Biology-Basel
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2020
·Vol. 9
·期 8
·205
·
IF 3.796
Xi Yang,Hanju Sun,Lijun Tu,Yuan Jin,Zuoyong Zhang,Muwen Wang,Shuyun Liu,Ying Wang,Shudong He
The interest in anthocyanins used in food, cosmetic, and pharmaceutical industries has increased the research in order to improve their stability while maintaining bioactivity. In this work, cyanidin-3-glucoside lauryl ester (Cy3glc-C12) was enzymatically synthesized, using Novozym 435 as a catalyst, as well as to obtain a kinetic model for the bioprocess. Its liposolubility, UV–VIS absorbance property, thermostability, and potential proliferative effect on intestinal probiotics were also studied. The maximum conversion yield (68.7 ± 2.1%) was obtained with a molar ratio (substrate:donor) of 1:56, 435 16.5 g/L Novozym, temperature of 56 °C, and a time of 28 h via the acylation occurred at 6′′-OH position of the glucoside. The kinetics of the reaction is consistent with a ping-pong bi-bi mechanism and the parameters of the respective kinetic equations are reported. Compared with native Cy3glc, the liposolubility, pH resistivity and thermostability of Cy3glc-C12 were significantly improved. The growth kinetics ofBifidobacteriaandLactobacilluswas established based on the Logistic equation, and Cy3glc-C12 could promote their proliferation especially during the logarithmic growth, in which lower pH and more bacteria population were found compared with those of media without anthocyanins. This research provided a reference for the industrial production of Cy3glc-C12 and extended its application to natural products in lipophilic systems.Keywords:Cyanidin-3-glucoside;kinetic model;enzymatic synthesis;physicochemical property;proliferative effect;intestinal probiotics
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ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Dan Zhao,Shi-Rui Zhang,Yan-Ping Fan,Bao-Zhong Liu,Ya-Nan Li,Lin-Ying Shi,Shao-Jie Dai
Developing broad-band-emitting phosphors is very important to light-emitting diode (LED) lighting and displays. We introduced Eu2+ to solid solutions K2YZr1–yHfy(PO4)3 with a langbeinite-type structure to prepare a series of new phosphors. In this structure, two K+ sites could be occupied by Eu2+ cations to provide two different kinds of coordination environments, leading to broad emitting bands in the range of 390–700 nm. The coordination circumstance of Eu2+ was analyzed by Gaussian fitting and time-resolved emission spectra. Furthermore, the emitting intensity and thermal stability can be improved by modulating the crystalline field via substituting Zr4+ by Hf4+. When the Zr4+ was fully substituted by Hf4+, the external quantum efficiency increased by 53.75%, giving a bright cyan emission. Finally, an archetype white-LED lamp was made using cyan phosphor K2YHf(PO4)3:0.04Eu, red phosphor CaAlSiN3:Eu2+, and a 365 nm LED chip, which realized an applicable color rendering index (Ra = 81) and a correlated color temperature (CCT = 3792 K).
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FOOD RESEARCH INTERNATIONAL
·
2020
·
IF 4.972
Shujie Wang,Guoqin Liu,Weiwei Cheng
3-Monochloropropanediol esters (3-MCPDEs) and glycidyl esters (GEs) with high toxicity have drawn global concerns due to their widespread occurrence in refined oils and oil-based foods . The effect mechanisms of organic chlorine compound lindane, inorganic chlorine compounds tetra- n -butylammonium chloride (TBAC) and sodium chloride (NaCl) on the formation of 3-MCPDEs and GEs were investigated in model oils and chemical models at 240 °C. Results showed that 3-MCPDEs contents increased with the addition of lindane and TBAC, whereas, surprisingly, GEs presented the same tendency as the results of 3-MCPDEs. This suggested that although chlorine compounds were not involved in the formation reaction of GEs, they could also promote GEs formation. Chemical model experiments confirmed that the presence of chlorine compounds led to the transformation of GEs to 3-MCPDEs and conversely 3-MCPDEs could also transform to GEs. The latter transformation rate from 3-MCPDEs to GEs was higher than the former, which might account for the fact that chlorine compounds promoted GEs formation. Additionally, it was also observed that solid NaCl did not induce the increase of 3-MCPDEs and GEs levels in chemical models, suggesting that the chlorine in NaCl, different from lindane and TBAC, was not available for 3-MCPDEs formation. The present findings give novel insights into the interactions between 3-MCPDEs and GEs formation mechanisms, which offer the theoretical basis for efficient and simultaneous inhibition of 3-MCPDEs and GEs.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2020
