ACS Nano
·
2025
·
IF 16
Kangjing Liu,Yemeng Shen,Shiguo Chen,Wentao Su,Yukun Song,Mingqian Tan
Growing concern about the prolonged exposure to blue light on eye health has driven interest in bioactive substances that can help protect the eyes. In this study, a type of mitochondrion targeted lutein nanoparticles with potential of hydrogen (pH) and reactive oxygen species (ROS)-responsive capabilities was designed and prepared for retinal degeneration caused by blue light. Lutein nanoparticles were initially prepared using a self-assembly method based on (3-carboxypentyl) (triphenyl) phosphonium modified casein-mannose (CAS-Man) conjugates. Subsequently, 3-aminobenzeneboronic acid modified sodium alginate was surrounded on the surface of the nanoparticles to generate hydrophilic corona. The nanoparticles exhibited pH- and ROS-responsive release properties and showed good mitochondrial targeted ability after 4 h of incubation, with a Pearson’s correlation coefficient of 0.88. Visual electrophysiology results indicated that lutein nanoparticles alleviated blue light damage by improving dark and light adaptation, preserving retinal vascular microcirculation, and enhancing optic nerve conduction function. Fluorescein fundus angiography showed that lutein nanoparticles significantly decreased the vessel percentage area by 6.93 ± 0.32%, average vessel length by 0.59-fold, and the number of junctions by 0.88-fold caused by blue light exposure. Lutein nanoparticles effectively protected mice from blue light-induced retinal degeneration by reducing ROS production in the retina by 1.44-fold and inhibiting cellular apoptosis by 2.29-fold. These findings suggested that the mitochondrion targeted lutein nanoparticles with pH and ROS-responsive capabilities provided a potential strategy for mitigating blue light-induced retinal degeneration.
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Catalysts
·
2025
·Vol. 15
·期 8
·739
·
IF 4
Xiao Ge,Hongrui Ding,Tong Liu,Yifei Du,Anhuai Lu
Photocatalytic redox processes significantly contribute to shaping Earth’s surface environment. Semiconductor minerals exhibiting favorable photocatalytic properties are ubiquitous on rock and soil surfaces. However, the sunlight-responsive characteristics and functions of TiO2, an excellent photocatalytic material, within natural systems remain incompletely understood, largely due to its wide bandgap limiting solar radiation absorption. This study analyzed surface coating samples, determining their elemental composition, distribution, and mineralogy. The analysis revealed enrichment of anatase TiO2and β-carotene. Informed by these observations, laboratory simulations were designed to investigate the synergistic effect of β-carotene on the sunlight-responsive behavior of anatase. Results demonstrate that β-carotene-sensitized anatase exhibited a 64.4% to 66.1% increase in photocurrent compared to pure anatase. β-carotene sensitization significantly enhanced anatase’s electrochemical activity, promoting rapid electron transfer. Furthermore, it improved interfacial properties and acted as a photosensitizer, boosting photo-response characteristics. The sensitized anatase displayed a distinct absorption peak within the 425–550 nm range, with visible light absorption increasing by approximately 17.75%. This study elucidates the synergistic mechanism enhancing the sunlight response between anatase and β-carotene in natural systems and its broader environmental implications, providing new insights for research on photocatalytic redox processes within Earth’s critical zone.
