JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 3
·1-13
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IF 2.8
Li Caixia,Lu Peng,Ma Xiaoxuan,Zhang Kun,Li Chenglong
The rapid advancement of wearable electronic devices demands high-performance sodium-ion battery (SIB) cathode materials, particularly in terms of stability and electrochemical performance. Sodium super ionic conductor (NASICON)-type Na 3 V 2 (PO 4 ) 3 (NVP) has attracted significant attention due to its unique framework structure and high theoretical capacity. However, the inherently low electrical conductivity of NVP limits large-scale application. To address this issue, a novel NVP@C-rGO composite was synthesized using metal–organic frameworks (MOF) and reduced graphene oxide (rGO). The structures of these two forms of carbon enhance the charge transfer kinetics of NVP and provide two stress-buffering layers, thereby improving the structural stability of the material while significantly facilitating charge transport. Electrochemical testing confirmed the effectiveness of this strategy: at a current density of 500 mA g⁻ 1 , the NVP@C-rGO composite retained 71.1% of capacity after 600 cycles, compared to only 21.2% for unmodified NVP. Furthermore, due to the synergistic effect between rGO and MOF-derived NVP, the composite achieved a high specific capacity of 89.9 mAh g⁻ 1 under the same conditions, while NVP reached only 62.7 mAh g⁻ 1 . This significant improvement in performance, combined with the exceptional cycling stability and rate capability of the NVP@C-rGO||HC-rGO full cell, highlights the potential of the composite as a next-generation energy storage material for flexible and wearable electronic devices.
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INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
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2020
·Vol. 93
·期 6
·707-714
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IF 1.935
Wang Fang,Yang Liuye,Zhang Bin,Liu Gaisheng,Wang Chongjian,Zhang Yawei,Wang Tong
Objective Coal miners are exposed to polycyclic aromatic hydrocarbons (PAHs), a group of neurotoxicants formed and released during incomplete combustion of coal. High levels of anxiety and depression have been reported in coal miners, but little is known about neurobehavioral functions in populations that are occupationally exposed to PAHs. We tested neurobehavioral performance in coal miners and correlated it with levels of urinary markers of PAH exposure. Methods Levels of urinary PAH metabolites were measured in 652 male coal miners as an indicator of exposure. Subjects were divided into a high-exposure group and a low-exposure group based on the median level of total PAH metabolites. A neurobehavioral core test battery and a questionnaire were used to assess neurobehavioral performance and collect demographic information, respectively. Results The median level of total PAH metabolites in urine was 4.88 μmol/mol creatinine. Highly exposed workers exhibited more fatigue-inertia than less-exposed workers ( p < 0.05), and had lower scores in forward digit span, digit symbol, and Benton visual retention tests ( p < 0.05). Multiple linear regression indicated that age, education, and shift work were significantly correlated with test scores. Conclusions PAH exposure may be associated with neurobehavioral alterations, which should be monitored in coal miners to prevent neurobehavioral disorders.
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Nature Communications
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2018
·Vol. 9
·期 1
·1-7
·
IF 12.353
Lv Bihu,Zhang Huichao,Wang Lipeng,Zhang Chunfeng,Wang Xiaoyong,Zhang Jiayu,Xiao Min
When closely packed into a high-density film, semiconductor nanocrystals (NCs) can interact with each other to yield collective optical behaviours, which are normally difficult to characterize due to the ensemble average effect. Here we synthesized semiconductor NC clusters and performed single-particle spectroscopic measurements to probe the electronic couplings of several giant CdSe/CdS NCs contained in one cluster with nanometer-scale separations. Such a single cluster exhibits multiple emission peaks at the cryogenic temperature with nearly identical photoluminescence decay dynamics, suggesting that the Förster-type energy transfer does not occur among the composing NCs. Surprisingly, strong photon antibunching is still observed from a single cluster, which can be attributed to the Auger annihilation of photo-excited excitons from different NCs. The isolation of several nearby NCs interacting with the above novel mechanism has marked a solid progress towards a full understanding and an efficient control of the operation parameters in NC-based optoelectronic devices.
