期 1
·1-27
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IF 15.2
Wang Jie,Ni Hong,Wang Yu,Wei Luyao,Ding Hanqing,Guo Zhongzhao,Pan Hao,Yu Ying,Luo Jia,Pan Weidong,Wang Deheng,Ke Zun-Ji
Background Alzheimer's disease (AD) is a neurodegenerative disease with major symptoms including memory and learning deficits. Neuroinflammation associated with reactive microglia promotes AD progression. These reactive microglia secrete prostaglandins, which are synthesized through the enzymatic activity of cyclooxygenase (COX)-1 and COX-2. Here, we aimed to elucidate the specific mechanisms of COX1 in AD pathogenesis and its interactions with neuroinflammatory processes.Methods We conducted backcrossing between COX-1 knockout (KO) and 5 × FAD mice to evaluate the effect of COX-1 deficiency on neuroinflammation. In addition, single-cell sequencing and microarray datasets from public databases and ingenuity pathway analysis in vitro were employed to explore gene expression profiles in the brains of AD mice.Results We identified a significant upregulation of COX-1 in 5 × FAD mice, with expression specifically localized to microglia in an age-dependent manner. Additionally, COX-1 KO alleviated neuroinflammation and accumulation of Aβ plaques, subsequently improving cognitive behavior in 5 × FAD mice. Moreover, microglia exhibited an amoeboid morphology in 5 × FAD mice, whereas in age-matched 5 × FAD/COX-1 KO mice, microglia had a ramified appearance. Additionally, our study demonstrated a pharmacological approach that inhibits the prostaglandin E2 (PGE2)/EP2 receptors via inhibition of the cAMP-PKA-NFκB-p65 pathway and NLRP3 inflammasome activation, producing similar beneficial effects as observed in COX-1 KO mice.Conclusion Our findings indicate that targeting the COX-1/PGE2/EP2 signaling pathway may alleviate neuroinflammation and impede AD progression. Moreover, the EP2 receptor presents a promising pharmacological target for mitigating the pathological effects associated with COX-1 activity in AD patients.
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npj Flexible Electronics
·
2025
·Vol. 9
·期 1
·1-10
·
IF 15.5
Ming Xiaojuan,Ding Xincheng,Wang Henry Ming,Lu Jing,Ke Yiming,Li Yue,Luo Jing,Li Mufang,Xiong Yi,Zhao Tao,Zhong Weibing
Flexible actuators have significant potential in intelligent micromachines, artificial muscle, and soft robotics. However, achieving actuators with high actuation performance and feedback sensitivity remains challenging. Inspired by the dual “command-execution-feedback” of the mimic octopus, a fiber actuator with high stroke and visual-electronic dual feedback is designed by introducing an ionic liquid conductive network and a visual component of spiropyrane. By constructing a unique interchain slipping structure inside the liquid crystal elastomer (LCE), the nematic to isotropic transition temperature and maximum stroke temperature dropped to 24.29 °C and 62.3 °C, with decreases of 73.51% and 39.28%, respectively. Besides, the actuation stroke increases to 43.41% with an improvement of 77.11%, and the feedback sensitivity reaches to 69.17, along with a high work capacity of 189.12 kJ/m 3 . These provide a promising strategy for next-generation flexible actuators capable of high work capacity, large stroke, and real-time feedback.
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Science China-Chemistry
·
2025
·
IF 9.7
Kang Kai,Wang Qiuxiang,Huang Hongpu,Zhuang Xinxin,Cai Junlin,Wang Tao,Wang Xue,Xie Zhaoxiong,Xie Shuifen
Despite utilization of state-of-the-art Cu-based catalysts, achieving high selectivity and stability in multicarbon (C 2+ ) compounds production through electrocatalytic CO 2 reduction reaction (CO 2 RR) remains a critical and challenging objective. Here we employ lattice chlorine-doped Cu 2 O nanocubes (Cl d -Cu 2 O NCs) with well-defined {100} facets as a model catalyst to demonstrate that halogen doping can serve as a versatile and effective strategy for modulating surface charge distribution, thereby enhancing asymmetric C–C coupling toward high-selectivity C 2+ products in CO 2 RR. Compared to Cl-free Cu 2 O NCs, Cl d -Cu 2 O NCs exhibit a greatly enhanced C 2+ Faraday efficiency, i.e., ∼85% at −1.1 V (versus the reversible hydrogen electrode). Additionally, the Cl d -Cu 2 O NCs demonstrate significantly enhanced long-term durability, attributed to better preservation of the cubic morphology and more stable Cu δ + states. In-situ electrochemical studies reveal that Cl d -Cu 2 O NCs facilitate the formation of the key asymmetric *COH and *OCCOH intermediates, ultimately leading to higher C 2+ products. Density functional theory (DFT) calculations confirm that the introduced Cl-dopants disrupt the charge balance of the Cu 2 O(100) surface, enriching the Cl-adjacent Cu atoms with more electrons compared to those near O atoms. This unbalanced charge distribution significantly reduces the free energy of the rate-determining step for asymmetric C–C coupling from the *CO to *OCCOH on Cl-doped Cu 2 O (100) surface, requiring only 1.04 eV, in contrast to 1.50 eV on pristine Cu 2 O(100) surface. This study provides valuable insights into the surface charge modulation of Cu 2 O catalysts via halogen doping for enhancing asymmetric C–C coupling and C 2+ production in CO 2 RR.
