Translational Neurodegeneration
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2025
·Vol. 14
·期 1
·1-27
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IF 15.2
Wang Jie,Ni Hong,Wang Yu,Wei Luyao,Ding Hanqing,Guo Zhongzhao,Pan Hao,Yu Ying,Luo Jia,Pan Weidong,Wang Deheng,Ke Zun-Ji
Background Alzheimer's disease (AD) is a neurodegenerative disease with major symptoms including memory and learning deficits. Neuroinflammation associated with reactive microglia promotes AD progression. These reactive microglia secrete prostaglandins, which are synthesized through the enzymatic activity of cyclooxygenase (COX)-1 and COX-2. Here, we aimed to elucidate the specific mechanisms of COX1 in AD pathogenesis and its interactions with neuroinflammatory processes.Methods We conducted backcrossing between COX-1 knockout (KO) and 5 × FAD mice to evaluate the effect of COX-1 deficiency on neuroinflammation. In addition, single-cell sequencing and microarray datasets from public databases and ingenuity pathway analysis in vitro were employed to explore gene expression profiles in the brains of AD mice.Results We identified a significant upregulation of COX-1 in 5 × FAD mice, with expression specifically localized to microglia in an age-dependent manner. Additionally, COX-1 KO alleviated neuroinflammation and accumulation of Aβ plaques, subsequently improving cognitive behavior in 5 × FAD mice. Moreover, microglia exhibited an amoeboid morphology in 5 × FAD mice, whereas in age-matched 5 × FAD/COX-1 KO mice, microglia had a ramified appearance. Additionally, our study demonstrated a pharmacological approach that inhibits the prostaglandin E2 (PGE2)/EP2 receptors via inhibition of the cAMP-PKA-NFκB-p65 pathway and NLRP3 inflammasome activation, producing similar beneficial effects as observed in COX-1 KO mice.Conclusion Our findings indicate that targeting the COX-1/PGE2/EP2 signaling pathway may alleviate neuroinflammation and impede AD progression. Moreover, the EP2 receptor presents a promising pharmacological target for mitigating the pathological effects associated with COX-1 activity in AD patients.
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npj Flexible Electronics
·
2025
·Vol. 9
·期 1
·1-10
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IF 15.5
Ming Xiaojuan,Ding Xincheng,Wang Henry Ming,Lu Jing,Ke Yiming,Li Yue,Luo Jing,Li Mufang,Xiong Yi,Zhao Tao,Zhong Weibing
Flexible actuators have significant potential in intelligent micromachines, artificial muscle, and soft robotics. However, achieving actuators with high actuation performance and feedback sensitivity remains challenging. Inspired by the dual “command-execution-feedback” of the mimic octopus, a fiber actuator with high stroke and visual-electronic dual feedback is designed by introducing an ionic liquid conductive network and a visual component of spiropyrane. By constructing a unique interchain slipping structure inside the liquid crystal elastomer (LCE), the nematic to isotropic transition temperature and maximum stroke temperature dropped to 24.29 °C and 62.3 °C, with decreases of 73.51% and 39.28%, respectively. Besides, the actuation stroke increases to 43.41% with an improvement of 77.11%, and the feedback sensitivity reaches to 69.17, along with a high work capacity of 189.12 kJ/m 3 . These provide a promising strategy for next-generation flexible actuators capable of high work capacity, large stroke, and real-time feedback.
