Biomaterials Science
·
2020
·Vol. 8
·期 16
·4603-4615
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IF 6.183
Tingting Wu,Binglin Li,Wanshun Wang,Lingling Chen,Zhan Li,Ming Wang,Zhengang Zha,Zefeng Lin,Hong Xia,Tao Zhang
The strontium-substituted hydroxyapatite (SrHA) is a commonly used material in bone regeneration for its good osteoconductivity and high alkaline phosphatase (ALP) activity. Scaffolds used in bone defects require a high compressive modulus. However, the SrHA nanoparticle-doped scaffold cannot properly fit the required mechanical properties. Therefore, a lot of effort has been used to fabricate synthetic bone scaffolds with biocompatibility, suitable mechanical properties, antibacterial ability and osteoconductivity. Here, we used a facile hydrothermal method to synthesize graphene oxide (GO)-reinforced SrHA nanoparticles. The incorporation of GO can be used as nucleation and growth active sites of hydroxyapatite. In addition, GO is easy to self-assemble into a layered structure in the dispersion, which can effectively regulate the deposition of hydroxyapatite on the surface of GO. The scaffold was fabricated using a freeze-drying method by incorporating SrHA/GO nanoparticles into chitosan (CS) and quaternized chitosan (QCS) mixed solutions. The compressive modulus of the CS/QCS/SrHA/GO scaffold reached 438.5 kPa, which was 4-fold higher than that of the CS/QCS scaffold. The CS/QCS/SrHA/GO scaffold exhibited significantly higher in vitro mineralization levels and ALP activity. In vivo rat skull repair indicated that the CS/QCS/SrHA/GO scaffold had a significant role in promoting bone regeneration. This study provides a new strategy for modifying hydroxyapatite to satisfy the biomedical demand of bone tissue engineering scaffolds.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Jian Chen,Jinbo Ouyang,Weixin Lai,Xiaohong Xing,Limin Zhou,Zhirong Liu,Wenqian Chen,Di Cai
A novel non-template method was used to prepare ultralight composite aerogel globules that were exploited for the removal of anti-inflammatory drug ketoprofen (KTP) from aqueous solution. The composite aerogel globules were synthesized by freeze-drying and characterized with FESEM, BET, FTIR, XRD and Zeta potential. Swelling behavior of these aerogel globules was strongly affected by the solution pH. The results showed that the presence of 10% activated biochar (ABC) in chitosan (CS), which was named CS-ABC2, was the most desirable aerogel globules as it had high mechanical property and remarkable sorption performance. The sorption kinetics and isotherms of KTP onto composite aerogel globules were studied in detail. In addition, the effects of ion strength and regeneration on sorption performance were investigated, indicating decent environment tolerance, complete recovery rate and excellent reusability of the composite aerogel globules. The composite aerogel globules also exhibited other outstanding advantages such as biodegradability, economy and ease of separation.
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Royal Society Open Science
·
2021
·Vol. 8
·期 9
·
IF 2.963
Bingxian Lin,Kaiming Liu,Yunren Qiu
Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by 1H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification.
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ADVANCED FUNCTIONAL MATERIALS
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2021
·Vol. 31
·期 34
·2102599
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IF 18.808
Kaikai Zheng,Yu Tong,Shihao Zhang,Ruiying He,Lan Xiao,Zoya Iqbal,Yuhong Zhang,Jie Gao,Lei Zhang,Libo Jiang,Yulin Li
Real-time monitoring of wound healing remains a major challenge in clinical tissue regeneration, calling the need for the development of biomaterial-guided on-site monitoring wound healing technology. In this study, multifunctional double colorimetry-integrated polyacrylamide-quaternary ammonium chitosan-carbon quantum dots (CQDs)-phenol red hydrogels are presented, aiming to simultaneously detect the wound pH level, reduce bacterial infection, and promote wound healing. The hybridization of CQDs and pH indicator (phenol red) with the hydrogels enables their high responsiveness, reversibility, and accurate indication of pH variability to reflect the dynamic wound status in the context of both ultraviolet and visible light. Furthermore, these visual images can be collected by smartphones and converted into on-site wound pH signals, allowing for a real-time evaluation of the wound dynamic conditions in a remote approach. Notably, the hydrogels exhibit excellent hemostatic and adhesive properties, maintain sufficient wound moisture, and promote wound healing via their high antibacterial activity (against Staphylococcus Aureus , and Escherichia Coli ) and skin repair function. Overall, the resulting hydrogels have high potential as a novel smart and flexible wound dressing platform for theranostic skin regeneration.
