MATERIALS & DESIGN
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2025
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IF 7.9
Wojciech Polkowski,Paolo Lai Zhong Lo Biundo,Jianmeng Jiao,Maria Wallin,Adelajda Polkowska,Filip Kateusz,Merete Tangstad
New ternary Fe-Si-B alloys were developed as potential metallic phase change materials (PCMs) for application in ultra-high temperature latent heat thermal energy storage systems (LHTES). By a thermodynamic re-assessment of the Fe-Si-B system, three new Si-rich (approx. 40–50 wt%) compositions were pre-selected for further analyses. The new alloys can provide very high energy density (even above 1 MWh/m 3 ) at melting temperatures around 1150–1200 °C. Furthermore, new PCM candidates have twice lower B content than already developed Fe-26Si-9B alloy, what is beneficial from the economic point of view. For the sake of experimental validation, the PCM candidates were produced by the arc melting technique. The outputs of thermodynamic calculations were verified in detailed microstructural studies and differential scanning calorimetry experiments. In the case of the newly developed Fe-46Si-5B and already designed Fe-26Si-9B alloy, the energy density higher than 1 MWh/m 3 was experimentally confirmed.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Raj Kumar Parajuli,Govinda Gurung,Shree Krishna Tamang,Dinesh Acharya,Xinzhi Wang,Jun Li,Du Zhonglin,Yao Wang,Yanxin Wang,Xinze Yu,Soo Wohn Lee,Laurence A. Belfiore,Jianguo Tang
Polymeric drug nanocarriers still face critical challenges, including poor water solubility, limited biocompatibility, insufficient drug loading capacity, uncontrolled drug release, and the lack of in situ sensing capabilities. This work aims to develop new polymeric drug nanocarriers with multifunctionalization of drug loading, releasing, and in situ sensing (D-LRS). Firstly, water-dispersible Eu 3+ -induced polymeric nanoaggregates (EIPAs) composed of EuCl 3 , 1,10-phenanthroline, and 2-thenoyltrifluoroacetone are synthesized as drug nanocarriers in a polystyrene- block -poly(acrylic acid) aqueous system. The as-synthesized EIPAs have an average diameter of 200 nm and intrinsic luminescence in an aqueous environment, as well as good biocompatibility. Secondly, both doxorubicin ( dox ) and paclitaxel ( pac ) are encapsulated with EIPAs for co-delivery, either separately or together, and the encapsulated drugs are found to be able to achieve pH-responsive controlled release. More importantly, the loading and releasing of the dox and pac drugs could be efficiently in situ monitored by tuning the emission intensity of EIPAs. Thanks to desired water solubility and biocompatibility, as well as intense aqua-luminescence and pH-responsive drug-releasing ability, the smart Eu 3+ -fluorescence-sensible drug carriers could have potential for D-LRS in the combinatory therapy of cancer.
