Journal of Water Process Engineering
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2026
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IF 6.6
Luyao Wang,Lei Du,Yuting Yang,Lulu Hu,Hao Yang,Zhe Zhai,Xiaoting Li,Shuaifei Zhao,Yuchao Zhao,Yan Huang
Nanofiltration (NF) has demonstrated considerable environmental sustainability potential in the separation and desalination of antibiotics. Polytetrafluoroethylene (PTFE) membranes possess exceptional chemical stability, thereby offering distinct advantages as substrate for fabricating highly robust NF membranes, particularly those intended for application under complex separation conditions. Nevertheless, the development of a defect-free polyamide (PA) selective layer on a macro-porous PTFE substrate remains challenging. Herein, a carbon nanotube (CNT) intercalated graphene oxide (GO) (CNT-i-GO) interlayer, crosslinked with ethylenediamine (EDA), was constructed to address this challenge. Notably, the CNT-i-GO interlayer enabled precise tuning of the pore structure and surface properties of the PTFE substrate, while suppressing the downward growth of the PA layer, thereby facilitating the formation of a uniform and defect-free PA layer. The fabricated PA/CNT-i-GO/PTFE NF membrane exhibited enhanced antibiotic separation performance, achieving a water permeance of 26.1 L·m −2 ·h −1 ·bar −1 with 96.4% tetracycline (TC) rejection, along with excellent stability over a broad range of operational conditions. Furthermore, the membrane exhibited favorable NaCl/TC selectivity, maintaining a value of 20.5 under high-salinity conditions (10 g·L −1 ). This study offers valuable insights into the development of high-performance NF membranes for practical antibiotic separation and desalination in pharmaceutical industry.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
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IF 19.9
Lin Gan,Tongtong Xu,Dandan Zheng,Ning Zhu,Sijia Li,Shiyu Deng,Qianyuan Lian,Jixian Wang,Wanlu Li,Zhijun Zhang,Guo-Yuan Yang,Wenguo Cui,Yaohui Tang,Huitong Ruan
The vascular hyperinflammatory microenvironment significantly influences the regeneration and repair of central nervous system (CNS) following injury. Training immune behavior of immune cells under stress conditions is crucial for maintaining vascular microenvironment homeostasis and restoring vascular function. In this study, we engineer a novel hyperinflammatory regulatory peptide (mND13) by rational grafting of a DJ-1-derived peptide with an MMP-2 responsive peptide motif. This modified peptide is further conjugated onto hyaluronic acid methacrylate (HAMA) microspheres via photo-click chemistry and microfluidic technology, generating mND13@HAMA microspheres. This platform induces microglia immuno-training, inhibits their pro-inflammatory polarization, thus orchestrating neurovascular niche remodeling and promoting neural recovery through immune-vascular crosstalk. Both in vitro and in vivo investigations show that these immune-functionalized peptide microspheres mND13@HAMA drastically decrease endothelial cell apoptosis and the expression of pro-inflammatory molecules like iNOS, CD86 and IL-1β in microglia. To further enhance post-stroke angiogenesis, we co-deliver VEGF liposomes with mND13@HAMA, which is proven to promote vascular sprouting and growth while inhibiting vascular apoptosis. This combined system markedly reduces brain atrophy volume in stroke mouse, improves neurobehavioral functions, and enhances angiogenesis. In conclusion, this immunomodulatory microsphere, capable of training immune cell behavior, holds significant therapeutic value for treating stroke along with other CNS injuries.
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Fire-Switzerland
·
2026
·Vol. 9
·期 2
·81
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IF 3.2
Zhi Li,Fang Zhou,Kai Shen,Miao Liu,Yumin Duan,Jiahui Chen,Shuai Li,Haoxuan Yu
Polyimide aerogels (PIAs) possess enormous application potential in high-temperature thermal insulation scenarios. As high-efficiency thermal insulation materials, their thermal safety and thermal insulation performance are of crucial importance. Currently, poor dimensional stability, high-temperature pyrolysis, and severe shrinkage remain the key factors restricting their development and practical application. In this work, we employ an in situ co-gelation synthesis strategy, where methyltrimethoxysilane (MTMS) is introduced as the silica precursor to fabricate SiO2/polyimide aerogels (Si@PIAs). This strategy enhances the interfacial bonding strength between the organic and inorganic phases, enabling their complementation of strengths. Experimental results demonstrate that the incorporation of the inorganic SiO2phase endows Si@PIAs with higher thermal safety, superior thermal insulation performance, lower density, and reduced shrinkage. Among them, Si10@PIA performs best with a density of 85 mg/cm3, a thermal conductivity of 23.28 mW/(m·K), and a heat flow peak temperature of 720.7 °C. More importantly, pyrolysis analysis reveals that the pyrolysis process of Si@PIAs shifts to a randomized nucleation and growth model (n= 2/5) with the mechanism functiong(α) = [−ln(1 −α)]5/2. Compared with pure PIAs, Si@PIAs possess stronger resistance to pyrolysis, lower gross calorific value, and improved thermal safety. This study provides theoretical and practical guidance for the development of high-performance aerogel materials, promoting their application in lithium-ion battery separators, high-temperature insulation, and fire-resistant materials.
