ACS Applied Electronic Materials
·
2026
·Vol. 8
·期 15
·6545-6553
·
IF 4.7
Liu Qianzuo,Sun Sifan,Li Jiawei,Yang Haoran,Xiang Xinyue,Hao Ying,Yan Xuehua,Zhang Ting,Li Tie
Hydrogen peroxide (H 2 O 2 ), a key reactive oxygen species in physiological and pathological processes, demands highly sensitive detection for biological and biomedical research, yet developing electrocatalytic materials with high sensitivity, low detection limit, and excellent stability remains a challenge. Herein, a Fe−C@Fe/Ce−C bilayer heterojunction composite was fabricated for H 2 O 2 detection. Benefiting from its unique heterojunction architecture and synergistic Fe/Ce/carbon interactions, the as-prepared nanocomposite exhibits the exceptional H 2 O 2 sensing performance, with a wide linear range of 0.5−6000 µM, a high sensitivity of 490.5 μA·mM −1 ·cm −2 , a low detection limit of 0.12 µM, excellent anti-interference selectivity against common biological interferents, and outstanding long-term stability with no obvious performance variation after 11 days of continuous testing. The robust built-in electric field arising from the heterojunction facilitates interfacial charge transfer and accelerates H 2 O 2 activation, boosting sensing behavior. Furthermore, the flexible electrochemical sensor was fabricated via the screen-printing technology, which enables reliable real-time monitoring of intracellular H 2 O 2 released from HeLa cells, showing great potential for biological sensing. This work provides a promising design strategy for high-performance flexible electrochemical sensors and deepens the understanding of heterojunction and built-in electric field roles in electrocatalytic sensing systems.
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ACS Applied Nano Materials
·
2026
·Vol. 9
·期 30
·14209-14222
·
IF 5.8
Li Hui,Fan Jingnan,Liao Jiamei,Chen Ke,Tang Qingxia,Tang Hua,Wang Dan
Hepatocellular
carcinoma (HCC) remains a significant therapeutic
challenge due to multiple bottlenecks, including low early diagnosis
rates, rapid disease progression, and limited efficacy of monotherapy.
Against this backdrop, multimodal integrated treatment has emerged
as a core solution. Here, we reported a tumor-microenvironment (TME)-activatable
“nano-cocktail” (UMDCAc) that synchronizes photodynamic
(PDT), chemodynamic (CDT), and starvation (ST) therapies for synergistic
HCC eradication. UMDCAc was engineered by growing hollow MnO 2 (HMnO 2 ) on upconversion nanoparticles (UCNPs), coloading
dihydroartemisinin (DHA) and the photosensitizer chlorin e6 (Ce6),
and in situ anchoring ultrasmall gold nanoparticles (AuNPs) that mimic
glucose oxidase (GOx). Surface modification with cyclic RGD peptides
enabled active targeting of α v β 3 integrin. The targeting strategy synergizes with near-infrared (NIR)
light-activated catalysis to enhance therapeutic efficacy. In vitro and in vivo data demonstrate that UMDCAc achieves tumor suppression
through synergistically amplified reactive oxygen species (ROS) generation,
hypoxia relief, and targeted delivery, while maintaining favorable
biocompatibility and safety and exhibiting superior efficacy over
monotherapy. The synergistically generated ROS compromise cellular
antioxidant defenses, induce lipid peroxidation, and double the apoptosis
rate, thereby producing effective antitumor effects. Therefore, this
innovative multimodal strategy offers opportunities for collaborative
cancer therapy.
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ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 31
·23335-23345
·
IF 7.3
Dong Hui,Lv Xiaoyu,Qian Yujia,Chang Aixin,Cheng Menghao,Yang Xue,Ding Jiahui,Yang Zimo,Zhou Yanli,Zhang Yintang,Li Zhaohui,Xu Maotian
Copper ions (Cu 2+ ) are
closely implicated in the pathogenesis
of Alzheimer’s disease (AD) by mediating oxidative stress and
promoting β-amyloid (Aβ) aggregation. Accurate quantification
of labile Cu 2+ in the brain extracellular microenvironment
is critical for elucidating its pathological roles and developing
AD diagnostic tools. Herein, we report a dual-mode sensing platform
integrating “turn-on” fluorescence and ratiometric electrochemistry
for sensitive and selective Cu 2+ quantification, based
on a resorufin-picolinate conjugate (RP) probe and a carbon nanotube-modified
carbon fiber microelectrode (CFME/CNT). Resorufin (Re) acts as both
the fluorescent reporter and electrochemical redox center, while picolinate
serves as the Cu 2+ -specific recognition moiety. Cu 2+ coordinates with picolinate to catalyze the ester hydrolysis
of RP, releasing free Re that triggers a fluorescence enhancement
at 594 nm and a ratiometric electrochemical response, corresponding
to the oxidation currents of free Re and intact RP, respectively.