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npj Science of Food
·
2025
·Vol. 9
·期 1
·1-8
·
IF 7.8
Pan Hui,Zhang Wei,Jin Meng,Zhang Fang,Chen Xuelei,Meng Xiao,Shao Hua,Song Liqun,Zhang Zhihu,Wang Cuijuan
Concerns over health risks associated with mixed pesticide residues have led to a demand for rapid analytical methods. We present a portable surface-enhanced Raman spectroscopy (SERS) device specifically designed for real-time monitoring of indoxacarb (INDX) and chlorfenapyr (CFP) in vegetable juice. This point-of-use sensor integrates silver nanoparticles with a metal-organic framework (Ag/MOF-808(Zr)) and employs a 19-well quartz plate alongside a portable Raman spectroscopy instrument, facilitating simultaneous adsorption, separation, and detection. Detection limits for INDX and CFP in ginger and spinach juices were 0.26–0.76 ppb. Notably, results closely matched those from liquid chromatography, and in-situ detection was achieved within 2 min without pre-treatment, significantly enhancing efficiency over conventional chromatographic methods. This innovative approach demonstrates substantial potential for detecting pesticide mixtures in non-laboratory settings, presenting a valuable option for point-of-use applications.
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npj Science of Food
·
2025
·Vol. 9
·期 1
·1-10
·
IF 7.8
Zhao Huamin,Zheng Xiaoxi,Su Jihao,Wang Jun,Wang Xinrui,Li Hang,Wang Juan,Shen Kexin,Zhao Chao
Electrochemical detection of foodborne pathogens requires simplified electrode modification and enhanced sensitivity. This study introduced Cd-decorated ternary FeCoNi layered double hydroxides (Cd-FeCoNi LDHs) platform for label-free Staphylococcus aureus ( S. aureus ) detection via Cu 2+ biosorption. The FeCoNi LDHs were engineered with optimized metal sites to create lamellar structures with high electrocatalytic surface area. Further incorporating with Cd particles deposition, the response of the Cd-FeCoNi LDHs to Cu 2+ exhibited a double-enhanced differential pulse voltammetry signal. Concurrently, S. aureus has been explored to adsorb Cu 2+ through surface carboxyl and phosphate groups. By integrating with specific magnetic separation, the variation of Cu 2+ derived from biosorption by S. aureus triggered the rapid electrical response of the Cd-FeCoNi LDHs platform. This approach achieved 5.4 CFU/mL detection without bio-labeling, while resisting matrix interference. This work highlighted the innovative application of bacterial metal ions biosorption and label-free sensing platform for foodborne pathogen detection.
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CELLULOSE
·
2025
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IF 4.8
Jiang Jie,Li Ze,Luo Jing,Meng Juan,Cheng Long,Qin Hengfei
As a renewable biomass nanomaterial, nanocellulose demonstrates immense potential for applications in reinforced composites, biomedicine, and nanoelectronics. The morphology of nanocellulose directly governs its properties and performance in specific applications. In this study, a hydrated citric acid/choline chloride deep eutectic solvent (DES) system was employed to modify straw cellulose for preparing nanocellulose. The kinetic interplay between citric acid-mediated hydrolysis and esterification reactions within cellulose during the modification process was systematically investigated. The carboxylate content of the modified cellulose exhibited a linear increase to 0.78 mmol/g within the initial one hour of DES treatment, followed by a plateau phase. Progressive hydrolysis of cellulose was observed throughout the DES treatment. By precisely controlling the carboxylate content and hydrolysis extent of modified cellulose, we successfully prepared nanocellulose with morphology controllably tailored from linear nanofibers to rod-like nanocrystals. The resulting nanocellulose with varying aspect ratios exhibited predictable variations in the mechanical properties of their corresponding films and hydrogels. Furthermore, the stabilization performance of Pickering emulsions using different types of nanocellulose was comparatively analyzed. This work elucidates the mechanism by which hydrated DES treatment conditions regulate the morphology of straw nanocellulose, while also providing a critical foundation and technical framework for nanocellulose production.