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ADVANCED MATERIALS
·
2026
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IF 29.1
Donglin Xie,Zhuopeng Liu,Zuo Pu,Jing Liu,Maosen Deng,Jiang Bian,Shuang Guo,Hui Zong,Yong Jiang,Jun Yue,Chang Shu,Zhe Li
Repairing abnormal vessels in the complex fluidic and biological environment of blood remains challenging. Current approaches, such as non-adhesive polymeric sealants or vessel coiling, have unsatisfactory outcomes. Here, we present an injectable magnetoactive adhesive hydrogel (iMAH) for vascular repair in the challenging blood environment. Designed with biocompatible functional components, including the superparamagnetic component, a bio-inspired tissue adhesive, and quick-crosslinking agents, the catheter-deployable iMAH can be magnetically guided to a targeted site, quickly crosslink within approximately 2 s, and strongly adhere to the vessel surface in dynamic conditions with circulating and pressurized blood. Moreover, magnetic actuation enables targeted gel deployment and can drive the iMAH into a narrow and confined space, squeezing out interfacial fluid to facilitate high-strength tissue adhesion, as systematically investigated in vitro. Magnetically controlled delivery of iMAH for vascular repair has been demonstrated in a large-animal beagle dog model; branching lumbar arteries from the abdominal aorta, mimicking the opening of a ruptured artery, were successfully embolized under magnetic guidance using a 5-axis magnetic vascular robot. With these demonstrated features, magnetically controlled delivery of injectable magnetoactive adhesive hydrogel provides a promising solution for vascular repair such as sealing ruptured vessels or embolizing abnormal arteries in the challenging blood environment.
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Advanced Healthcare Materials
·
2026
·
IF 9.6
Huifang Du,Shuming Hu,Yinhua Qin,Zezhong Lu,Yanzhao Li,Ju Tan,Gang Li,Ning Li,Jianhua Xu,Chuhong Zhu,Ji Zheng,Youqian Xu
The development of assembly interfaces that emulate subcellular chemical communication at the biotic-abiotic interface is a central pursuit in synthetic biology. However, engineering in situ self-assembling systems that combine robust retention against mucosal flushing and microenvironmental regulatory functions remains a formidable challenge. Herein, we present an intravesical in situ synthetic strategy that exploits endogenous microenvironmental triggers to construct a glycosaminoglycan (GAG)-mimetic coating for durable mucosal repair. By leveraging catalase (CAT) and hydrogen peroxide (H 2 O 2 ) inherent to inflammatory microenvironments, we drive the polymerization of alginate oligosaccharide-conjugated polydopamine (AOS-PDA). The resulting coating recapitulates the anionic and barrier properties while exhibiting anti-inflammatory activity. In rat models of cyclophosphamide (CYP)-induced interstitial cystitis, AOS-PDA treatment significantly restored urothelial barrier integrity, reduced vascular permeability, and alleviated bladder dysfunction. Histological and molecular analyses confirmed the attenuation of inflammation, characterized by decreased mast cell infiltration and downregulation of key inflammatory mediators. Furthermore, the coating demonstrated sustained retention for up to three days post-administration. These findings highlight a bio-responsive, endogenous enzyme-driven approach to synthesizing functional GAG-like interfaces, offering a versatile therapeutic platform for broader mucosal repair applications.
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Qiu Wang,Yi Lin,Jiahui Xiao,Keqing Xu,Zijin Luo,Hongyu Ren,Fan Liu,Lu Jia,Tuo Wei,Qiang Cheng
Highly efficient mRNA lipid nanoparticle (LNP) often presents potential safety risks. Here, we establish a structure–activity relationship framework for peptide ionizable lipids (PILs) to facilitate the rational design of safe and effective mRNA-LNPs. The PIL structure comprises three modular components: building block, side-chain length, and hydrophobic tail. Through systematic optimization, a lead compound (Dab4) with four building blocks and a moderate side chain length was identified, demonstrating minimized hepatotoxicity while maintaining superior delivery performance. Leveraging this framework, a series of Dab4-derived PILs with three tail types, including alkyl (a-tail), ester (aat-tail), and hydroxyl (e-tail), were synthesized. This tail chemistry determined organ tropism, with B12-a13Dab4 (a-tail) showing optimal performance in the liver. The B12-a13Dab4 LNP exhibited significantly higher hepatic delivery efficiency and markedly improved biosafety compared with the FDA-approved SM-102 formulation. Moreover, B12-a13Dab4 LNP efficiently triggers in vivo prime editing by co-delivering PE7 mRNA and epegRNA, and achieves significant therapeutic effects in a Hereditary Tyrosinemia Type 1 (HT-1) model through repeated delivery fumarylacetoacetate hydrolase (FAH) mRNA. This study establishes rational design principles for PILs that strike a balance between efficacy and safety, offering a versatile mRNA-LNP platform for the advancement of gene editing and protein replacement therapies.
