CELL PROLIFERATION
·
2021
·Vol. 55
·期 1
·e13173
·
IF 6.831
Jinping Huang,Xiao Sheng,Zhangpeng Zhuo,Danqing Xiao,Kun Wu,Gang Wan,Haiyang Chen
Objectives Adult stem cells uphold a delicate balance between quiescent and active states, which is crucial for tissue homeostasis. Whereas many signalling pathways that regulate epithelial stem cells have been reported, many regulators remain unidentified. Materials and Methods Flies were used to generate tissue-specific gene knockdown and gene knockout. qRT-PCR was used to assess the relative mRNA levels. Immunofluorescence was used to determine protein localization and expression patterns. Clonal analyses were used to observe the phenotype. RNA-seq was used to screen downstream mechanisms. Results Here, we report a member of the chloride channel family, ClC - c , which is specifically expressed in Drosophila intestinal stem/progenitor cells and regulates intestinal stem cell (ISC) proliferation under physiological conditions and upon tissue damage. Mechanistically, we found that the ISC loss induced by the depletion of ClC - c in intestinal stem/progenitor cells is due to inhibition of the EGFR signalling pathway. Conclusion Our findings reveal an ISC-specific function of ClC - c in regulating stem cell maintenance and proliferation, thereby providing new insights into the functional links among the chloride channel family, ISC proliferation and tissue homeostasis.
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DOI
PubMed
高影响因子
Journal of Integrative Plant Biology
·
2019
·Vol. 62
·期 8
·1080-1092
·
IF 3.824
Danyun Xu,Qing Liu,Gang Chen,Zhiqiang Yan,Honghong Hu
Flowering time regulation is one of the most important processes in the whole life of flowering plants and FLOWERING LOCUS C ( FLC ) is a central repressor of flowering time. However, whether metabolic acetate level affects flowering time is unknown. Here we report that ALDEHYDE DEHYDROGENASE ALDH3F1 plays essential roles in floral transition via FLC -dependent pathway. In the aldh3f1-1 mutant, the flowering time was significant earlier than Col-0 and the FLC expression level was reduced. ALDH3F1 had aldehyde dehydrogenase activity to affect the acetate level in plants, and the amino acids of E214 and C252 are essential for its catalytic activity. Moreover, aldh3f1 mutation reduced acetate level and the total acetylation on histone H3. The H3K9Ac level on FLC locus was decreased in aldh3f1-1 , which reduced FLC expression. Expression of ALDH3F1 could rescue the decreased H3K9Ac level on FLC, FLC expression and also the early-flowering phenotype of aldh3f1-1 , however ALDH3F1 E214A or ALDH3F1 C252A could not. Our findings demonstrate that ALDH3F1 participates in flowering time regulation through modulating the supply of acetate for acetyl-CoA, which functions as histone acetylation donor to modulate H3K9Ac on FLC locus.
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DOI
PubMed
高影响因子
Nanoscale
·
2014
·Vol. 6
·期 21
·12532-12539
·
IF 6.739
Xuejiao Feng,Jun Yang,Yitian Bie,Jiulin Wang,Yanna Nuli,Wei Lu
Nano/micro-structured pSi and pSi/CNT particles were synthesized from nano-SiO2 as both a template and silicon precursor via a combination of spray drying and magnesiothermic reduction, followed by a nano-layer carbon coating by chemical vapor deposition to obtain a nano/micro-structured pSi/C and pSi/CNT/C composite. In the hierarchical microstructure of the pSi/CNT/C composite, Si nanoparticles less than 20 nm in size were homogenously dispersed in an electronically conductive and porous network of multiwall carbon nanotubes, which can accommodate the volume changes in Si and improve the structural and conductive stability during repeated cycles leading to excellent electrochemical performance. The pSi/CNT/C presented reversible capacities of ca. 2100 mA h g−1 at 1 A g−1 and ca. 1370 mA h g−1 at a high current rate of 5 A g−1. Its capacity retention after 100 cycles was 95.5% at 1 A g−1.
