Nature Communications
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2025
·Vol. 16
·期 1
·1-11
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IF 15.7
Zhang Yue,Ming Zechang,Zhou Zijie,Wei Xiaojie,Huang Jingjing,Zhang Yufan,Li Weikang,Zhu Liming,Wang Shuang,Wu Mengjie,Lu Zeren,Zhou Xinran,Xiong Jiaqing
Temperature-adaptive elastic conductive fibers (ECFs) are crucial for seamlessly integrating electronic textiles, promoting the development of wearables, soft robotics, and high/low-temperature electronics. Realizing ECFs with balanced elasticity, conductivity, and temperature adaptivity remains challenging due to the difficulty of coupling the mechano-electrical-thermal properties at a microscale fiber. We design a wet-spun ECF consisting of thermoplastic polyurethane (TPU), silver flakes (AgFKs) and liquid metal microspheres (LMMSs) with regularly arranged filler architecture, revealing a cold/thermal stretching activated tricomponent-dynamic-coordination mechanism for autonomously-enhanced electrical conductivity (from ~1070 S cm −1 at 25 °C to 1160 S cm −1 at −30 °C and 3020 S cm −1 at 180 °C) and improved electrical stability to sustain 1000 stretching cycles (60% strain at 80 °C). The fiber exhibits scalability and favorable knittability, demonstrating e-textiles such as biomedical electrodes, high/low-temperature near-field communication gloves, and intelligent firefighting suits. The autonomous mechano-thermo-electrical coupling strategy can inspire high-performance and environment-adaptive ECFs for extreme applications.
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Nature Communications
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2025
·Vol. 16
·期 1
·1-10
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IF 15.7
Fan Yun,Yan Yunhui,An Qizheng,Xia Zhongcheng,Pan Yuping,Lu Yuxuan,Zhu Zhonghuan,Wang Ruiqi,Liu Qinghua,Zou Yuqin,Li Yongjun,Wang Shuangyin
The use of renewable electricity to drive the electrocatalytic coupling of CO with nitrogen-containing organics offers a promising strategy for producing high-value chemicals. In this work, we conduct a systematic investigation of the coordination effect between iodide and copper oxide to generate Cu δ+ active sites. These Cu δ+ sites enable the electrosynthesis of dimethylacetamide from CO and dimethylamine. Through precise regulation of the electrode surface microenvironment, a dimethylacetamide Faradaic efficiency of 45.6% is achieved at a partial current density of 182.4 mA·cm -2 , with a production rate of 435.9 mmol·g cat. −1 ·h -1 and selectivity approaching 70%. Mechanistic studies reveal that specific adsorption of I - forms an iodide-enriched Cu 0 /Cu + interface that synergistically promotes dimethylacetamide formation by enhancing adsorption of ketene intermediates (*CCO) and facilitating C–N bonds formation. This anion-coordination interfacial engineering strategy demonstrates broad applicability for synthesizing various acetamide derivatives from CO 2 /CO and amine, providing a foundational framework for electrocatalytic C-N coupling in acetamide synthesis.
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Journal of Translational Medicine
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2025
·Vol. 23
·期 1
·1-19
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IF 7.5
Xing Chunyang,Hu Wei,Zhao Liyuan
Background Osteosarcoma (OS) is one of the most common malignancies arising in bone. Hypoxia and immune regulation are pivotal in tumor biology. However, their combined effects and mechanisms in OS remain understudied. This study aimed to explore the role and mechanism of hypoxic-induced M2 macrophages in promoting the progression of OS.Methods Differentially expressed proteins in hypoxic macrophage supernatants were detected by antibody array. Cell functional experiments, siRNA-mediated gene silencing, and overexpression transfection were used to study osteopontin (OPN) and its supernatant effect. Bioinformatics analysis was applied to investigate downstream targets and pathways, and a xenograft model was established to assess in vivo effects.Results Our data revealed that hypoxic M2 macrophage supernatant enhanced OS malignancy and epithelial-mesenchymal transition, activating cancer pathways. Hypoxia upregulated OPN in M2 macrophages, and OPN inhibition reduced its tumor-promoting effect. Early growth response 3 (EGR3) was differentially expressed in OS cells treated with the supernatant, and its overexpression inhibited OS cell migration, reversing tumor promotion. Interferon-stimulated gene 15 (ISG15), a key differentially expressed gene related to OPN and EGR3 overexpression, inhibited OS cell proliferation and migration. Additionally, OPN increased retinoic acid-inducible gene I (RIG-I) expression and enhanced signal transducer and activator of transcription 3, nuclear factor