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高影响因子
Advanced Science
·
2026
·
IF 14.1
Xiaochen Feng,Ying Fang,Hongwei Yu,Yicheng Wang,Yunze Xu,Chunxiao Shi,Haike Xia,Ranjith Kumar Kankala,Aizheng Chen,Shibin Wang,Chaoping Fu
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, chronic inflammation, and subchondral bone remodeling. Conventional intra-articular therapies provide limited relief and fail to address its multifactorial pathogenesis. Here, we present an injectable hydrogel microsphere platform that integrates antioxidative, anti-inflammatory, and regenerative functions for localized OA management. Uniform (∼125 µm) chondroitin sulfate methacrylate (ChSMA)-based microspheres are fabricated via microfluidic photocross-linking. Manganese dioxide nanoparticles provided catalytic reactive oxygen species (ROS) scavenging, while dexamethasone sodium phosphate enabled sustained release, reducing TNF-α and IL-6 levels by ∼30%. Bone marrow mesenchymal stem cells (BMSCs) are co-delivered to promote cartilage repair. In vitro, the microspheres reduce intracellular ROS, induce M2 macrophage polarization, and suppress inflammatory cytokines by 60–70%, with IL-10 levels increased by ∼90%. 3D co-culture supports chondrocyte/BMSC viability and matrix production. In vivo, intra-articular injection in a rat OA model markedly reduces cartilage erosion, decreases osteophyte volume by 80%, and improves subchondral bone microarchitecture. Histological staining confirms matrix restoration and structural preservation, with Osteoarthritis Research Society International (OARSI) scores reduced by 88%. Collectively, this injectable hydrogel microsphere system offers a minimally invasive and integrated strategy, simultaneously delivering antioxidative, anti-inflammatory, and regenerative effects for comprehensive OA management.
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PHYTOTHERAPY RESEARCH
·
2026
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IF 8.1
Pengru Wang,Xin Hu,Haiyan Pu,Junjie Bai,Lei Sun,Tingting Ma,Yichao Du,Wenguang Fu
Hepatic ischemia–reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57BL/6 mice were pretreated with SCM-198 for 7 days, then subjected to hepatic I/R and sampled at the reperfusion endpoint. AML12 cells were pretreated with SCM-198 for 24 h, exposed to hypoxia/reoxygenation (H/R), and immediately analyzed. Injury, inflammation, apoptosis, and cell-cycle changes were assessed using assay kits, histology, IHC, WB, and qPCR; network pharmacology, docking, and MD simulations explored potential targets. SCM-198 sharply cut hepatic necrosis and serum transaminases, suppressed pro-inflammatory cytokines, reduced leukocyte infiltration, blocked apoptosis and restored cyclin D1/cyclin E1. In hypoxia-reoxygenation AML12 cells, it improved viability, limited oxidative stress and mirrored the anti-apoptotic effects. Network and dynamic simulation identified stable phosphoinositide 3-kinase (PI3K) binding, and the compound raised PI3K, protein kinase B and mammalian target of rapamycin phosphorylation; the PI3K inhibitor LY294002 abolished these changes. SCM-198 protects liver I/R by curbing inflammation, apoptosis, and cell-cycle arrest via PI3K/AKT/mTOR activation, offering a promising therapeutic candidate.
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Advanced Science
·
2026
·
IF 14.1
Hao Song,Liang Yi,Lixiang Huang,Wajid Ali,Linhan Cai,Chao Wang,Jianhua Huang,Ziwei Li,Anlian Pan
Flexible alternating current electroluminescent (ACEL) devices have garnered significant research interest due to their potential applications in illumination and display. However, challenges remain in fabricating ACEL devices with high brightness and excellent working stability over a large luminescent area. In this study, we demonstrate a simple aerosol spraying method with modified luminescent ink to fabricate meter-scale flexible ACEL devices. In the fabrication process, the particle dispersibility of luminescent ink and the uniformity of sprayed film have been significantly improved. This improvement is primarily attributed to the introduction of long-chain molecular groups of the surfactant, which can bind to the surface of ZnS:Cu luminescent particles at one end, while the other end remains suspended in the oily solvent, providing substantial steric hindrance. The fabricated planar thin-film ACEL devices demonstrated excellent substrate compatibility and flexibility, with exceptional operational stability in high-temperature, humid, and water-rich environments. Remarkably, we achieved a maximum brightness of nearly 500 cd·m −2 in small-sized devices, while a brightness of 303.3 cd m −2 from an ultra-large device of 1.2 m × 1.2 m. These devices have been further explored as navigation signs for autonomous takeoff and landing of industry drones.