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DOI
PubMed
高影响因子
Algal Research-Biomass Biofuels and Bioproducts
·
2021
·
IF 4.401
Minxi Wan,Haoyu Zhao,Jiacai Guo,Lulu Yan,Daojing Zhang,Wenmin Bai,Yuanguang Li
C-phycocyanin is a natural blue-colored biliprotein with various biological activities. Commercial C-phycocyanin from Spirulina platensis has poor stability, which severely limits its application in food, medicine, cosmetics, and other industries. Extremophilic red algae Galdieria sulphuraria is found in hot springs with a pH of 1–3 and temperature above 40 °C. Hence, C-phycocyanin from G. sulphuraria has the potential to withstand high temperatures. This study aimed to compare the stability of C-phycocyanins from G. sulphuraria and S. platensis under different pH, temperature, stabilizer concentration, and light conditions. The results showed that C-phycocyanin from G. sulphuraria was more stable than that from S. platensis under all conditions, especially in the range of 50–65 °C, and in neutral environment of pH 7. After 30 min incubation at 60 °C and pH 7, the color preservation rate of C-phycocyanins from G. sulphuraria and S. platensis were 86.66% and 60.83%, respectively. The kinetic analysis revealed that under the influence of the stabilizer, the stabilities of both phycocyanins were improved. However, C-phycocyanin from G. sulphuraria obtained the highest mid-unfolding temperature of 73.00 °C compared with 69.81 °C for that of C-phycocyanin from S. platensis . In addition, the antioxidant capacity of two phycocyanins was similar. Therefore, C-phycocyanin from G. sulphuraria is an excellent alternative to the current commercial C-phycocyanin.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Yang Liu,Zhuo Chen,Wenhan Xie,Feng Qiu,Yang Zhang,Shaokun Song,Chuanxi Xiong,Lijie Dong
Microwave absorbers with broadband absorption and lightweight features are highly desirable in electromagnetic interference and pollution treatment. Here, porous and hollow CoNi@C (CNC) microspheres derived from metal-organic frameworks (MOFs) are fabricated by a facile solvothermal route and subsequent annealing process. The morphology, structure, microwave absorption properties and their internal relationship are systematically investigated. For the porous and hollow CNC microspheres, the minimum RL can reach −44.8 dB at 10.7 GHz and the ultra-wide effective absorption bandwidth can reach up to 13.3 GHz (4.7–18.0 GHz) within the thickness of 1.6–4.0 mm. The CNC microspheres exhibit superior microwave absorption performance, attributing to the improved impedance matching and attenuation ability. The hollow structure, interfacial polarization, the synergistic effect between CoNi alloy and graphitized carbon simultaneously account for the microwave absorption mechanisms. Therefore, the present work provides the promising options on the design and preparation of lightweight and high-efficient microwave absorber with tunable component and specific morphology.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Wenyu Wang,Yu Feng,Shuaiguo Zhang,Miao Wang,Wei Song,Luchao Yue,Mingzheng Ge,Jie Mi
Premixed flame configuration is considered as an effective method for the synthesis of carbon materials. In this work, flexible single-walled carbon nanotube network decorated by carbon-encapsulated Fe 2 O 3 nanoparticles (C@Fe 2 O 3 /SWCNT) membrane was in-situ fabricated via a facile floating catalyst premixed ethanol flame method, and followed by annealing treatment. In this process, low-cost ethanol and ferrocene were used as carbon source and catalyst precursor for the synthesis of C@Fe 2 O 3 /SWCNT, respectively. Benefiting from the interconnected conductive network, the as-fabricated C@Fe 2 O 3 /SWCNT membrane was used as a free-standing anode for lithium-ion batteries. Structural characterization revealed that the ultrafine Fe 2 O 3 nanoparticles homogeneously anchored on the SWCNT network, which facilitates the fast diffusion for electron. Furthermore, the carbon layers uniformly enwrap on Fe 2 O 3 can effectively suppress the aggregation and buffer the volume change of Fe 2 O 3 during the lithiation/delithiation process. Consequently, this material delivered an excellent lithium storage performance with a high reversible capacity of 1294.7 mAh g −1 at 50 mA g −1 , and an excellent cyclability of 82.5% retention is obtained after cycles at 2 A g −1 . This study provides a novel low-cost and fast method for preparing flexible advanced electrode for next-generation rechargeable batteries.
