查找使用阿拉丁产品的科研文献

Noninvasive Visualization of Sub-5 mm Orthotopic Hepatic Tumors by a Nanoprobe-Mediated Positive and Reverse Contrast-Balanced Imaging Strategy

Peng Lei,Hong Chen,Cai Feng,Xi Yuan,Zongling Xiong,Yanlan Liu,Weihua Liao

Delineation of small malignant lesions and their vasculature enables early and accurate diagnosis of hepatocellular carcinoma (HCC). However, it remains challenging to identify these features simultaneously by noninvasive imaging technology. Reverse contrast imaging emerges as a powerful means to detect early-stage HCC by taking inspiration from the intrinsic liver phagocytosis toward exogenous agents to generate negative tumor-to-normal tissue signals. However, this mechanism conflicts with the signal-enhancing requirements for vasculature visualization. Here, we solve this conundrum by designing a positive and reverse contrast-balanced imaging strategy based on a multifunctional PEG-Ta2O5@CuS nanoprobe that combines advanced gemstone spectral computer tomography (GSCT) with photoacoustic (PA) imaging. The nanoprobe exhibits preferential accumulation in Kupffer cells and hepatocytes over tumor cells, and its spectral properties are well matched with GSCT, leading to the enhancement of reverse contrast signals that enable clear delineation of 2–4 mm orthotopic HCC lesions. Meanwhile, its strong PA imaging capability at the second near-infrared (NIR-II) window makes vascular evaluation accessible by monitoring the positive signal enhancement derived from the limited tumor accumulation of the nanoprobe. In addition, the nanoprobe enables NIR-II photohyperthermia for timely tumor ablation. Overall, this proposed strategy shows potential in early detection and theranostics of HCC for improved clinical outcomes.

The integration of catalyst design and process intensification in the efficient synthesis of 5-hydroxymethyl-2-furancarboxylic acid from fructose

Wei He,Congcong Zhang,Wenyan Zhang,Yuchen Zhu,Zheng Fang,Lili Zhao,Kai Guo

The integration of catalyst design and process intensification in the synthesis of 5‑hydroxymethyl-2-furancarboxylic acid was realized directly from fructose. A novel bifunctional catalyst derived from lignin was developed for the dehydration of fructose. Supported catalysts derived from silver was developed for the oxidation of 5-hydroxymethylfurfural for 5‑hydroxymethyl-2-furancarboxylic acid. The product distribution both in dehydration and oxidation process would be controlled through the adjustment of solvent effect. The structure in bifunctional catalysts was adjusted to reveal the effect of molecular skeletons on the catalytic performance. The constitution of supported catalysts was investigated to illustrate the support effect. Accordingly, the mechanism and synergetic effect in the catalyst were proposed through computational studies based on density functional theory and control experiments. Microwave irradiation was applied in the dehydration reaction, requiring adequate and efficient energy supply. Flow chemistry was employed in the oxidation of HMF, improving reaction efficiency.

Fabrication of targeted and pH responsive lysozyme-hyaluronan nanoparticles for 5-fluorouracil and curcumin co-delivery in colorectal cancer therapy

Maolin Li,Yin Liu,Yanbo Liu,Jiawei Lin,Lei Ding,Songgu Wu,Junbo Gong

Green nanotechnology is considered a promising method to construct functional materials with significant anticancer activity , while overcoming the shortcomings of traditional synthesis process complexity and high organic solvents consumption. Thus, in this study, we report for the first time the rational design and green synthesis of functionalized 5-fluorouracil and curcumin co-loaded lysozyme-hyaluronan composite colloidal nanoparticles (5-Fu/Cur@LHNPs) for better targeted colorectal cancer therapy with minimized side effects. The functionalized 5-Fu/Cur@LHNPs exhibit stabilized particle size (126.1 nm) with excellent homogeneity (PDI = 0.1), favorable colloidal stabilities, and excellent re-dispersibility. In vitro cell experiments illustrate that the cellular uptake of 5-Fu/Cur@LHNPs was significantly improved and further promoted a higher apoptosis ratio of HCT-116 cells. Compared with the control group, the 5-Fu/Cur@LHNPs formulation group achieved effective inhibition (60.1 %) of colorectal tumor growth. The alcohol-free self-assembly method to construct 5-Fu/Cur@LHNPs is simple and safe for a translational chemotherapy drug, also to promote more robust delivery systems for treating colorectal cancer.

