CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2024
·
IF 3.1
Xu Dejun,He Liu,Zeng Fudong,Liu Bo,Ma Jinli,Han Dongmei,Yang Qingbiao,Du Jianshi
Polyvinylpyrrolidone-iodine (PVP-I) complexes are widely used in the medical and health field due to its strong antimicrobial properties and good biocompatibility, but their water solubility negates the possibility to be used as a wound dressing. In this work, the problem of PVP dissolving in water was solved by the method of thermally crosslinking, and it was found that the thermally crosslinked PVP nanofiber heated at 170 °C for 6 h had good liquid absorption capacity, stability and good fiber morphology. In addition, the thermally crosslinked PVP nanofiber is complexed with I 2 to endow it with excellent antibacterial properties. It has been demonstrated to have good biocompatibility through cytotoxicity and hemolysis experiments, which provides the possibility for it to be a dressing for the treatment of infectious wounds.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
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IF 3.8
Pan Yalong,Han Lijun,Shen Junxue,Li Jing,Sun Taolei,Yu Yao
Pesticide contamination is a global challenge, threatening agricultural production and environmental safety. To address the urgent need for efficient and reliable pesticide detection methods, we developed a novel multi-channel colorimetric sensor array based on HAuCl 4 -mediated oxidation reactions. This innovative system incorporates six distinct colorimetric channels coupled with advanced multivariate statistical analysis, enabling simultaneous detection and discrimination of multiple pesticide residues. Through systematic optimization of key reaction parameters, the developed sensor improved selectivity and classification accuracy, particularly for structurally similar pesticides. The platform successfully identifies 11 different classes of pesticides and distinguishes five specific pesticides across various concentration levels. This approach overcomes the limitations of traditional single-target detection methods by employing multi-parameter analysis for accurate pesticide identification. Notably, the proposed method offers several practical advantages, including simple operation, rapid detection (within 30 min), high sensitivity (detection limits of 6 μg/mL), and cost-effectiveness by eliminating the need for expensive instrumentation. These features make the developed sensor array particularly suitable for on-site pesticide screening and food safety monitoring applications. Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Zhang Chunyu,Li An-Zhen,Yuan Bo-Jun,Liu Xiang,Liu Yuanbo,Kong Kejian,Shi Qiujin,Zhang Yixuan,Luo Yiqi,Li Shengnan,Zhou Hua,Duan Haohong
H 2 S capture and valorization from polluted natural gas offer environmental and resource recovery benefits, but current approaches produce moderate-value sulfur with intensive carbon footprint. Herein, we develop an electrochemical deep oxidation method that converts H 2 S from polluted natural gas into value-added K 2 SO 4 using in-situ cathodically generated H 2 O 2 . We first validate this concept using commercial H 2 O 2 and then in-situ generated H 2 O 2 in H-cell, revealing the importance of high H 2 O 2 concentration for deep H 2 S oxidation, especially sluggish S 2 O 3 2− -to-SO 3 2− conversion. We then showcase its application potential in 4-cm 2 and then 100-cm 2 flow reactor with high interfacial H 2 O 2 concentration and large current, with the latter achieving H 2 S removal (100,000 ppm to <15 ppm), >70% K 2 SO 4 selectivity, and 100-h stable operation. Life-cycle assessment and techno-economic analysis confirm the strategy’s sustainability advantages and economic viability. We finally extend this method to produce a 1.4 wt% H 2 SO 4 solution by modifying the flow reactor with a solid-electrolyte type.
