MATERIALS & DESIGN
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2026
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IF 7.9
Minghui Cui,Yu Liu,Guohui Tian,Junyi Zhou,Fenglong Li,Xiaolin Wang,Jing Chen,Haiming Chen,Jin Zhu,Jing Chen
Conventional polyurethanes for implants suffer from hydrolytic/oxidative degradation due to ester/ether bonds. To overcome this, in this research, we have developed aging-resistant implantable medical polyurethanes to address the issue of their limited durability. The synthesis involves ethanethiol for the click reaction-mediated elimination of the C C in terminal hydroxy polybutadiene (HTPB), resulting in the creation of HTPB-SH. Subsequently, an aging-resistant implantable polyurethane, HTPB-SH-PU, is synthesized. This material demonstrates not only remarkable thermal stability (T d5% >290°C) but also superior mechanical performance, evidenced by a tensile strength of 35.1 MPa and an elongation at break of 196.74%. Moreover, HTPB-SH-PU is exhibiting outstanding aging resistance. In a hydrolysis aging test, it retains 71% of its tensile strength after 35 days, with negligible yellowing. To enhance biocompatibility, gastrodin is incorporated at various concentrations (0%, 0.5%, 1.0%, 2.0%), and the modified polyurethanes display excellent cytocompatibility, haemocompatibility, and histocompatibility. Therefore, the HTPB-SH-PU series represents a promising candidate for implantable medical devices such as pacemakers and artificial blood vessels, offering a solid theoretical foundation and material options for future research and development in medical polymers.
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Journal of Future Foods
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2026
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IF 7.2
Bingkun Bao,Ying He,Jufang Li,Xiangyu Li,Hao Shi,Jinkuan Chen,Jinhan Zhao,Koukou Duan,Hongyu Zhang,Qinggang Xie,Jane Shearer,Zhigang Liu,Yongbo She
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder primarily characterized by social deficits and repetitive behaviors. 2’-Fucosyllactose (2’-FL) and Lacto-N-neotetraose (LNnT), the two human milk oligosaccharides (HMOs) approved for infant formulas in China, have exerted potentials to modulate gut microbiota, immune system, and cognitive function. Yet the exact mechanism underpinning the etiology of HMOs on improving neurodevelopment and particularly the ASD-related cognitive impairments remain unclear. In this study, mouse model of ASD was established via maternal immune activation (MIA), specifically by introducing polyinosinic:polycytidylic acid (poly(I:C)) to pregnant mice. Male offspring were selected and received either an individual (2’-FL or LNnT) or a combination (2’-FL+LNnT) interventions for 6 weeks. As expected, ASD mice exhibited significant social deficits and repetitive stereotyped behaviors, accompanied by neuroinflammation and decreased expression of BDNF, and morphological changes in cortex as well as hippocampal area. Regardless of the type of sources, HMOs ameliorated ASD-like behaviors in ASD mice, attenuated neuroinflammatory responses, and elevated BDNF expression. Additionally, the HMOs alleviated intestinal inflammation, enhanced gut barrier, and modulated the gut microbiota structure by upregulating the abundance of beneficial bacteria ( Akkermansia, Lactobacillus , and Butyricicoccus ). Notably, the combination of two HMOs also promoted the production of short-chain fatty acids (SCFAs). In addition, flow cytometry analysis showed a significant increase in the regulatory T cell (Treg) ratio and an decrease in T helper 17 cell (Th17) ratio in the mesenteric lymph nodes of ASD mice following the combination intervention. These findings suggest that the promising efficacy of HMOs, particularly the combination of 2’-FL and LNnT, on counteracting ASD-related pathophysiological changes may be mediated by the gut-immune-brain axis.