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高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Shuangze Yang,Zhimin Zou,Chunhai Jiang
Manganese monoxide (MnO) has been widely studied as a potential anode material of Li-ion batteries because of its high specific capacity and abundant raw materials. However, the poor cycling stability of MnO associating to its large volume change during the repeated conversion reaction with Li + has restricted its practical applications. Herein, ternary MnO/MnTiO 3 @C composite anode materials are prepared by in situ capturing TiO 2 nanoparticles into sea urchin-like MnO 2 in a mild hydrothermal reaction , followed by resorcinol-formaldehyde (RF) resin coating and thermal treatment. With the strong stabilization effect of the MnTiO 3 component, the optimized ternary MnO/MnTiO 3 @C composite anode exhibits greatly enhanced cycling performance as compared to MnO@C. A reversible capacity of 383 mAh g −1 is preserved after 500 cycles at 1000 mA g −1 . This improved cycle performance can be originated from the stable TiO crystals and the highly reversible amorphous Li x MnTiO 3 phase generated in the first lithiation process. The reasonably high specific capacity and robust cycle stability enable the ternary MnO/MnTiO 3 @C composites to be promising alternative anode materials to graphite for Li-ion batteries.
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高影响因子
JOURNAL OF POWER SOURCES
·
2022
·
IF 9.794
Zhaoyu Zhang,Yufei Zhang,Minghui Ye,Yongchao Tang,Xiaoqing Liu,Cheng Chao Li
SiO x /C composites are highly potential anode alternatives for next-generation lithium-ion batteries (LIBs) owing to their low cost and high theoretical capacity. However, the sluggish lithium-ion diffusion kinetics severely limit their practical capacity and rate performance. Herein, a high-capacity and high-rate anode based on commercial SiO x /C is facilely achieved by in situ constructing a Li + conductive interphase (LCI) to simultaneously boost the transport efficacy of Li + ions and buffer the volume expansion. The as-designed, LCI-protected SiO x /C anode delivers an exceptionally high capacity of 1420.9 mAh g −1 at 0.2 A g −1 , excellent rate performance (91.4% capacity retention from 0.2 A g −1 to 1 A g −1 ) and long cycling stability, substantially outstripping the pristine SiO x /C counterpart and most recently reported Si-based electrodes. More importantly, taking advantages of the fast and stable lithiation/delithiation processes, this electrode can also be adapted to further applications at large current densities (766.44 mAh g −1 at 5 A g −1 ) or high mass loadings (5.02 mAh cm −2 at 0.1 A g −1 , ∼3.5 mg cm −2 ). A full battery with satisfactory electrochemical performance is also demonstrated. The strategy of building ion conductive interphase to subtly tailor the transport behavior of Li + ions is anticipated to unlock the practical deployment of Si-based LIBs.
