BMC Oral Health
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2025
·Vol. 25
·期 1
·1-16
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IF 3.1
Li Congcong,Zhao Li,Chen Xiaotao,Aierken Aikepaer,Yu Min,Kong Chuifan,Baheti Wufanbieke
Background Pure titanium and titanium alloy implants have been widely utilized in dental implantology due to their excellent biocompatibility and favorable elastic modulus. However, the inherent bioinertness of titanium-based implant surfaces often results in suboptimal osseointegration with surrounding bone tissue. Consequently, surface modification is essential to enhance the osseointegrative capacity of titanium implants. Methods We fabricated hydroxyapatite-graphene oxide (HA-GO) coatings via electrochemical deposition and systematically compared four distinct protein loading methods. Ultimately, we developed a hydroxyapatite-graphene oxide/interleukin-4 (Ti@HA-GO@IL-4) coating on pure titanium substrates to investigate its physicochemical properties and biocompatibility. Results The composite coating was successfully fabricated on pure titanium substrates, inducing significant surface modifications including the incorporation of bioactive functional groups, enhanced hydrophilicity, and altered surface morphology. Comparative characterization revealed that the composite coating exhibited superior hydrophilic properties, improved mechanical compatibility with bone tissue, stable Interleukin-4 (IL-4) adsorption and sustained-release behavior, as well as excellent biosafety confirmed by proliferation and adhesion assays using mouse embryo osteoblast precursor (MC3T3-E1) cells, when compared to unmodified titanium controls. Conclusions Ti@HA-GO@IL-4 represents a composite coating material with exceptional physicochemical properties and biological performance. This material demonstrates efficient IL-4 loading capacity and sustained release characteristics, thereby effectively promoting osteogenesis. These findings provide valuable insights for developing bioactive functional materials to enhance implant osseointegration.
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MOLECULAR NEUROBIOLOGY
·
2025
·Vol. 63
·期 1
·39
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IF 4.3
Hu Yingying,Qian Rengcheng,He Yifeng,Gao Qiqi,Wang Xun,Lin Huilin,Lin Wei,Fang Yu,Zhu Jianghu,Wang Xingyun,Nan Yan,Lin Zhenlang
Neonatal hypoxic-ischemic brain damage (HIBD) is a devastating disease for which no treatments that effectively mitigate severe neurological consequences exist. Recent studies have shown that costunolide (COS), a well-known bioactive sesquiterpene lactone, possesses potent anti-inflammatory and neuroprotective properties, but its efficacy in the context of HIBD remains unclear. Here, we investigated the neuroprotective effects of COS in both in vivo and in vitro models of hypoxic-ischemic (HI) brain injury. In vivo, we found that COS intervention following a HI event dramatically reduced the brain infarction volume, ameliorated the inflammatory response, promoted histological recovery, and improved the prognosis. To explore the underlying molecular mechanisms, we performed an in vitro study and reported that COS protected PC12 cells from oxygen‒glucose deprivation (OGD) insult by reducing the levels of inflammatory mediators. Furthermore, COS activated the PI3K/AKT signaling pathway to suppress NF-κB and inflammation. In contrast, the PI3K inhibitor LY294002 reversed these therapeutic benefits. Our findings reveal that COS is a promising neuroprotective agent and could be used to treat HIBD and other related brain injuries.
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JOURNAL OF MATERIALS SCIENCE
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2025
·Vol. 60
·期 47
·24439-24453
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IF 3.9
Wang Yabo,Duan Xiaohui,Wei Yiguo,Du Gangfeng,Tian Zhengshan,Bai Suzhen,Pan Zihong,Bai Ruibing
An efficient Ag 2 WO 4 /BiFeO 3 heterojunction was successfully synthesized using a facile hydrothermal and in situ precipitation method. A comprehensive investigation was conducted into the morphological, structural, and optical properties of the Ag 2 WO 4 /BiFeO 3 heterojunction. The optimally synthesized Ag 2 WO 4 /BiFeO 3 heterojunction demonstrated an impressive removal efficiency toward Lanasol Red 5B (95.62%) within 100 min under simulated solar irradiation, which was 5.18-fold higher than pristine BiFeO 3 . The engineered heterojunction effectively optimized the electron transfer pathway, significantly enhancing the separation efficiency of photogenerated electrons and holes. A notable selectivity of the Ag₂WO₄/BiFeO₃ heterostructure was observed in the photocatalytic degradation of organic dyes under simulated solar irradiation. The removal efficiencies followed the order: Lanasol Red 5B (95.62%) > Congo red (50.47%) > Methyl red (47.16%) > Safranin T (22.22%) > Rhodamine B (8.07%) > Methyl orange (3.04%). Furthermore, active species trapping experiments confirmed that holes and superoxide radicals were the predominant reactive species driving the photocatalytic process. This simple synthesis method opens up new possibilities for developing efficient BiFeO 3 -based photocatalysts for environmental remediation purposes.