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BIODEGRADATION
·
2025
·Vol. 36
·期 4
·1-15
·
IF 3.2
Shao Pengfei,Yao Jun,Li Miaomiao,Min Ning
Phthalate esters (PAEs) are widely used as plasticizers and beneficiation flotation agents in ore smelters, which are ubiquitously distributed emerging contaminants in the environment. The biodegradation of PAEs by degrading microbes is a promising method for their remediation. In this study, we isolated a novel PAE-degrading bacteria, Sinomonas sp. S2, from a contaminated area of a metal(loid) smelter in Guangxi Zhuang Autonomous Region, China. Strain S2 is capable of degrading short-chain PAEs, including dimethyl phthalate (DMP), diethyl phthalate (DEP), di-iso-butyl phthalate (DIBP) and di-n-butyl phthalate (DBP). Sinomonas sp. S2 can completely degrade DBP at concentrations of 400 mg·L −1 within 24 h. The degradation kinetics of PAEs followed the modified Gompertz model. Strain S2 demonstrated good environmental adaptability thriving at pH ranging from 5 to 9 and temperatures between 20 and 40 °C, indicated by its growth on DBP. The optimal pH and temperature for degradation were found to be 7 and 40 °C, respectively. Additionally, several metabolites of DBP were identified, including phthalic acid (PA), butyl acetate, ethyl propionate and methyl 2-methylbutyrate. The reconstructed degradation pathway of DBP may involve protocatechuic acid, β-carboxy-cis, cis-mucronate and γ-carboxy muconolactone, ultimately leading to the tricarboxylic acid (TCA). In a bioaugmentation experiment involving soil artificially contaminated with DBP, strain S2 could promote the degradation of DBP in soil. The results indicate that strain S2 had high degradation capacity and environmental tolerance, which had the potential to be applied in the bioremediation of DBP-contaminated environments.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-11
·
IF 5.3
Wang Sailan,Huang Ling,Ma Guangran,Xu Fugang
A hybrid material GO@Ag composed of graphene oxide (GO) decorated with silver nanoparticles (AgNPs) was prepared for sensitive detection of hydrogen sulfide (H 2 S), a food spoilage indicator and a toxic gas. The GO@Ag nanocomposite demonstrated excellent oxidase-like activity and Raman signal enhancement capability, which can effectively catalyze colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to produce oxidized TMB (ox-TMB) with blue color and strong surface-enhanced Raman scattering (SERS) signals. The presence of H 2 S reacts with AgNPs on the GO surface to form Ag 2 S, which inhibits the nanozyme activity and SERS enhancement activity of the GO@Ag, resulting in decreased absorbance value and SERS signal, thereby achieving colorimetric and SERS dual-mode detection of H 2 S. The method exhibits a wide linear range of 10 nM ~ 50 μM (colorimetry) and 5 nM ~ 50 μM (SERS) and low detection limits of 9 nM (colorimetry) and 0.9 nM (SERS) with simple operation, good selectivity, and high reproducibility. Furthermore, the composite material has been successfully applied to the detection of H 2 S in actual fish samples, providing a new technical means for gas sensing in food safety monitoring. Graphical
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Wu Shaojun,Xu Xianglai
The electromagnetic wave-absorbing materials provide an efficient solution to notable electromagnetic pollution issues. However, as for the design of ultra-wideband, layered absorbing materials remain a critical challenge in the field of wave absorption. This paper first designs a series of broadband tri-layered absorbing structures using the prepared hybridized absorbers of EG-TEA@Fe 3 O 4 @GO with wrinkled morphology and MoO 3 @MWCNT with necklace-like morphology, as well as common dielectric and magnetic absorbers via particle swarm optimization algorithm, determining the appropriate range of electromagnetic parameters for the transmission layer (0 < ε ′ < 5, 0 < ε ″ < 1; 0 < μ ′ < 1, 0 < μ ″ < 0.5), absorption layer (5 < ε ′ < 7, 1 < ε ″ < 2; 1 < μ ′ < 1.2, 0.5 < μ ″ < 0.7) and reflection layer ( ε ′ > 7, ε ″ > 2; μ ′ > 1.2, μ ″ > 0.7) in wideband absorbing materials. Based on these findings, tri-layered absorbing structure with a wider effective absorption bandwidth of 15.63 GHz, stronger stealth capability with maximum RCS reduction of 17.9 dB m 2 and relatively thinner thickness was constructed, which was consistent with the predicted result. The absorption mechanism of the designed tri-layered absorbing structure, dominated by dielectric loss below 4 GHz and magnetic loss above 4 GHz, as well as multiple reflections induced by the fabricated absorber’s unique morphologies, is analyzed through CST simulations and electromagnetic analysis. The tri-layered absorbing structures we developed demonstrate significant advantages over similar reported counterparts, indicating great potential for applications in the ultra-wideband absorption field, and providing an effective method for the fabrication of ultra-wideband absorbing materials via controlling each layer’s electromagnetic parameters to a suitable range and adjusting the unique morphology of the absorbers with high specific surface area. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Gao Yang,Hu JiaMing,Wu LuKun,Zhang Shuai,Li Jing,Du Kai