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ANALYTICAL LETTERS
·
2026
·
IF 1.8
Quanxiu Wang,Zijin Chen,Jiaoyan Gao,Xingshuo Wang,Xinlei Huang,Yuting Shen,Hui Lu,Leilei Guo
Glutathione (GSH) is a critical bioactive molecule that plays an essential part in regulating the body’s redox homeostasis, and its concentration is of significant importance for the diagnosis of clinical conditions. In recent years, colorimetric techniques utilizing nanoenzymes have emerged as a novel approach for GSH determination. The development of nanoenzymes featuring straightforward synthesis, high catalytic efficiency, and cost-effectiveness is essential for achieving rapid and sensitive GSH determination. In this study, palladium nanocrystals (PdNCs) exhibiting peroxidase-like activity were successfully synthesized via a facile microwave-assisted method. Based on the specific thiol-PdNCs interaction and the associated color change of the catalytic system, a fast, straightforward, and highly sensitive colorimetric method was developed for the determination of GSH. Small-sized PdNCs with exposed (100) crystal planes exhibited exceptional peroxidase-like activity and efficiently catalyzed the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2 to produce a blue product. By exploiting the inhibitory effect of GSH on this catalytic system, sensitive GSH determination was achieved with linear ranges of 3–40 μM and 55–110 μM, as well as a low limit of detection (LOD) of 0.14 μM, outperforming previously reported methods. The method was further validated using serum samples, showing recovery rates of 96.36%–103.65% and relative standard deviations (RSDs) of 1.99%–3.38%. This PdNCs-based colorimetric strategy demonstrates promising potential for real-time GSH determination in clinical diagnostics.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Shuanglong Tang,Xi Wang,Jingyu Li,Xiaodan Wen,Hao Chen,Mei Yan,Xi Chen,Chongshen Guo
Although photothermal therapy (PTT) has been deemed as an effective approach for tumor ablation, the ubiquitous overheat over 50 °C in the PTT process would damage surrounding normal tissue. The combination of nutrient depletion at the tumor site with mild PTT seems like an efficient way to overcome this dilemma. In this work, cobalt-doped polydopamine (CP) behaved as both photothermal agent and glucose oxidase (GOx) carrier to achieve a starvation assisted photothermal therapy. CP possesses more weak acid sites than pure polydopamine, and it gives higher encapsulation efficiency and loading capacity of 89.71% and 47.29% towards GOx, respectively. The CPGP was prepared by coating the GOx-loaded CP with a phase change material (PCM) layer. The solidified PCM prevents the binding between the GOx and glucose, thereby inhibiting GOx activity. The PCM melts at 45 °C and then the GOx activity restores to normal level. The CPGP could cause reduction of intracellular levels of NAD + , NADH and ATP, as well as mitochondrial dysfunction and the induction of apoptosis or necrosis. Hence, CPGP-mediated starvation-photothermal combination therapy exhibits an effective tumor-killing effect. In addition, upregulated M1-polarized macrophages, CD4 + T cells and CD8 + T cells were observed in the mouse model.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yi Chen,Bowen Jia,Junjie Zhou,Guojun Jin,Hou-Yong Yu
Designing oral solid preparations with responsive release mechanisms is crucial for achieving precise therapeutic efficacy in gastrointestinal diseases. In this work, a dual pH/temperature-responsive cellulose nanocrystal (CNCs-D-N) was engineered by grafting a stimuli-sensitive copolymer onto carboxylated cellulose nanocrystal, thereby endowing tailored dual-triggered structural adaptability. The CNCs-D-N exhibited pH-dependent protonation–deprotonation equilibria and thermally induced chain conformational transitions, which cooperatively regulated molecular extension and contraction, enabling rapid and controllable drug release. Tetracycline hydrochloride was subsequently wet-loaded into CNCs-D-N to fabricate stimuli-sensitive tablets (CNC@DNWT), which showed excellent mechanical robustness (hardness: 32.64 N; brittleness: 0.31%), high drug loading capacity (99%), and ultrafast release initiation (7 s). Importantly, CNC@DNWT achieved a cumulative release of 99% under simulated gastric conditions (pH = 3, 37 °C), underscoring synergistic role of dual stimuli in tuning release kinetics. By bridging molecular-level adaptability with macroscopic delivery performance, this study provides a mechanistic strategy for the development of intelligent cellulose-based oral formulations with promising potential for targeted gastric cancer therapy.
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