Investigating the impact of amine-functionalized ZSM-5 with varying Si/Al ratios on the adsorption of radioactive gaseous iodine

Rui-Li Yu,Qian-Fan Li,Hao-Ran Sun,Zhen-Le Li,Liang-Zhi Xia

In order to efficiently and rapidly capture radioactive iodine that impacts the environment, this study involves impregnating Tetraethylenepentamine (TEPA) into ZSM-5 zeolite with varying Si/Al ratios and evaluating its adsorption performance towards iodine. It is found that the optimal preparation level is 30 %, leading to a significant increase in the saturated adsorption capacity compared to non-impregnated molecular sieves , with a four-fold improvement. The adsorption rate is also enhanced. Various amines are utilized for impregnation, and FT-IR and molecular computation techniques are employed to investigate the adsorption mechanisms between these amines and iodine. The discovery reveals potential interactions between the amine groups and iodine, such as N ⋅ ⋅ ⋅ I halogen bonding and N–H ⋅ ⋅ ⋅ I hydrogen bonding . These findings provide valuable insights for developing iodine adsorbents, offering promising solutions for protecting ecological and living environments.

Synthesis of a phosphomolybdic acid-modified AlPO4-5/SAPO-34 composite catalyst and its catalytic performance in the MTO reaction

Jinbo Zhu,Xu Chen,Xiangge Sang,Gang Yang

SAPO-34 catalysts with high selectivity for light olefins were first synthesized via the introduction of phosphomolybdic acid (HPMo) and AlPO 4 -5 zeolite into the initial gel. The physical and chemical characteristics of the synthesized catalysts were determined by a series of techniques and the catalytic performance of the modified composite zeolites for the methanol-to-olefin (MTO) reaction was investigated. The results indicated that HPMo-modified SAPO-34 was featured with more Brønsted acid sites, more mesopores, and a smaller crystal size, thereby demonstrating superior catalytic performance. The further combination with AlPO 4 -5 (16.7 wt%) prolonged the lifetime of the HPMo-modified SAPO-34, which is thought in this paper related to its 12-ring straight channel (0.7–0.8 nm) and the absence of any Brønsted acid sites. The MTO tests showed that the light olefins selectivity for the modified composite zeolites reached 95.1 %, while the catalyst lifetime remained at 445 min

Semirational engineering of Cytophaga hutchinsonii polyphosphate kinase for developing a cost-effective, robust, and efficient adenosine 5′-triphosphate regeneration system

Qi Shen,Shi-Jia Zhang,Bin-Hui Xu,Zhi-Yu Chen,Feng Peng,Neng Xiong,Ya-Ping Xue,Yu-Guo Zheng

Adsorption behavior of a tri-functionalized imprinted resin with high selectivity for 5-sulfosalicylic acid: Batch experiments and DFT calculation

Yue Sun,Yingpeng Gu,Yu Jiang

The presence of aromatic compounds with multiple functional groups such as 5-sulfosalicylic acid (SSA) in water bodies is a threat to aquatic organisms and human health. Phenol (PH) with the -OH group, benzoic acid with -COOH and benzenesulfonic acid (BSA) with -SO 3 H can be considered as SSA structural unit. In this study, three functional monomers , namely, N-methylallylamine, diallylamine, and triallylamine, with strong affinity for PH, BA, and BSA, respectively, were selected from 16 monomers by using density functional theory (DFT). Molecularly imprinted resin (MIP-4) with tri-functional groups and excellent selectivity for SSA was synthesized using a macroporous polystyrene resin (NDA-1800) as the carrier. In binary systems, MIP-4 exhibited excellent imprinting effect and adsorption selectivity for SSA. X-ray spectroscopy data and DFT calculations illustrated that the adsorption of SSA on MIP-4 was mainly dependent on the strong electrostatic interaction between the protonated amine group on the resin and -SO 3 - of SSA, as well as, the hydrogen bond between the neutral amine group and -OH and -COOH of SSA; the order of the three functional groups in identification was -OH > -COOH > -SO 3 H. In addition, the adsorption performance of MIP-4 was retained after five adsorption–desorption cycles.