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WATER RESEARCH
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2026
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IF 12.4
Hao Li,Xingrui Tang,Qiang Xian,Shibing Zuo,Yiyang Zeng,Chen Xu,Jun Wen
Electrochemical method offers a promising route for the continuous uranium extraction from seawater, thereby holding significant potential to ensure a sustainable supply of uranium for the nuclear energy industry. The electrode material plays a critical role in determining uranium extraction efficiency, demanding excellent mass transfer performance and high selectivity for effective extraction. Herein, inspired by the hierarchically ordered, porous, and intercross-linked vascular bundle structure of lotus petiole, we report the rational design and successful synthesis of zwitterionic ordered porous electrodes (SBMA-MPAO). This biomimetic architecture not only enhances charge/ion transfer rate and ensures sufficient seawater transport, but also provides numerous adsorption sites for uranyl capture. Furthermore, the integration of zwitterionic moieties enables a synergistic interaction with uranyl species, significantly enhancing extraction efficiency. In natural seawater, the SBMA-MPAO electrode achieves an outstanding uranium adsorption capacity of 9.54 mg/g within 72 hours, including a remarkably high uptake rate of 4.58 mg/g/d on the first day, while maintaining excellent selectivity throughout the process. This work proposes a novel strategy to construct high-performance electrodes for uranium extraction from seawater.
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APPLIED CATALYSIS A-GENERAL
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2026
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IF 4.8
Yan Wang,Yuxi Si,Feiyue Zhang,Zhanqi Yang,Libin Liu,Yanming Hou,Hairui Lin,Zhuohan Li,Hu Li,Lele Zhang,Pengfei Xie,Youwei Cheng
Complete oxidation of propane has attracted widespread attention in the treatment of volatile organic compounds (VOCs) from Fischer-Tropsch synthesis tail gas. Pt-based catalysts have been considered highly promising catalysts for the catalytic oxidation of propane due to their high-activity. However, despite the recognized importance of the synergistic effect between Pt nanoparticles (NPs) and support materials, the detailed reaction mechanism investigation remains limited. In this work, we demonstrate that the Pt/Al 2 O 3 catalyst exhibits improved propane catalytic performance, which is attributed to the synergistic interaction between Pt NPs and surface hydroxyl groups on the support. The improved Pt dispersion in Pt/Al 2 O 3 catalysts with smaller Pt NPs facilitates the spillover of gaseous oxygen species and the stabilization of active sites for propane oxidation. Furthermore, in- situ DRIFTS characterization and density functional theory (DFT) calculation confirm that surface hydroxyl groups on Al 2 O 3 effectively reduce the activation barrier for C-H bond cleavage, thereby improving the reactivity of propane molecules. This work provides a novel insight into metal-support synergy for propane oxidation, which offers strategic guidance for the rational design of efficient catalysts in hydrocarbon conversion processes.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Ce Wu,Di Wu,LiJie Xie,HouYong Yan,Wei Zhang,Fei Yu
Postoperative pain poses significant challenges for patients, with insufficient management leading to adverse outcomes. The efficacy of local anesthetics is often limited by short action duration and the need for repeated administration. To address these limitations, we developed a near-infrared (NIR) responsive injectable nanocomposite hydrogel (MSNs-Rop@PDA/Gel-DEX) that enables sustained, controllable local anesthetic delivery. In this system, ropivacaine-loaded, polydopamine-modified mesoporous silica nanoparticles were incorporated into a dexmedetomidine-loaded F127 hydrogel matrix. In vitro characterizations demonstrated that the hydrogel possesses excellent injectability and photothermal conversion efficiency. The system exhibited a distinct sequential release profile: DEX was preferentially released (90.4% in 24 h) to induce vasoconstriction, thereby reducing systemic diffusion, while ropivacaine was released in a sustained manner that could be pulsatile-triggered by NIR irradiation. Cytotoxicity assays confirmed high cell viability (>92%). In vivo experiments using a rat sciatic nerve block model showed that the composite hydrogel significantly extended the duration of analgesia to approximately 48 hours, far surpassing the effect of ropivacaine alone. Furthermore, in vivo fluorescence imaging confirmed that the vasoconstrictive effect of DEX and the NIR trigger effectively prolonged drug retention. Histological analyses of the sciatic nerves and major organs revealed gradual biodegradation of the hydrogel and confirmed satisfactory biosafety with no evidence of neurotoxicity or significant inflammatory response. Together, these results establish that the hydrogel composite provides synergistic, persistent, and controllable analgesia, demonstrating substantial clinical potential.
