RESEARCH ON CHEMICAL INTERMEDIATES
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2025
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IF 3.5
Wang Shanshan,Zhang Kai,Taran Oxana P.,Li Siqi,Sun Fubao,Yan Hong,Li Fen
Lignin quantum carbon dots (CQDs) were prepared using basic lignin as the carbon source. They were loaded onto Z-type ZnIn 2 S 4 /WO 3 heterojunction semiconductor materials by a one-step hydrothermal method to construct a ternary composite photocatalyst. Taking the photocatalytic water hydrogen evolution reaction performance as an indicator, it was found that the 33% CQDs/ZnIn 2 S 4 /WO 3 composite photocatalyst exhibited the highest hydrogen evolution reaction rate of 15.355 mmol·h −1 ·g −1 , which was twice as high as that of ZnIn 2 S 4 /WO 3 (7.522 mmol·h −1 ·g −1 ). This study successfully constructed CQDs/ZnIn 2 S 4 /WO 3 tenary heterojunction photocatalyst with excellent and stable hydrogen production performance, which fully demonstrated the feasibility of loading lignin-based CQDs to enhance the photocatalytic performance of ZnIn 2 S 4 for high-value utilization of lignin.
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CELLULOSE
·
2025
·
IF 4.8
Cui Xiaolong,Yu Yatong,Wang Xiaoying,Wang Shoujuan,Zhang Chunling,Kong Fangong,Zhao Joe R.,Fatehi Pedram
Bacterial cellulose (BC), a natural biopolymer, exhibits excellent biocompatibility and mechanical properties but lacks inherent antibacterial and hemostatic properties, which hinders its application in wound dressing. In this study, we developed a novel BC-derived hydrogel loaded with nano-silver (AgNPs) and Panax notoginseng (PN) powder (BC@AgNPs/PN) to address these limitations. The hydrogel exhibited exceptional porosity, eco-friendly degradability (33% degradation within 35 days), outstanding mechanical strength (52 kPa), and water retention capacity (1622%), making it suitable for accommodating various body movements and maintaining a moist environment conducive to wound healing. The hydrogel demonstrated excellent antibacterial properties, achieving 99% and 98% inhibition against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), respectively. The incorporation of PN significantly enhanced its hemostatic performance, with a coagulation index of 41%. The hydrogel demonstrated excellent biocompatibility with L929 cells, with cell viability exceeding 85%, highlighting its potential in biomedical applications. Additionally, in vivo studies using a mouse model confirmed its effective promotion of wound healing, with a wound healing rate exceeding 90% within 18 days. Overall, the developed BC-derived hydrogel exhibits superior antibacterial activity, efficient hemostatic properties, and excellent biocompatibility, making it a promising candidate for advanced wound dressing applications. Graphical abstract
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COLLOID AND POLYMER SCIENCE
·
2025
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IF 2.3
Mao Xiaoxi,Zhou Haijing,Wang Xiaotian,Jiao Enguang,Gao Meng,Wang Kunhua,Guan Meili,Ning Liangmin,Fu Min,Chen Wei
Ribavirin (RBV) is a broad-spectrum antiviral agent with proven clinical efficacy. Improper RBV disposal however may cause substantial ecosystem contamination and human health hazards, attributable to its confirmed developmental toxicity. Consequently, operationally simple RBV extraction strategies urgently needed for environmental waters. In this work, leveraging the superior chemical durability, extensive active surface area, and eco-friendly nature of biomass-activated carbon (BAC), a novel molecularly imprinted polymer (PC@PEI/PBA/MIPs) was engineered through dopamine-mediated surface polymerization using rapeseed pollen carbon (PC) as the substrate, specifically designed for selective RBV separation. Furthermore, branched polyethyleneimine (PEI) was covalently grafted onto the porous carbon surface to add the density of boronic acid groups, resulting in a high density of recognition sites in a mild environment. The adsorption experiments show that PC@PEI/PBA/MIPs has a significant binding efficiency (158.03 mg /g) for RBV, and can quickly reach the adsorption equilibrium time within 60 min, with good selectivity and regeneration performance. Finally, PC@PEI/PBA/MIPs were used to capture RBV from real water samples, achieving > 80% recovery efficiency. The prepared PC@PEI/PBA/MIPs plays a decisive role in the separation and enrichment of RBV in complex systems.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 12