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POWDER TECHNOLOGY
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2021
·
IF 5.134
Hongyang Wang,Lizhangzheng Wang,Siyuan Yang,Cheng Liu,Yanling Xu
Depressant carboxymethyl chitosan (CMCS) was introduced to reverse flotation of quartz from hematite using collector DDA. Microflotation experiments presented that CMCS completely depressed the hematite flotation while it had little effect on quartz flotation. The mineral mixture flotation confirmed the reagent scheme of DDA/CMCS could achieve efficient separation of quartz from hematite. It was also found that CMCS has better selective depression ability than the widely-used starch . Zeta potential measurements illustrated that CMCS could prevent DDA adsorption onto the hematite surface, while it did not affect the interaction between DDA and quartz surface. X-ray photoelectron spectroscopy (XPS) indicated that CMCS interacted with the Fe(III) components of hematite by chemisorption , which was stronger than the bonding between starch and hematite. Molecular dynamics simulation (MDS) further revealed the twice interaction energy of CMCS with (001) hematite surface than that of starch. Hence, CMCS has the potential to replace starch in practice.
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ACS Sustainable Chemistry & Engineering
·
2021
·
IF 8.198
Weixin Xiao,Ping Wang,Xiaorui Song,Bin Liao,Kaiqi Yan,Jing-Jie Zhang
Traditional isotropic thermal insulators have been unable to meet the increasing demand for thermal insulation and the requirement of sustainable development, hence exploring a novel and advanced thermal management material is urgent. Previous studies indicated that the anisotropic porous materials with hierarchically aligned porous structures could improve the thermal management capability; however, the relationship between thermal properties and structure is unclear. Herein, a lightweight, large-scale, elastic, and anisotropic chitosan aerogel with excellent thermal management capability was fabricated via unidirectional freeze casting and silylation modification. Theoretical calculation had been used to analyze the effect of microstructure on the mechanical and thermal properties, as well as the anisotropic heat-transfer behavior. The anisotropic chitosan aerogel exhibited a honeycomb-like porous and lamellar structure, resulting in an advanced thermal management capability with a lower radial thermal conductivity (30.4 mW m–1 K–1) and two times higher axial thermal conductivity (60.1 mW m–1 K–1). The calculated results demonstrated that the thermal management capability of anisotropic chitosan aerogel was better than that of the isotropic materials (thermal conductivities of 10 and 22 mW m–1 K–1). It is helpful for further design of biopolymer aerogels for thermal superinsulation applications.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2021
·Vol. 22
·期 15
·7769
·
IF 5.924
Xueying Song,Liu Liu,Xiaoxia Wu,Yongfeng Liu,Jialu Yuan
The aims of this study were to develop the magnolol–chitosan films and study the positive effect of the combination of magnolol and chitosan. The addition of magnolol made the magnolol–chitosan films exhibit higher density (1.06–1.87 g/cm3), but the relatively lower water vapor permeability (12.06–7.36 × 10−11·g·m−1·s−1·Pa−1) and water content (16.10–10.64%). The dense and smooth surface and cross-section of magnolol–chitosan films were observed by environmental scanning electron microscopy (ESEM) images. The interaction of magnolol and chitosan was observed by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). After the addition of magnolol, the antioxidant capacity of magnolol–chitosan films was increased from 18.99 to 82.00%, the growth ofP. aeruginosawas inhibited and the inhibition percentage of biofilm formation was increased from 30.89 to 86.04%. We further verified that the application of magnolol–chitosan films on chilled pork significantly reduced the increases in pH value, inhibited the growth of microorganisms and extended the shelf life. Results suggest that magnolol had a positive effect on magnolol–chitosan films and could be effectively applied to pork preservation.Keywords:magnolol;chitosan;film;antimicrobial;pork
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FIBERS AND POLYMERS
·
2021
·Vol. 22
·期 12
·3261-3270
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IF 2.153
Liu Kainan,Cao Liqin
Nylon mesh has been applied in various fields because of its intrinsic mechanical and chemical stability. However, its application is limited by its surface property. In this work, nylon mesh was first designed to integrate with a zeolitic imidazolate framework-67 (ZIF-67) with a distinct hydrophobic property. Herein, the mechanically stable nylon mesh/carboxymethyl chitosan/ZIF-67 (NY/CMCS/ZIF-67) composite membranes were prepared via layer-by-layer self-assembly of CMCS surface functional groups to coordinate with cobalt ion and in situ growth of ZIF-67. The prepared NY/CMCS/ZIF-67 membranes were characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermogravimetric analysis. After modifications, the ZIF-67 content in the membranes reached 22 %. The water contact angle increased from 47.5 ° for nylon mesh to 128.8 ° for NY/CMCS/ZIF-67. The NY/CMCS/ZIF-67 composite membranes exhibited good oil-water emulsion separation property and oil absorption ability. After 15 oil absorption-drying cycle experiments, the oil absorption ability of the membrane was still greater than 95 %, and the oil absorption rate was 6.8 g/g. The modified nylon mesh could still be used for dye removal, the adsorption capacity of the membrane increased by 50 % compared with that of NY/CMCS, and the adsorption processes followed the pseudo-second-order model. Thus, this research provides new insights into the preparation of efficient modified nylon film with great application potential for filtration and separation in complex environments.