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Science China-Chemistry
·
2025
·
IF 9.7
Li Ran,Yin Hang,Jing Wen-Kai,Cheng Jia-Lin,Qin Xue-Rong,Lu Tong-Bu,Wang Hong-Juan,Yu Zi-You
As important catalysts for C–C coupling, copper-based materials have great potential for electrocatalytic reduction of CO 2 to C 2+ products. In this work, Cu 2 O catalysts modified with different lanthanide hydroxides were successfully synthesized and used for CO 2 electroreduction. The results showed that compared with Cu 2 O/Gd(OH) 3 and Cu 2 O/Yb(OH) 3 catalysts, Cu 2 O/La(OH) 3 exhibited the highest electrocatalytic performance for CO 2 reduction. This catalyst was able to maintain a high Faraday efficiency for C 2+ products ( \({\rm FE}_{{\rm C}_{2+}}\) ) of about 60% within the current density range of 400–800 mA cm −2 . The highest \({\rm FE}_{{\rm C}_{2+}}\) reached 66% at 600 mA cm −2 and the partial current density for C 2+ products reached a maximum of 488 mA cm −2 . Meanwhile, the catalyst could run stably for 40 h with a remained \({\rm FE}_{{\rm C}_{2+}}\) of about 60%. Multiple characterizations reveal that the introduction of La(OH) 3 promotes the formation of *CO intermediates, and also helps to stabilize the Cu(I) species in Cu 2 O under cathodic potentials, thus facilitating the C–C coupling for C 2+ production. This work provides a new strategy to enhance the C 2+ production via stabilizing Cu(I).
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Journal of Analysis and Testing
·
2025
·
IF 7
Chen Jiajing,Lin Juan,Ouyang Dan,Lin Zian
Metabolomics, based on laser desorption/ionization mass spectrometry (LDI-MS), has been successfully utilized for the high-throughput metabolic analysis of biofluids. This technique shows great promises as a powerful tool for disease screening. Although various nanomaterials have been developed as alternatives to traditional organic matrices in LDI-MS, the signals of most metabolites are limited due to their low abundance in complex biofluids. Herein, four hydroxyl-functionalized covalent organic frameworks (COFs) were designed as substrates for LDI-MS, named COF-OH- n ( n = 0–3, demonstrating the number of hydroxyl units). Since hydroxyl groups can facilitate proton transfer and promote the ionization process effectively, hydroxyl-rich COF-OH-2 enabled sensitive and efficient LDI-MS analysis of serum directly, resulting in highly reproducible serum metabolic profiles (SMPs). An orthogonal partial least squares discriminant analysis (OPLS-DA) model was successfully used to distinguish 30 gout patients from 38 healthy volunteers, with an area under the curve (AUC) of 0.974. Furthermore, the roles of 12 biomarker candidates, which were characterised following statistical analysis, in the metabolic pathway of gout were initially explored. Furthermore, the roles of 12 biomarker candidates, which were characterized following statistical analysis, in the metabolic pathway of gout were initially explored. This work demonstrates the potential of COF-OH-2-assisted LDI-MS in clinical metabolic analysis and offers a rational design strategy for advanced LDI-MS substrates.