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MATERIALS LETTERS
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2013
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IF 2.224
Zhuang Zhuang,Libin Yang,Xue Jiang,Feng Xin
Highly b -oriented Titanium Silicalite-1 (TS-1) film grew on the surface of glass modified with TS-1 precursor solution . By means of a facile sol–gel method, the glass surface was covered with TS-1 precursor, which modified the glass surface property to make it suitable for the growth of oriented TS-1 film. The influence of different immersion times for the growth of the oriented TS-1 films on the glasses was studied. X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and attenuated total reflection infrared spectra (AT-FTIR) were used to study the crystal orientations , morphologies and the existence of framework Ti of the TS-1 films. The results showed that a highly b -oriented TS-1 monolayer could be prepared with the immersion time of 12 h, following with hydrothermal synthesis at 448 K for 24 h.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2026
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IF 2.5
Han Liu,Zhuo Li,Xilin Zhu,Ying Liu,XiaoPan Wu
Background & aims Caspase-10 (CASP10) participates in death receptor–mediated apoptosis, but the relevance of the CASP10 coding variant rs13006529 (T > A; p.Leu522Ile) to PEG-IFN-α response in chronic hepatitis B (CHB) is unknown. We assessed this association and whether differential apoptotic activity explains variant-associated HBV burden. Methods rs13006529 was genotyped in 262 patients receiving PEG-IFN-α with or without nucleos(t)ide analogues. Allele and genotype frequencies were compared by χ 2 tests; sustained virological response (SVR) was analyzed by univariable and multivariable logistic regression. HBV-infected HepG2-NTCP cells expressing empty vector or either CASP10 variant were compared; variant-expressing cells received vehicle or zVAD-fmk. Apoptosis was assessed by flow cytometry, caspase-3/7 activity, and Western blotting. HBV total RNA and pgRNA, intracellular DNA, cccDNA, and HBsAg/HBeAg were measured by RT-qPCR, qPCR, Southern blotting, and ELISA, respectively. Results The A allele was more frequent in patients without than with SVR (30.6% vs 17.1%; P = 0.002) and independently associated with lower odds of SVR (adjusted OR per A allele, 0.50; 95% CI, 0.27–0.86; P = 0.017). SVR rates were 36.9% in TT and 19.8% in AT/AA carriers (P = 0.003). Leu522-expressing cells showed greater apoptosis and lower HBV total RNA, pgRNA, intracellular DNA, and cccDNA than Ile522-expressing cells. zVAD-fmk attenuated the between-variant difference in apoptosis and partially narrowed the corresponding differences in HBV RNA and intracellular DNA. Conclusions rs13006529 was independently associated with PEG-IFN-α response. Differential caspase-dependent apoptotic activity partly accounts for variant-associated HBV burden differences.
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European Journal of Wood and Wood Products
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2026
·Vol. 84
·期 3
·78
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IF 2.7
Gao Jian,Ma Yuzhen,Wang Yahui,Dong Wanru,Li Hongyi,Li Changgui,Wang Jun,He Mingming
Facing the global shortage of forest resources, oriented strand board (OSB) has attracted increasing attention for its efficient use of small-diameter timber and wood-processing residues. However, its inherent flammability and the deterioration of mechanical properties induced by conventional flame retardants remain critical challenges. In this study, a low-dosage borax (BX)-melamine cyanurate (MCA)-nano-alumina (Al 2 O 3 ) synergistic compatibilization strategy was proposed to simultaneously enhance the fire safety and mechanical performance of OSB. The designed system forms a robust “ceramic–carbon composite expanded protective layer” during combustion, effectively suppressing heat transfer and thermal decomposition. Compared with neat OSB, the residual char yield increased by 78%, while the peak heat release rate, total heat release, total smoke production, and peak smoke production were reduced by 15%, 32%, 69%, and 89%, respectively. Meanwhile, BX-mediated interfacial bonding enabled strong chemical interactions among flame retardants, Wood shavings (WS), and 4,4′-methylenediphenyl diisocyanate (MDI), improving interfacial compatibility. As a result, both longitudinal and transverse bending strength and modulus of OSB were well maintained at high levels. This work provides a novel and practical route for developing high-performance flame-retardant OSB, which not only enables the high-value utilization of wood but also significantly advances the engineering applications of OSB in advanced technology fields.