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JOURNAL OF COORDINATION CHEMISTRY
·
2024
·
IF 2.2
Fang-Zhong Zhang,Yan Zeng,Mu-Yue Zheng,Hao Zheng,Meng Fang,Bao-Xuan Xie,Rong-Guang Lin
Ag NPs were generated by reducing silver ions with sodium borohydride and then loaded into a zirconium-based MOF, PCN-222, resulting in a deep purple powder, PCN-222@AgNPs, which exhibited photocatalytic activity. The material was characterized and found to have Ag NPs uniformly dispersed in the pores of PCN-222, with a content of 6.0306%. PCN-222@AgNPs had rod-shaped structures of micrometer sizes with irregular spherical Ag NPs on their surfaces, as revealed by scanning electron microscopy and transmission electron microscopy. In experiments on Ag NPs release and reactive oxygen species (ROS) detection, PCN-222@AgNPs effectively released Ag NPs into an aqueous solution and promote ROS generation. Finally, the antibacterial activities of PCN-222@AgNPs against Escherichia coli and Staphylococcus aureus were assessed by in vitro experiments. Results indicated that PCN-222@AgNPs had lower minimum bactericidal concentration (MBC) compared to PCN-222 in both light and dark environments. The MBC further decreased under light conditions due to the enhanced photocatalytic performance of the composite material and the promotion of Ag NPs release by ROS. These findings demonstrate that PCN-222@AgNPs have synergistic antibacterial effects under visible light irradiation.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
Xiao Yequan,Fan Zeyu,Nakabayashi Mamiko,Li Qiaoqiao,Zhou Liujiang,Wang Qian,Li Changli,Shibata Naoya,Domen Kazunari,Li Yanbo
The trade-off between light absorption and carrier transport in semiconductor thin film photoelectrodes is a major limiting factor of their solar-to-hydrogen efficiency for photoelectrochemical water splitting. Herein, we develop a heterogeneous doping strategy that combines surface doping with bulk gradient doping to decouple light absorption and carrier transport in a thin film photoelectrode. Taking La and Mg doped Ta 3 N 5 thin film photoanode as an example, enhanced light absorption is achieved by surface La doping through alleviating anisotropic optical absorption, while efficient carrier transport in the bulk is maintained by the gradient band structure induced by gradient Mg doping. Moreover, the homojunction formed between the La-doped layer and the gradient Mg-doped layer further promotes charge separation. As a result, the heterogeneously doped photoanode yields a half-cell solar-to-hydrogen conversion efficiency of 4.07%, which establishes Ta 3 N 5 as a leading performer among visible‐light‐responsive photoanodes. The heterogeneous doping strategy could be extended to other semiconductor thin film light absorbers to break performance trade-offs by decoupling light absorption and carrier transport.
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RSC Advances
·
2020
·Vol. 10
·期 44
·26059-26066
·
IF 3.119
Shuwei Liu,Lu Wang,Bin Zhao,Ze Wang,Yinyu Wang,Bin Sun,Yi Liu
In clinical tumor therapy, traditional treatments such as surgery, radiotherapy and chemotherapy all have their own limitations. With the development of nanotechnology, new therapeutic methods based on nanomaterials such as photothermal therapy (PTT) have also emerged. PTT takes advantage of the poor thermal tolerance of tumor cells and uses the heat generated by photothermal reagents to kill tumor cells. A transition metal sulfide represented as Cu2S is an ideal photothermal reagent because of its easy preparation, high extinction coefficient and photothermal conversion efficiency. Surface modification of nanoparticles (NPs) is also necessary, which not only can reduce toxicity and improve colloidal stability, but also can provide the possibility of further chemotherapeutic drug loading. In this work, we report the fabrication of Tween-20 (Tw20)-modified and doxorubicin (Dox)-loaded Cu2S NPs (Cu2S/Dox@Tw20 NPs), which significantly improves the performance in tumor therapy. Apart from the enhancement of colloidal stability and biocompatibility, the drug loading rate of Dox in Tw20 reaches 11.3%. Because of the loading of Dox, Cu2S/Dox@Tw20 NPs exhibit chemotherapeutic behaviors and the tumor inhibition rate is 76.2%. Further combined with a near-infrared laser, the high temperature directly leads to the apoptosis of a large number of tumor cells, while the release of chemotherapeutic drugs under heat can not only continue to kill residual tumor cells, but also inhibit tumor recurrence. Therefore, with the combination of PTT and chemotherapy, the tumor was completely eliminated. Both hematological analysis and histopathological analysis proved that our experiments are safe.