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Nature Communications
·
2025
·Vol. 16
·期 1
·10680
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IF 15.7
Xie Wenhao,Deng Quanzheng,Wu Jibiao,Li Fangsen,Dan Wenyan,Wang Xuefeng,Han Lu,Gu Hongbo
Semiconducting polymers are crucial in flexible and wearable intelligent organic electronic devices. However, their crystallization remains a significant challenge because the crystallization kinetics is limited by the rigid conjugation structure and strong intermolecular π - π stacking. This leads to energetic disorder in electronic structure and poor charge transport, which severely hinders electrical performances of devices. Herein, we report highly oriented semiconducting polymers with enhanced crystallinity prepared by low-temperature plasma-driven evaporation process, during which polymer chains cross the energy barrier and crystallization kinetic for approaching torsion-free conformations. This material possesses an extended intrachain conjugation, ordered interchain stacking, high crystallinity and narrowed density of states contribution, which causes the extraordinary electrical response to stimulations with the emphatic Seebeck coefficient and power factor 1017% and 8295% times those of spin-coated film, respectively.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
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IF 15.7
Lyu Xiaolin,Yu Kun,Zhang Haoqi,Zhou Piaopiao,Shen Zhihao,Zou Zhigang
Ion-conductive materials have received much attention because of their good mechanical and electrical properties. However, their practical applications are still hampered by limited toughness and crack resistance, stemming from the restricted size of energy dissipation zones, which impacts their reliability and durability. Herein, tough fiber-reinforced composite ionogels (FRCIs) with crack resistance are fabricated by incorporating high-performance fibers into elastic ionogels to efficiently dissipate energy. The FRCIs exhibit good tearing toughness, high strength, high elastic modulus, and low bending modulus. The toughness and crack resistance of the FRCI far exceed that of previously reported gel materials, even outperforming metals and alloys. Furthermore, the electrical resistance of FRCI shows high sensitivity to deformation. Moreover, it remains undamaged after undergoing 10,000 bending cycles when fixing the artificial bone, and possesses self-sensing impact resistance, demonstrating great potential in intelligent robots and smart protective equipment.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
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IF 15.7
Chen Ronghua,Li Chaozheng,Zhao Di,Yang Guili,Zeng Lingda,Lin Fei,Xu Hanhong
Controlling weeds before their emergence is crucial for minimizing their impacts on crop yield and quality. Bipyridyl herbicides (BPyHs), a class of highly effective and broad-spectrum herbicides, cannot be used as pre-emergence herbicides because they can be absorbed and inactivated by negatively charged soil after application. Here, we design and fabricate an adsorbed-but-active supramolecular pre-emergence herbicide consisting of cationic polyacrylamide and bipyridyl herbicides (CPAM-BPyHs). CPAM is a positively charged polymer. It can preferentially bind to soil particles and shift their electric potential to a more positive value. Thus, it prevents not only runoff but also inactivation of BPyHs. We also develop a BPyHs-resistant rice line by mutation of the gene encoding L-type amino acid transporter 5 ( OsLAT5 ). Field trial results show that the weed control efficiency of CPAM-diquat for direct-seeded herbicide-resistant rice line exceeds 90%. The herbicidal activity can maintain up to one month with only one application. This work offers a method for rice weed control and provides insights into the design of pesticides to prevent soil inactivation and runoff.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-12
·
IF 17.694
Wang Sihong,Jiang Qu,Ju Shenghong,Hsu Chia-Shuo,Chen Hao Ming,Zhang Di,Song Fang
Unraveling the precise location and nature of active sites is of paramount significance for the understanding of the catalytic mechanism and the rational design of efficient electrocatalysts. Here, we use well-defined crystalline cobalt oxyhydroxides CoOOH nanorods and nanosheets as model catalysts to investigate the geometric catalytic active sites. The morphology-dependent analysis reveals a ~50 times higher specific activity of CoOOH nanorods than that of CoOOH nanosheets. Furthermore, we disclose a linear correlation of catalytic activities with their lateral surface areas, suggesting that the active sites are exclusively located at lateral facets rather than basal facets. Theoretical calculations show that the coordinatively unsaturated cobalt sites of lateral facets upshift the O 2p -band center closer to the Fermi level, thereby enhancing the covalency of Co-O bonds to yield the reactivity. This work elucidates the geometrical catalytic active sites and enlightens the design strategy of surface engineering for efficient OER catalysts.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2015
·Vol. 13
·期 1
·1-10
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IF 4.115
Chen Jun,Yang Xiao-Quan,Qin Meng-Yao,Zhang Xiao-Shuai,Xuan Yang,Zhao Yuan-Di
Background X-ray computed tomography (CT) imaging can be used to reveal the three-dimensional structure of deep tissue with high spatial resolution. However, it cannot reveal molecular or cellular changes, and has great limitations in terms of specificity and sensitivity. Fluorescence imaging technology is one of the main methods used for the study of molecular events in vivo and has important applications in life science research. Therefore, the combination of CT and fluorescence imaging is an ideal dual-modal molecular imaging method, which can provide data on both molecular function and tissue structure, and has important research value. In a previous study, Bi2S3 nanoparticles were wrapped with quantum dots in SiO2 to generate CT and fluorescence imaging. However, this type of probe led to low survival and caused innegligible in vivo toxicity in mice. Therefore, it is necessary to develop new multifunctional probes that demonstrate biocompatibility and safety in vivo.Methods A polyethylene glycol-phospholipid bilayer structure was used to synthesize hybrid clusters containing hydrophobic Bi2S3 nanoparticles and quantum dots for combined CT/fluorescence imaging. Mean particle size, polydispersity index, and zeta potential were used to study the stability over an 8-week test period. In vivo CT and fluorescence imaging experiments were performed, and the in vivo safety of the probe was evaluated, using histopathological, biochemical, and blood analyses.Results The probe distinctly enhanced the CT contrast and had fluorescence imaging capability. In addition, the nanocomposite hybrid clusters showed a longer circulation time (>4 h) than iobitridol. The results also showed that the Bi2S3-QD@DSPE probe had good biocompatibility and safety, and did not affect normal organ functioning.Conclusion sBi2S3-QD@DSPE hybrid clusters exhibited remarkable performance in CT angiography and fluorescence imaging in vivo.