·Vol. 56
·期 4
·1788-1800
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IF 2.773
Huanhuan Dong,Xin Yin,Wusigale,Hao Cheng,Narangerel Choijilsuren,Xing Chen,Li Liang
Summary Ligand-binding proteins were proposed as ideal carriers for the co-encapsulation of bioactive compounds. Multiple compounds co-encapsulated in food formulation may give rise to different effects on bioactivity and stability. The protein effect on the interplay between bioactive compounds was investigated for selecting suitable co-encapsulation strategy. α-Tocopherol, resveratrol and epigallocatechin-3-gallate (EGCG), as model compounds, interacted with bovine serum albumin (BSA) to form tri-ligand complexes when added in the sequence. For ferric-reducing antioxidant power, the mixtures of α-tocopherol and resveratrol,α-tocopherol and EGCG, resveratrol and EGCG were respectively additive, antagonistic and synergistic, while their ternary mixture were antagonistic. For ABTS+ scavenging capacity, all pairs were antagonistic. BSA improved FRAP of α-tocopherol, resveratrol and EGCG mixture but decreased their ABTS inhibition. Although structural stability and antioxidant activity of resveratrol decreased when alone interacted with BSA, they were improved when α-tocopherol and EGCG were co-presented. Mixing the antioxidants improved their stability and the complexation with BSA can further stabilise them. BSA could thus be a suitable carrier for co-encapsulation/protection of α-tocopherol, resveratrol and EGCG in functional foods.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
·
IF 6.953
Jin Xu,Yanfei Chen,Yuanfang Tian,Zhaojie Yang,Zhixin Zhao,Wenhao Du,Xi Zhang
As a promising biodegradable resin, poly (butylene succinate) (PBS) is often blended with starch to reduce the cost. In this paper, 1-buyl-3-methylimidazolium halide pre-plasticized corn starch (CS) was blended with PBS to prepare PBS/corn starch blend material modified by ionic liquid (PBS/CS-IL). Ionic liquid (IL) acted as plasticizer and compatibilizer, and the effects of 1-butyl-3-methylimidazolium halide with different halogen anion on PBS/Starch blends were explored. The effects of IL on the structure and tensile property of PBS/Starch blends were evaluated by FTIR, SEM, DSC , TGA and XRD, respectively. Test results showed that the addition of IL significantly reduced the crystallinity of PBS/Starch blends, and the size of starch particles in the PBS matrix was also effectively reduced. IL also acted as a compatibilizer of starch and PBS, and induced the morphology of the blends to change from “sea-island” structure to homogeneous phase. The results of the tensile test showed that compared with the PBS/Starch blend without IL, the elongation at break of PBS/CS-IL increased from 22% to 93%. This study provided a simple and feasible method for the preparation of low-cost PBS bio-composite materials, and provided theoretical support for future industrial production.
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TOXICOLOGICAL SCIENCES
·
2020
·Vol. 175
·期 2
·279-291
·
IF 3.703
Li Caiyu,Wang Xue,Bi Yajuan,Yu Heshui,Wei Jing,Zhang Yi,Han Lifeng,Zhang Youcai
Organic anion transporters 1 and 3 (OAT1 and OAT3) play a critical role in renal drug-drug interactions and are involved in the nephrotoxicity of many anionic xenobiotics. To date, relatively little is known about the interaction of natural compounds with OAT1 and OAT3. Of the 270 natural compounds screened in the present study, 21 compounds inhibited OAT1 and 45 compounds inhibited OAT3. Further concentration-dependent studies identified 7 OAT1 inhibitors and 10 OAT3 inhibitors with IC50 values of <10 μM, and most of them were flavonoids, the most commonly ingested polyphenolic compounds in the diet and herbal products. Computational modeling of OAT1 and OAT3 revealed the important residues for the recognition of inhibitors. The two strong OAT inhibitors, namely wedelolactone and wogonin, were evaluated for their in vivo interactions with the OAT substrate aristolochic acid I (AAI), a natural compound causing aristolochic acid-induced nephropathy (AAN) in many species. The cytotoxicity of AAI increased in two OAT-overexpressing cell lines, with more cytotoxicity in OAT1-overexpressing cells, suggesting a more important role of OAT1 than OAT3 in AAN. Both wedelolactone and wogonin markedly increased serum AAI concentrations in AAI-treated rats and ameliorated kidney injuries in AAI-treated mice. To conclude, the present findings are of significant value in understanding natural compound-drug interactions and provide a natural source for developing treatments for AAN.
