ULTRASONICS SONOCHEMISTRY
·
2021
·
IF 7.491
Danli Wang,Jiayuan Liu,Shaoping Qiu,Jingjing Wang,Gongshuai Song,Bingquan Chu,Ling Li,Gongnian Xiao,Jinyan Gong,Fuping Zheng
Caffeoylquinic acids are existed in many plant species with various biological and pharmacological activities. 3- O -caffeoylquinic acid and 4- O -caffeoylquinic acid are two isomers of caffeoylquinic acids, which may be degraded and transformed to their isomers in processing. The present paper found that the stability of 3- and 4- O -caffeoylquinic acid had decreased with the increasing solution alkalinity. 3- O -caffeoylquinic acid was more stable than 4- O -caffeoylquinic acid at the same condition. During degradation, 3- and 4- O -caffeoylquinic acid were partially converted to their isomers. Additionally, ultrasonic effects on the degradation and isomerization of 3- and 4- O -caffeoylquinic acid at different pH were studied. Ultrasound facilitated the degradation and isomerization of these compounds. The degradation kinetics were described by the Weibull equation. The protective effect of ascorbic acid and epigallocatechin gallate were also explored. Ascorbic acid and epigallocatechin gallate could alleviate the degradation of 3- and 4- O -caffeoylquinic acid under certain conditions.
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高影响因子
LANGMUIR
·
2023
·
IF 3.9
Ruijuan Wang,Chunliu Ma,Haitao Yan,Pu Wang,Shuyan Yu,Tongyan Zhang,Zhigang Yin
Co-encapsulated xanthoxylin (GX-50) and vitamin C (Vc) microcapsules (GX-50-Vc-M) were prepared by the combination of a water-in-oil-in-water (W1/O/W2) double emulsion with complex coacervation. The W1/O/W2 double emulsion was prepared by two-step emulsification, and it has a uniform particle size of 8.388 μm and high encapsulation efficiencies of GX-50 (85.95%) and Vc (67.35%) under optimized process conditions. Complex coacervation occurs at pHs 4.0–4.7, which has the highest encapsulation efficiency of GX-50 and Vc at pH 4.5. The complex coacervate with tannic acid solidifying (namely, wet microcapsules) has better mechanical properties and also enhances the ability of co-encapsulation of active ingredients. The resulting microcapsules by freeze-drying of wet microcapsules were characterized by UV–vis absorbance spectroscopy (UV–vis), Fourier infrared spectroscopy (FI-IR), confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM), X-ray diffraction (XRD), 2,2-diphenyl-1-picrylhydrazyl (DPPH·) radical scavenging, and in vitro permeation measurements. Under optimal conditions, the encapsulation efficiency and drug loading of GX-50-Vc-M for GX-50 and Vc are, respectively, 78.38 ± 0.51 and 59.34 ± 0.56%, and 35.6 ± 0.68 and 29.8 ± 0.92%. A slight shift in the FTIR peak between single GX-50 or Vc and GX-50-Vc-M confirmed the successful co-encapsulation of GX-50 and Vc in microcapsules. GX-50-Vc-M has bridged irregular spherical aggregates, while GX-50 and Vc are, respectively, encapsulated in hydrophobic and hydrophilic cavities of microcapsules in an amorphous dissolved state. GX-50-Vc-M has the highest DPPH· radical scavenging rate of 62.51%, and the scavenging process of GX-50-Vc-M on DPPH· radicals is more in line with the pseudo-second-order kinetic equation model. Moreover, the in vitro permeation of GX-50 and Vc in GX-50-Vc-M can reach maximum values of 40 and 60%, respectively. This concludes that GX-50-Vc-M is a promising delivery system for the penetration of the antioxidant into the deeper layers of the skin for the antioxidant effect.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2020