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JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Yong Hu,Guojing Mo,Ying Wang,Juan Guo,Chao Huang
The TPP-β-cyclodextrin/chitosan (TPP-β-CD/CS) nanoparticles loading with curcumin (Cur) and vitamin C (Vc) was prepared via controllable self-assembly. The cross-linking reaction between TPP-β-CD and CS, and co-encapsulation of Cur and Vc in TPP-β-CD/CS nanoparticles were confirmed by the fourier-transform infrared (FTIR), UV–Vis (UV), X-ray diffraction (XRD), atomic force microscope (AFM), and particle size analyzer. The results of stability and antioxidant activity indicated that co-encapsulation not only enhanced the chemical stability of Cur and Vc, but also improved antioxidant properties compared with the active ingredients used alone. Release kinetic fitted by Ritger–Peppas model revealed that the release of dual active ingredients were mainly dominated by Fickian diffusion in pH 1.2, while followed non-Fickian or anomalous diffusion in pH 7.4. Furthermore, the two-dimensional UV correlation spectroscopy (2D-UV-COS) confirmed that the release rate of Cur was faster than that of Vc during co-delivery, which helps to precisely elucidate the synergistic nutraceuticals effect of each active ingredient.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Yuqi Li,Hui Zhang,Cen Ma,Hao Yin,Lingzhu Gong,Yihshing Duh,Ren Feng
Hydrogels with low-adhesive superoleophobicity are ideal candidates for modifying filtration substrates to achieve efficient and antifouling oil/water separation. However, there are still some unfavorable factors hindering their practical application, including expensive raw materials, complex fabrication process, poor stability and durability. In this work, a durable, cost-effective and superhydrophilic chitosan-alginate (CS-ALG) hydrogel coated mesh was developed by a facile, two-step dip-coating method for efficient oil/water separation in hypersaline environments. By integrating polysaccharide-based superhydrophobic surfaces and the hierarchical micro-/nanostructures, the as-fabricated CS-ALG hydrogel coated mesh exhibits excellent underwater superoleophobicity and anti-oil-fouling performance. Benefiting from that, the mesh could separate various oil/water mixtures with high separation efficiency (> 99%). It is worth mentioning that the double-cross-linked CS-ALG hydrogel based on sequential electrostatic interaction and ionic cross-linking shows excellent durability in hypersaline environments. All these attractive advantages make the hydrogel-coated mesh a promising candidate for oily wastewater treatment and oil spill cleanup.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Jiaoyan Liu,Bin Yang,Minhui Li,Jing Li,Ying Wan
Thiolated chitosan (CS-NAC) was synthesized and the selected CS-NAC was used together with silk fibroin (SF) to produce dual network CS-NAC/SF hydrogels. The CS-NAC/SF solutions with formulated compositions were able to form hydrogels at physiological temperature and pH. Rheological measurements showed that elastic modulus of some CS-NAC/SF gels could reach around 3 kPa or higher and was much higher than their respective viscous modulus, indicating that they behaved like strong gels. Deformation measurements verified that CS-NAC/SF gels had well-defined elasticity. The optimized CS-NAC/SF gels exhibited jointly enhanced properties in terms of strength, stiffness and elasticity when compared to the gels resulted from either CS-NAC or SF. Examinations of dry CS-NAC/SF gels revealed that they were highly porous with well-interconnected pore features. Cell culture demonstrated that CS-NAC/SF gels supported the growth of chondrocytes while effectively maintaining their phenotype. Results suggest that these dual network gels have promising potential in cartilage repair.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Xuejie Guo,Haocheng Yang,Qi Liu,Jingyuan Liu,Rongrong Chen,Hongsen Zhang,Jing Yu,Milin Zhang,Rumin Li,Jun Wang
Biofouling is the most affecting factor in the recovery of uranium due to the presence of large number of marine microorganisms in the seawater. Herein, a chitosan – graphene oxide/ZIF (GCZ8A) foam adsorbent with antifouling properties was prepared via in situ growth of silver ions doped ZIF-8 on a chitosan-GO foam substrate to overcome the challenges of traditional powder types for real applications. The mechanical properties and degradation tests was investigated to confirm that the GCZ8A adsorbent exhibited high mechanical properties with nearly 352.41 KPa of compression stress and low degradation with 3.26% of mass loss in seawater. Moreover, for Nitzschia , the GCZ8A composites not only displayed growth inhibitory behavior (more than 70% cell death rate), but also inhibited cell adhesion on its surface. The maximum U -uptake capacity of antibiofouling adsorbent (361.01 mg g −1 ) was 1.9 times than pure ZIF-8 (189.75 mg g −1 ) at pH 8.0, owing to its large specific surface area (200.79 m 2 /g) and nitrogen/oxygen functional groups. The adsorbent displayed an excellent reusability and achieved the 121.7 mg g −1 adsorption capacity at fifth cycles. Moreover, GCZ8A adsorbent exhibited high U-uptake capacity (12.24 μg g −1 ) with 66.31% of U (VI)-removal rate in natural seawater (Bohai, China). All of uranium removal rate of GCZ8A was nearly 70% in simulated contaminated seawater, which further affirmed its potential for actual application.
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