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JOURNAL OF MATERIALS SCIENCE
·
2025
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IF 3.9
Dong Wentao,Zhang Mingguang,Peng Tao,Peng Yangyi,He Zanhua,Yao Daojin
With the rapid development of high-speed railway, real-time monitoring of operation safety becomes more and more crucial. However, power supply for microsensors in railway monitoring systems is still demanding and challenging. Stable energy to onboard sensing devices is essential to ensure the safe operation of rail transit systems. Herein, a hybrid piezoelectric–triboelectric nanogenerator (HPTG) is proposed to harvest the vibration energy on the bogie, which is also used as the self-powered sensing for continuous structural health monitoring (SHM) of train bogie. HPTG is designed and fabricated with polyvinylidene fluoride (PVDF)/zinc oxide (ZnO) composite and polydimethylsiloxane (PDMS) film. The experiment results demonstrate that incorporating ZnO simultaneously enhances piezoelectric and triboelectric outputs while improving the overall output performance of the device, fully realizing the synergistic effect of piezoelectric effect and triboelectric effect. Under the condition of external load, the maximum power of the hybrid output is 3.256 μW with excellent working stability. Through the integration of rectifier circuit and energy storage module, the microthermohygrometer is successfully driven. In addition, the feasibility of vibration energy harvesting of HPTG in the actual operating environment is further verified on the small-scale wheel rolling test bench, which provides a solution for the power supply problem of microelectronic equipment for train bogie monitoring, and can effectively help to develop the self-powered monitoring system of rail transit.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·Vol. 60
·期 34
·15098-15112
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IF 3.9
Zeng Daiwei,Li Zhou,Su Yue,Liu Chen-chen,Li Fang,Chen Jianxing,Lin Tengfei,Lin Cong,Zhao Chunlin,Gao Min,Wu Xiao,Wen Na,Chen Weisheng
As advanced optical storage materials, fluorescent hydrogels still face significant challenges in achieving multi-stimulus responsiveness and broad spectral tunability. This study presents a novel aggregation-induced emission (AIE)-active hydrogel system with dual fluorescence emission characteristics, synthesized via a facile one-pot approach. Through controlled freeze–thaw processing cycles, tetrakis(4-hydroxyphenyl)ethylene (TPE-4OH) and tetrakis(4-aminophenyl)ethylene (TPE-4NH 2 ) were successfully incorporated into the three-dimensional polymer matrix. The developed system demonstrates programmable fluorescence modulation through three distinct stimulus–response mechanisms: solvent composition (DMSO/H 2 O), pH variation (HCl/NaOH), and ion coordination (Fe 3 ⁺/EDTA). Notably, these stimuli enable precise individual or synergistic control over both fluorescence intensity and chromatic characteristics of the hydrogel system. Furthermore, fluorescence modulation precision was enhanced through proportional control of the dual fluorophores, enabling tunable ion recognition sensitivity and a spectral shift from blue to green emission. The integrated multi-stimulus responsiveness and reversible emission characteristics confer dual functionality to this hydrogel system: serving as a patterned substrate fabrication platform while demonstrating promising applicability in multidimensional encryption technologies, analyte-specific sensing probes, and smart optical devices. Graphical abstract Multistimuli-responsive hydrogel system with color changing capabilities.
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BIOLOGICAL TRACE ELEMENT RESEARCH
·
2025
·
IF 3.6
Xu Hao,Yang Jingyi,Ye Ruiqi,Cao Mixia,Li Shenghe,Liu Chang,Li Lei
Acute cadmium (Cd) exposure induces hepatic toxicity in murine models, where oxidative stress and subsequent inflammatory responses are recognized as principal contributors to hepatocyte damage. The NLRP3 inflammasome, a pivotal member of the NOD-like receptor family, mediates pyroptotic cell death in diverse hepatic inflammatory pathologies. While murine liver exhibits heightened susceptibility to heavy metal toxicity, the mechanistic basis of Cd-induced hepatocyte injury remains incompletely characterized. This study aims to clarify the cytotoxic effects of Cd on murine hepatocyte line BNL CL.2 and systematically dissect the underlying molecular mechanisms. Via molecular and cellular assays, we evaluated mitochondrial function, reactive oxygen species (ROS) levels, NLRP3 inflammasome activation, and pyroptotic features in BNL CL.2 cells post Cd exposure; intervened with ROS scavengers N-acetylcysteine (NAC) and Mito-TEMPO, and detected transcriptional activity of the antioxidant regulator Nrf2. Experimental data demonstrate that Cd exposure triggers mitochondrial dysfunction coupled with excessive ROS production, concomitant NLRP3 inflammasome activation, and characteristic plasma membrane rupture confirming pyroptosis. Notably, NAC and Mito-TEMPO effectively attenuate these pathological responses, establishing ROS as critical regulators of Cd-induced NLRP3 inflammasome activation; mechanistically, Cd suppresses Nrf2 transcriptional activity and downstream antioxidant gene expression, thereby disrupting redox homeostasis. These findings collectively delineate a pathogenic cascade where Cd impairs mitochondrial integrity and disrupts Nrf2-dependent antioxidant defenses, synergistically driving ROS-mediated NLRP3 inflammasome activation and subsequent hepatocyte pyroptosis. This mechanism provides novel insights into heavy metal hepatotoxicity and identifies potential targets for treating Cd-induced liver injury.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Wang Jing,Li Shuangbao,Ren Lu,Wang Zian,Liu Yanqi,Zhang Dawei