MicroRNA‑9‑5p increases the sensitivity of colorectal cancer cells to 5‑fluorouracil by downregulating high mobility group A2 expression

Huizhe Zheng,Bin Yan,Qi Wu,Jingli Zhang

Chemotherapy drug 5‑fluorouracil (5‑FU) is the first‑line treatment for colorectal cancer (CRC); however, 5‑FU resistance decreases CRC therapeutic efficiency. A previous study revealed that microRNA (miR)‑9‑5p serves an antitumor effect in CRC. However, the effect of miR‑9‑5p in CRC chemoresistance remains unknown. In the present study, two CRC cell lines, including HT‑29 and HCT‑116 cells, were used to investigate the impact of miR‑9‑5p in overcoming 5‑FU resistance. The results revealed that treatment with 5‑FU decreased CRC cell viability and upregulated miR‑9‑5p expression in both CRC cells. Knockdown of miR‑9‑5p decreased HCT‑116 cell sensitivity to 5‑FU and inhibited apoptosis. By contrast, miR‑9‑5p overexpression enhanced the sensitivity of HT‑29 cells to 5‑FU and induced apoptosis. Additionally, it was confirmed that miR‑9‑5p directly targeted high mobility group A2 (HMGA2). HMGA2 overexpression reversed miR‑9‑5p‑induced HT‑29 apoptosis. The present study indicated that miR‑9‑5p enhanced the sensitivity of CRC cells to 5‑FU via downregulating HMGA2 expression.

Preparation of Sulfur-Modulated Nickel/Carbon Composites from Lignosulfonate for the Electrocatalytic Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid

Fanhao Kong,Min Wang

Electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) is a promising way to produce 2,5-furandicarboxylic acid (FDCA). Here, a flowerlike hybrid composed of sulfur-modulated metallic nickel nanoparticles coupled with carbon frameworks (S–Ni@C) is synthesized via two steps, achieving high selectivity and efficiency for HMF oxidation. Lignosulfonate, which is pulp waste, is used as a carbon and sulfur precursor. The optimized S–Ni@C electrode exhibits a nearly 100% conversion of HMF, 96% yield of FDCA, and 96% high faradaic efficiency. This work provides insights into the design and synthesis of electrocatalysts for biomass upgrading.

A core-shell structured Zn/SiO2@ZSM-5 catalyst: Preparation and enhanced catalytic properties in methane co-aromatization with propane

Guohao Xu,Xuedong Zhu

A core-shell structured Zn/SiO 2 @ZSM-5 catalyst was prepared by a hydrothermal coating method, and its physicochemical properties and catalytic performance in methane co-aromatization with propane were studied using a conventional solid catalyst (Zn/ZSM-5) as the comparison. Results revealed that methane was activated on Zn sites to form a large number of Zn methyl species and then incorporated during the aromatic formation process to promote the formation of aromatics. At a space velocity of 3600 mL g −1  h −1 and the reaction temperature of 550 ℃, the methane, propane conversion and the aromatics selectivity of Zn/SiO 2 @ZSM-5 catalyst were 7.9 %, 95.9 % and 88.1 %, respectively, which were higher than those of Zn/ZSM-5 catalyst by 2.8 %, 6.7 % and 6.8 %, respectively. The unique reaction pathway of core (Zn/SiO 2 , Zn sites)-shell (ZSM-5, acid sites) was mainly responsible for the superior performance in methane co-aromatization with propane. Meanwhile, the core-shell structured Zn/SiO 2 @ZSM-5 catalyst aroused the formation of distinct micro-macroporous system, which facilitated quick diffusion of desired products out of the intraframework channels and inhibited the formation of carbon deposits. These features of Zn/SiO 2 @ZSM-5 catalyst granted it superb diffusion ability and unique core-shell structure, which greatly enhanced the methane, propane conversion and aromatic selectivity together with a preeminent catalytic stability.