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JOURNAL OF MATERIALS SCIENCE
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2020
·Vol. 55
·期 14
·6017-6029
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IF 3.553
Liang Shujie,Han Cuilian,Meng Qinghan,Tian Guiying
In this study, a nitrogen and sulfur co-doped sodium titanium phosphate/hole graphene (N,S-NTP/rHGO) was synthesized by one-step hydrothermal method using thiourea as N/S source. The microstructure characterization confirms that N and S heteroatoms have been integrated into the graphene skeleton. The electrochemistry and electrosorption properties of the N,S-NTP/rHGO electrodes were investigated for hybrid capacitor deionization (HCDI). The results indicate that the specific capacitance of N,S-NTP/rHGO electrodes can reach 530.46 F g −1 at a scan rate of 0.2 mV s −1 , which is 33.8% higher than that of the sample without doping. Moreover, the HCDI cell based on the N,S-NTP/rHGO-2 shows a high desalination capacity of 36.87 mg g −1 and a rapid ion removal rate of 0.66 mg g −1 s −1 , which is more than twice as high as the sample without doping (0.3 mg g −1 s −1 ) at an initial NaCl concentration of 800 mg L −1 and applied voltage of 1.4 V. Further, the N,S-NTP/rHGO electrode exhibits excellent regeneration ability. Therefore, this study suggests that as-prepared N,S-NTP/rHGO composite exhibits a great potential application for high-performance HCDI systems.
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Inorganic Chemistry Frontiers
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2020
·Vol. 7
·期 5
·1289-1297
·
IF 5.958
Zhaoyang Wang,Jinmei Liu,Zijuan Du,Haizheng Tao,Yuanzheng Yue
Na3V2(PO4)3 (NVP) features a three-dimensional open structure, which allows fast migration of Na+ ions, and thus, NVP is a superior cathode material for sodium ion batteries. However, the application of the NVP cathode is limited by its low electronic conductivity. To overcome this limitation, we developed an NVP nanocomposite cathode by doping carbon with bromine (Br) and nitrogen (N) during the sol–gel assisted hydrothermal reaction. The Br- and N-doping leads to the formation of amorphous carbon (a-C) on the surface of NVP particles. The nanocomposite possesses multilevel structures containing both pores with different sizes and aggregated grains (200–300 nm). Since the doped N provides electrons to the carbon matrix, the electronic conductivity of the nanocomposite is enhanced. Br-Doping leads to the drop of activation energy for V4+/V5+ redox reaction. The nanocomposite cathode exhibits a high reversible capacity of 41 mA h g−1 at 10C. Both the superior rate and cycling performances could be attributed to the synergistic effect of the multilevel structure and amorphous carbon.
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CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Xiangxiang Li,Peng Gao,Jiangtao Li,Li Guan,Xuanlin Li,Fenghe Wang,Dawei Wang,Zhiqiang Li,Xu Li
Trivalent Er 3+ -doped La 2 (MoO 4 ) 3 upconversion phosphors with intense green emmision were synthesized at 800 °C by the solid-state reaction route, promoting the development of novel optical thermometry. The color emitted from the samples was minorly affected by the excitation power and doping concentration. Yb 3+ is a better sensitizer for the La 2 (MoO 4 ) 3 : Er 3+ phosphor and it can enhance the emission intensity when a certain amount is co-doping in the system. The up-conversion luminescent mechanism was investigated using the pump power-dependent UC emission spectra. Alkali metal doping increased the up-conversion emission intensities drastically, and Li + ions can enhance the luminous intensity by more than 20 times. The fluorescence intensity ratio of the transition emission 2 H 11/2 - 4 I 15/2 and 4 S 3/2 - 4 I 15/2 was used to study upconversion optical temperature sensing. The sensitivity changes from doping with diverse alkali metal ions and their effects on the optimal temperature range are discussed in detail. Alkali metal ions doping extended the temperature range, indicating that this phosphor is a potential candidate for temperature-sensing probes.