·1-10
·
IF 2.4
Wang Zhenzhen,He Shaofeng,Ji Xing,Fang Zefeng,Wang Jing
Transition metal nitrides (TMNs) have emerged as promising alternatives to commercial Pt/C in hydrogen evolution reaction (HER) owing to high conductivity and electronic structure similar to that of Pt. Nevertheless, the applications of TMNs-based catalysts are limited by the complex preparation processes. Developing highly efficient TMNs-based catalysts via simple and eco-friendly synthesis strategies still poses a substantial challenge. In the research, Ru/FeN x /C catalysts are in-situ synthesized through combining ion-exchange and confined pyrolysis strategies by leveraging the intrinsic Fe-N coordination structure of Prussian Blue. The Ru components are preferentially anchored adjacent to FeN x , forming abundant synergistic active centers. The contents of Ru and Fe in Ru/FeN x /C-900 are as low as 0.31 wt% and 0.05 wt%, respectively. The Ru/FeN x /C-900 attains a current density of 10 mA cm −2 at an overpotential of merely 15 mV in a 1.0 M KOH solution, exhibiting superior performance to the commercial Pt/C. The systematic experimental results unveil that the electron transfer between Ru and FeN x optimizes the distribution of active Ru and Fe-N x species, thereby accelerating the reaction kinetics and improving the catalytic activity. Graphical
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ARCHIVES OF MICROBIOLOGY
·
2025
·Vol. 207
·期 12
·1-19
·
IF 2.6
Xu Jingjing,Sun Meng,Chang Jiangcheng,Xie Qingchao,Wang Yongjie,Chen Lanming
Klebsiella oxytoca can cause gastrointestinal infections in humans. Within the instestinal tract, the bacterium encounters diverse host-derived signals (most notably bile salts, BS) and secondary metabolites (such as short-chain fatty acid salts, SCFAs) produced by microbial community. However, the mechanism of K. oxytoca response to BS and SCFAs stresses has been rarely reported. Recently, we found K. oxytoca in 14 species of aquatic food animals, of which K. oxytoca 7-7-27 of mussel origin had strong biofilm formation characteristics and many putative virulence-associated genes. Herein, we investigated the impact of normal physiological concentrations of BS (0.2% – 2.2%) and SCFAs (0.4% – 2.0%) in the tract on survival and virulence of K. oxytoca 7-7-27. The results revealed that the major BS (0.2% sodium cholate, or 0.8% sodium glycocholate) and SCFAs (0.4% sodium acetate, or 0.4% sodium butyrate) stimulated the bacterial growth, and significantly increased cell surface hydrophobicity, auto-aggregation rate and biofilm formation, as well as adhesion and invasion rates of K. oxytoca 7-7-27 toward the human colon Caco-2 cell ( p < 0.05). Notably, comparative secretomic and proteomic analyses uncovered a number of differentially secreted (i.e., 53) and produced (i.e., 1,049) proteins, as well as putative virulence-associated proteins (i.e., 69) triggered by the BS and SCFAs. K. oxytoca adopted multiple strategies to cope with the BS and SCFAs stresses. The results of this study highlighted the potential risk of ingestion of K. oxytoca -contaminated aquatic products.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2025
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IF 3.2
Wang Haitao,Liu Xiang,Gu Xin,Wang Yao,Wang Zhenyu,Chen Zihao,Liang Xiaolu,Luo Yuping,Tan Songlin
Y 2 O 3 : MgO (YMO) composite materials exhibit outstanding optical and thermal stability, and are widely used in optics, catalysis, ceramics and other fields. Attaining high-performance YMO materials hinges upon the use of high purity finely ground raw materials, precise component ratios, and uniform distribution. In this study, YMO composite nanoparticles with a volume ratio of 50:50 were synthesized using oxidizer (magnesium nitrate hexahydrate and yttrium nitrate hexahydrate) and fuel (citric acid). Optimizing the particle size and specific surface area of the nanoparticle was achieved by adjusting the oxidizer to fuel ratio ( O/F ) in the precursor (the molar ratio ranges from 0.18 to 0.33), and the optimal O/F was obtained. When the molar ratio is at 0.28, nanoparticles with particle size of 14 nm and specific surface area of 44 m 2 /g are synthesized. Furthermore, this study revealed that nanoparticles synthesized at different molar ratios of O/F produce different agglomeration degree after calcination at 800 °C, with the agglomeration factor (AF) gradually decreasing as the molar ratio of citric acid to nitrate increases; the results show that AF is at least 2.0 when O/F = 0.28.