·
IF 4.551
Niu Liu,Jun Cheng,Wen Hou,Xiao Yang,Junhu Zhou
In order to form strengthened active sites for superior CO 2 adsorption on core shell ZIF-8@ZIF-67 nanocomposites , graphene oxide (GO) with oxygen-containing functional groups was used as support to synthesize hybrid adsorbents with unsaturated Zn–N 2 –O active sites. The results of XPS O 1s and FTIR analysis revealed that the Me–O functional group content in the 0.5 wt% graphene oxide (GO)-supported core shell ZIF-8@ZIF-67 nanocomposite (38.9 at.%) was much higher than that in the 0.5 wt% reduced graphene oxide (RGO)-supported nanocomposite (19.4 at.%). This was because hydroxyl functional groups in the GO formed coordination bonds with zinc atoms in core shell ZIF-8@ZIF-67. XPS N 1s spectra indicated that the incorporation of oxygen-containing functional groups in GO resulted in the transition of binding form from Me–N 4 to Me–N 2 . The CO 2 adsorption capacity of GO-supported core shell ZIF-8@ZIF-67 gradually decreased from 2.15 to 1.30 mmol/g as GO weight percentage increased from 0.5 to 4 wt%, which was consistent with the decrease in BET surface area from 1378 to 585 m 2 /g and increase in peak pore diameter from 7.7 to 8.2 Å. Density functional theory (DFT) calculations demonstrated that unsaturated Zn–N 2 –O active sites in GO-supported core shell ZIF-8@ZIF-67 nanocomposites resulted in a decreased O C⋯Zn interaction distance from 4.65 (Zn–N 4 sites in core shell ZIF-8@ZIF-67) to 3.46 Å and an increased binding energy from 34.02 to 38.87 kJ/mol. Therefore, 0.5 wt% GO-supported core shell ZIF-8@ZIF-67 nanocomposites exhibited the highest CO 2 adsorption capacity of 2.15 mmol/g (at 273 K and 1 bar), 1.34 times higher than that of core-shell ZIF-8@ZIF-67.
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JOURNAL OF SEPARATION SCIENCE
·
2020
·Vol. 43
·期 12
·2290-2300
·
IF 2.878
Guanghui Ren,Huili Chen,Mei Zhang,Nan Yang,Hui Yang,Chuanru Xu,Jiaming Li,Chen Ning,Zhongjin Song,Shiyu Zhou,Siliang Zhang,Xiaoqian Wang,Yang Lu,Ning Li,Yongjie Zhang,Xijing Chen,Di Zhao
Oroxylin A, obtained from the root of Scutellaria baicalensis Georgi , is a flavonoid with antitumor and other pharmacological activities. Our previous studies showed for the first time that it is mainly metabolized to oroxylin A sodium sulfonate by sulfotransferase enzymes in beagle dogs. In this study, rapid, universal, selective, and robust ultra-high-performance liquid chromatography–tandem mass spectrometry methods were established and fully validated to quantitatively detect oroxylin A, oroxylin A 7-O-glucuronide, and oroxylin A sodium sulfonate in beagle dog plasma. The quantitative analysis for oroxylin A sodium sulfonate was reported for the first time. Plasma samples were processed with acetonitrile, a universal protein precipitant. Gradient elution was performed to resolve carryover effects and to achieve separation efficiency and sufficient chromatographic retention. The linear relationships of oroxylin A, oroxylin A 7-O-glucuronide, and oroxylin A sodium sulfonate in plasma were in the range of 2.0–500.0, 5.0–500.0, and 1.881–940.5 ng/mL, respectively. The assay method was successfully applied to pharmacokinetic study. This is the first paper that reveals the pharmacokinetic profile of oroxylin A, oroxylin A 7-O-glucuronide, and oroxylin A sodium sulfonate after single-dose intravenous and oral administration of Oroxylin A in beagle dogs.