The RP probe exhibits high selectivity for Cu 2+ over other
metal ions, with limits of detection of 19 nM (fluorescence) and 7.2
nM (electrochemistry). The dual-mode platform was successfully applied
to the accurate quantification of endogenous labile Cu 2+ in cerebral cortex dialysate from AD mice and age-matched wild-type
(WT) mice, and noninvasive in vivo fluorescence imaging further confirmed
the elevated Cu 2+ level in living AD mouse brains. Quantitative
results revealed that the labile Cu 2+ concentration in
AD mouse cerebral cortex dialysate was significantly higher than that
in WT mice. The two detection modes yielded highly consistent results,
validating the reliability of the dual-mode platform in complex biological
matrices. This dual-mode strategy synergizes the merits of fluorescence
and ratiometric electrochemistry, providing a robust and selective
tool for investigating AD pathogenesis related to Cu 2+ dyshomeostasis
and holds great potential for clinical translational applications
in AD diagnosis.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Zhang Huifeng,Li Mengyang,Wang Tao,Zhu Huifen,Deng Lin,Guo Fulian,Zhang Zhihua,Hu Tingting,Liang Ruizheng,Cao Min,Li Zhangping
Cancer remains a critical global health burden, posing a severe threat to human life. Photo-sonodynamic therapy (PSDT), which combines photodynamic (PDT) and sonodynamic (SDT) modalities, has emerged as a promising strategy to overcome limitations in tissue penetration and therapeutic precision. Despite progress, the broader application of PSDT is hindered by PDT’s potential phototoxicity/limited therapeutic penetration depth and SDT’s thermal/mechanical damage under high ultrasound (US) power, as well as the complex synthesis of sensitizers and their suboptimal reactive oxygen species (ROS) generation. Here, we engineer Mg-doped defect-rich CoMo-LDH (a-CoMgMo-LDH) nanosheets via a doping-etching strategy to address these challenges, enabling on-demand treatment from superficial to deep-seated tumors. This sensitizer exhibits exceptional dual responsiveness to NIR-II light and US. It achieves a relative singlet oxygen quantum yield (1.53) superior to most reported photosensitizers, while its sonodynamic ROS yield surpasses that of commercial TiO 2 by 22.3 times and outperforms most reported sonosensitizers, ranking among the highest reported. After bovine serum albumin (BSA) functionalization, a-CoMgMo-LDH-BSA triggers ROS-driven apoptosis and immunogenic cell death under dual irradiation, effectively suppressing tumor growth and metastasis. By integrating NIR-II-enhanced PDT/SDT into a single-component platform, this work advances precision oncology with deep-tumor targeting and immune modulation, offering a transformative strategy for clinical translation. Graphical Mg-doped defect-rich CoMo-LDH (a-CoMgMo-LDH) nanosystem is engineered through doping-etching strategy as a new photo-sonosensitizer for highly efficient photo-sonodynamic therapy, which exhibits remarkable ROS generation efficiency under NIR-II/US stimulation, achieving a 1 O 2 quantum yield of 1.53 under NIR-II light irradiation and 22.3 times ROS yields that of commercial TiO 2 under US irradiation, respectively. After bovine serum albumin (BSA) modification, a-CoMgMo-LDH-BSA efficiently kills cancer cells and eliminates tumors by inducing dual-modal ROS generation and immunogenic cell death
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Xu Yizhao,Zhao Tao,Li Zixuan,Chen Jiale,Li Xin,Zhou Xiaomei,Khouchani Mouna,Abdelmajid Takoui,Jiang Zhiqiang,Zhao Long,Zhang Zhanlin