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POLYMER
·
2021
·
IF 4.43
Lei Chen,Gangyan Zhang,Guangshun Wu,Peng Wang,Yuanming Zhang,Minghua Li,Qing Li,Tonghua Zhang
The surface of poly( p -phenylene benzobisoxazole) (PBO) fibers was modified by a hybrid coating composed of polydopamine (PDA) and the hydrolysis products of 3-aminopropyltrimethoxysilane (KH551) using a facile and environment-friendly mussel-inspired co-deposition strategy. The surface morphologies and chemical composition of the obtained hierarchical reinforcement (PBO@PDA/Si) were measured for confirming the successful deposition of the coating. Compared to untreated PBO fiber, the surface roughness and wettability of PBO@PDA/Si were increased remarkably. Importantly, PBO@PDA/Si showed a 50.2% increase in the interfacial shear strength (IFSS) of resulting composite without any decrease in its tensile strength (TS). In addition, its atomic oxygen (AO) erosion and hydrothermal aging resistances were significantly improved. The “one-step” mussel-inspired surface modification strategy starts from simple chemistry and cheap raw materials, and may provide a novel and versatile design for fabricating multifunctional hierarchical reinforcements.
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JOURNAL OF CHROMATOGRAPHY A
·
2021
·
IF 4.759
Xue Zhao,Xiaoying Fu,Xinyi Yuan,Aerduosi Shayiranbieke,Ru Xu,Fang Cao,Jianping Ren,Qi Liang,Xinfeng Zhao
The pursuit of new ligands binding to muscarinic-3 acetylcholine receptor (M 3 R) is viewed as challenging due to the lack of screening methods with high efficiency. To address such challenges, this work developed and characterized an approach to the rapid discovery of M 3 R ligands using the immobilized receptor as the chromatographic stationary phase. We fused haloalkane dehalogenase (Halo) as a tag at the C-terminus of M 3 R. The fusion M 3 R was immobilized on 6-chlorocaproic acid-activated ammino-microspheres by the specific covalent reaction between the Halo-tag and the linker. Comprehensive characterizations of the immobilized M 3 R were performed by scanning electron microscope, X-ray photoelectron spectroscopy, and the investigation on the binding of three specific ligands to the receptor. The feasibility of the immobilized M 3 R in complex matrices was tested by screening the bioactive compounds in Zhisou oral liquid, assessing the interaction between the screened compounds and the receptor using zonal elution, and evaluating the in vivo activity of the targeted compounds. The results evidenced that the immobilized M 3 R has high specificity, good stability, and the capacity to separate M 3 R ligands from complex matrices. These allowed us to identify naringin, hesperidin, liquiritigenin, platycodin D, and glycyrrhizic acid as the potential ligands of M 3 R. The association constants of the five compounds to M 3 R were 4.44 × 10 4 , 1.11 × 10 4 , 7.20 × 10 4 , 4.15 × 10 4 , and 3.36 × 10 4 M −1 . The synergistic application of the five compounds exhibited an equivalent expectorant activity to the original formula. We reasoned that the current method is possible to provide a highly efficient strategy for the discovery of receptor ligands.
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RSC Advances
·
2019
·Vol. 9
·期 48
·28006-28018
·
IF 3.049
Huanhuan Xu,Titi Liu,Jing Xu,Jin Li,Fei Chen,Zemin Xiang,Yewei Huang,Dongying Zhang,Lihong Hu,Banglei Zhang,Chengting Zi,Xuanjun Wang,Jun Sheng
Galloylated catechins, the most important secondary metabolites in green tea including (−)-epigallocatechin-3-gallate (EGCG) and (−)-epicatechin-3-gallate, constitute nearly 75% of all tea catechins and have stronger health effects than non-galloylated catechins such as (−)-epigallocatechin and (−)-epicatechin. EGCG is the most abundant, active, and thoroughly investigated compound in green tea, and its bioactivity might be improved by complexing with β-cyclodextrin (β-CD). We investigated interactions between four catechins and β-CD in a PBS buffer solution of pH 6.5 at 25 °C using biolayer interferometry and isothermal titration calorimetry, and to determine whether β-CD could enhance the anti-osteoclastogenesis effect of EGCG. β-CD could directly bind galloylated catechins at a stoichiometric ratio close to 1 : 1, with high specificities and affinities, and these inclusion interactions were primarily enthalpy-driven processes. We synthesized the EGCG–β-CD complex and identified it using infrared radiation and nuclear magnetic resonance spectra. Interestingly, we revealed that the EGCG–β-CD complex could inhibit osteoclastogenesis significantly more than EGCG.
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危险品化学品经营许可证（带存储）