kappa B, and extracellular signal-regulated kinase signaling, while EGR3 and ISG15 overexpression inhibited these effects. Silencing ISG15 restored pathway activation and reversed the inhibitory effect of EGR3 on OS cell migration. Dual-Luciferase reporter gene assay confirmed that EGR3 activates ISG15 transcription. OPN treatment upregulated DNA (cytosine-5)-methyltransferase 1 (DNMT1) expression, and ChIP assays demonstrated that EGR3 overexpression enhanced DNMT1 binding to the EGR3 promoter. These findings suggest that OPN promotes OS malignancy by downregulating EGR3 and ISG15, and by enhancing RIG-I expression, as validated in a xenograft model of OS.Conclusion Our findings demonstrate that hypoxic-induced M2 macrophages promote OS progression through OPN-dependent mechanisms, including inhibition of EGR3 and ISG15 expression and upregulation of RIG-I.Graphical abstract
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Science China-Materials
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2025
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IF 7.4
He Lihua,Zou Yi,Li Chengtai,Duan Shuming,Ren Xiaochen,Hu Wenping
The development of brain-inspired neural network computing synaptic devices based on organic field-effect transistors (OFETs) represents a pivotal research frontier in neuromorphic computing and flexible electronics. These devices elucidate fundamental mechanistic parallels between biological neural networks and artificial systems, facilitating the paradigm shift in organic electronics from passive “sensing” to active “cognition”. This technological evolution enables loop perception-computation-decision architectures while unlocking transformative opportunities in intelligent hardware and medical technologies. Such pioneering advancements are poised to redefine the global semiconductor industry landscape by bridging neuromorphic engineering with next-generation bioelectronic applications, ultimately driving the convergence of adaptive learning systems and human-machine symbiotic interfaces. A low-voltage (1 V) C 8 -BTBT optoelectronic synaptic array (coefficient of variation in synaptic weight modulation: 8%) emulated human visual information processing under distinct cognitive states: dispersed-attention mode achieved rapid response and short-term plasticity, while focused-attention mode enabled noise suppression and long-term potentiation via carrier trapping modulation. This platform advances hardware-level perception-computation integration for biomimetic vision chips.
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npj Materials Degradation
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2025
·Vol. 9
·期 1
·1-14
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IF 7.6
Xiang Tengfei,Chen Xuxin,Wang Jihuai,Liu Di,Cui Linjing,Wang Tao,Zhang Zhenya,Yang Yang,Zhang Shihong
Metal corrosion poses significant economic and safety challenges across industries, necessitating efficient cathodic protection strategies. Triboelectric nanogenerator (TENG) offers a promising self-powered solution by harvesting ambient mechanical energy. This study presents the design of TENG based on fluorinated ZIF-67/PDMS (F-ZIF-67/PDMS) composites for enhanced cathodic protection of 304 stainless steel (304SS). The present study integrates dual regulation of microstructure and surface energy to synergistically enhance the triboelectric performance. While loading 5 wt.% ZIF-67, the TENG achieved remarkable output performance with an open-circuit voltage of 187.14 V, short-circuit current of 37.46 μA, and transferred charge of 72.54 nC, delivering a peak power of 3.08 mW. When integrated with a cathodic protection system, the TENG significantly reduced the open-circuit potential (OCP) and the corrosion rate. This work advances the integration of MOF-based triboelectric materials with energy harvesting technologies, offering a sustainable approach to mitigating metal corrosion.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2025
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IF 1.6
Tang Hui,Jiang Qiao,Zhu Songlin,Yang Qiang,Gu Hong,Liu Pei,Hong Tao,Li Zehua,Leng Yangchun
CO 2 may erode cement structure of geological disposal repository in the long-term disposal process. This study investigates the adsorption behavior and mechanism of carbonated cement for Co 2+ via characterization and adsorption experiments. Characterization experiments show that the carbonation does not change the adsorption mechanism of cement for Co 2+ . Adsorption experiments show that carbonation reduces the adsorption capacity of cement. In general, the adsorption of Co 2+ by both pristine and carbonated cement involves multiple mechanisms including ion exchange and chemical adsorption. This study provides critical data for safety assessments of the geological disposal repository.