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CELLULOSE
·
2024
·
IF 4.9
Zhao Junchai,Chen Long,Zhou Wentao,Zhao Pengbo,Peng Zheng,Lin Xiaobo,Yang Jinhui
Here, a facile method to extract the carboxylated cellulose nanocrystals (CNCs) with high yield from microcrystalline cellulose (MCC) at room temperature (RT) is put forward that uses a solvent system of zinc chloride (ZnCl 2 ) and citric acid (CA) aqueous solution. The rod-like carboxylated CNCs were achieved with a maximum yield of 72.3% and a maximum carboxyl group content of 0.75 mmol/g. Meanwhile, the crystal transformation from cellulose I to II was detected with variation of solvent composition. In addition, to the best of our knowledge, this is the first time that the iridescent phenomenon was observed in extremely thin films which were prepared from carboxylated CNC suspension with a concentration of only 0.08–0.15 wt% via evaporation-induced self-assembly. The possible formation mechanism is considered to be related to the synergistic effects of film confinement and drying stresses. Furthermore, the interaction between Petri dish substrate and the film played a role. As the first example of isolation of carboxylated CNCs with high yield at RT using ZnCl 2 /CA aqueous solution, this work provides a facile and practical strategy for the preparation of functional cellulose nanomaterials.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Fang Dan,Xu Tianqi,Li Fulei,Sun Yue,Sun Jingyi,Yin Yanqing,Zhang Haijie,Wang Zhiqiang,Liu Yuan
Tigecycline is a last-resort antibiotic to treat complicated infections caused by multidrug-resistant pathogens, while the emergence of plasmid-mediated tet (X) family severely compromises its clinical efficacy. Novel antimicrobial strategies not limited to new antibiotics in pharmaceutical pipeline are urgently needed. Herein, we reveal the metabolic disparities between tet (X)-negative and -positive E. coli , including distinct energy demand patterns under tigecycline exposure. In particular, the cysteine and methionine metabolism pathway is remarkably downregulated in tet (X)-positive bacteria. More importantly, we find that the addition of exogenous L-methionine (Met) effectively resensitizes tet (X)-positive pathogens to tigecycline. Our mechanistic analysis demonstrates that exogenous Met promotes intracellular tigecycline accumulation by upregulating bacterial proton motive force. Moreover, Met accelerates the conversion to S-adenosyl-L-methionine, an essential methyl donor, thereby enhancing 5mC methylation modification in the promoter region of tet (X4) gene and reducing its expression. Consistently, the potentiation of Met to tigecycline is abolished in tet (X4)-carrying E. coli Δ dcm but restored in dcm -complementary bacteria, which encodes DNA-cytosine methyltransferase. In multiple animal models of infection, Met markedly potentiates the effectiveness of tigecycline against pathogenic E. coli and K. pneumoniae . Overall, this work highlights the therapeutic potential of Met in overcoming plasmid-mediated high-level tigecycline resistance, and provides a new paradigm to enhance antibiotic efficacy by harnessing cellular metabolic networks as well as epigenetic modifications.
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Nature Cardiovascular Research
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2025
·
IF 10.8
Zhang Jingjing,Tang Yuyi,Zhang Shan,Xie Zhuxin,Ma Wenrui,Liu Shaowen,Fang Yixuan,Zheng Shufen,Huang Ce,Yan Guoquan,Abudupataer Mieradilijiang,Xin Yue,Zhu Jingqiao,Han Wenjing,Wang Weizhong,Shen Fenglin,Lai Hao,Liu Yang,Ye Dan,Yu Fa-Xing,Xu Yanhui,Pan Cuiping,Wang Chunsheng,Zhu Kai,Zhang Weijia
Thoracic and abdominal aortic aneurysm poses a substantial mortality risk in adults, yet many of its underlying factors remain unidentified. Here, we identify mitochondrial nicotinamide adenine dinucleotide (NAD)⁺ deficiency as a causal factor for the development of aortic aneurysm. Multiomics analysis of 150 surgical aortic specimens indicated impaired NAD + salvage and mitochondrial transport in human thoracic aortic aneurysm, with expression of the NAD + transporter SLC25A51 inversely correlating with disease severity and postoperative progression. Genome-wide gene-based association analysis further linked low SLC25A51 expression to risk of aortic aneurysm and dissection. In mouse models, smooth muscle-specific knockout of Nampt , Nmnat1 , Nmnat3 , Slc25a51 , Nadk2 and Aldh18a1 , genes involved in NAD + salvage and transport, induced aortic aneurysm, with Slc25a51 deletion producing the most severe effects. Using these models, we suggest a mechanism that may explain the disease pathogenesis: the production of type III procollagen during aortic medial matrix turnover imposes a high demand for proline, an essential amino acid component of collagen. Deficiency in the mitochondrial NAD⁺ pool, regulated by NAD⁺ salvage and transport, hinders proline biosynthesis in mitochondria, contributing to thoracic and abdominal aortic aneurysm.