Photothermal therapy (PTT) is recognized for its precise manipulability and exceptional spatiotemporal control but faces challenges such as thermotolerance, weak penetration, and collateral tissue damage. Herein, we presented a strategy that enabled tumor-targeted PTT, reduced interstitial fluid pressure (IFP), promoted deep tumor penetration, enhanced radiosensitization, and counteracted thermoresistance. An engineered bacteria-based delivery system (R.S@BiOI) responsive to low-dose X-ray was constructed via electrostatic adsorption of bismuth oxyiodide quantum dots (BiOI QDs) onto the natural photothermal agent Rhodobacter sphaeroides (R.S). Leveraging the hypoxic targeting capability of R.S, R.S@BiOI facilitated tumor-specific enrichment and penetration. Meanwhile, X-ray-triggered radiolysis of water by surface-bound BiOI QDs generated hydroxyl radicals, which reduced tumor IFP, enhanced the deep and uniform distribution of the R.S@BiOI composite, and minimized collateral thermal damage to surrounding healthy tissues. Furthermore, X-ray irradiation downregulated the expression of heat shock proteins, attenuating cellular thermotolerance and synergistically improving the efficacy of PTT. Meanwhile, R.S@BiOI elicited a robust anti-tumor immune response, which acted in synergy with radiotherapy and PTT to potentiate the overall antitumor efficacy. The bacteria-based delivery system enhanced intratumoral accumulation and improved tumor distribution, resulting in markedly superior tumor growth suppression, prolonged survival in animal models, and a well-tolerated safety profile with no significant systemic toxicity observed in critical organs. Thus, this study presents a strategy for fabricating X-ray-responsive engineered bacteria that potentiate the therapeutic efficacy of PTT in the treatment of prostate cancer. Graphical abstract
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Rongmao Qiu,Yimin Zeng,Yiming Chen,Shuting Huang,Binghua Luo,Dechan Lu,Kui Huang
Surface-enhanced Raman scattering (SERS) is a powerful tool for rapid on-site detection of pesticide residues, but its performance heavily relies on the substrate. Herein, a gelatin‑silver nanocube (Ag NC) composite hydrogel SERS substrate was developed via mild EDC-NHS crosslinking coupled with low-temperature gelation. The three-dimensional porous hydrogel efficiently enriches target molecules, while the sharp edges of Ag NCs generate abundant electromagnetic hotspots. Using rhodamine 6G as a probe, the optimized substrate (20% gelatin, Ag NC/gelatin volume ratio 3:1) exhibited good uniformity, reproducibility, and stability. For thiram detection, a linear response was obtained from 10 −4 to 10 −7 M with a limit of detection (LOD) of 4.45 × 10 −8 M in standard solution. Practical applicability was demonstrated in orange juice, where thiram was detected down to 1.0 × 10 −6 M (LOD = 4.78 × 10 −7 M) with recoveries of 96.9–97.9%. This work provides a gelatin-based, stable and sensitive SERS platform for food safety monitoring.
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Food Bioscience
·
2026
·
IF 6.2
Shijie Yu,Fangxia Dai,Jinyi Wu,Bochun Ning,Huan Zhu,Qixing Jiang,Dawei Yu
To enable more sustainable utilization of waxberry pomace, this study developed an ultrasound-assisted deep eutectic solvent (UAE-DES) method for efficiently recovering total phenolic content (TPC) and total anthocyanin content (TAC). Based on physicochemical properties and extraction efficiency, choline chloride–lactic acid (ChCl–LA, 1:2) was identified as the best system. Low-field nuclear magnetic resonance (LF-NMR) and Fourier-transform infrared spectroscopy (FTIR) revealed the DES's hydrogen-bonding architecture restricted molecular mobility, explaining its superior solvation capacity. Optimization by single-factor and response surface methodology (RSM) gave the optimization conditions, including ultrasonication for 58 min at 360 W (16W/L), a solid-liquid ratio of 1:35 g/mL, and a water volume fraction of 36% (v/v). Under these settings, TPC and TAC reached 44.26 mg GAE/g DW and 6.92 mg C3GE/g DW, respectively. Furthermore, comprehensive UPLC-QTOF-MS profiling identified 11 major bioactive constituents in the extract. In comparative antioxidant assays, the DES extract markedly outperformed the ethanol extract, with IC 50 values of 0.025 mg/mL for DPPH•, 0.038 mg/mL for ABTS• + , 0.114 mg/mL for •OH, and 0.675 mg/mL for total antioxidant capacity (T-AOC). These results indicated ultrasound-assisted ChCl-LA extraction offered a sustainable and tunable strategy that achieved both high phytochemical recovery and preserved antioxidant functionality from waxberry pomace.