The compounds with an imidazole structure, DHH and DHM, were synthesized using benzoyl, ammonium acetate, 2-hydroxy-5-methylisophthalaldehyde, and 2-(3-aldehyde-4-hydroxyphenyl)- 4-methylthiazole-5-carboxylate as raw materials. The structures of probes DHH and DHM were characterized by FT-IR, 1 H NMR, 13 C NMR, and HR-MS. This study found that DHH and DHM can rapidly and highly selectively recognize Cu 2+ in EtOH-H 2 O (1:1 v/v). The spectral characteristics of DHH and DHM were studied using fluorescence spectroscopy and UV–vis spectroscopy. The results show that the combination of DHH and DHM with Cu 2+ produces a significant fluorescence quenching effect, and the influence of other metal ions can be neglected. Subsequently, through Job’s plot analysis, 1 H NMR titration, and DFT calculations, the binding mechanisms of probes DHH and DHM with Cu 2+ were explored, and it was found that they coordinate in a 2:1 ratio. The experimental study on standard addition recovery showed that probes DHH and DHM could be used for the quantitative detection of Cu 2+ in actual water samples. The probes were also successfully applied to the monitoring of Cu 2+ in living cells. Graphical abstract
The compounds containing imidazole structures in probes DHH and DHM were successfully synthesized and characterized. Test strips made of DHH and DHM were used for rapid “naked-eye” detection of Cu2 + in an aqueous medium. The probes were successfully used to monitor Cu2 + in living cells and real water samples.
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BIOMEDICAL MICRODEVICES
·
2025
·Vol. 27
·期 3
·1-11
·
IF 3.3
Bashir Muhammad Noman,Wang Miaomiao,Chen Yating,Yuan Yuxuan,Noureen Beenish,Liu Minggao,Liu Yage,Qu Zhan,Du Liping,Wu Chunsheng
The urgent need for adenosine triphosphate (ATP) detection spans various fields, particularly in biology and medicine. Developing a simple, quick, label-free, and highly sensitive biosensor for ATP detection is crucial. In this study, we created a label-free biosensor using a field-effect device, specifically an electrolyte-insulator-semiconductor (EIS) sensor, which was functionalized with aptamer and graphene. We prepared a nanocomplex by combining graphene with bovine serum albumin (BSA) in PBS and subjecting it to ultrasonication. This Graphene/BSA mixture was then combined with 70% glutaraldehyde to form the Graphene/BSA/GA nanocomplex. The successful modification of the EIS biosensor surface with Graphene/BSA/GA and aptamer immobilization was confirmed using atomic force microscopy (AFM), which indicated successful molecule attachment through surface roughness. Electrochemical characterization revealed that the biosensor is sensitive to ATP concentrations ranging from 0.1 nM to 100 nM, with a detection limit as low as 0.32 nM. Statistical analysis demonstrated the biosensor’s high sensitivity and specificity for ATP. Furthermore, the biosensor maintained stable performance for ATP detection over a period of 5 days. This sensing approach effectively detected ATP with outstanding performance, showing significant potential for advancing label-free ATP detection technologies. Graphical abstract
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JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Wang Lubiao,Zhang Weiwei,Wu Linfang,Li Feng,Wang Mengyu
Although Rhodamine 6G (R6G) has previously been considered insensitive to pH and stress, with no established applications in sensing these specific parameters, this article presents a breakthrough by re-evaluating its potential as active materials for temperature, pH, and stress sensing. This breakthrough is achieved by employing “balance center” instead of peak maximum or mean wavelength for characterizing the spectral emission band. To verify the improvement, R6G/resin composite samples were prepared. Then the balance center among all the spectral characteristics ensured the most precise identification of the fluorescence band shifts caused by any environmental changes onto the samples. Sensitivities of the prototype sensors with balance center output were calibrated as 0.0653(3) nm/°C in the range of 20 ~ 60 °C, 0.339(8) nm/pH in the pH range of 5.71 ~ 9.44, and − 0.63(2) nm/MPa (equivalently 18 cm -1 /MPa) in the stress range of 0.07 ~ 1.43 MPa, respectively. Corresponding resolutions of the sensing systems were determined as 0.15 °C, 0.18 pH, and 0.03 MPa. These example sensors can be utilized in cytobiology research, demonstrating the potential for extensive sensing applications with a wide range of other fluorescent dyes.