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高影响因子
Reaction Chemistry & Engineering
·
2020
·Vol. 5
·期 5
·886-895
·
IF 3.441
Xing-Gang Si,Yun-Peng Zhao,Qing-Lu Song,Jing-Pei Cao,Rui-Yu Wang,Xian-Yong Wei
A highly efficient Ni/N–C catalyst was synthesized by facile pyrolysis of a Ni-containing metal–organic framework (Ni-MOF), and its catalytic hydrogenolysis performance towards C–O bonds in lignin was evaluated in detail using diphenyl ether (DPE) as a model compound. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses show that the flower-like nanosheets of the Ni-MOF shrink, forming a loose and ordered spherical structure during pyrolysis. Under the optimal conditions, DPE was completely converted and the selectivity to monomers (benzene, cyclohexanol and cyclohexane) reached 99.1%. During the catalytic hydrogenolysis conversion (CHC) of DPE, the direct cleavage of the Caromatic–O bond affording benzene and phenol is the major reaction pathway, and a low H2 pressure is crucial to increase the monomer selectivity. Furthermore, Ni/N–C-450 shows high hydrogenolysis activity for other lignin-derived aryl ethers, such as benzyl phenyl ether, dibenzyl ether, dinaphthalene ether, benzyl 2-naphthyl ether and 3-methoxyphenol.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yishu Qiu,Zheng Hu,Hui Li,Qianqian Ren,Yanan Chen,Shi Hu
The commercial catalysts for oxygen reduction reaction (ORR) are highly dependent on the scarce and expensive Pt to achieve high activity and reasonable durability, especially for the fuel cells used in automobiles. Ag alloys have been proposed as promising candidates for non-Pt ORR catalysts in alkaline media, with reasonably high activity at significantly lower cost. Herein we demonstrate the synthesis of Ag/Co/C hybrid electrocatalyst for ORR via radiative flash Joule heating. Unlike the previously reported solid-solution structure of the quenched immiscible alloys by flash Joule heating, the large immiscibility gap in the liquid state of the Ag-Co alloy prevents the formation of solid solution. The hybrid catalyst exhibits a specific activity 40 times and a mass activity 52 times higher than that of the pristine Ag/C at 0.8 V vs. RHE in alkaline media, and its tolerance to methanol and ethanol is superior to that of commercial Pt/C. The enhanced activity and good stability are attributed to the enhanced oxygen adsorption energy on silver due to the strong interaction between silver and cobalt.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Mingqian Wang,Ying Liang,Zhicheng Zhang,Guohong Ren,Yajun Liu,Shishan Wu,Jian Shen
Novel multifunctional core-shell nanoparticles (NPs) have attracted widespread attention due to their easy-to-modify surface properties and abundant functional groups. This study introduces a facile approach to synthesize Ag@ iron oxide (Fe 3 O 4 ) @C NPs, and modify with amino-poly (ethylene glycol) (PEG)-carboxyl and folate (FA) on the exposed carbon surface to produce high contrast for excellent stability, good biocompatibility, cancer cell targeting, and synergistic treatment. The multi-armed PEG at the edge of Ag@Fe 3 O 4 @C NPs provides the materials an excellent capacity for doxorubicin (DOX) loading. The carbon layer could be used as a photothermal reagent due to its excellent near-infrared (NIR) absorbance capacity, and Fe 3 O 4 was used as a reagent for magnetic resonance (MR) imaging. In vivo combination therapy with this agent was administered in a mouse tumor model, and a remarkable synergistic antitumor effect that is superior to that obtained by monotherapy was achieved. Concerning these features together, these unique multifunctional Ag@Fe 3 O 4 @C-PEG-FA/DOX NPs could be regarded as an attractive nanoplatforms for chemo-photothermal synergistic tumor therapy with dual-modal fluorescence and MR imaging-guided targeting.
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DOI
PubMed
高影响因子
CORROSION SCIENCE
·
2021
·
IF 7.205
Lu Zhu,Xuanru Ren,Guochao Wang,Xueqin Kang,Ping Zhang,Xiaohong Wang,Peizhong Feng
Spark Plasma Sintering technique was applied to fabricate MoSi 2 and MoSi 2 -bentonite coatings on molybdenum. The phase composition, morphologies and anti-oxidation properties of the coatings at 1500 °C were investigated. Penetrated cracks generated in MoSi 2 coating after SPS while the composite coating was crack-free because of the reduction of CTE mismatch. Cracks existed in the silica layer of MoSi 2 coating after oxidation while the silica layer of bentonite-containing coating showed dense and crack-free morphologies. Compared with MoSi 2 , the composite coating possessed thinner Mo 5 Si 3 diffusion layer and silica layer, exhibiting less loss of substrate and coating with improved oxidation resistance.
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高影响因子
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