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ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
W.Q. Yang,Y.X. Hua,Q.B. Zhang,H. Lei,C.Y. Xu
The development of earth-abundant, low-cost, highly active, and durable bifunctional catalysts competent for efficient electrochemical water-splitting is intensively demanding and of vital importance to realize high-purity hydrogen production . Herein, we report that 3D quasi-amorphous pompon-like Co-O and Co-Se hybrid films grown on copper foil (Co-O@Co-Se/Cu) can be electrochemically synthesized from a choline chloride and urea mixed deep eutectic solvent , denoted as Reline, via a facile one-step electrochemical deposition approach. Benefiting from the induction effect of Se, the obtained Co-O@Co-Se/Cu hybrid electrode exhibits strongly enhanced catalytic activity. The optimal Co-O@Co-Se/Cu sample shows good activity and excellent durability for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in an alkaline solution with low overpotentials of 85 mV for HER and 340 mV for OER, respectively to reach a catalytic current of 10 mA cm −2 . The Co-Se component within the hybrid films is gradually converted into Co-O species during the course of the OER, which are responsible for the good OER performance. In addition, when performed as bifunctional catalysts in a two-electrode configured electrolyzer, the Co-O@Co-Se/Cu couple displays a water-splitting current of 10 mA cm -2 at 1.65 V with reasonable stability for long-term electrolysis over 100 h. This simple one-step electrochemical synthesis route operated in the Reline-based deep eutectic solvent is demonstrated as an efficient strategy to fabricate active non-noble-free electrocatalysts toward overall water splitting applications.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Weimin Chen,Min Luo,Chaozheng Liu,Shu Hong,Xin Wang,Pei Yang,Xiaoyan Zhou
As ZnCl 2 is a good microwave absorber, it was usually used as an porogen to produce porous carbon from biomass by microwave heating . In this study, a facile microwave self-activation with the absence of ZnCl 2 was proposed to produce chitosan-hydrogel-bead-based porous carbons (CPC-Air) for a short duration of 10 min. KOH was used as a substitute for the typically used NaOH to form chitosan-based hydrogen beads. During microwave irradiation , KOH acted as a chemical porogen to generate abundant micropores with a pore volume of 0.39 cm 3 g −1 in CPC-Air, while water wrapped in hydrogel beads was transformed into steam, serving as a physical porogen to form a considerable content of mesopores (41.8%) and creating a air-free atmosphere. Microwave irradiation led to fast pyrolysis of chitosan, generating meso-/macropores. Combined with self-activation process, it resulted in a high defects degree in CPC-Air. Nitrogen with a high content of 3.4% remained in CPC-Air after self-activation. In addition, a significantly high oxygen content of 17.5% was introduced by the post-oxidation in air atmosphere. Consenquently, the proposed approach can produce a hierarchical and O, N co-doped CPC material with a high defects degree at air-free atmosphere, and with comparable electrochemical properties but with much simpler process and less production duration than the conventional method using ZnCl 2 . Particularly, owing to the combined effects of those characteristics in CPCs, an excellent rate capability was achieved in the prepared electrode, demonstrating an ultra-high capacitance retention of 87.5% when the current load was increased from 0.5–10 A g −1 . The supercapacitor prepared by this electrode can deliver the energy densities of 17.3–20.6 W h kg −1 and the power densities of 0.5–9.0 kW kg −1 .
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JOURNAL OF HAZARDOUS MATERIALS
·
2015
·
IF 4.529
Chiyao Bai,Meicheng Zhang,Bo Li,Yin Tian,Shuang Zhang,Xiaosheng Zhao,Yang Li,Lei Wang,Lijian Ma,Shoujian Li
Cyanuric chloride was chosen as a core skeleton which reacted with desired linker molecules, urea, thiourea and thiosemicarbazide, to prepare three novel functional covalent triazine-based frameworks, CCU (O-donor set), CCTU (S-donor set) and CCTS (S, N-donor set) respectively, designed for selective adsorption of U(VI). The products have high nitrogen concentration (>30 wt%), regular structure, relatively high chemical and thermal stability. Adsorption behaviors of the products on U(VI) were examined by batch experiments. CCU and CCTU can extract U(VI) from simulated nuclear industrial effluent containing 12 co-existing cations with relatively high selectivity (54.4% and 54.2%, respectively). Especially, effects of donor atoms O/S on adsorption were investigated, and the outcomes indicate that the difference in coordinating ability between the donor atoms is weakened in large conjugated systems, and the related functional groups with originally very strong coordination abilities may not be the best choice for the application in selective adsorption of uranium and also other metals. The as-proposed approach can easily be expanded into design and preparation of new highly efficient adsorbents for selective separation and recovery of uranium through adjusting the structures, types and amounts of functional groups of adsorbents by choosing suitable linkers.