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Acta Biomaterialia
·
2026
·
IF 10.4
Bingcheng Yi,Kunyang Zhang,Xuejing Chen,Ruijie Xu,Xiyuan Zhang,Chunling Zhang,Yihui Feng,Bo Xue,Qihui Zhou
Peripheral nerve injury (PNI) results in the loss of motor function and sensory perception. Effective repair of the injured peripheral nerves hinges on the coordinated actions of Schwann cell recruitment, neurite outgrowth, and immunoregulation. Herein, we develop an electroconductive and immunomodulatory nerve patch composed of collagen-like aligned hydrogel nanofibers. This patch is constructed using electrospinning and photo-crosslinking, followed by tannic acid (TA) and poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS) modification to impart antioxidant and electroconductive properties. TA modification significantly enhances substrate surface hydrophilicity, fosters cell adhesion and spreading, alleviates the toxic effects of inflammation on cells. Although PEDOT:PSS deposition decreases substrate hydrophilicity, it exhibits no significant effect on cell spreading and oxidation resistance. Moreover, it effectively improves electroconductive features and accelerates neuronal differentiation through mechanosensor-mediated calcium and focal adhesion kinase/protein kinase B (FAK/AKT) pathways. In vivo experiments using a rat sciatic nerve injury model demonstrate that the bioinspired patch maintains close conformal contact with the injured nerve and form a tightly coupled electrical bridge with the electroresponsive neural tissue. This ultimately facilitates nerve regeneration and enables both anatomical and functional recovery without evident muscle atrophy. Collectively, our findings highlight the potential of the bioinspired patch as a promising platform for enhancing PNI repair. Statement of significance Bioinspired materials that mimic the native extracellular matrix (ECM) represent a promising strategy for peripheral nerve injury (PNI) repair by supporting endogenous neurogenesis and guiding tissue regeneration. Herein, we developed an electroconductive and immunomodulatory nerve patch consisting of collagen-like aligned hydrogel nanofibers, sequentially functionalized with tannic acid (TA) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) to introduce antioxidant and electroconductive capabilities. This bioinspired patch effectively promoted cell adhesion and spreading, mitigated immune responses, and established a stable electrical interface with electroresponsive neural tissues, ultimately accelerating neuronal differentiation and regeneration by activating the mechanosensor-mediated calcium and focal adhesion kinase/protein kinase B (FAK/AKT) signaling pathways. Our findings highlight this functionalized patch as a promising platform for enhancing PNI repair. Download: Download high-res image (371KB) Download: Download full-size image
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BIOMASS & BIOENERGY
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2025
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IF 5.8
Xu Liu,Zewang Liu,Haojie Chen,Guang zai Nong
This study developed a synergistic activation-doping strategy using Wild Jujube Pits as a carbon source. The K 2 CO 3 /(NH 4 ) 2 SO 4 /H 3 BO 3 ternary system synchronously modulates pore evolution and heteroatom doping, successfully constructing N/O/B/S-co-doped hierarchical porous carbon (JS1211). Characterisation results demonstrate that JS1211 possesses a high SSA of 1496 m 2 g −1 with hierarchical porosity (micropores: 0.4–0.8 nm; mesopores: 2–10 nm). XPS analysis confirms uniform co-doping of N (7.55 at%), B (6.04 at%), S (0.56 at%), and O (15.78 at%), where pyridinic-N (49.4 %) and BC 2 O (43.6 %) configurations dominate. DFT calculations reveal a three-tiered doping mechanism proceeding through structural distortion → electronic reconstruction → property optimisation. Electrochemical testing shows JS1211 delivers a specific capacitance of 411 F g −1 at 0.5 A g −1 , with 81.75 % capacity retention at 20 A g −1 and 97.31 % capacitance retention after 5000 cycles (Coulombic efficiency: 100.46 %). The assembled symmetric supercapacitor achieves an energy density of 12.85 Wh kg −1 (Power density: 129.71 W kg −1 ) in a 6 M KOH electrolyte, while retaining 7.85 Wh kg −1 at a power density of 10,335 W kg −1 . This work provides new insights for developing biomass-derived high-performance supercapacitor electrodes.