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CELLULAR AND MOLECULAR LIFE SCIENCES
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2025
·Vol. 82
·期 1
·1-16
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IF 6.2
Du Li,Cui Yinghong,Chen Wei,Li Chunyun,He Zuping
Sertoli cell-only syndrome (SCOS) is one of the most severe non-obstructive azoospermia (NOA) types, since only Sertoli cells with not any male germ cells exist with the seminiferous tubules. As such, it is of particular significance to elucidate molecular mechanisms underlying SCOS for improving the diagnosis and treatment strategies for this disease. Due to the difficulties in obtaining sufficient human testicular tissues and the limited availability of human cells, the traditional proteomics is inadequate for comparing the differences in large scale of protein expression patterns of human Sertoli cells between SCOS and normal men. To solve this issue on the requirement of large amount of cell numbers, we employed micro-proteomics to reveal distinct global protein expression profiles of human Sertoli cells between SCOS and obstructive azoospermia (OA) with normal spermatogenesis utilizing single human Sertoli cells. We found a significant downregulation of proteins involved in cell adhesion pathways in SCOS Sertoli cells, whereas proteins related to apoptosis were markedly upregulated. Interestingly, we identified the lower expression of SPARC (secreted protein acidic and rich in cysteine) and the higher expression of FGF2 (fibroblast growth factor 2) in human Sertoli cells of the SCOS compared to normal men. SPARC silencing led to upregulation of FGF2 in human Sertoli cells, and SPARC may be associated with the occurrence of SCOS and serves as a reliable marker for the diagnosis of this disease. This study thus comprehensively offers the proteomic landscape of human Sertoli cells in the testes of SCOS patients and it sheds a novel insight into the pathogenesis of SCOS.
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Journal of Translational Medicine
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2025
·Vol. 23
·期 1
·1-20
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IF 7.5
Zhang Bin,Bai Miao,Yang Mengshi,Wang Yumei,Chen Xiyu,Liu Baiyun,Shi Guangzhi
Background Glucocorticoids (GCs) have been widely used in the treatment of severe traumatic brain injury (TBI) to inhibit neuroinflammation and alleviating brain edema and cannot be replaced by other drugs. However, their systemic application still faces many obstacles, such as the poor blood-brain-barrier (BBB) penetration and severe side effects. Therefore, new treatment strategy or compounds are urgently needed in clinic.Methods Herein, an injectable nanocomposite hydrogel is developed as a biofunctionalized delivery platform for intraoperative administration of dexamethasone (DEX) after TBI. By using a mice TBI model, the safety and efficacy of the nanohydrogels in treating BBB disruption, brain edema and nerve injury were evaluated after TBI.Results The hydrogel is composed of polysaccharide matrix (carboxymethyl chitosan and oxidized dextran) and mesoporous polydopamine (MPDA) nanoparticles loaded with DEX (MPDA@DEX@gel) that could realize in situ injection, self-assembly, a high DEX loading rate and sustained release around the lesion. The MPDA@DEX@gel exhibits excellent antibacterial and hemostatic properties, good biocompatibility and antioxidation, and self-healing capability in vitro. These in vitro and in vivo results show that local application of MPDA@DEX@gel not only alleviates brain edema, promotes neuronal survival, and improves neurological function by restoring the integrity of BBB and inhibiting neuroinflammation after TBI, but also effectively avoids the peripheral and central side effects.Conclusion Our study provides a promising treatment strategy for the rational use of GCs in patients with severe TBI.