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Communications Biology
·
2025
·Vol. 8
·期 1
·1-12
·
IF 5.1
Li Yating,Liu Yiran,Yin Xueyong,Yu Xiaohui,Li Bingyu,Liu Xiao,Liu Xiaoyu,Li Xincheng,Zhao Ye,Song Li,Shi Haishui
Sociocultural changes in recent decades have promoted fathers’ involvement in childcare, which is crucial for the brain and behavioral plasticity of offspring. The study elucidates the effect and mechanism of father’s companionship on defensive attack behavior of adult male offspring mice. The study comprises a father companionship group, where offspring cohabited with sire and dam until weaning, and a control group, where offspring cohabited solely with the dam until weaning. The study shows that father’s companionship increases defensive attack behavior of adult offspring. Additionally, the metabolite L-aspartic acid is upregulated in the father’s companionship group compared to the control group in male offspring, and intracerebroventricular micro-injection of L-aspartic acid confirms its impact on defensive attack behavior. C-Fos immunohistochemistry reveals that c-Fos expression in lateral periaqueductal gray (LPAG) is activated. Subsequently, micro-injection of L-aspartic acid into LPAG increases defensive attack behavior. Additionally, 16S rRNA sequencing reveals a higher abundance of Bilophila and a lower abundance of Bifidobacterium in the father companionship group, which correlates with L-aspartic acid levels, suggesting a gut-brain axis mechanism for the effect of father companionship on defensive attack behavior.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 4
·1-12
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IF 21.8
Li Cong,Liu Dizhou,Yu Hongxuan,Zhao Han,Guo Jingran,Song Chuanyun,Zhao Yingde,Zhang Jianing,Deng Yuanpeng,Dang Shixuan,Wang Duola,Chen Jiali,Yan Zhengli,Lin Tiande,Li Hui,Xu Xiang
Advanced fire protection for infrastructures and facilities requires fireproof coatings that can possess high fire resistance, thermal insulation, flexibility, and durability. Conventional coatings are usually developed by composing inorganic fillers and organic binders, still suffering from limited fireproof effect, severe fracture, and short working life. Here, we report a dual-aerogel design of robust aluminosilicate ceramic coating with natural-dried nanoporous aerogel for thermal insulation and electro-spun nanofibrous aerogel for flexible deformation. The resulting coating, with a thickness of only 3 mm, exhibits a fire superprotection performance with fire resistance up to 1400 °C, thermal conductivity of only 103.55 mW·m −1 ·K −1 at 1000 °C, hydrophobicity of contact angle up to 154°, and ultraflexibility of a 90° bending angle with 10,000 times of fatigue resistance. This unique dual-aerogel design can well resolve the formidable thermal–mechanical trade-off in fireproof coatings and establish a set of fundamental considerations in material design for fire superprotection.
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npj Clean Water
·
2025
·Vol. 8
·期 1
·1-10
·
IF 11.4
Lu Tianxin,Wu Qinglin,Zhou Yu,Wang Xuanzhi,Shi Weiwei
Interfacial solar evaporation is an innovative technique that has attracted significant attention for its potential applications across a variety of fields. Traditional evaporators either apply the hydrophobic surface or the hydrophilic, exposed to solar irradiation. However, both situations result in the poor heat and mass transfer with the long-term operations, further lower down evaporation performance. Herein, Janus membranes (FePP) were designed with dynamically reversible solar evaporation interfaces; the top surface exhibited superhydrophobic exposed to solar irradiation while superhydrophilic in the dark environment. This property minimizes salt fouling by regulating salt deposition during evaporation cycles, while facilitating easy recovery during the hydrophilic state. The solar evaporation performance has improved with the average rate of 1.48 ± 0.05 kg m −2 h −1 , 2.6 times more than the control group of water interface without FePP under one-sun irradiation. Furthermore, it demonstrated excellent stability and strong salt-resistance ability in the long-term desalination and highly saline water operation. Even outdoor field tests, FePP also showed strong solar evaporation and desalination performance exposed to the changing irradiation under the sun. This work further promotes the practical applications of the solar interfacial evaporators into the wastewater treatment, water desalination and purification, and energy production.
