MICROCHIMICA ACTA
·
2016
·Vol. 184
·期 1
·279-287
·
IF 4.831
Wang Rong,Xu Yi,Wang Renjie,Wang Chunyan,Zhao Huazhou,Zheng Xiangquan,Liao Xing,Cheng Li
This article describes a microfluidic SERS chip-based rapid and high-throughput method for the determination of chemical and biological analytes, specifically of melamine. The chip consists of an indium tin oxide (ITO) glass plate modified with silver-gold nanocomposites (Ag-Au NCs) and a polydimethylsiloxane (PDMS) cover plate. The chip has five parallel microfluidic channels. The ITO glass provides electrical conductivity and has a smooth surface which makes it well suited for the deposition of the Ag-Au NC by electrodeposition and galvanic replacement. This technique allows good control of the morphology and composition of the composite. Under optimized conditions, the microfluidic SERS chip provides excellent sensitivity for 4-mercaptobenzoic acid (4-MBA). The detection limit is 0.1 nM and the SERS enhancement factor is 2.7×10 10 . The chip exhibits good stability over time and good reproducibility, with a RSD of 8.6 % between the 5 micro-channels. The chip was successfully applied to the determination of melamine in milk with a 10 nM detection limit and an analytical range from 10 nM to 0.1 mM. It is demonstrated that the microfluidic SERS chip developed here shows great promise for use in biochemical assays.
A microfluidic SERS chip employing gold nanocomposites (Ag-Au NCs) as SERS-active substrate was fabricated. Its SERS enhancement factor is 2.7⋅10 10 . The chip was applied to determinate melamine in milk with detection limit of 10 nM.
✓ 已验证
产品关联
DOI
高影响因子
SENSORS
·
2016
·Vol. 16
·期 8
·1241
·
IF 2.033
Jing Liu,Haoyuan Cai,Chaoyang Chen,Guangsong Yang,Cheng-Fu Yang
In this study, the hybrid Au–Ag hexagonal lattice of triangular and square lattice of quadrate periodic nanoparticle arrays (PNAs) were designed to investigate their extinction spectra of the localized surface plasmon resonances (LSPRs). First, their simulating extinction spectra were calculated by discrete dipole approximation (DDA) numerical method by changing the media refractive index. Simulation results showed that as the media refractive index was changed from 1.0 to 1.2, the maximum peak intensity of LSPRs spectra had no apparent change and the wavelength to reveal the maximum peak intensity of LSPRs spectra was shifted lower value. Polystyrene (PS) nanospheres with two differently arranged structures were used as the templates to deposit the hybrid Au–Ag hexagonal lattice of triangular and square lattice of quadrate periodic PNAs by evaporation method. The hybrid Au–Ag hexagonal lattice of triangular and square lattice of quadrate PNAs were grown on single crystal silicon (c-Si) substrates, and their measured extinction spectra were compared with the calculated results. Finally, the fabricated hexagonal lattices of triangular PNAs were investigated as a sensor of polychlorinated biphenyl solution (PCB-77) by observing the wavelength to reveal the maximum extinction efficiency (λmax). We show that the adhesion of β-cyclodextrins (SH-β-CD) on the hybrid Au–Ag hexagonal lattice of triangular PNAs could be used to increase the variation ofλmax. We also demonstrate that the adhesion of SH-β-CD increases the sensitivity and detection effect of PCB-77 in hexagonal lattice of triangular PNAs.Keywords:hybrid Au–Ag periodic nanoparticle arrays;discrete dipole approximation (DDA);sensor;β-cyclodextrins (SH-β-CD);polychlorinated biphenyl
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Yujiang Gou,Xinglan Fu,Jian Zhang,Jingyu Jiang,Yuehua Huang,Shixiang Ma,Chunjiang Zhao,Guanglin Li