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BMC Medicine
·
2025
·Vol. 23
·期 1
·1-14
·
IF 8.3
Cheng Xin,Wang Zerui,Liu Yadong,Ma Liyan,Wang Zhiyi,Qiao Yuxin,Du Wenbin,Guo Shuilong,Chen Dongwei,Su Jianrong
Background Heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) is associated with suboptimal glycopeptide treatment outcomes. However, conventional antimicrobial susceptibility testing fails to distinguish hVISA from vancomycin-susceptible Staphylococcus aureus (VSSA), potentially delaying effective therapy. The gold standard population analysis profiling with area under the curve (PAP-AUC) method is labor-intensive and time-consuming, necessitating rapid detection alternatives. Methods This study introduces a microfluidic platform based on fluorescence-activated droplet sorting (FADS) for the rapid detection and isolation of hVISA. Through systematic optimization of key parameters such as droplet generation conditions, bacterial suspension concentration, fluorescence probe selection, fluorescence duration, and vancomycin screening concentration, we established a rapid hVISA screening system. The efficacy of this system was evaluated using the hVISA standard strain Mu3, followed by validation with 15 clinical hVISA isolates. Genomic analysis further elucidated the genetic basis of drug resistance in hVISA strains. Results We developed a high-throughput detection platform for hVISA by integrating a microfluidic system with FADS. Based on a Poisson distribution theoretical model, the bacterial suspension concentration was optimized to 10 6 CFU/mL, achieving a single-bacterium droplet encapsulation rate of approximately 30%. The selected fluorescent probe exhibited detectable fluorescence signals as early as 6 h post-cultivation, with stability maintained for at least 1 week. Drug concentration validation demonstrated that 4 μg/mL vancomycin effectively inhibited susceptible bacteria without interfering with fluorescence detection. This platform successfully isolated resistant subpopulations from the hVISA reference strain Mu3 within 12 h, and its efficacy was further validated using 15 clinical hVISA isolates. Conclusions This study innovatively integrated a microfluidic detection platform and FADS to achieve rapid detection of hVISA. This technology reduced the detection time to just 12 h and significantly improved the enrichment efficiency of drug-resistant bacterial populations.
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JOURNAL OF THROMBOSIS AND THROMBOLYSIS
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2025
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IF 2.2
Lin Shan,Li Yingjie,Zhang Yue,Wang Qi,Qu Xinrui,Wang Na,Zhong Xinrui,Zhang Shuang,Zhang Daiyan,Wang Zeyu,Li Sen
Atherosclerosis is the main cause of cardiovascular diseases. These diseases can lead to mortality and morbidity worldwide. Macrophage apoptosis plays an important role in the progression of atherosclerosis. ASA-X 3 has anticancer effects by inducing significant apoptosis in gastric cancer cells. We conducted a preliminary experiment and reported that ASA-X 3 promotes macrophage apoptosis. Therefore, we hypothesize that ASA-X 3 might play a role in anti-atherosclerosis by inducing macrophage apoptosis. The effects of ASA-X 3 and ASA on RAW264.7 cells (in vitro) and mice (in vivo) were investigated. In vitro, RAW264.7 cell viability and apoptosis rates were assessed, and the levels of PARP, caspase-9, p-JNK, and p53 in cells treated with the two substances were compared. In vivo, Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling (TUNEL) assays revealed macrophage apoptosis in mice treated with medium- or high-dose ASA-X 3 or ASA. Aortic plaques in mice treated with either drug were examined using oil red O and H&E staining. Masson and collagen staining was performed on the aortic rings of mice treated with high-dose ASA-X 3 or ASA. In vitro, unlike ASA, which had no effect, ASA-X 3 markedly reduced RAW264.7 cell viability. ASA-X 3 induced apoptosis at a rate about four times higher than ASA, with increased levels of PARP, caspase-9, phosphorylated JNK, and p53. In vivo, medium- and high-dose ASA-X 3 significantly increased macrophage apoptosis in mice compared with ASA. In addition, ASA-X 3 (at medium and high doses) reduced the number of aortic plaques, as shown by oil red O and H&E staining. Masson and collagen staining of aortic rings revealed similar results for the high-dose ASA-X 3 and ASA treatments. ASA-X 3 appeared to exhibit anti-atherosclerosis effects via a mechanism that involves the induction of macrophage apoptosis and the lowering of blood plasma lipid levels, eventually resulting in reduced aortic plaque. ASA-X 3 could, therefore, be considered a promising candidate for the treatment of this cardiovascular disease. Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·10264
·
IF 15.7
Li Boyu,Ma Jiabin,Yang Ke,Li Yuhang,Ng Maggie,Ma Yuetao,An Xufei,Cheng Xing,Mi Jinshuo,Tang Man-Chung,He Yan-Bing,Kang Feiyu
The limited proton transfer kinetics within organic positive electrodes restricts the proton storage capacity and hinders achieving high energy density in aqueous zinc-organic batteries. Herein, we obtain superharmonic motion of proton by crosslinking short hydrogen-bonds network within the positive electrode matrix to achieve fast proton transfer. Specifically, the pyrazino[2, 3-g]quinoxaline-5, 10-dione owing strong electrostatic and hydrogen-bond interactions with hydrogen ions is synthesized, which could attract concentrated hydronium and trigger local proton enrichment. Spatially confined water-hydronium domains are therefore formed to generate short hydrogen bonds around pyrazino[2, 3-g]quinoxaline-5, 10-dione molecules. Moreover, the 4,4’-diaminodiphenylamine and polytetrafluoroethylene binder exhibits a mutual affinity with pyrazino[2, 3-g]quinoxaline-5, 10-dione due to the strong hydrogen-bond interactions of them, which reduce the intermolecular distance within positive electrode and construct a highly interconnected state of water-hydronium domains, thereby establishing the short hydrogen bonds network throughout the electrode matrix. The rapid proton transport through short hydrogen bonds consequently reduces the polarization of aqueous zinc-organic batteries (1.47 × 10 −3 S cm −1 ). As a result, the composite positive electrode delivers specific energy of 400 Wh kg −1 at 0.1 A g −1 .