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Journal of Environmental Sciences
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2026
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IF 6.3
Jia Wang,Piao Yi Jiang,Jia Bing Liu,Wang Kai Tong,Han Tang,Min-tian Gao,Nan Liu,Jiajun Hu,Jixiang Li
Surfactants, essential chemicals in daily life, are widely utilized across industries, from pharmaceuticals to agriculture, leading to their extensive presence in soils and aquatic environments. Meanwhile, as microbial metabolites, surfactants play a crucial role in enhancing nutrient utilization and promoting the rapid growth of microorganisms. This study aimed to use anionic, nonionic, and cationic surfactants to promote the growth of autotrophic microorganisms and break through the bottleneck of low microbial CO 2 fixation efficiency. Among them, only anionic surfactants exhibited significant and universal promoting effects, with a maximum enhancement of 59 %–95 % on autotrophic strains utilizing the Calvin cycle. Furthermore, anionic surfactants, in combination with autotrophic microorganisms, were applied as amendments to improve soil, effectively increasing soil organic carbon content by 27 %–54 %. The long-term effects of these amendments depend on several mechanisms: promoting the Calvin cycle, enhancing soil organic carbon metabolism, facilitating nutrient transport, and reducing the abundance of genes associated with surfactant-degrading enzymes. This study contributes to a deeper understanding of the impacts of surfactants on the environmental CO 2 fixation capacity and introduces a novel approach for enhancing soil carbon sink capacity.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.5
Jiaojiao Yan,Haoxin Cai,Shuai Ma,Xin Wen,Ze Zhao,Shixin Wang,Yiming Qi,Jun Wu,Hongbing Deng
Articular cartilage defects represent a persistent clinical challenge in orthopedics. Articular cartilage, the load-bearing tissue of diarthrodial joints, possesses a hierarchically organized extracellular matrix (ECM) dominated by type II collagen and aggrecan, yet its avascular, aneural nature and low cellularity severely limit intrinsic repair capacity. Left untreated, such defects often progress to post-traumatic osteoarthritis. Despite significant advancements in tissue engineering for osteochondral regeneration, the hierarchical complexity and biomechanical demands of articular cartilage remain critical challenges. To address these limitations, we developed an injectable nanocomposite hydrogel by incorporating 2 % silk fibroin nanofibers and glucosamine into a thiolated chitosan matrix, enabling in situ gelation. The system achieved a 100.3 % increase in compressive strength over pristine chitosan hydrogel, alongside enhanced bioactivity: 26.2 % greater cellular proliferation, 150 % improved migration, and elevated chondrogenic differentiation. In a rat osteochondral defect model, the hydrogel promoted seamless tissue integration, articular surface restoration, and significant upregulation of cartilage-specific markers (COL-II, SOX-9). Collectively, this study presents a potentially translatable strategy that aims to address the longstanding trade-off between mechanical stability and bioactivity in cartilage repair.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.7
Anna Tan,Furong Sun,Wanjing Zhu,Chuanru Zheng,Xueyu Shi,Hongmei Chen,Xiuchen Li
In this work, we developed a piezoelectric cantilever energy transducer integrated with a self-oscillating polymer gel (NPC-Rux). The gel features a dual-crosslinked network—combining physical crosslinker (Laponite XLG) and chemical crosslinker (N,N′-Methylene diacrylamide (MBA)) - for improved structural stability. Grafting with hydrophilic 2-Hydroxyethyl acrylate (HEA) enhanced its swelling capacity in the oxidized state, enabling a large volume oscillation amplitude of up to 64 μm during the Belousov-Zhabotinsky reaction (B-Z reaction). A flush-type coupling structure was designed to directly transfer the gel's deformation to a Polyvinylidene fluoride (PVDF) piezoelectric cantilever. This configuration achieved a voltage output between 0.17 V and 0.23 V under mechanical stresses from 6.64 × 10 −3 N to 11.54 × 10 −3 N, establishing an effective chemo-mechano-electrical energy conversion pathway. The system enables real-time monitoring of both gel volume changes and electrical signals, offering promising applications in self-powered sensors and adaptive soft robotics.