The detection of heavy metals in soil is of great scientific significance for food security and human health. However, traditional detection methods are complicated, time-consuming, and labor-intensive. Herein, we developed a novel method using Au@SiO 2 nanoparticles (NPs) and surface microstructure combined with laser-induced breakdown spectroscopy (Au@SiO 2 NPs-SMS-LIBS) for the rapid detection of lead (Pb), chromium (Cr), and copper (Cu) in soil samples. The surface microstructures and Au@SiO 2 NPs were prepared to improve detection sensitivity and stability. The limits of detection (LODs) for Pb, Cr, and Cu were 0.36 mg/kg, 0.32 mg/kg, and 0.28 mg/kg, respectively, with relative standard deviations (RSDs) of 5.47–6.72 %. The mechanisms of spectral performance enhancement of LIBS detection were thoroughly investigated. Furthermore, the stacking combination model was developed to improve quantitative accuracy, with the correlation of the prediction set (R p 2 ) for Pb, Cr, and Cu being 0.9285, 0.8625, and 0.9160, respectively. This work offers a very promising solution to improve the sensitivity, stability, and accuracy of heavy metal detection. The developed method holds great application potential for large-scale soil assessments and real-time heavy metal pollution monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 7
·1-10
·
IF 5.3
Gao Bao,Ding Yu,Cai Zhihe,Wu Shi,Wang Juan,Ling Na,Ye Qinghua,Chen Moutong,Zhang Youxiong,Wei Xianhu,Ye Yingwang,Wu Qingping
A dual-recognition strategy is reported to construct a one-step washing and highly efficient signal-transduction tag system for high-sensitivity colorimetric detection of Staphylococcus aureus ( S. aureus ). The porous (gold core)@(platinum shell) nanozymes (Au@PtNEs) as the signal labels show highly efficient peroxidase mimetic activity and are robust. For the sake of simplicity the detection involved the use of a vancomycin-immobilized magnetic bead (MB) and aptamer-functionalized Au@PtNEs for dual-recognition detection in the presence of S. aureus. In addition, we designed a magnetic plate to fit the 96-well microplate to ensure consistent magnetic properties of each well, which can quickly remove unreacted Au@PtNEs and sample matrix while avoiding tedious washing steps. Subsequently, Au@PtNEs catalyze hydrogen peroxide (H2O2) to oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) generating a color signal. Finally, the developed Au@PtNEs-based dual-recognition washing-free colorimetric assay displayed a response in the range of S. aureus of 5 × 10 1 –5 × 10 5 CFU/mL, and the detection limit was 40 CFU/mL within 1.5 h. In addition, S. aureus -fortified samples were analyzed to further evaluate the performance of the proposed method, which yielded average recoveries ranging from 93.66 to 112.44% and coefficients of variation (CVs) within the range 2.72–9.01%. These results furnish a novel horizon for the exploitation of a different mode of recognition and inexpensive enzyme-free assay platforms as an alternative to traditional enzyme-based immunoassays for the detection of other Gram-positive pathogenic bacteria. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 25
·11319-11332
·
IF 3.5
Wang Yutong,Liang Xiao,Lv Yiyiwu,Li Xiao,Xia Qinghai,Yang Dezhi,Yang Yaling
This study synthesized Fe-doped dopamine carbon dots (Fe-DACDs) as a reducing agent and template hybrid Au and Pt nanoparticles (Au@Pt/Fe-DACDs). Au@Pt/Fe-DACDs with core–shell structures show strong peroxidase (POD)-like activity at physiological pH. A colorimetric and surface-enhanced Raman scattering (SERS) dual-mode detection system for glucose in human serum was constructed by combining Au@Pt/Fe-DACDs with natural glucose oxidase (GOx). The cascade catalysis reactions convert glucose into hydrogen peroxide (H 2 O 2 ), and then, the Au@Pt/Fe-DACDs as both POD-like nanozyme and Raman-enhancers oxidize colorless and weak Raman-active 3,3′,5,5′-tetramethylbenzidine (TMB) into blue and strong Raman-active ox-TMB. The linear response ranges of glucose are from 0.02 to 1 mM, with a detection limit of 2.3 μM for colorimetric detection and 0.01 mM to 0.7 mM with a detection limit of 1.4 μM for SERS sensors. Glucose content in human serum samples was successfully assayed with a good recovery from 97.6 to 105.3%. Overall, these results demonstrate a new way of designing biological detection systems based on SERS and colorimetric dual-mode sensing.
