COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
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2022
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IF 4.52
Long Zhu,Mingrong Wang,Shuo Fu,Kaiqi Li,Jialin Liu,Zaizhao Wang
Bisphenol A (BPA) is a widely used endocrine disruptor , which has attracted much attention due to its harmful effects on male reproduction. To investigate the interference of BPA on steroid synthesis in males, male rare minnows ( Gobiocypris rarus ) were exposed to 15 μg L −1 BPA for 7, 14 and 21 d. Meanwhile, a positive control group was performed with 25 ng L −1 17α-ethynyl estradiol (EE2). Results showed that BPA exposure induced lower testosterone (T) levels, while affecting the transcripts of steroidogenic gene StAR . Moreover, BPA induced abnormal germ cells proliferation in the testis in rare minnow. Transcriptome analysis showed that 354 transcripts significantly differentially expressed after BPA exposure for 14 d, several of them were enriched in the signaling pathways of cell cycle process, PPAR signaling pathway, the steroid synthesis pathway and estrogen signaling pathway. BPA significantly increased estrogen receptor (ER) levels and induced abnormal protein levels of PPARγ. BPA disrupted the StAR expression by interfering ER enrichments within StAR 5′ flanking region . Additionally, our study also revealed that BPA and EE2 might have different mechanisms for interfering with steroid hormone levels and germ cells proliferation in the testis.
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Biomass Conversion and Biorefinery
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2022
·Vol. 13
·期 5
·4305-4315
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IF 4.05
Yan Lishi,Li Liangzhi,Zhou Yuanzhuo,Hu Cuiying,Lu Chenxi,Shen Xin
Kinetic model is an important approach for quantitative expression of the mechanism of polysaccharide degradation to value-added products. This study conducted a mechanistic kinetic comparison for acidic degradation of terrestrial biomass-derived cellulose and marine algae-derived agarose to monosaccharides and 5-hydroxymethylfurfural (5-HMF). A pseudo-homogeneous first-order reaction kinetic model with Arrhenius-type temperature dependence was applied to interpret acidic degradation process of cellulose and agarose. The subsequent sensitivity analysis of the impact of rate constants on the production of monosaccharides and 5-HMF predicted in the kinetic model was performed. Results showed that rate constant of polysaccharide hydrolysis (k 1 ) exceeded rate constants of monosaccharide dehydration (k 2 ) and 5-HMF degradation (k 3 ) during agarose decomposition process, but was opposite in cellulose depolymerization process. The corresponding activation energy of agarose hydrolysis (64.5 kJ mol −1 ) was much lower than that of cellulose hydrolysis (121.4 kJ mol −1 ). Agarose was demonstrated to be superior to cellulose for producing monosaccharides and 5-HMF. The desired yields of monosaccharides and 5-HMF from agarose were obtained 58.5% and 27.5%, respectively. Subsequent sensitivity analysis revealed that rate constants k 1 and k 3 were the key factors controlling production of monosaccharides and 5-HMF from agarose, respectively.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Yuanyuan Peng,Xinjing Du,Daolian Zhu,Yu Nie,Shengbin Shi,Jinfeng Xing
Drug-loaded nanogels have attracted extensive research interest and shown great potential for many biomedical applications. A facile preparation method for drug-loaded nanogels is desirable to be developed. In this study, a range of nanogels were prepared by combining thiol-ene click reaction and photopolymerization at 532 nm for in situ loading 5-Fluorouracil (NG-S). The drug loading amount was improved by introducing mercaptosuccinic acid (MCA) to trigger thiol-ene click reaction. The drug loading capacity and swelling ratio characteristics of NG-S could be tuned by changing the proportion of PEGDA/MCA and the initial dose of drug. Especially, the drug release performance of the NG-S showed that 5-Fluorouracil presented the relatively excellent behavior of controlled release with a sustained release time up to 20 h in PBS (pH 7.4) at 37 °C. The fitting results of NG-S based on R 2 were consistent with the First order, Weibull and Biexponential kinetic models .