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JOURNAL OF MOLECULAR MEDICINE-JMM
·
2024
·
IF 4.8
Wang Pengtao,Tao Wei,Li Qiujie,Ma Wanting,Jia Wei,Kang Yuting
Indole-3-aldehyde (I3A) is an intestinal microbial metabolite that regulates inflammation in various inflammatory diseases; however, its role in chronic obstructive pulmonary disease (COPD) remains unclear. This study aimed to investigate the anti-inflammatory effects and molecular mechanisms of I3A in COPD. We constructed in vivo models using cigarette smoke (CS)-stimulated mice and in vitro models using cigarette smoke extract (CSE)-stimulated MH-S cells. The results demonstrated that I3A significantly alleviated bronchial obstruction in mice with COPD and reduced the expression of inflammatory factors such as TNF-α, IL-1β, and IL-6. Additionally, I3A decreased the levels of matrix metalloproteinases MMP2, MMP12, and inhibited the NF-κB p65/NLRP3 pathways. Further investigation revealed that I3A inhibited NF-κB activity by suppressing p65 phosphorylation and nuclear translocation in CSE-stimulated MH-S cells. The activation of the NF-κB and NLRP3 signaling pathways is mediated by histone deacetylase 5 (HDAC5) and HDAC6, both of which are inhibited by I3A. Subsequent experiments indicated that aryl hydrocarbon receptor (AHR) knockdown attenuated the inhibitory effect of I3A on pro-inflammatory cytokines and the HDACs/NF-κB/NLRP3 signaling pathways, highlighting the dependence of I3A's anti-inflammatory effects on the AHR receptor. Key messages
I3A effectively reduced lung inflammation in COPD mice by inhibiting the NF-κB pathway.
In CSE-stimulated MH-S cells, I3A suppressed p65 phosphorylation and nuclear translocation, thereby inhibiting NF-κB activity.
The activation of the NF-κB/NLRP3 pathways by HDAC5 and HDAC6 was diminished by I3A.
Through the activation of the AHR receptor, I3A suppressed the activities of HDAC5/6, leading to a decrease in inflammatory factor levels.
Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Zhou Xing,Chang Chia-Yu,Yu Dongfang,Zhang Kai,Li Zhi,Jiang Shi-Kai,Zhu Yizhou,Xia Yongyao,Hwang Bing Joe,Wang Yonggang
The application of high-voltage positive electrode materials in sulfide all-solid-state lithium batteries is hindered by the limited oxidation potential of sulfide-based solid-state electrolytes (SSEs). Consequently, surface coating on positive electrode materials is widely applied to alleviate detrimental interfacial reactions. However, most coating layers also react with sulfide-based SSEs, generating electronic conductors and causing gradual interface degradation and capacity fading. To address this, we propose a Li 2 ZrF 6 coating layer on LiCoO 2 , which exhibits minimal reaction with SSEs, and its decomposition products are electron-conductive-free. Furthermore, this coating layer also efficiently mitigates the layered-to-spinel/rock-salt surface structural transformation in LiCoO 2 . As a result, the In-Li|Li 6 PS 5 Cl | Li 2 ZrF 6 -LiCoO 2 all-solid-state cell demonstrates an initial areal capacity of 5.2 mAh cm −2 and a capacity retention of 80.5% after 1500 cycles at 70 mA/g with high LiCoO 2 areal mass loading (30.19 mg cm −2 ) and a cut-off voltage of 3.9 V (corresponding to potential of 4.5 V versus Li + /Li), at 25 °C.
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