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MICROCHIMICA ACTA
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2025
·Vol. 192
·期 6
·1-11
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IF 5.3
Chen Yun-Ting,Han Jing-Wen,Yu Zi-Wei,Yang Ruo-Yu,Wu Mei-Juan,Huang Pin-Fang,Liu Meng-Meng
A decentralized electrochemical immunosensor was developed using a smartphone and a portable electrochemical workstation. The system employs a gold nanoflower-modified screen-printed carbon electrode (AuNFs/SPCE) for the sensitive measurement of adalimumab (ADL) in human serum via antigen‒antibody recognition. Scanning electron microscopy, X-ray photoelectron spectroscopy, and atomic force microscopy were used to investigate the AuNFs/SPCE. Compared with the bare SPCE, the AuNFs/SPCE has a 1.47-fold larger specific surface area, which enhances the capture efficiency of ADL for signal amplification. Electrode modification and antigen‒antibody assembly processes are characterized by cyclic voltammetry and electrochemical impedance spectroscopy. The immunosensor achieves excellent electrochemical properties by optimizing experimental conditions, which improves the signal-to-noise ratio and thus the analytical performance. Under the best experimental conditions, the immunosensor has a quantitative range of 0.05‒4 μg/mL in diluted human serum with a detection limit of 9.1 ng/mL, which is consistent with the effective therapeutic window of ADL in clinical settings. The prepared electrodes maintain 10-day stability, while with high reproducibility at different ADL concentrations. High recoveries in the range 94.08‒108.6% are obtained in human serum samples. Furthermore, ADL in the serum samples was measured by both ELISA and the developed sensor. Pearson and Bland‒Altman analyses revealed a consistent trend between the two methods. Therefore, this immunosensor is a promising tool for the point-of-care (POC) measurement of ADL in clinical samples, providing valuable insights for personalizing ADL dosing regimens in clinical practice. Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-17
·
IF 15.7
Ma Dingtao,Li Fan,Ouyang Kefeng,Chen Qiuting,Zhao Jinlai,Chen Minfeng,Yang Ming,Wang Yanyi,Chen Jizhang,Mi Hongwei,He Chuanxin,Zhang Peixin
Aqueous Zn ion batteries are advantageous in terms of safety and cost, while their sustainable applications are usually impeded by dendrite growth and interfacial side reactions. Here, we present the development of an electrochemically driven artificial solid-state electrolyte interphase, utilizing a metal surface coupling agent phosphate ester as a protective layer for Zn negative electrodes. Upon cycling, the protective layer in situ transforms into a hybrid phase enriched with well dispersed Zn 3 (PO 4 ) 2 nanocrystals. This transformation ensures a uniform Zn 2+ flux, effectively suppresses dendrite growth, and mitigates side reactions. In addition, such protective layer ensures Zn electrode stable plating/stripping performance for 1500 h at 10 mA cm −2 and 1 mAh cm −2 , while pouch cells coupled with NaV 3 O 8 ·1.5H 2 O deliver ampere-hour level capacity. Beyond that, its robust adhesion and flexibility enable the Zn electrode to maintain good performance under a variety of harsh conditions. This approach provides valuable insights into the advancement of Zn metal batteries.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Liu Feihong,Yao Shasha,Li Jia,Huang Kejie,Zhang Dongdong,Wong Tak Man,Tang Ruikang,Yeung Kelvin W. K.,Wu Jun
In the pursuit of replicating the remarkable mechanical properties of natural biological composites like bone and seashell, developing artificial bulk materials that seamlessly integrate rigid inorganic components with ductile organic constituents has been a longstanding challenge. A key hurdle has been the establishment of robust and reliable linkages between these disparate building blocks. Mechanical metamaterials achieved by well-designed chemical structures, however, offer a promising solution to address this challenge. In this study, we demonstrate that the calcium phosphate-based inorganic-organic hybrid metamaterials trapping inorganic nanoparticles within long-chain polymeric networks and anchoring inorganic blocks to these networks via short-chain organic crosslinkers exhibit switchable and tunable high stiffness and elasticity. Additionally, these metamaterials not only exhibit peculiar mechanical characteristics, but also present excellent biocompatibility, as demonstrated by the in vivo tests using male rats and the in vitro tests. These results suggest a wide range of potential clinical applications.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2025
·
IF 0
Xu Qian,Zheng Zhihong,Zhang Jingyun,Luo Jinjing,Chen Jianwen,Lai Zheng
A series of manganese-iron-based (MnFeOx) polytetrafluoroethylene (PTFE) catalytic filter materials were prepared by combining acid pretreatment and ultrasound-assisted coupling method to achieve simultaneous treatment of nitrogen oxides and dust. Surface acid pretreatment of the filter materials can improve PTFE’s surface roughness and provide more attachment sites for catalyst loading. The ultrasound-assisted coupling technology significantly improves the loading capacity of the catalyst and the bonding strength with the filter material. Compared to previous catalytic filter materials, the preparation of the optimal catalytic filter material in this study had achieved gratifying catalytic performance (NO conversion of 95% at 200 ℃) and could reach 99.95% filtration performance. In addition, the catalytic filter material also exhibited outstanding catalyst stability and mechanical properties of filter material, which made the catalytic filter material suitable for complicated working conditions. The functional integrated filter material has great significance for the collaborative treatment of multiple pollutants and could significantly benefit future development of air pollution control.
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