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NATURE MATERIALS
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2025
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IF 38.5
Lin Yi,Li Mengyao,Luo Zijin,Meng Yanan,Zong Yan,Ren Hongyu,Yu Xiaolu,Tan Xiaoqiong,Liu Fan,Wei Tuo,Cheng Qiang
Lipid nanoparticles for mRNA delivery and gene editing have the potential to transform the current therapeutic landscape. Nonetheless, a major bottleneck using this technology is the difficulty in achieving cell- and tissue-specific delivery and avoiding liver accumulation. Here we report the rational design of peptide ionizable lipids to assemble lipid nanoparticles with organ-selective mRNA delivery. Structure–activity and structure–selectivity relationship analyses enable us to obtain a general and predictable strategy for peptide ionizable lipid design. By incorporating artificial ionizable and natural amino acids and/or functional molecules into peptide ionizable lipids, we create lipid nanoparticles with tissue-specific targeting, including the lungs, liver, spleen, thymus and bone. In particular, lipid nanoparticles containing peptide lipids targeting the liver show comparable efficacy and safety compared with FDA-approved formulations. Furthermore, lipid nanoparticles with peptide lipids achieve the efficient co-delivery of PEmax mRNA and engineered prime editing guide RNA for prime editing of the liver and lungs. Overall, our platform offers a predictable methodology for the rational design of tissue-targeting lipid nanoparticles that might aid the development of improved mRNA-based gene editing therapeutics.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
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IF 15.7
Zhang Kexin,Liang Xiao,Wang Yucheng,Zou Yongcun,Zhao Xiao,Chen Hui,Zou Xiaoxin
The dynamic reconstruction of oxygen evolution electrocatalysts dictates their performance, yet conventional Ir-based materials face an inherent activity-stability trade-off due to surface amorphization into hydrous IrO x phases accompanied by lattice oxygen mechanisms. Here, we uncover a distinct reconstruction pathway for supported Ir nanoparticles, where a TiO x @Ti substrate drives a bulk phase transition from metallic Ir to crystalline rutile IrO 2 during electrocatalysis. Unlike surface-limited amorphization, this support-guided crystallization shifts the reaction mechanism from involving lattice oxygen mechanism to the complete adsorbate evolution mechanism, as confirmed by mechanistic and structural analyses. Consequently, the Ir/TiO x @Ti catalyst achieves both high activity and durability in acidic media, demonstrated in three-electrode systems and proton exchange membrane water electrolyzers. This work redefines support roles in electrocatalyst reconstruction, demonstrating that bulk phase engineering—rather than surface modification—resolves the long-standing efficiency-durability conflict in acidic oxygen evolution.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Cheng Yuan,Lv Lijun,Cao Zhiqiu,Huang Xiaoqing,Wang Yuqiong,Tang Yue,Gao Wen,Tang Bo
Myocardial ischemia (MI), caused by insufficient blood supply, is a pathological condition where cardiomyocytes lack oxygen and energy supply. Herein, we developed a natural photosynthetic system (HCU) consisting of chlorella pyrenoidosa ( C. pyre ), hyaluronic acid methacryloyl (HAMA) and degradable upconversion nanoparticles (UCNPs, NaCeF 4 :Yb,Tm,Zr). Upon near-infrared irradiation, HCU was photo-crosslinked in situ, thereby facilitating C. pyre photosynthetic oxygen generation within the myocardium. Concurrently, cytochrome c oxidase (CCO) in mitochondria was activated to enhance electron transport along the respiratory chain, synergistically boosting cardiac energy metabolism. Consequently, the ATP levels were elevated, and the hypoxic microenvironment was mitigated. In MI mouse models, echocardiography readings returned to normal levels, and the infarct size was significantly reduced following a 7-day treatment with HCU. Based on the photosynthetic system, this study proposes an in situ oxygen and energy metabolic regulation strategy for MI, holding certain inspiration for other ischemia diseases.