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Engineering
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2022
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IF 12.834
Youwen Shuai,Xue Huang,Benyin Zhang,Lu Xiang,Hao Xu,Qian Ye,Jinfeng Lu,Jing Zhang
The heterogeneous catalytic activation of peroxymonosulfate (PMS) for wastewater treatment is attracting increased research interest. Therefore, it is essential to find a sustainable, economical, and effective activated material for wastewater treatment. In this study, metal–organic framework (MOF)-5 was used as the precursor, and a stable and recyclable material ZnO@Ni 3 ZnC 0.7 that exhibited good adsorption and catalytic properties, was obtained by the addition of nickel and subsequent calcination. To investigate and optimize the practical application conditions, the elimination of rhodamine B (RhB) in water was selected as the model process. This study demonstrated that the degradation of organic matter in the system involved a coupling of the adsorption and degradation processes. Based on this, the mechanism of the entire process was proposed. The results of scanning electron microscopy, infrared spectrum analysis, and theoretical analysis confirmed that the van der Waals forces, electrostatic attraction, and hydrogen bonding influenced the adsorption process. Electron paramagnetic resonance analysis, masking experiments, and electrochemical tests conducted during the oxidative degradation process confirmed that the degradation mechanism of RhB included both radical and non-free radical pathways, and that the surface hydroxyl group was the key active site. The degradation of the adsorbed substrates enabled the regeneration of the active sites. The material regenerated using a simple method exhibited good efficiency for the removal of organic compounds in four-cycle tests. Moreover, this material can effectively remove a variety of organic pollutants, and can be easily recovered owing to its magnetic properties. The results demonstrated that the use of heterogeneous catalytic materials with good adsorption capacity could be an economical and beneficial strategy.
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Biomass Conversion and Biorefinery
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2022
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IF 4.05
Zhang Yameng,Shen Xinming,Hu Lei,Wu Zhen,Wang Xiaoyu,Jiang Yetao
The Meerwein-Ponndorf-Verley (MPV) reduction is an extremely attractive strategy for the selective hydrogenation of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-bis(hydroxymethyl)furan (BHMF) in which constructing a low-cost and high-efficiency catalyst is very essential and crucial. In this work, the enzymatic hydrolysis lignin (EL), which is a waste residue in the production process of lignocellulosic ethanol, was firstly and directly adopted as the cheap organic ligand to prepare a new zirconium-lignin hybrid catalyst (Zr-EL) by a simple solvothermal self-assembly method. Amazingly, Zr-EL displayed superior catalytic activity for the MPV reduction of HMF to BHMF, providing 98.9% yield with a high turnover frequency (TOF) of 10.86 h -1 in 2-propanol ( i PrOH) at 140 °C for 4 h. Intensive characterization and analysis results indicated that this superior catalytic activity of Zr-EL was principally attributed to the cooperative effects of Lewis acid-base sites (Zr 4+ -O 2− ) under the assistance of good hydrophilicity. Additionally, Zr-EL showed excellent catalytic stability, and when it was recovered and reused for five successive reaction cycles, an apparent loss in the yield of BHMF was not observed. More meaningfully, Zr-EL also exhibited outstanding applicability, allowing it to convert various ketone and aldehyde compounds to the corresponding alcohol products with satisfactory yields in i PrOH via MPV reduction. Conclusively, this work presents a newfangled idea to utilize the low-rank biorefinery residues and construct more practical zirconium-based catalysts for the selective synthesis of high-value chemicals. Graphical abstract
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CELLULOSE
·
2022
·Vol. 29
·期 4
·2257-2272
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IF 6.123
Shi Ning,Zhu Yuju,Qin Bangzhi,Liu Ying,Zhang Hongyan,Huang Hongsheng,Liu Yunhua
