Nature Communications
·
2022
·Vol. 13
·期 1
·1-12
·
IF 17.694
Zhang Zeyu,Sun Qingde,Lu Yue,Lu Feng,Mu Xulin,Wei Su-Huai,Sui Manling
Development of lead-free inorganic perovskite material, such as Cs 2 AgBiBr 6 , is of great importance to solve the toxicity and stability issues of traditional lead halide perovskite solar cells. However, due to a wide bandgap of Cs 2 AgBiBr 6 film, its light absorption ability is largely limited and the photoelectronic conversion efficiency is normally lower than 4.23%. In this text, by using a hydrogenation method, the bandgap of Cs 2 AgBiBr 6 films could be tunable from 2.18 eV to 1.64 eV. At the same time, the highest photoelectric conversion efficiency of hydrogenated Cs 2 AgBiBr 6 perovskite solar cell has been improved up to 6.37% with good environmental stability. Further investigations confirmed that the interstitial doping of atomic hydrogen in Cs 2 AgBiBr 6 lattice could not only adjust its valence and conduction band energy levels, but also optimize the carrier mobility and carrier lifetime. All these works provide an insightful strategy to fabricate high performance lead-free inorganic perovskite solar cells.
✓ 已验证
DOI
PubMed
高影响因子
CARDIOVASCULAR DRUGS AND THERAPY
·
2024
·
IF 3.1
Ye Bozhi,Cai Xueli,Liang Xiaohe,Chen Yunxuan,Dai Shanshan,Huang Zhuqi,Huang Weijian,Zhang Lei,Wang Zixuan,Xing Jincheng,Lai Xianhui,Huang Zhouqing,Jia Zhuyin
Purpose Inflammatory responses induced by NLRP3 inflammasome contribute to the progression of atherosclerosis. This study seeks to investigate the effect of emodin on the NLRP3 inflammasome in atherogenesis and to probe the underlying mechanism. Methods ApoE-knockout (ApoE −/− ) mice were treated with a high-fat diet (HFD) for 12 weeks and intragastrically with emodin for 6 weeks. Human mononuclear cell line THP-1 was pretreated with emodin or signaling pathway inhibitors and induced into macrophages using phorbol 12-myristate 13-acetate (PMA) for 48 h. The NLRP3-mediated inflammatory response was studied both in vivo and in vitro. The level of the inflammation was detected by western blot, real-time PCR analysis, and ELISA. Results Emodin attenuated atherosclerotic lesions in HFD-treated ApoE −/− mice. Emodin dramatically decreased the expression of NLRP3, GSDMD, IL-1β, and IL-18 in HFD-treated ApoE −/− mice and PMA-induced macrophages. Moreover, emodin significantly hindered the activation of nuclear factor kappa-B (NF-κB) by inhibiting the formation of the TLR4/MyD88 complex in PMA-induced macrophages. Conclusion Our data demonstrate that emodin can inhibit the development of atherosclerotic plaques by alleviating NLRP3/GSDMD-induced inflammation through repressing the TLR4/MyD88/NF-κB signaling pathway in macrophages. This finding suggests that emodin can be a potential candidate for the treatment of atherosclerosis.
✓ 已验证
DOI
PubMed
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-12
·
IF 3.9
Wu Zhiwei,Zhang Fan,Yang Kai,He Wenfei
Breast cancer is the leading cause of cancer-related death in women worldwide, and its developmental mechanisms involve complex factors. Recent studies have shown that ferroptosis is closely related to the occurrence and progression of breast cancer. However, the role of circular RNAs (circRNAs) in regulating ferroptosis in breast cancer remains unclear. In this study, we investigated the regulatory role of circSCD1 (hsa_circ_0019512) in breast cancer. We examined the expression of circSCD1 in breast cancer cell lines and explored its impact on cell viability and colony formation. We also evaluated the involvement of circSCD1 in ferroptosis by measuring the levels of malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS), and intracellular iron. In vivo xenograft experiments were performed to confirm the role of circSCD1 in promoting tumor growth and inhibiting ferroptosis.Furthermore, we investigated the mechanism by which circSCD1 regulates SCD1 protein stability through ubiquitination and identified the interaction between circSCD1 and the deubiquitinase OTUB1. Our results showed that circSCD1 was upregulated in breast cancer cell lines and promoted cell viability and colony formation. Knockdown of circSCD1 increased MDA and ROS levels, decreased GSH levels, and enhanced ferroptosis in breast cancer cells. In vivo, circSCD1 knockdown significantly reduced tumor size and weight, while its overexpression enhanced tumor growth. Mechanistically, circSCD1 interacted with OTUB1 to inhibit the ubiquitination and degradation of SCD1 protein, thereby stabilizing its expression. Rescue experiments demonstrated that SCD1 overexpression partially reversed the effects of circSCD1 knockdown on cell proliferation and ferroptosis. Our findings suggest that circSCD1 plays a crucial role in promoting breast cancer cell growth and inhibiting ferroptosis by regulating SCD1 protein stability. Targeting the circSCD1/OTUB1/SCD1 axis may provide a potential therapeutic strategy for breast cancer treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Silicon
·
2025
·
IF 3.3
Yang Yonghui,Fan Chao,Yang Pengchen,Liu Zhanwei,Yan Hengwei
This study investigated the effect of aluminum oxide (Al 2 O 3 ) additives on the properties of NaF-AlF 3 -SiO 2 melts. The liquid-phase line temperature was determined through thermal analysis, while the solubility and volatilization loss of silicon dioxide (SiO 2 ) were evaluated using the rotating quartz disk method and volatilization experiments. The dissolution mechanism of Al 2 O 3 in the melt was explored through thermodynamic analysis and experimental validation. The results indicated that Al 2 O 3 addition significantly decreased liquid-phase line temperature, enhanced SiO 2 solubility, and reduced volatilization losses. These findings provide a theoretical basis for optimizing the electrolysis process of Al–Si alloys, which contribute to improved melt performance, enhanced energy efficiency, and reduced volatilization losses, thereby promoting increased efficiency in industrial applications.