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Advanced Science
·
2026
·
IF 14.1
Xiangxiang Xu,Xianlan Chen,Jin Wang,Yuhan Liu,Sidra Mustafa,Lu Diao,Rongrong Zhao,Haiyang Chi,Kang Hu,Jiashan Zhu,Jun Zhao,Mi Liu
Dendritic cells (DC) play core roles in inducing antigen-specific T cells. However, limited effectiveness hinders their applications as vaccines. To improve the efficacy of traditional DC vaccines, this study optimized three aspects: tumor antigens, cell sources and co-incubating molecules, and thus proposed a new DC-BC vaccine: co-priming B cells and DC at a precise ratio. The therapeutic efficacy was significantly improved by co-incubating DC and B cells. Regarding tumor antigens, utilizing nanoparticles loading whole-tumor lysates performed better than utilizing nanoparticles loading multiple neo-antigens, or nanoparticles loading only water-soluble lysates, or free whole-tumor lysates. Moreover, adding IL-15 and αPD-L1 antibody further bettered DC-BC vaccines. The optimal DC-BC vaccines showed excellent therapeutic efficacy with a 100% response rate and could cure most tumor-bearing mice on several different cancer models, including melanoma, lung cancer and orthotopic pancreatic cancer. The mechanism investigation demonstrated that several molecules, including Ticam1 (TRIF), Traf3, Mavs, and Ifnar2, were involved in promoting APC maturation and improving therapeutic efficacy of vaccines by activating innate immune pathways (TLR/NLR/RLR). In summary, this study provides a new DC-BC vaccine that has much better therapeutic efficacy and explores the underlying mechanism of why co-incubating DC and B cells improved the therapeutic efficacy.
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JOURNAL OF MATERIALS SCIENCE
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2022
·Vol. 57
·期 47
·21693-21708
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IF 4.682
Du Jinyan,Xu Na,Wang Chaofeng,Shu Qin,Xu Qidi,Zhang Ping,Zhuo Shujuan,Zhu Changqing
Novel red-emitting B, N, S-co-doped carbon dots (B,N,S-CDs) were prepared via a one-step hydrothermal carbonization. The obtained B,N,S-CDs are found to be responsive to the pH changes, i.e., the fluorescence intensities obviously change with the watershed of pH 7.4, accompanied by a blue-shift of the fluorescence emission wavelengths with the pH from 1 to 13. The surface state and size of the B, N, S-CDs are responsible for the fantastic responses. Furthermore, introduction of Ag + into the B, N, S-CDs resulted in fluorescence quenching and apparent changes of extinction value, thereby the quantitative assay can be successfully realized where a linear range of 0.1–400 and 0–700 μM with a detection limit of 38 and 107 nM is obtained, respectively. The mechanism might be due to static quenching and induced electron/energy transfer (ET) resulted from the formation of non-fluorescent complex. Strikingly, Ag + can be visualized via evident color changes from red to navy blue under UV light and from maroon to dark brown under sunlight, respectively. These findings indicate that the as-obtained B, N, S-CDs possess a great potential as a dual probe of pH and Ag + ions for biosensing. Graphical Abstract The red-emitting fluorescent B, N, S-CDs with a fantastic pH-sensitive feature, as a dual-mode nanosensor via colorimetric and fluorescence outputs, were applied to detect Ag + ions with the LOD of 107 and 38 nM, respectively.
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JOURNAL OF POWER SOURCES
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2023
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IF 9.2
Ziyan Yuan,Fuyu Xiao,Yixing Fang,Peixun Xiong,Xiaoli Sun,Xuehui Duan,Xuhui Yang,Haosen Fan,Mingdeng Wei,Qingrong Qian,Qinghua Chen,Lingxing Zeng
Designing cathodes with long service life, remarkable rate capability and all-climate workable is crucial to improve the performance of aqueous zinc-ion batteries (AZIBs). Herein, we constructed a vanadium dioxide/graphene oxide (VO 2 (B)/GO) sample that combines VO 2 with GO through hydrothermal route and can simultaneously provide rate capability. VO 2 (B)/GO is rich in oxygen vacancies , which weakens the electrostatic force , and GO prevents vanadium oxidation . Density functional theory (DFT) calculations elucidate oxygen vacancies can offer more storage sites with increased reaction kinetics. The electrode exhibited a high reversible capacity of 423 mAh g −1 at 0.5 A g −1 and preserved long-life cycling properties at 15 A g −1 . The presence of oxygen vacancies and GO can contribute to the excellent performance and prevent the structure of VO 2 from collapsing during cycling. We successfully lit up commercial light-emitting diode (LED) lights with a VO 2 (B)/GO electrode. In addition, VO 2 (B)/GO exhibits excellent performance in all-climate conditions (-15-60 °C). This combinatorial design strategy provides a broadly applicable approach for durability and all-climate workable batteries .