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Chinese Journal of Natural Medicines
·
2017
·
IF 1.667
Qiong YU,Li-Long JIANG,Na LUO,Ya-Xi FAN,Jiang MA,Ping LI,Hui-Jun LI
Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones has been discovered and a hypothesis is proposed that the interaction between stilbene glucoside-enriching fraction and emodin may contribute to the side effects of PMR. To further support our previous in vivo results in rats, the present in vitro study was designed to evaluate the effects of 2, 3, 5, 4′-tetrahydroxystilbene-2- O-β -D-glucopyranoside (TSG) on the cellular absorption and human liver microsome metabolism of emodin. The obtained results indicated that the absorption of emodin in Caco-2 cells was enhanced and the metabolism of emodin in human liver microsomes was inhibited after TSG treatment. The effects of the transport inhibitors on the cellular emodin accumulation were also examined. Western blot assay suggested that the depressed metabolism of emodin could be attributed to the down-regulation of UDP-glucuronosyltransferases (UGTs) 1A8, 1A10, and 2B7. These findings definitively demonstrated the existence of interaction between TSG and emodin, which provide a basis for a better understanding of the underlying mechanism for PMR-induced liver injury.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Cheng Li,Yu Lu,Zhijun Zhang,Linjuan Huang,Zhongfu Wang
The highly sulfated polysaccharide sea cucumber chondroitin sulfate (SCCS) can alleviate intestinal damage and display strong anti-food-allergic activity. The O -glycopattern levels in colonic mucin are closely related to the its protective effect on function of the intestinal barrier. However, the effect of the SCCS on colonic mucin O -glycan has not been investigated. In this study, ovalbumin (OVA)-sensitized allergic mice and SCCS treatment were used. Mouse colonic mucin O -glycome was released and analyzed through reductive β-elimination combined with PGC–LC–MS. A total of presumptive 20 neutral and 28 acidic O -glycan structures were identified, in which the core 2 type acidic O -glycan structure is predominant in Balb/c female mice. Treatment with OVA and SCCS did not change the numbers of colon mucin O -glycan type, but the expression level of total O -glycosylation was more abundant in the SCCS group mice than in the OVA group (1.8-fold), especially for acidic O -glycans (co-modified by fucose and sulfate groups). Furthermore, supplementation with SCCS reversed most of the O -glycan decreasing trend, which may be associated with a return to healthy levels of gut microbiota. In conclusion, our results demonstrate that SCCS could restore colonic mucin O -glycosylation levels and intestinal homeostasis and contribute to enhancing intestinal barrier function.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Zhikang Deng,Yongfei Ma,Jinyao Zhu,Chenyu Zeng,Rui Mu,Yifan Liu,Ping Li,Zulin Zhang
Ferrate (Fe (VI)), as a versatile oxidizer, has been widely employed for water treatment. However, the rapid self-decomposition of Fe (VI) diminishes its practical application efficiency. In this study, a novel Mn-modified sludge biochar (MSBC) was synthesized for the first time to activate Fe (VI) and generate highly reactive Fe (IV)/Fe (V) for the rapid removal of sulfamethoxazole (SMX). The results showed that MSBC (0.10 g/L) effectively activated Fe (VI) (100 μM), and 87.39 % of SMX (10 μM) and 40.26 % of total organic carbon (TOC) were removed within 10 min. Notably, raising the solution pH (e.g., from 6.0 to 11.0) would result in decreasing the reactivity of Fe (VI) and a lower removal efficiency of SMX. The quenching, electron paramagnetic resonance and probe experiments suggested that •O 2 – and high-valent iron species (Fe (V)/Fe (IV)) were identified as the major