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COMPOSITES PART B-ENGINEERING
·
2026
·
IF 14
Lei Duan,Fan Jiang,Wen-Yao Zhang,Yu-Han Zhou,De-Yi Li,Gong Chen,Yan-Long Luo,Cheng-Hui Li,Wei-Song Zhang
Carbon fiber-reinforced polymers (CFRPs) have shown significant potential for application in personal protective equipment (PPE). However, conventional CFRPs suffer from critical drawbacks including catastrophic brittle fracture, insufficient toughness, and poor recyclability. In this study, a reversibly crosslinked poly(thioctic acid) elastomer (denoted as LATZ) was successfully synthesized and combined with carbon fiber fabric to fabricate a CF/LATZ composite. The resulting material exhibits outstanding comprehensive mechanical performance: the single-layer CF/LAT 0.75 Z composite (T300, 300 gsm fabric, ∼0.55 mm thick) achieves a tensile strength of 429.6 MPa; the three-layer CF M /LAT 0.75 Z composite (T700, 400 gsm fabric, ∼1.31 mm thick) reaches a puncture force of 46.2 N; and the CF/LAT 0.5 Z composite (T300 fabric, 300 gsm) delivers an exceptionally high tear fracture energy of 1465.4 kJ m −2 . Consequently, the CF/LAT 0.75 Z composite displays remarkable resistance to both cutting and puncture, primarily attributed to the excellent flexibility and favorable interfacial compatibility of the LATZ polymer, which enables efficient energy dissipation under loading. Furthermore, the composite exhibits outstanding protective performance against high-speed arrow impact, demonstrating promising potential for use in PPE such as protective clothing and shields, and possibly in impact-resistant gear after further development. Benefiting from the dynamic reversible bonds and weak interactions within the polymer network, the CF/LAT 0.75 Z composite also possesses excellent closed-loop recyclability. This study provides a novel strategy for the design and sustainable recycling of high-performance, carbon fiber composites.
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Bioengineering-Basel
·
2026
·Vol. 13
·期 8
·908
·
IF 4.4
Dandan Zhang,Zhigang Zhang,Dingxing Huang,Zhuoran Sun,Jiamin Huang,Chi Zhang,Qingyang Zeng,Qiling Liu,Wenzhuo Chen
Osteoarthritis is an irreversible degenerative joint disease driven by sustained NF-κB-mediated inflammatory responses, and conventional intra-articular hyaluronic acid or small-molecule NF-κB inhibitors cannot achieve targeted on-demand treatment due to poor solubility, rapid clearance and lack of lesion microenvironment responsiveness. OA with inherent anti-chondrolytic activity can self-assemble into nanocarriers in water, yet it lacks stimuli-responsive capacity. Herein, we rationally designed and synthesized an OA-Der by covalently conjugating o-phenylenediamine fragments to the OA backbone.1H NMR and HRESI-MS spectra fully verified the accurate chemical structures of intermediate and final OA-Der. Blank OA-Der micelles exhibited uniform spherical core–shell nanostructures (50–150 nm) under TEM and AFM, while pathological high NO triggered complete disassembly of micellar assemblies. We further co-assembled OA-Der with NF-κB inhibitor BAY 11-7082 to construct NO-responsive BAY@OA-Der supramolecular micelles. In vitro experiments using human C28/I2 chondrocytes with LPS-induced inflammatory injury demonstrated that BAY@OA-Der significantly improved cell viability and reduced apoptotic chondrocyte proportion. At mRNA and protein levels, the supramolecular micelle formulation remarkably suppressed NF-κB p65 phosphorylation, downregulated cartilage-degrading ADAMTS5, and upregulated ACAN compared with free BAY or blank OA-Der. Collectively, this natural bioactive self-assembled NO-responsive delivery platform achieves synergistic anti-inflammatory and matrix-protective effects by precisely releasing drugs at NO-overexpressed osteoarthritis inflammatory sites and offers an in vitro design strategy for osteoarthritis responsive delivery systems.