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2023
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IF 3.4
Bingqing Zhang,Xueyong Li,Yiying Chen,Bo Chen,Yu Cheng,Hailing Lin,Wancai Que,Maobai Liu,Lili Zhou,Hui Zhang,Hongqiang Qiu,Chaoyang Wu
Polymyxin B (PB) is currently one of the last resort treatment options against carbapenem-resistant gram-negative bacterial pathogens. Pharmacokinetics/pharmacodynamics (PK/PD) guided therapeutic drug monitoring (TDM) of antibiotics is critical for optimizing dosage regimens to maximize efficacy, minimize toxicity, and delay the emergence of resistance. Currently, methods for determining PB in human plasma and epithelial lining fluid (ELF) are limited. In this study, we developed and validated a simple method for PB determination in human plasma and ELF using LC-MS/MS. Protein precipitation of the sample was conducted with 0.1% formic acid-acetonitrile. Polymyxin B1 and B2 were separated on a C 18 column and detected within 4 min by the mass spectrometer in the positive mode coupled with multiple reaction monitoring. The calibration curve range was 0.156–10.0 and 0.0156–1.00 μg/mL in the plasma for polymyxin B1 and B2, respectively, and was 0.0625–2.00 and 0.00625–0.200 μg/mL for polymyxin B1 and B2, respectively in bronchoalveolar lavage fluid. The accuracy of the intra- and inter-assay studies ranged from 80.6% to 114.9%, and the coefficients of variation for intra- and inter-day assays were less than 14.8%. Among a considerable number of patients, the average steady-state plasma concentration of PB was suboptimal. Moreover, the exposure to PB in patients with acute kidney injury (AKI) was considerably higher than that in patients without AKI. Meanwhile, a higher concentration of PB in ELF could be achieved than that in plasma after PB nebulization treatment. The established method was proven to be rapid, simple, and suitable for TDM of PB and PK/PD studies in human plasma and ELF.
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JOURNAL OF SOLID STATE CHEMISTRY
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2022
·
IF 3.656
Zhaoyang Li,Yongshuai Xie,Yifan Wang,Ying Peng,Zhezhe Deng,Benxue Liu,Guanghui Zhang,Xinqiang Wang,Fengqing Zhang,Luyi Zhu
In this paper, we conducted a study on the structural modulation and photocatalytic performance of single-phase hollow BiFeO 3 nanofibers (SPH–BFO NFs) photocatalysts , investigated the effect of heat treatment temperature on the structure of BFO NFs and the formation mechanism of a hollow structure. The SPH-BFO NFs consist of BiFeO 3 nanocrystals without other heterogeneous phases, with diameters of 400–600 nm and extraordinary flexibility, allowing easy separation of the catalyst from the solution. As a result, the SPH-BFO NFs possess outstanding photocatalytic performance and higher photocatalytic efficiency compared with other forms of BiFeO 3 . In addition, the effects of different environments and water quality on RhB degradation were investigated. It was found that the vacancies (h + ) and superoxide radicals (·O 2 − ) as active substances were less environment-dependent, making the SPH-BFO NFs more resistant to environmental interference. The RhB degradation efficiency of BFO NFs was about 99% in 10 mg/L of RhB dye solution at pH = 6. This work provides valuable insights into the application of SPH-BFO NFs in photocatalysis and the design of nanofiber photocatalysts.
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危险品化学品经营许可证（带存储）