Polymeric materials with self-healing capabilities have garnered considerable attention across diverse fields such as aerospace and soft robotics in recent years. However, attaining an optimal equilibrium between mechanical strength and self-healing properties remains a formidable challenge, thereby impeding their widespread adoption. To surmount this hurdle, our research endeavors focus on harnessing the dynamic reversible properties of C–N bonds via triazolinedione (TAD) and indole-derived groups. This click chemistry plays a crucial role in crafting high-strength self-healing materials. In this investigation, we introduced C–N dynamically reversible covalent bonds amidst polyvinyl alcohol (PVA) chains, yielding notable enhancements in both mechanical robustness and self-repairing capabilities of thin film materials. The tensile strength of the film surged from 16.3 to 37 MPa, while elongation at break increased from 194 to 440%. These mechanical attributes outstrip the majority of self-healing materials documented to date. Furthermore, the films exhibit remarkable scratch repair proficiency attributed to the abundant hydrogen bonds and dynamically reversible C–N bonds embedded within the polymer network. Upon heating at 85 °C for 6 h without external stimuli, the films exhibited near-complete healing, with a self-healing efficiency reaching up to 71%, accompanied by a strength of 27 MPa and an elongation at break of 309%. Hence, our investigation adeptly achieves a harmonious amalgamation of mechanical prowess and self-healing capacity in polymeric materials, thereby broadening the horizons for research and application of self-healing materials endowed with exceptional mechanical attributes.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Jia Zhongqi,Hao Linlin,Zhao Xinggui,Liu Xianbin
A highly efficient persulfate (PS) catalyst was prepared for the removal of bio-refractory phenol. Nano-zero-valent iron (nZVI) has a high reduction potential and can effectively activate PS, but its susceptibility to agglomeration, oxidation and low electron transfer efficiency limit its application. In this study, nZVI was incorporated into activated carbon acidified with hydrochloric acid (HAC-nZVI) to improve its usability. The optimal conditions were determined as follows: the C/Fe ratio was 2:1, the dosage of HAC-nZVI was 0.5 g L −1 , the PS concentration was 5.5 mM, and the optimal initial pH was 7.0. The 100 mg L −1 phenol removal efficiency of over 90% was achieved within 30 min by using HAC-nZVI. The results of the free radical quenching, XPS and EPR characterization experiments indicate that both free and non-free radicals play a synergistic role in the degradation of phenol. Fe(0/II/III) conversion was the main cause of free radical production. The non-radical pathway involves the transfer of electrons from organic contaminants to PDS through a conducting medium. The intermediate products of the phenol degradation were identified, and two possible degradation pathways were inferred. The toxicity prediction software indicated that the toxicity and environmental risk of the phenol intermediates formed during degradation are generally reduced. Consequently, this study provides a HAC-nZVI composite material for treating high-concentration phenol. In addition, it provided a comprehensive analysis of the environmental effects of phenol degradation intermediates.
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EMBO REPORTS
·
2025
·
IF 6.2
LiXiao-Hu,WangMeng,XuYi-Ran,GuoQian-Huan,LiuPeng,WuChang-Ai,YangGuo-Dong,HuangJin-Guang,ZhangShi-Zhong,ZhengCheng-Chao,YanKang
Drought stress significantly impacts plant growth and productivity, requiring complex adaptive responses to ensure survival. In eukaryotes, autophagy and the ubiquitin-proteasome system (UPS) are critical pathways for maintaining cellular homeostasis under stress. While their interaction is well-studied in animals, it remains poorly understood in plants, particularly under drought conditions. Here, we identify the E3 ubiquitin ligase SRAS1.1 as a key regulator of selective autophagy and drought tolerance in Arabidopsis, mediating its function through the ubiquitination and degradation of the autophagy receptor DSK2A. Loss of SRAS1.1 enhances drought tolerance by reducing water loss, increasing survival rates, and accelerating flowering. SRAS1.1 directly interacts with and ubiquitinates the autophagy receptor DSK2A, promoting its degradation via the 26S proteasome. Notably, under drought stress, SRAS1.1 relocates from the nucleus to the cytoplasm, associates with autophagosomes, and modulates autophagy-related gene expression and BES1 accumulation. These findings provide novel insights into UPS-autophagy crosstalk in plants and highlight SRAS1.1 as a promising target for genetic engineering to develop drought-resilient crops and to advance sustainable agriculture.
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危险品化学品经营许可证（带存储）