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Bingliang Wang,Yongjiao Sun,Yimeng Dong,Yuchen Hou,Zhiyuan Lu,Zihan Wei,Wendong Zhang,Koichi Suematsu,Jie Hu
The construction of a novel Au nanoparticles loaded In 2 S 3 /In 2 O 3 hybrid microflowers composite was conducted through a well-designed hydrothermal and partial oxidation method and used for NO 2 sensing at room-temperature (RT). The characterization data confirmed the hybrid structures and demonstrated that the ratio of adsorbed oxygen species on the surface increased after partial oxidation. The sensing performance of flexible gas sensors based on In 2 S 3 /In 2 O 3 , In 2 O 3 , Au x In 2 S 3 /In 2 O 3 (x = 0.5, 1 and 2 wt%) were tested and compared at RT. Heterostructure construction and Au NPs loading significantly improved the sensing properties at RT. Peculiarly, the response value of 1 wt% Au NPs loaded In 2 S 3 /In 2 O 3 (Au 1 In 2 S 3 /In 2 O 3 ) sensor for 100 ppm NO 2 at RT was 20.7, which was 9.2 times higher than that of In 2 O 3 sensor. Meanwhile, it also possessed excellent selectivity, fast response/recovery time (12/27 s), good repeatability, long-term and mechanical stability. The outstanding sensing performance for NO 2 at RT mainly associated to the heterojunction between In 2 S 3 and In 2 O 3 and the catalytic effect of Au NPs. Finally, density functional theory (DFT) was used to calculate and analyze the gas adsorption and charger transfer, which related to the enhanced sensing performance.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yashi Wang,Zhaoguo Wu,Junwei Yang,Aiwu Zhao,Jin Wang
In order to efficiently keep activities of enzymes and enhance stabilities of enzymes, intercalation of enzymes into core of Au nanorod and MOFs shell has been designed. Vice versa, enzymes immobilized on the surface of Au nanorod can guide MOFs shell growth via biomineralization interplay accompany with surfactant directed growth of MOFs on an anisotropic plasmonic template, leading to formation of a porous layer-by-layer nanostructure. Due to incorporation of stimuli-responsive enzyme and MOFs skeleton, loaded anticancer drug can be efficiently released under endogenous stimuli. In-situ SERS and UV-Vis analysis indicate that porous Au nanorod@enzymes@ZIF-8 nanocomposites can perform superior drug releasing behavior compared to Au nanorod@ZIF-8. Hence, the porous Au nanorod@enzymes@ZIF-8 nanocomposites can give more efficient enzymatic biocascade reaction in the nanoreactor in contrast with Au nanorod@ZIF-8@enzymes. Based on porous characteristics of ZIF-8 shell in the Au nanorod@enzymes@ZIF-8 nanocomposites, the nanocomposites can cause complete apoptosis of HeLa cell via enzymatic biocascade reaction and loaded anticancer drug. It can be expected that the unique biological-inorganic-organic hybridized nanosystem would be extensively applied in quantitative evaluation of multi-modal tumor therapy.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2017
·Vol. 5
·期 1
·1700376
·
IF 9.034
Jingwen Feng,Jia Liu,Xiaoyan Cheng,Jiajia Liu,Meng Xu,Jiatao Zhang
Yolk–shell hybrid nanoparticles with noble metal core and programmed semiconductor shell composition may exhibit synergistic effects and tunable catalytic properties. In this work, the hydrothermal cation exchange synthesis of Au@ZnS–AgAuS yolk–shell nanocrystals (Y–S NCs) with well-fabricated void size, grain-boundary-architectured ZnS–AgAuS shell and in situ generated Au cocatalyst are demonstrated. Starting from the novel cavity-free Au@AgAuS core-shell NCs, via aqueous cation exchange reaction with Zn 2+ , the gradual evolution with produced Au@ZnS–AgAuS Y–S NCs can be achieved successfully. This unprecedented evolution can be reasonably explained by cation exchange initialized chemical etching of Au core, followed by the diffusion through the shell to be AgAuS and then ZnS. By hydrothermal treatment provided optimal redox environment, Au ions in shell were partially reduced to be Au NCs on the surface. The UV–vis absorption spectra evolution and visible light photocatalytic performances, including improved photodegradation behavior and photocatalytic hydrogen evolution activity, have demonstrated their potential applications. This new one-pot way to get diverse heterointerfaces for better photoinduced electron/hole separation synergistically can be anticipated for more kinds of photocatalytic organic synthesis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2017
·Vol. 21
·期 11
·3071-3082
·
IF 2.316
Liu Xin,Zhong Ji,Rao Hanbing,Lu Zhiwei,Ge Hongwei,Chen Bingyao,Zou Ping,Wang Xianxiang,He Hua,Zeng Xianyin,Wang Yanying
A novel molecularly imprinted electrochemical sensor based on Fe 3 O 4 @Au nanoparticles immobilized on amine-multi-walled carbon nanotubes by the strong chemisorption had been developed for detecting dipyridamole (DIP) in human serum using precipitation polymerization method. DIP can be detected by this electrochemical sensor through the response current change before and after binding DIP with the formation of hydrogen bonds. The experimental binding data for this study was modeled with the Freundlich isotherm (FI) equation, demonstrating the high imprinting efficiency. The molecularly imprinted electrochemical sensor based on Fe 3 O 4 @Au-MWCNT nanocomposite amplifies the response current in differential pulse voltammetry measurement, allowing the detection limit reaching 0.03 ng mL −1 in a wide linear range from 0.5 to 1900 ng mL −1 , which is remarkably better than those of currently used methods and the previous reports. Moreover, this molecularly imprinted electrochemical sensor has first been developed for the detection of DIP based on the Fe 3 O 4 @Au-MWCNT composite, which has a promising potential in the detection of DIP in human serum which enables low-cost, effective, and sensitive determination.