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2025
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IF 3.2
Kong Feng,Geng Zitao,Wang Songqi,Cheng Jiehong,Liu Kejiang,Zhu Jun,Chen Xian,Cheng Shi
Phenothiazines are new synthetic pollutants that have attracted attention in the present years. In order to remove such novel pollutants, in this paper, novel catalytic composites loaded with iron metals (SFCs) were prepared by high-temperature pyrolysis of sewage sludge for the degradation of novel pollutants of phenothiazines, represented by methylene blue (MB). It was found that among the five SFCs prepared, SFC700, prepared at a pyrolysis temperature of 700 °C, had the best pore structure, the largest specific surface area (452.3 m 2 g −1 ), the richest functional groups (such as carboxyl, hydroxyl, and C = O bonds, etc.), the most Fe 3 O 4 content, which exhibited the best performance. SFC700 composites could remove 99.9% of MB within 60 min, and the optimal initial pH was 11. SFC700 had a certain decolorization stability, and the degradation rate could still be maintained at about 90%. It was presumed that SFC700 played the dual role of adsorption and catalysis.
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npj Science of Food
·
2025
·Vol. 9
·期 1
·1-10
·
IF 7.8
Sun Zhi,Wang Fangfang,Zhou Peipei,Chen Di,Zuo Lihua
5-Hydroxymethylfurfural (HMF), a product of the Maillard reaction and caramelization in honey, serves as a crucial marker of food quality and thermal processing, underscoring the importance of regulatory surveillance for consumer safety. This study introduces a method for rapid, high throughput and eco-friendly detection of HMF, using derivatization in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). 5,10,15,20-Tetrakis-(4-aminophenyl)-porphyrin was employed for in-situ derivatization of aldehydes after extraction by ethyl acetate, enhancing detection sensitivity by shifting low-molecular-weight aldehydes to higher regions. The calibration curves for HMF determination exhibited outstanding linearity. The detection limit reached 0.347 mg/kg with good accuracy and precision. Variations in the content of HMF in honey during heating were also assessed, revealing the increased formation of HMF under high temperature and prolonged heating. The method’s proficiency was evidenced through the detection of various aldehydes. This method represents an advance in rapid analysis for food safety, aligning with green chemistry principles.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Liu Feihong,Yao Shasha,Li Jia,Huang Kejie,Zhang Dongdong,Wong Tak Man,Tang Ruikang,Yeung Kelvin W. K.,Wu Jun
In the pursuit of replicating the remarkable mechanical properties of natural biological composites like bone and seashell, developing artificial bulk materials that seamlessly integrate rigid inorganic components with ductile organic constituents has been a longstanding challenge. A key hurdle has been the establishment of robust and reliable linkages between these disparate building blocks. Mechanical metamaterials achieved by well-designed chemical structures, however, offer a promising solution to address this challenge. In this study, we demonstrate that the calcium phosphate-based inorganic-organic hybrid metamaterials trapping inorganic nanoparticles within long-chain polymeric networks and anchoring inorganic blocks to these networks via short-chain organic crosslinkers exhibit switchable and tunable high stiffness and elasticity. Additionally, these metamaterials not only exhibit peculiar mechanical characteristics, but also present excellent biocompatibility, as demonstrated by the in vivo tests using male rats and the in vitro tests. These results suggest a wide range of potential clinical applications.
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