A Carbon Catalyst Co-Doped with P and N for Efficient and Selective Oxidation of 5-Hydroxymethylfurfural into 2,5-Diformylfuran

Huifa Zhang,James H. Clark,Tong Geng,Huixian Zhang,Fahai Cao

Graphical A new world for carbon : Phosphorus and nitrogen co-doped carbon (P−C−N) catalyst demonstrates a superb catalytic activity towards selective aerobic oxidation of 5-hydroxymethylfurfural (HMF) into 2,5-diformylfuran (DFF). A newly designed N and P co-doped carbon material has been developed to catalyze the conversion of 5-hydroxymethylfurfural (HMF) to 2,5-furandialdehyde (DFF) with unprecedented yield and selectivity and demonstrating a synergistic effect between the heteroatoms. The desired catalyst was first synthesized via a pyrolysis method using urea as the nitrogen and carbon source followed by calcination with phytic acid solution as the phosphorus source. The mass ratio of phytic acid to C 3 N 4 and calcination temperature were varied to investigate their effects on catalyst synthesis and microstructure as well as subsequent catalytic activity in simple reaction systems under oxygen. The effect of reaction conditions on the final HMF conversion and DFF selectivity were also investigated systematically. The P−C−N-5-800 catalyst obtained with the optimized annealing temperature of 800 °C and mass ratio of phytic acid/C 3 N 4 of 5 enabled a 99.5 % DFF yield at 120 °C for 9 h under 10 bar oxygen pressure, being the highest among any reported metal-free heterogeneous catalyst to date. The excellent performance of P−C−N-5-800 could be ascribed to the synergy between N and P heteroatoms as well as the high content of graphitic-N and the P−C species within the carbon structure. Reusability studies show that the P−C−N-5-800 catalyst was stable and reusable without deactivation. These results strongly suggest that P−C−N-5-800 is a promising catalyst for large-scale production of DFF in a green manner.

Switchable (pH driven) aqueous two-phase systems formed by deep eutectic solvents as integrated platforms for production-separation 5-HMF

Xiaojie Yu,Mo Li,Abu ElGasim A. Yagoub,Li Chen,Cunshan Zhou,Dong Yan

The function to induce dynamic-phase shifts between mono/biphasic systems is crucial to separation processes. Switchable (pH driven) ATPS composed of DESs and salts are here disclosed to act as integrated platforms for the production-separation processes. The catalytic carbohydrate conversion to 5-hydroxymethylfurfural (5HMF) was conducted in a homogeneous acidic aqueous-DES medium. Then, the formation of the biphasic region was induced by tailoring the pH of the aqueous homogeneous medium, leading to the complete separation of 5-HMF from the carbohydrate. Herein, the effects of the phase-forming DES species (composed of ethanol/n-propanol and [N 4444 ]Cl), the K 3 C 6 H 5 O 7 concentration and pH on the distribution of 5-HMF and fructose in DES-ATPSs were investigated. The optimal composition of the DES-ATPS system was 30 wt% [N 4444 ]Cl:ethanol (1:2) or [N 4444 ]Cl:n-propanol (1:2) and 35 and 40 wt% K 3 C 6 H 5 O 7 , respectively. The results showed that the integrated platforms have good catalytic effect, and the conversion rate of fructose reached 87.21%, with a 5-HMF yield of 46.76% and 0.1 g of apple peel produced 15.43 mg 5-HMF. The extraction efficiency of the DES-ATPS composed of [N 4444 ]Cl:ethanol (1:2) and [N 4444 ]Cl:n-propanol (1:2) were the highest within 20 min (5-HMF extraction efficiency 98.53% and 98.59%, respectively), which has economic benefits and comprehensiveness.