A simple and efficient biphasic system comprising H 2 O, tetrahydrofuran (THF), cyclohexane (CHX) and Al 2 (SO 4 ) 3 was employed to convert cellulose into 5-hydroxymethylfurfural (HMF). The volume ratio of the organic phase to the aqueous phase (V org /V aque ), concentration of Al 2 (SO 4 ) 3 in the aqueous phase (C[Al 2 (SO 4 ) 3 ] aque ) and concentration of Al 2 (SO 4 ) 3 in the organic phase (C[Al 2 (SO 4 ) 3 ] org ) of the biphasic system played critical roles in the conversion of cellulose into HMF. In the biphasic systems with H 2 O/THF/Al 2 (SO 4 ) 3 of 4/18/0.4 and H 2 O/THF/CHX/Al 2 (SO 4 ) 3 of 3/16/3/0.4, > 80% of the added H 2 O was dissolved in the organic phase, whereas most of the added Al 2 (SO 4 ) 3 remained in the aqueous phase under the reaction temperature, jointly leading to high V org /V aque , high C[Al 2 (SO 4 ) 3 ] aque and low C[Al 2 (SO 4 ) 3 ] org in the biphasic system. All of these results yield the excellent performance of these biphasic systems in the conversion of cellulose into HMF. The addition of CHX into the biphasic system can decrease the solubility of Al 2 (SO 4 ) 3 in the organic phase, thus improving the stability of HMF in the reaction system. The influences of catalyst usage, reaction temperature and time, and cellulose/solvent ratio were all explored, and a high HMF yield of 71.2% was obtained in the H 2 O–THF–CHX biphasic system with an H 2 O/THF/CHX volume ratio of 3/16/3 under optimized conditions. Graphical abstract
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Frontiers in Pharmacology
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2022
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IF 5.988
Zhang Wensen,Cui Na,Su Fazhi,Wang Yangyang,Yang Bingyou,Sun Yanping,Guan Wei,Kuang Haixue,Wang Qiuhong
Radix Rehmanniae (RR, from Radix Rehmanniae (Gaertn.) DC.) is a natural medicine used in traditional Chinese medicine (TCM) since ancient times for the treatment of blood disorders. RR is steamed to get Rehmanniae Radix Praeparata (RP), which has a tonic effect on blood; the content of 5-hydromethylfurfural (5-HMF) increases more than four times after steaming. Studies have shown that 5-HMF has positive pharmacological effects on cardiovascular and hematological disorders. This study aimed to explore and verify the impact of 5-HMF on rats with chemotherapy-induced blood deficiency syndrome (BDS). Rats were given cyclophosphamide (CP) and acetophenhydrazine (APH) to induce BDS, the coefficients of some organs (liver, spleen, and kidney) were measured, and a routine blood test examined the coefficients of several peripheral blood cells. Metabolomics and network pharmacology were combined to find important biomarkers, targets, and pathways. Western blot was used to detect the expression of CYP17A1 and HSD3B1 proteins in the spleen. All these findings suggested that the 5-HMF significantly increased the number of peripheral blood cells and reversed splenomegaly in rats. In addition, 5-HMF upregulated CYP17A1 and HSD3B1 protein expression in splenic tissues. Also, 5-HMF ameliorated chemotherapy-induced BDS in rats, and its therapeutic mechanism might depend on steroid hormone biosynthesis and other pathways. It acts on blood deficiency via multiple targets and pathways, which is unique to Chinese medicine.
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Bioactive Materials
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2022
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IF 16.874
Yihao Liu,Haoyi Niu,Chengwei Wang,Xiaoxiao Yang,Wentao Li,Yuxin Zhang,Xiaojun Ma,Yuanjing Xu,Pengfei Zheng,Jinwu Wang,Kerong Dai
Uncontrolled hemorrhage and wound infection are crucial causes of trauma-associated death in both the military and the clinic. Therefore, developing an efficient and rapid hemostatic method with biocompatibility, easy degradation, and wound healing is of great importance and desirability. Inspired by spontaneous blood cell plug formation in the hemostasis process, an adenosine 5′-diphosphate modified pro-coagulation hyaluronic acid (HA-ADP) coordinated with enhanced antibacterial activity of undecanal-modified chitosan (UCS) was fabricated through physical electrostatic cross-linking and freeze-drying. The as-prepared hydrogel sponges showed a porous structure suitable for blood cell adhesion. In particular, the hydrogel exhibited excellent antibacterial ability and promoted the adhesion of platelets and red blood cells, thus inducing a prominent pro-coagulation ability via platelet activation, which exhibits a shorter hemostasis time (58.94% of control) in vitro . Compared with commercially available CELOX and gelatin sponge (GS), HA-ADP/UCS accelerates hemostasis and reduces blood loss in both rat tail amputation and rat artery injury models. Furthermore, all the samples exhibited superior cytocompatibility and biodegradability. Due to these performances, HA-ADP/UCS promoted full-thickness skin defect healing significantly in vivo . All the properties of HA-ADP/UCS suggest that it has great potential for translation as a clinical application material for hemostatic and wound healing.