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 6
·1-13
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IF 2.8
Yin Changjie,Wang Boyu,Li Huimin,Yin Dezhong,Zhang Qiuyu
A new well controllable vinyl silane grafted styrene butadiene rubber (SBR) was firstly prepared by atom transfer radical polymerization (ATRP) in latex. The brominated SBR (SBR-Br) was prepared by the reaction between the SBR and N-bromosuccinimide (NBS), then vinyl silane grafted SBR with well-controlled branch chain was prepared by the ATRP initiated by SBR-Br. The best grafting condition was obtained, that is the reaction temperature and time were 70 °C and 12 h, the mass ratio of monomer: CuBr: dNbpy (4,4'-Dinonyl-2,2'-bipyridine) was 3: 0.02: 0.01. The SBR-Br and grafted SBR were characterized by ATR-FTIR and 1 H-NMR. The reaction kinetics study proved that the process of grafting reaction had active/controllable characteristics. The grafted yield of SBR could reach to 11.62%. The significant phase separation of grafted SBR was observed, and it also had a typical core–shell structure. The tensile strength of vinyltrimethylsilane grafted SBR were increased by 2.66 times than that of raw SBR.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2025
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IF 1.6
Yuan Yijun,Li Jiawei,Zhang Sinan,Dong Ceyu,Tang Shun,Tu Zimeng,Liu Nana
Nuclear power stands as a linchpin in decarbonization efforts, primarily due to its dense energy output per unit and the virtual absence of emissions when operational. Exploiting the vast uranium reserves in the ocean is crucial for overcoming land resource scarcity and providing a sustainable, long-term solution. This research aimed to evaluate the adsorptive capacity of a novel marine-derived diatom species, Phaeodactylum tricornutum , for low-concentration uranium in simulated seawater. Biosorption results across varying experimental conditions demonstrate that Phaeodactylum tricornutum exhibits outstanding uranium adsorption capacity ( q max = 13.67 mg g −1 ). Additionally, Phaeodactylum tricornutum sustained exceptional uranium (U(VI)) selectivity and demonstrated favorable reusability in aqueous solution systems. A chemisorption process featuring uniform monolayer adsorption was corroborated by the pseudo-second-order and Langmuir model fittings. Thermodynamic analysis revealed that the adsorption process was spontaneous, endothermic, and characterized by increased randomness. The dominant adsorption mechanism was identified as coordination between uranyl ions and hydroxyl, carboxyl and amino groups. Owing to its abundant sources, easy accessibility, eco-friendliness and recyclability, the marine diatom Phaeodactylum tricornutum demonstrates significant promise for application in seawater uranium extraction.
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PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2025
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IF 3.2
Li Fenglan,Zhang Yuanyuan,Ye Chenliu,Zhuang Junyang
The treatment of breast cancer (BC) faces multiple challenges, including high recurrence rates, drug resistance, and toxic side effects. This study constructed a cell membrane-mimicking biomimetic cascade nanoreactor, mCGH@ZIF, which is loaded with the photosensitizer chlorin e6 (Ce6), glucose oxidase (GOx), and hemin, enabling synergistic starvation-photodynamic therapy. Within the tumor microenvironment, GOx depleted glucose and generated H₂O₂; hemin converted H₂O₂ into O₂ in situ, effectively alleviated hypoxia and amplified the generation of Ce6-mediated singlet oxygen; and the cancer cell membrane coating enabled both immune evasion and homologous targeting. In vitro experiments demonstrated that mCGH@ZIF significantly suppressed 4T1 breast cancer cell proliferation while preserving excellent biocompatibility. This strategy established a closed-loop system integrating glucose depletion, oxygen production, and reactive oxygen species (ROS) generation, overcame the limitations of monotherapies, and offered a novel approach for precision combination therapy in breast cancer.
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Food Production Processing and Nutrition
·
2025
·Vol. 7
·期 1
·1-15
·
IF 5.7
Cao Tianzhuo,Hai Xiaoya,Zhao Chenchen,Wang Mengjin,Tong Zihan,Cui Hao,Zhou An,Liu Juan,Yu Nianjun,Xing Lihua
Polygonatum cyrtonema Hua ( P. Hua) has been demonstrated with several biological potentials, such as lipid lowering and anti-inflammatory effects. To evaluate protective the effect of P. Hua aqueous extract (PCHE) on metabolic-associated fatty liver disease (MAFLD), PCHE was analyzed by UPLC-Q-TOF MS to characterize the chemical composition and pharmacodynamic experiments in vivo and in vitro were conducted using PCHE to intervene in MAFLD models. In vitro, a MAFLD cellular model was established by inducing HepG2 cells with free fatty acid (FFA). In vivo, a MAFLD murine model was generated via a high-fat/high-fructose (HFHF) diet in C57BL/6 J mice. The results showed that a total of 32 chemical compounds were detected in PCHE. In both HepG2 cells and HFHF-induced MAFLD mice, high-dose PCHE significantly improved lipid profiles, inhibited excessive hepatic lipid droplet accumulation, and up regulated the mRNA and protein expression of PPARα/CPT-1A/MCAD. In conclusion, PCHE exerted regulatory effects on MAFLD, possibly associated with the modulation of the PPARα/CPT-1A/MCAD signaling pathway. These results provided an vital basis for the development of functional food made up of P. Hua to prevent MAFLD. Graphical
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