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Food Analytical Methods
·
2025
·
IF 3
Yue Jia-Hui,Zhou Jie-Fang,Zhu Feng-Mei,Li Rong-Di,Liu Xiao-Jing
With the rapid development of nanomaterials, carbon quantum dots (CQDs) with diverse and superior physicochemical characteristics have garnered considerable attention. In this work, we report a sustainable and green synthetic strategy for fabricating novel blue-emissive, water-dispersible CQDs utilizing grape pomace (a winemaking waste) as a renewable carbon precursor, achieving a quantum yield of 32% without requiring additional surface modification. This approach not only promotes waste valorization but also aligns with principles of environmental sustainability. The as-prepared CQDs demonstrate remarkable selectivity toward tetracycline (TC), inducing significant fluorescence quenching via the inner filter effect (IFE). Conversely, enrofloxacin (ENR) triggers notable fluorescence enhancement, predominantly governed by the surface passivation (SP) mechanism. A linear response range of 0–100 µM for TC was established and 0–100 µM for ENR, with a remarkably low detection limit (LOD) of 0.48 µM and 0.94 µM. Furthermore, the CQDs demonstrated robust performance in the quantification of TC and ENR in real-world samples, with stable analytical responses achieved within 1–60 min. Collectively, these findings underscore the potential of the CQDs as a cost-effective, facile, and highly sensitive fluorescence-based sensing platform for monitoring veterinary drug residues.
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FIBERS AND POLYMERS
·
2024
·Vol. 25
·期 11
·4271-4281
·
IF 2.2
Hou Mohan,Wang Lifang,Xu Qiuyu,Zhang Xuepeng,Yang Xue,Zhang Lei,Bai Yun,Li Yanyun,Liu Lifang
Waste cotton fibers are an ideal raw material for extracting nanocellulose crystals (CNCs), benefitting from their high cellulose content. In this study, the waste cotton fibers from the calendering finishing process were used to extract CNCs by sulfuric acid, TEMPO oxidation, and phosphoric acid methods, aiming to create a new way to reutilize the waste cotton fiber and also to verify the practicability that the phosphoric acid method can replace sulfuric acid and TEMPO oxidation methods. The CNCs obtained from the three methods are all in cellulose I state with an average length of 200-500nm and diameter of 15-20nm, indicating that the waste cotton fiber can extract CNCs. However, the CNCs from the phosphoric acid method showed the highest thermostability but the lowest crystallinity, while the ones from the sulfuric acid and TEMPO oxidation methods had higher crystallinity but lower thermal stability. Overall, the three methods are all acceptable for preparing CNCs, but the phosphoric acid method has more significant potential due to its low cost, environmental friendliness, and safety. Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Sun Lin,Feng Wenwen,Liu Yuncong,Chen Lili,Chen Tao,Jin Zhekai,Wang Chao
There is a pressing need for soft robots capable of rapid movement at extreme environments, necessitating the development of ionic conductors with high ionic conductivity, low Young’s modulus, high elasticity, and high stability at extreme environments. However, existing ionic conductor materials cannot meet all of above needs. The preparation of water-free ionic conductive organogels is expected to solve the above problems. In this work, we design a synergy strategy to combine ion-dipole interactions with hydrogen bonds and successfully obtain ethylene glycol (EG) gels at a low polymer concentration of 5 mol%. Our EG gels possess high ionic conductivity (1.31 mS cm −1 ), low Young’s modulus (7.3 kPa), high elasticity (~100%), and good extreme environmental stability. The EG gels can work stably for long time at extreme environments (−27 to 123 °C and 10% to 70% relative humidity (RH)). Furthermore, we successfully achieved dielectric elastomer actuator devices stable operation at extreme environments and with 42 times longer lifetime than commonly used ionogels. We also achieved a soft robot that can work stably at extreme environments with a high speed of 3.6 BL s −1 (body lengths per second).
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