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ACS Catalysis
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2022
·
IF 13.7
Shaowei Yang,Chen Wu,Jinhui Wang,Haidong Shen,Kai Zhu,Xi Zhang,Yueling Cao,Qiuyu Zhang,Hepeng Zhang
For tandem reactions with several intermediate products, improving the reaction rate of each step is vital for accelerating the entire reaction. However, simultaneously enhancing the conversions of different intermediates using a single-active-site catalyst remains a challenge because the catalyst commonly promotes only one type of reaction. Herein, a Co-based double-active-site relay catalyst (denoted as (Co1→Cop)/N-CNTs) is reported. Due to the preferable catalytic activities of Co single atoms (Co1) and Co nanoparticles (Cop) for the oxidation of hydroxyls to aldehyde groups and aldehydes to carboxyl groups, respectively, the prepared (Co1→Cop)/N-CNTs exhibited good catalytic performance for the aerobic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA). The catalyst achieved 100% HMF conversion efficiency and 96% FDCA yield under a 0.1 MPa O2 atmosphere at 100 °C for 8 h. The presented strategy offers prospects for the development of highly active catalysts for complex tandem reactions.
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INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Haoran Yuan,Chengyu Li,Rui Shan,Jun Zhang,Yong Chen
In the present study, selective transformation of waste cassava residues into aromatics via catalytic pyrolysis over as-prepared La and P modified ZSM-5 was systematically investigated, especially in the aspects of product regulation and kinetic analysis. Comprehensive physicochemical characterizations were undertaken for unveiling the essential structural properties of La and P modified ZSM-5. The introduction of La and P species significantly enriched the Lewis and Brønsted acid sites in ZSM-5, thus facilitating the directional pyrolysis of waste cassava residues into aromatics. Higher apparent activation energy for aromatics formation from waste cassava residues pyrolysis in the presence of La and P modified ZSM-5 might be due to the fact that the catalytic pyrolysis belonged to diffusion-controlled gas-solid reaction. In comparison with that of the parent ZSM-5, LaP 2 /ZSM exhibited better performance towards aromatics formation in waste cassava residues pyrolysis, wherein the relative content of aromatics reached 83.3% at a temperature of 650 °C. Gratifyingly, the relative content of aromatics was increased to 90.5% for the catalytic pyrolysis of acid pretreated cassava residue, in the case of LaP 1 /ZSM catalyst.
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BIORESOURCE TECHNOLOGY
·
2021
·
IF 9.642
Song Li,Lele Jin,Haiyong Wang,Xiangqian Wei,Wenzhi Li,Qiying Liu,Xinghua Zhang,Lungang Chen,Longlong Ma,Qi Zhang
Herein, WO x –decorated Ir/SiO 2 (W/Ir = 0.06) and HZSM-5 were coupled to selectively convert microcrystalline cellulose (MCC) into C 6 alkanes. A 92.8% yield of liquid alkanes including an 85.3% yield of C 6 alkanes was produced at 210 °C. Cellulose hydrolysis, glucose hydrogenation and sorbitol hydrodeoxygenation were integrated to produce alkanes via a sorbitol route. Ir-WO x /SiO 2 showed high performance for hydrogenation and hydrodeoxygenation reactions after hydrolysis catalyzed by HZSM-5. The intimate contact between WO x and Ir enhanced the synergistic interaction through the electron transfer from Ir to WO x . The interaction strengthened the reduction capability of Ir for hydrogenations, as well as improved the adsorption and activation of C-O bonds on reduced WO x for deoxygenations. The monotungstate WO x species provided moderate Lewis acids to cooperate with Ir to accelerate hydrodeoxygenations with alleviated retro -aldol condensation to yield more C 6 alkanes.
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JOURNAL OF COORDINATION CHEMISTRY
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2021
·
IF 1.751
Hanyuan Zhang,Xiaomeng Li,Qin Wang,Jiaxin Zhong,Liang Zhao,Xinlong Wang,Chao Qin
Two new coordination polymers constructed from 5-sulfoisophthalic acid sodium salt (NaH2SIPA) and Co or Cu cations, [Co3(SIPA)2(4,4′-bpy)4(H2O)6]·4H2O (1) and [Cu6O3(HSIPA)3(4,4′-bpy)6(H2O)3]·7H2O (2), have been synthesized under hydrothermal conditions and characterized by single-crystal X-ray diffraction (SXRD), powder X-ray diffraction (PXRD), IR spectroscopy, thermogravimetric analysis, UV-Vis spectroscopy, and elemental analysis. Compound 1 represents a twofold-interpenetrating 3-D framework based on Co, SIPA, and 4,4′-bipyridine ligands with a qzd topology. Different from 1, compound 2 shows a 3-D self-penetrating framework based on Cu, HSIPA, and 4,4′-bipyridine ligands. Furthermore, the photocatalytic performance in reduction of CO2 of 1 under visible light was investigated.
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