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Microbiome
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2025
·Vol. 13
·期 1
·1-23
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IF 12.7
Lin Chunxiu,Lin Yugui,Xiao Rui,Guo Min,Zhang Hao,Chen Wei,Wang Gang
Background Recent studies suggest a role of gut microbiota in the development of neonatal hyperbilirubinemia, with bifidobacteria showing promise in alleviating symptoms. However, uncertainties persist regarding gut bifidobacterial species composition and their effects on bilirubin metabolism. Therefore, the study investigated the association between the gut microbiota and neonatal hyperbilirubinemia, assessing the potential and underlying mechanisms of Bifidobacterium in managing the condition. Results Compared to the high-risk group (requiring clinical intervention), low-risk neonates (designated as controls without therapeutic needed) demonstrated a higher abundance of breastfeeding-associated Bifidobacterium species, including Bifidobacterium longum subsp. infantis , B. bifidum , and B. breve . In an experimental neonatal hyperbilirubinemia rat model, these Bifidobacterium species’ protective effects were demonstrated by reducing serum bilirubin levels, maintaining growth and development, and improving neurobehavioral reflexes. These benefits are associated with improved liver and intestinal barrier functions and reduced enterohepatic circulation of bilirubin. Among the various treatment groups, B. longum subsp. infantis exhibited the most potent effect, followed by B. bifidum and B. breve . Intestinal metabolism analysis revealed that the levels of arachidonic acid and docosahexaenoic acid were increased and negatively correlated with bilirubin levels. These findings were further confirmed in the neonatal cohort study. Direct supplementation of these metabolites into the colon of neonatal rats improved disease phenotypes. In addition, both in vitro and in vivo experiments demonstrated the specific inhibitory effect of arachidonic acid and docosahexaenoic acid on β-glucuronidase enzyme activity. Notably, both in vitro intestinal fermentation models and genomic analyses demonstrated that the three Bifidobacterium species cannot synthesize these unsaturated fatty acids due to the lack of related genes. However, data suggested that these species might promote the accumulation of arachidonic acid and docosahexaenoic acid by regulating the gut microbiota’s structure and function. Moreover, these species show species-specific genomic distribution patterns, which might influence the gut microbiota's α-linolenic and linoleic acid metabolism pathways, thereby affecting bilirubin levels. Conclusions The results indicate that Bifidobacterium species associated with breastfeeding can prevent neonatal hyperbilirubinemia by regulating the gut microbiota–α-linolenic and linoleic acid metabolism–enterohepatic circulation axis, increasing gut metabolites arachidonic acid and docosahexaenoic acid, and reducing the enterohepatic circulation of bilirubin.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2025
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IF 4
Si Lu-Lu,Yang Jing-Zhi,Kong An-Nan,Song Yan,Zhang Da-Wei,Li Guo-Liang
Development of polymers with underwater self-healing and antifouling properties is crucial, particularly in harsh marine environments. In this study, polydimethylsiloxane (PDMS)-based antifouling polymers with tunable self-healing capabilities in aqueous conditions were fabricated by incorporating amphiphilic segments and Fe 3+ -catechol dynamic coordination crosslinking. The microphase formed within the PDMS matrix imparted static antifouling properties to the coatings. The mechanical properties of the damaged sample were restored at room temperature in an aqueous environment for 24 h, achieving a self-healing efficiency of almost 100%. The synthesized material exploited the dynamic coordination between Fe 3+ and catechol to facilitate underwater self-healing. No bacterial adhesion was observed at the scratch site after the coating was repaired. This material enables the long-term antifouling and autonomous repair of marine vessels and sensors, thereby reducing maintenance costs.
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CURRENT MICROBIOLOGY
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2025
·Vol. 82
·期 9
·1-18
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IF 2.6
Xu Wenyi,Guan Yinghua,Tian Liping,Fu Yu,Zhang Yinghui,Liu Yanhong,Hu Yanfei,Zhao Bowen,Wu Chongming
The global prevalence of type 2 diabetes mellitus (T2DM) is currently surging, posing significant health and socioeconomic burdens. Probiotics have emerged as promising interventions due to their safety and potential metabolic benefits. Gut microbiota plays a critical role in the pathophysiology of metabolic diseases in humans, offering valuable insights for therapeutic strategies such as probiotics. Here, aiming to identify novel probiotics from the human gut microbes to combat T2DM, a total of 203 human intestinal bacterial strains were screened in vitro to evaluate their enzymatic inhibition of α-glucosidase and α-amylase, in which Lacticaseibacillus paracasei Glu-07 (= QH-142 = CGMCC 23796) exhibited the highest inhibitory efficacy (81.05% and 72.56% for α-glucosidase and α-amylase, respectively). In HepG2 cells, L. paracasei Glu-07 elevated glucose uptake and consumption by 22.4% and 85.8%. Oral administration of strain Glu-07 in diabetic mice significantly improved hyperglycemia, hyperlipidemia, and restored the structure and composition of gut microbiota toward a healthier profile. Mechanistically, strain Glu-07 activated the AMPK-AKT1-GSK3β/FOXO1 signaling pathways by modulating the expression of key genes, enhanced glycolysis and fatty acid ꞵ-oxidation, and inhibited gluconeogenesis and lipogenesis. It also stimulated GLP-1 secretion, potentially via triggering the GPR41/43-GLP-1 axis, and increased the abundance of beneficial gut microbes, such as Akkermansia muciniphila (~ threefold). The dual regulations synergistically support strain Glu-07 as a promising probiotic candidate for T2DM management.