contributions to the removal of SMX. The detailed activation sites of MSBC were –OH and Mn-O, as corroborated by density functional theory (DFT) calculation and characterization. These activation sites facilitated activation of Fe (VI) through efficient electron transfer . The Fukui index indicated that the N, S, and O atom of SMX were the primary attacked sites. Subsequently, five potential degradation pathways were proposed, with the cleavage of the S-N bond being the predominant one. The toxicity of these products was examined using ECOSAR program, revealing that main products showed low toxicity or non-toxicity. The Cl - , SO 4 2- , and NO 3 – had negligible effect on SMX degradation, although excessive concentrations of HCO 3 – and humic acid (HA) showed slightly inhibition. Additionally, the Fe (VI)/MSBC system also effectively removed 87.34 % of sulfadiazine (SDZ) and 93.91 % of sulfamethoxypyridazine (SMP). Overall, this study offered a practical and cost-effective approach for the activation of Fe (VI) and provided new insights to the degradation mechanism.
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Foods
·
2025
·Vol. 14
·期 6
·935
·
IF 5.1
Kun Tang,Cong Chen,Yutong Liu,Suxuan Li,Yiye Luo,Xiaoyu Chen,Zhiyong Wu
Pandan leaves have a prominent glutinous-rice aroma; however, few studies have explored their volatile aroma compound composition. Herein, the differences in the volatile aroma components of fresh and dried pandan leaves were investigated for the first time using HS–SPME–GC–O–MS combined with principal component analysis, orthogonal partial least squares discriminant analysis, and HS-GC-IMS with aroma fingerprinting. A total of 93 volatile compounds were identified, exceeding previous reports, including 43 main flavor components with odor activity values (OAV) > 1. OAV and aroma extract dilution analysis tests reveal 13 main aroma volatiles including 2-acetyl-1-pyrroline, hexanal, nonanal, phenylacetaldehyde, β-cyclocitral, butanal, ethyl caprylate, ethyl nonanoate, ethyl caprate, ethyl laurate, 3-hydroxy-2-butanone, acetophenone, and α-ionone. Sixteen types of aromas were classified, and the results are presented as flavor wheels. The findings of this study elucidate the changes and retention of aroma volatiles in differently processed leaves, which could benefit food industry applications.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Yingjie Zhou,Lijie Zhu,Yingyan Li,Feng Guo,Lei Chen,Guozhen Wang,Qian Shen,Xiuying Liu,Wenping Ding
In this study, soyasaponin (Ssa), corn oil, and soybean protein isolate (SPI) were used to prepare a water-in-oil-in-water (W/O/W) double emulsion system that can protect Lactobacillus plantarum (L.P) in the upper gastrointestinal tract for delivery to the small intestine and colon. Incorporating different amounts of L.P (0.1–0.6% (w/v)) in the W/O/W double emulsion caused the viscoelastic modulus and droplet size of the L.P-embedded emulsion system to change, and the emulsion system transformed from a non-Newtonian fluid to a “solid-like” gel. These results revealed that L.P encapsulation led to significantly improved stability of the W/O/W emulsion. In addition, different concentrations of L.P had different effects on the survival rate of L.P in simulated digestive fluids, and after in vitro digestion, L.P was naturally delivered from the stomach into the intestines. The optimal concentration of L.P for obtaining a stable emulsion was found to be 0.3%, and the survival rate of the encapsulated L.P in the small intestine was as high as 78.96% after 1 h. Thus, choosing an appropriate amount of L.P was crucial. The W/O/W emulsion system effectively maintained the viability of L.P and successfully delivered it to the small intestine and colon.
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危险品化学品经营许可证（带存储）