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Xinxing Jiang,Jihong Fu,Shuxian Ren,WenXia Xue
Substrate materials with high sensitivity and good reproducibility are highly desirable for the practical applications of surface-enhanced Raman scattering (SERS) techniques. In this study, a novel Ni-based metal-organic frameworks loaded gold nanoparticles (Ni-BDC-NH2/Au NPs) SERS substrate was successfully synthesized via electrostatic self-assembly method. The enhancement of the SERS signal is achieved owing to the synergy between chemical enhancement (CM) effect of Ni-BDC-NH2 and the electromagnetic enhancement (EM) of Au NPs, and the enriching of the analyte near the SERS “hot spots” through the strong adsorption capacity of the Ni-BDC-NH2. The Ni-BDC-NH2/Au NPs exhibited a high enhancement factor (EF) of 1.10×107 and a low detection limit of 5×10-9 mol/L. Besides, the substrate material showed exceptional stability up to 45 days at room temperature. The Ni-BDC-NH2/Au NPs was used to detect methylene blue (MB) that displayed a wide linearity (5×10-7-5×10-5 mol/L) and high recoveries (86.82-104.46%). These indicate that the Ni-BDC-NH2/Au NPs hybrid substrate has great potential for the detection of environmental pollution in practical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2024
·Vol. 42
·期 22
·2757-2764
·
IF 5.5
Wei Wei,Jun Sun,Songtao Zhang,Litao Sun,Feng Xu
Comprehensive Summary Designing new materials and architectures to maintain activity and stability requires a better understanding on the anticorrosion dynamics of nanoparticles. Under-coordinated atoms on the surface of nanoparticles can be protected by deposited shells. Real-time observation on how protective shells grow and play a role is challenging but worthwhile. Here, protective effects of AuCl 3 shells on Au nanobipyramids (NBPs) are studied in HAuCl 4 aqueous solutions by in-situ liquid cell transmission electron microscopy (LCTEM). This study is the first to observe the formation of Au-AuCl 3 core-shell nanostructure and the corresponding anticorrosion behaviors of AuCl 3 deposited shell. The presence of CTAB can substantially influence the growth mode and structure of AuCl 3 shell, by a direct or indirect way, intervene the dissolution of Au NBP. These growth or dissolution kinetics here revealed at the nanoscale provide insights towards engineering of the surface anticorrosion to pursue Au nanoparticles with improved stability in acidic environment.
✓ 已验证
产品关联
DOI
高影响因子
Catalysis Science & Technology
·
2024
·
IF 4.4
Huixin Yan,Xingyan Wang,Xiaoyu Liang,Xinxin Zhang,Longfei Liu,Min Ji,Min Wang,Xinkui Wang
The regulation of the electronic state of catalytic sites is essential to improve the intrinsic activity of the catalysts. Herein, we modulated the metal state of Au species by varying their particle size on nitrogen-rich triazine-based porous organic polymer supports. Due to the different interface percentages between Au and nitrogen species in selected supports, the electronic state of metal can be modulated. The catalyst with the smallest Au particle size presented the most negative metallic state and the highest surface energy, thus exposing more sites for H2 activation and providing sufficient reactive H species to CO2 hydrogenation absorbed on the adjacent N. The designed Au/Trz-TETA (1.23 nm) exhibited high catalytic activity for the CO2 hydrogenation to formic acid and the turnover number (TON) up to 1687 over 10 h, which is higher than that of Au/Trz-DETA (2.24 nm) and Au/Trz-TEPA (1.96 nm) with a bigger metal particle size. This work shows a size dependent CO2 hydrogenation for various sizes of Au metal catalysts and provides a new way for regulating the metal electronic state.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）