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RSC Advances
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2026
·Vol. 16
·期 1
·501
·
IF 4.6
Huanrui Wang,Hongxin Wang,Fei Yan
Highly sensitive and selective detection of interleukin-1β (IL-1β) enables dynamic monitoring of IL-1β levels in complex samples, providing significant clinical value for the prevention of early pathogenesis of urosepsis. Herein, a dual-functional “internal probe-external recognition” immunosensor was developed on nanochannel array, spatially separating signal generation from target recognition for label-free detection of IL-1β. A polydopamine (PDA) adhesive layer was utilized to stabilize the growth of amino-functionalized vertically-ordered mesoporous silica film (NH 2 -VMSF) on a glassy carbon electrode (GCE). Using the dual functionality of NH 2 -VMSF, gold nanoparticles (AuNPs) were electrochemically deposited within the NH 2 -VMSF nanochannels as immobilized electrochemical probes, while antibodies were covalently immobilized on the outer surface of NH 2 -VMSF to act as biological recognition elements. Upon binding with IL-1β, the immunosensor specifically recognized and captured the target, resulting in an increase in interface resistance and a corresponding decrease in the electrochemical signal of AuNPs. This mechanism enabled the quantitative analysis of IL-1β, with a linear detection range from 1 pg mL −1 to 100 ng mL −1 and a limit of detection (LOD) of 0.6 pg mL −1 . The immunosensor was successfully applied to IL-1β detection in fetal bovine serum (FBS). By eliminating the need for additional signal probes, the developed immunosensor simplifies the detection process, demonstrates excellent anti-interference and stability, and offers a new approach for reagent-free biomarker detection in complex samples. An “internal probe-external recognition” immunosensor was developed on nanochannel array, spatially separating signal generation from target recognition for label-free detection of IL-1β.
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Talanta Open
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2026
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IF 3.7
Xiaoyue Shan,Ji Shao,Ling Zhang,Yan Jin,Siwei Tan,Haipeng Ye,Luoxian Yang
In this study, a novel magnetic adsorbent (AC/β-CD/Fe 3 O 4 ) was prepared for the magnetic solid phase extraction (MSPE) of hippuric acid (HA) from urine. The adsorbent combined the high surface area of activated carbon (AC), the host-guest recognition of β-cyclodextrin (β-CD), and the magnetic responsiveness of Fe 3 O 4 . Under the optimal conditions, the method demonstrated excellent performance for HA detection, with a linearity range of 0.0064-1.0 µg/mL, low limit of detection of 1.9 µg/L, and high precision (RSDs < 5%). Recoveries from spiked urine matrices ranged from 95% to 99%, confirming the method's accuracy and practicality for monitoring HA in real biological matrices.
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FOOD CHEMISTRY
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2026
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IF 9.8
Yan Zhao,Chen-Yang Shao,Han Yan,Yue Zhang,Qun-Hua Peng,Zhi Lin,Xiao-Ting Zhai,Hai-Peng Lv,Yin Zhu
Tea cultivars significantly influence aroma, yet essential odorants linked to specific cultivars remain underexplored. In this study, an integrated sensomics approach identified 57, 50, and 59 odorants in three representative baked green tea cultivars using sequential stir-bar sorptive extraction coupled with gas chromatography–mass spectrometry/olfactometry, ultimately pinpointing eight key cultivar-specific odorants. The “sweet/green” notes in ‘Zhongcha 108’ were primarily attributed to cedrol (18.52 ng/mL, enhancing aroma by up to 176 % compared to the blank matrix). Indole, methyl salicylate, geraniol, and γ -dodecalactone were closely associated with the “floral” character of ‘Zhongcha 302’ (1.30–895.86 ng/mL, increasing aroma by up to 510 %). Viridiflorol, theaspirane B, and α -ionone contributed to the “sweet/floral” notes in ‘Fuding Dabaicha’ (trace levels to 12.47 ng/mL, enhancing aroma by up to 163 %). Furthermore, the aroma profile of ‘Zhongcha 302’ was successfully reconstructed based on its quantified odorants, achieving >90 % similarity to the original tea.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·171
·
IF 36.3
Dai Xin-jian,Wang Xin,Hu Ji-hang,Jiang Pan,Wang Xiao-qing
Highly elastic, fatigue-resistant, and conductive lamellar wood sponges are developed via a cell wall reconfiguration strategy.
The strain-induced conductivity changes in lamellar wood sponge enable tunable electromagnetic interference shielding effectiveness and high-sensitivity pressure sensing (0.72 kPa −1 ).
The wood sponge exhibits a low through-plane thermal conductivity of 0.037 W m −1 K −1 , which is compression-tunable for smart thermal management.
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危险品化学品经营许可证（带存储）