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Marine Drugs
·
2026
·Vol. 24
·期 8
·278
·
IF 5.7
Meng-Yue Liu,Dong-Li Yin,Jia Yu,Wei-Xia Wang,Sheng-Can Zou,Shuang Zhao,Chun-Ze Zou,Fei Li,Yu-Xi Wei
Oral administration represents the primary route for administering polysaccharides. Pharmacokinetics serves as a critical bridge between the administration of polysaccharides and the manifestation of their bioactivities. However, the pharmacokinetic behavior of polysaccharides remains poorly understood. This study aimed to investigate thein vivopharmacokinetics of an orally administeredRuditapes philippinarumpolysaccharide (ERPP), including its plasma concentration–time profile, tissue distribution, and excretion. Moreover, a sensitive quantitative method was developed using 5-DTAF as a fluorescent probe to quantify ERPP levels in rat plasma and tissues. The results revealed that ERPP was absorbed in the gut (Tmax= 3 h), reaching a peak concentration (Cmax) of 22.7 ± 2.7 mg/L. Subsequently, it predominantly accumulated in the kidneys, liver, and lungs. Complementarily, near-infrared fluorescence (NIR) imaging provided real-time qualitative visualization of ERPP-Cy5.5 tissue distribution, corroborating the organ-level accumulation pattern observed in the quantitative study. Excretion studies over a 24 h observation window indicated that ERPP was primarily excreted via feces, with 45.7 ± 4.4% of the recovered dose within this period; the complete excretion profile warrants further investigation at extended time points. These findings provide pharmacokinetic insights into thein vivofate of marine polysaccharides and support further biological evaluation.
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Gels
·
2026
·Vol. 12
·期 8
·722
·
IF 6.4
Xue Shao,De-Jing Ma,Ya-Ni Zhang,Bang-Yun Liu,Yi-Fei Gao,Ge Zhang,Zi-Yan Hua,Yan-Yun Yang,Xue-Tao Li,Liang Xu
(1) Background: Impaired diabetic wound healing stems from systemic dysregulation of the wound-healing cascade under hyperglycemic conditions, producing a disordered microenvironment marked by sustained inflammation, defective angiogenesis, and aberrant extracellular matrix remodeling, multifactorial, multistage pathological interactions demanding multi-target intervention. (2) Methods: We constructed a multifunctional nanocomposite hydrogel dressing (PGAs@CDV) based on a “drug-carrier integration” strategy, targeting the dysregulated hemostasis, inflammation, and proliferation phases of diabetic wound healing. An amphiphilic micelle carrier (PNO-GA) was synthesized by covalently conjugatingPanax notoginsengoligosaccharide with gallic acid, loaded with Anemoside B4 to yield drug-loaded nanomicelles (PGAs), embedded into a carboxymethyl chitosan-dopamine-vanillin hydrogel (CDV) matrix to form PGAs@CDV. We then examined how PGAs@CDV affected diabetic wound healing. (3) Results: In vitro, PGAs@CDV enhanced cell migration and angiogenic capacity, exhibited potent antioxidant activity, and promoted M1-to-M2 macrophage polarization. We tested PGAs@CDV in a streptozotocin-induced diabetic mouse wound model. Wounds treated with PGAs@CDV closed faster than those treated with the control, CDV, PNO@CDV, and AB4@CDV. Four readouts tracked this difference: hemostasis was quicker, inflammation was lower, more blood vessels formed, and collagen deposition was higher. At the pathway level, PGAs@CDV suppressed NF-κB signaling and activated PI3K/AKT/HIF-1α. These two arms map onto the anti-inflammatory and pro-angiogenic effects observed above. (4) Conclusions: This nanocomposite hydrogel integrates a bioactive carrier with a therapeutic payload to enable coordinated intervention across multiple phases of diabetic wound repair. By combining structural support with sustained pharmacological activity, it offers a promising strategy for the treatment of chronic diabetic wounds.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Liuqing Yang,Zhuoting Xiong,Haowen Zou,Bin Zhao,WingKei Ho,Dingze Lu
Improving the efficiency of nitric oxide (NO) removal while reducing the formation of toxic nitrogen dioxide (NO 2 ) is a challenge. Nonetheless, it remains uncertain regarding the distinct roles of carbon versus nitrogen vacancies in graphitic carbon nitride (g-C 3 N 4 ) in governing the oxidation pathway. In this study, g-C 3 N 4 enriched with carbon or nitrogen vacancies, along with the corresponding polyvinylidene fluoride (PVDF)-supported composite films, are prepared. The adsorptions and anchoring of NO and its intermediates are significantly enhanced by the carbon vacancies. Despite a high free energy barrier of the conversion from nitrite to nitrate, the strong anchoring suppresses the release of gaseous NO 2 . The formation of Nitrogen vacancies gives rise to polarization of the spin, leading to a significant negative displacement of the potential of the conduction band and increased carrier lifetime along with a considerable decrease in the barrier for the conversion of nitrite to nitrate. This mechanism leads to enhanced reaction flux that will improve deep oxidation. The incorporation of these materials into the PVDF film greatly enhances performance and provides reusability. This work elucidates the distinct mechanisms by which carbon and nitrogen vacancies regulate NO oxidation, providing a theoretical basis for designing efficient and selective air purification materials.
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