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Nature Photonics
·
2026
·
IF 38.1
Liu Yangyu,Zhou Yuhan,Chang Jianing,Yang Jie,Yuan Dongqin,Xu Weidong,Wang Wang,Li Zhonghua,Feng Xingjiao,Fu Liuchong,Wang Jianpu,Li Zhaosheng,He Bingchen,Yu Tao,Zou Zhigang,Gao Feng,Bao Chunxiong
Thermal evaporation of perovskite films holds considerable promise for the scalable manufacturing and pixel patterning of perovskite light-emitting diodes (PeLEDs). However, the performance of evaporated PeLEDs remains inferior to their solution-processed counterparts due to the lack of effective strategies to regulate perovskite crystallization during vacuum deposition. Here we address this challenge and achieve precise control over crystallization pathways. Dual-amide additives suppress premature perovskite phase formation during deposition and decelerate crystallization kinetics during post-annealing. We realize thermally evaporated near-infrared PeLEDs with a maximum external quantum efficiency of 25.0% for emission at 805 nm, and a T 50 lifetime of 23 h at a driving current density of 100 mA cm −2 . To show the advantages of thermal evaporation in pixelization, we realize monolithic dual-colour-emitting PeLEDs at 805 nm and 759 nm by integrating different PeLEDs on the same substrate and demonstrate dual-wavelength wearable pulse oximetry. This work provides insights into vacuum deposition crystallization dynamics and establishes a crystallization regulation methodology to advance evaporated perovskite optoelectronics.
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ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Yang Zhang,Danfeng Wang,Mengyue Gao,Bin Xu,Jiangying Zhu,Weijiang Yu,Depeng Liu,Guohua Jiang
Near-infrared (NIR) light-triggered and separable segmented microneedles (MNs), consisting of lauric acid and polycaprolactone (LA/PCL) arrowheads and poly(vinyl alcohol) and polycaprolactone (PVA/PVP) supporting bases, have been fabricated. A hypoglycemic drug (metformin) and photothermal conversion factor (Cu7S4 nanoparticles) are encapsulated into LA/PCL arrowheads. Due to the dissolution of soluble supporting bases after the absorption of tissue fluid, the separable MNs arrowheads can be embedded into skin after insertion. Under the NIR-light irradiation, the LA/PCL arrowheads exhibit an excellent thermal-ablation change with a low amount of Cu7S4 nanoparticles (0.1 wt %) due to the low melting point of LA and PCL, thus enabling the release behavior of the encapsulated model drug to be photothermally triggered. Compared to the hypodermic injection of metformin, the thermal ablation of separable MNs triggered by NIR irradiation in the current research exhibit an excellent hypoglycemic effect in vivo. It suggests that the NIR-induced thermal-ablation MNs comprise a prospective transdermal drug-delivery system for the precise control of the timing and dosage of a drug that is dependent on NIR administration.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2018
·Vol. 32
·期 4
·e4231
·
IF 3.581
Xue-Wen Liu,Yang Xiao,Wei-Gen Peng,Li-Jin Zhao,You-Ming Shen,Song-Bai Zhang,Ji-Lin Lu
Two ruthenium complexes containing a new ligand phipz (phipz = 2-(1,10-phenanthroline)-1H-imidazo[4,5-b]phenazine) were designed and synthesized. These complexes were found to inhibit the DNA supercoiled relaxation mediated by topoisomerase I (topo I), cleave DNA under irradiation and bind to calf thymus DNA through intercalative mode. Furthermore, complex 2 shows higher photocleavage activity, topo I inhibition activity and DNA affinity than complex 1 . Additionally, introduction of phenazine unit may be the reason that two complexes exhibit DNA ‘light switch’ behavior. The present work shows that two complexes might be potential as new DNA ‘light switches’, DNA photocleavers and topo I inhibitors.