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FIBERS AND POLYMERS
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2025
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IF 2.3
Tang Xiaoyan,Guo Xun,Qian Xiaoming,Duo Yongchao,Tang Yuanbing,Lan Yina,Fu Hiroshi
The compatibility of low-density polyethylene (LDPE) and polyamide 6 (PA6) during melt-blending spinning plays a crucial role in ensuring good spinnability, while the drawing and fiber-splitting processes are key to forming ultrafine fibers. This study systematically investigates the Flory–Huggins interaction parameters between LDPE and PA6, as well as the fiber-splitting and drawing behaviors of unfigured sea–island composite fibers, with a focus on compatibility and fabrication techniques. The results reveal that the Flory–Huggins interaction parameters for LDPE and PA6 at different blend ratios are 0.0517 ± 0.0014, significantly exceeding the critical interaction threshold of 0.0091, indicating complete incompatibility between the two polymers. Through an in-depth analysis of the drawing process, it was found that after the drawing ratio of 4, the fiber fineness reached 3.7 dtex, with a fiber orientation of 78%, a breaking strength of 5.56 cN/dtex, and a breaking elongation of 41%. During the fiber-splitting process of LDPE/PA6 sea–island composite fibers, the optimal conditions were determined to be a splitting temperature of 90 °C, a splitting time of 60 min, and a degradation rate of 43%. Under these conditions, the composite fiber diameter significantly decreased from 27.04 μm to 0.85 μm. These findings provide valuable insights into optimizing the manufacturing process and enhancing the performance of LDPE/PA6 composite fibers.
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FIBERS AND POLYMERS
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2025
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IF 2.3
Mesbah Md Rubin,Imran Hossain Md,Hu Yi
Thermoplastic polyurethane (TPU) nanofibers were successfully fabricated using natural dyes derived from turmeric and black tea via an electrospinning process, offering a sustainable and eco-friendly alternative to synthetic dyes. This study addresses the environmental and health concerns associated with synthetic dyes by systematically optimizing the dyeing process. We determined that 80 °C for 60 min is ideal for turmeric dye extraction, while 60 °C for 60 min yields the best results for black tea, achieving superior color yield and mechanical performance. The incorporation of natural dyes significantly enhanced the mechanical properties of the nanofibers, with turmeric-dyed nanofibers exhibiting a tensile strength of 31 MPa and strain elongation of 153.21% and black tea-dyed nanofibers achieving a tensile strength of 45 MPa and 99% strain elongation. The dyed nanofibers demonstrated excellent colorfastness to washing, rubbing, and light exposure as evaluated by the ISO 105-C10:2006 standard method, ensuring their durability in practical applications. Additionally, the nanofibers exhibited functional properties, including UV protection, antibacterial activity, and antioxidant effects, making them suitable for applications in protective clothing, filtration membranes, tissue engineering scaffolds, and drug delivery systems. This research highlights the dual advantages of natural dyes in improving both the mechanical performance and functional properties of TPU nanofibers. By replacing synthetic dyes with natural alternatives, this study offers a sustainable solution to reduce the environmental impact of textile production and supports their commercialization.
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CELLULOSE
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2025
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IF 4.8
Sun Yanyan,Natsuki Jun,Zhou Wanyu,Zou Lihua,Wang Zhen,Li Bingbing,Gao Yamin,Chu Changliu,Natsuki Toshiaki
Wearable electronics have gained considerable attention in recent years owing to their softness, flexibility, and compatibility with the human body. However, most conventional multifunctional smart textiles are developed by integrating various fibers or fabrics with single functionalities, facing challenges such as high integration complexity and poor stability, and struggling to meet the demands of wearable electronics. In this study, we present a simple and scalable method involving dip-coating and spray-coating to produce multifunctional, wearable, high-performance MXene/CuS/cotton fabrics. Leveraging the conductive networks formed by synergistic MXene/CuS and the porous structure of the fabrics, these MXene/CuS/cotton fabrics demonstrate impressive electromagnetic interference (EMI) shielding effectiveness (51.1 dB at a thickness of 335 μm) and notable Joule heating performance (approximately 60 °C at a voltage of 6 V). Moreover, when pressure is applied, MXene/CuS/cotton fabrics exhibit negative piezoresistivity, high sensitivity (− 18.2 kPa −1 for 1–4 kPa pressures), rapid response and recovery times (0.4 s), along with exceptional long-term durability and stability (over 2000 cycles). These remarkable properties suggest that MXene/CuS/cotton fabrics are highly promising for future applications in human motion detection, EMI shielding, thermal management, and other applications.
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