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-16
·
IF 14.919
Wang Yongchao,Gong Ningqiang,Ma Chi,Zhang Yuxuan,Tan Hong,Qing Guangchao,Zhang Jimei,Wang Yufei,Wang Jinjin,Chen Shizhu,Li Xianlei,Ni Qiankun,Yuan Yuan,Gan Yaling,Chen Junge,Li Fangzhou,Zhang Jinchao,Ou Caiwen,Zhao Yongxiang,Liu Xiaoxuan,Liang Xing-Jie
Immunological adjuvants are essential for successful cancer vaccination. However, traditional adjuvants have some limitations, such as lack of controllability and induction of systemic toxicity, which restrict their broad application. Here, we present a light-activable immunological adjuvant (LIA), which is composed of a hypoxia-responsive amphiphilic dendrimer nanoparticle loaded with chlorin e6. Under irradiation with near-infrared light, the LIA not only induces tumour cell lysis and tumour antigen release, but also promotes the structural transformation of 2-nitroimidazole containing dendrimer to 2-aminoimidazole containing dendrimer which can activate dendritic cells via the Toll-like receptor 7-mediated signaling pathway. The LIA efficiently inhibits both primary and abscopal tumour growth and induces strong antigen-specific immune memory effect to prevent tumour metastasis and recurrence in vivo. Furthermore, LIA localizes the immunological adjuvant effect at the tumour site. We demonstrate this light-activable immunological adjuvant offers a safe and potent platform for in situ cancer vaccination.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Junxian Xie,Jiahui Xie,Junjun Chen,Shiyun Zhu,Jun Xu,Haitao Yang
Light-colored lignin nanoparticles (LNPs) have shown great potential in their conversion and high value-added applications. However, the direct extraction of light-colored LNPs from lignocellulosic materials remains a significant challenge in the field. In this study, we developed a very effective strategy for rapid extraction (1 h) of light-colored LNPs from radiata pine using a new ternary deep eutectic solvent (TDES) composed of benzyltrimethyl-ammonium chloride (BTMAC), formic acid (FA) and maleic acid (MA). The results indicated the obtained average particle size of LNPs ranged from 127 nm to 171 nm. The extraction process was optimized to achieve high yields (84.7 %), purity (94.1 %) and low polydispersity index (PDI = 1.96) while maintaining the light-colored LNPs (brightness ISO 24.15 %), which was 9.7, 10.5 and 2.5 folds higher than Kraft lignin, alkali lignin and lignosulfonate, respectively. Further evaluation revealed that the IC50 of the three LNPs samples were less than 60 μg·mL −1 , exhibiting significant antioxidant activity. In addition, the introduction of MA could protect the β-O-4 linkage from excessive cleavage and recondensation as well as avoid the deepening of LNPs color. This work not only presents an effective method for extracting light-colored LNPs but also highlights their advantageous properties, paving the way for sustainable product development utilizing lignocellulosic biomass.
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Small
·
2025
·
IF 12.1
Xiaohan He,Weiwen Xin,Pengbo Song,Shicheng Wan,Chaowen Yang,Yongbo Deng,Liuyong Shi,Teng Zhou,Liping Wen
Osmotic energy, a clean and renewable energy source, holds vast potential at the confluence of rivers and seas. 2D nanofluidic membranes offer a promising avenue for its efficient harvesting, yet their practical application is hampered by insufficient power density. Here we report a photoresponsive 2D nanofluidic membrane constructed by intercalating molybdenum disulfide with cotton nanofibers to form a stable composite structure. Under 50- and 500-fold salinity gradients, the membrane achieves power densities of 6.48 and 13.57 W m − 2 , respectively. By introducing asymmetric illumination on the low-concentration side, we create asymmetric temperature and charge gradients, which substantially enhance the osmotic energy conversion performance. Under a light intensity of 220 mW cm − 2 , the membrane achieves a power density of 9.93 W m − 2 , representing a 53% increase compared to non-illuminated conditions. This enhancement is accompanied by a 62% rise in the short-circuit current and an 8% increase in the open-circuit voltage. In tests using real seawater, the membrane delivers a power density of 6.06 W m − 2 , a 67% improvement over the non-illuminated condition. This study establishes a new strategy for highly efficient osmotic energy harvesting and demonstrates the potential of light-assisted osmotic energy conversion in practical marine environments.
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BIORESOURCE TECHNOLOGY
·
2020
·
IF 7.539
Yu Wang,Hua Fan,Po Keung Wong,Yonghong Wu,Bruce Rittmann
To develop a more green and effective method for tetracycline (TC) removal, a hybrid material (conversion phosphors-TiO 2 , UCPs-TiO 2 ) was coupled with a biofilm to achieve enhanced removal of TC. The removal of TC by biofilm coupled with UCPs-TiO 2 under visible light reached 82%, which was 35% higher than that in treatment using only the biofilm. Extracellular polymeric substance (EPS) promoted the production of hydroxyl radicals by UCPs-TiO 2 , as the EPS acted as an electron transfer medium and accelerated the TC mineralization. Biofilm in the coupled system tolerated TC stress by regulating its antibiotic resistance genes (ARG) and superoxide dismutase (SOD), and allowed it to maintain stable and efficient removal of TC. This study documents a method to couple a hybrid material with microbial aggregates, creating a promising system for removing refractory organics, such as TC, from water. The study also offers insight into the mechanisms underlying TC removal by microbial aggregates combined with new functional materials.
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