✓ 已验证
产品关联
DOI
高影响因子
Food Production Processing and Nutrition
·
2025
·Vol. 7
·期 1
·1-14
·
IF 5.7
Sun Teng,Wang Zhaojun,Dai Yiqiang,Zhai Kang,Fang Xiangna,Chen Yitian,Zhao Baomin,Dong Mingsheng
In this study, Rhizopus oligosporus RT-3 was utilized to ferment soybean meal to obtain a tempe-like food with low fat and high bioactivity. To investigate the impact of fermentation on soybean meal’s nutritional value, we detected the protein-related indices and conducted a non-targeted metabonomic analysis on both fermented soybean meal (FSM) and soybean meal (SM) in order to explore changes in a certain type of metabolite and its corresponding metabolic pathways. The results showed a significant increase in crude protein, peptides and amino acids while getting porous after fermentation. A reduction of raffinose and stachyose to 18.1% and 8.5%, respectively, due to the action of α-galactosidase and β-furanofructosidase occurred. As to amino acid metabolites, essential amino acids for human bodily functions such as lysine, histidine, and threonine were significantly upregulated. Furthermore, nine peptide metabolites were identified as angiotensin-converting enzyme (ACE) inhibitors and dipeptidyl peptidase-4 inhibitors (DPP-IV). After feeding with different doses of FSM, levels of insulin-like growth factor-1 (IGF-1), hemoglobin (HB), albumin (ALB), and total protein (TP) of malnourished mice all returned to normal. In conclusion, fermentation with Rhizopus oligosporus RT-3 can improve the quality of SM by reducing the level of oligosaccharide anti-nutrition factors and increasing the contents of free amino acid and small bioactive peptides, which provide a theoretical basis and new ideas for the application of FSM. Graphical
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Liu Shuohan,Tian Wensheng,Shen Jieqing,Wang Zhikai,Pan Hui,Kuang Xuchen,Yang Cheng,Chen Shunwei,Han Xiujun,Quan Hengdao,Zhu Shenmin
Stable operation of Li metal batteries with gel polymer electrolytes in a wide temperature range is highly expected. However, insufficient dynamics of ion transport and unstable electrolyte-electrode interfaces at extreme temperatures greatly hinder their practical applications. We report a bioinspired gel polymer electrolyte that enables high-energy-density Li metal batteries to work stably in a wide temperature range from –30 to 80 °C. The wide-temperature gel polymer electrolyte is fabricated by using a branched polymer of which side chains are double coupled with their asymmetric analogues. The double dipole coupling regulates the Li + coordination environment to form a weak solvation structure that offers fast and uniform Li + deposition at extreme temperatures. Consequently, the non-flammable gel polymer electrolyte displays an ionic conductivity of 1.03 × 10 –4 S cm −1 at –40 °C and a Li + transference number of 0.83. The Li metal batteries with LiNi 0.8 Co 0.1 Mn 0.1 O 2 positive electrode deliver initial specific discharge capacities of 121.4 mAh g –1 at –30 °C and 172.2 mAh g –1 at 80 °C, with corresponding discharge currents of 18.8 mA g –1 and 188 mA g –1 , respectively. Additionally, a pouch cell delivers a specific energy up to 490.8 Wh kg −1 .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 9
·1-12
·
IF 2.8
Cai Chenglin,Zhu Kongjun,Rao Yu,Kong Zhihan,Li Ziyun,Wu Xiaorao,Yang Yuqing,Huang Miaomiao,Zhou Heng,Yan Kang,Wang Jing,Shi Feng,Guo Jun
Sulfide-based solid-state electrolytes (SSEs) have great potential for realizing high-energy all-solid-state lithium metal batteries. However, their application is seriously hindered by their moisture sensitivity and lithium incompatibility. Herein, various elements, including Si, O, and Br, were used for doping to modify the lithium argyrodite Li 5.5 PS 4.5 Cl 1.5 SSE. The Li 5.55 Si 0.05 P 0.95 S 4.4 Cl 0.75 Br 0.75 O 0.1 (LSiPSClBrO) SSE was synthesized via a mechanical milling and annealing method to improve its stability in humid air while retaining a high ionic conductivity of 7.5 mS cm −1 . Lithium symmetric cells with the LSiPSClBrO electrolyte exhibited stable lithium plating/stripping over 1000 h at a current density of 0.1 mA cm −2 , along with a high critical current density of 1.65 mA cm −2 . The all-solid-state Li–In/NCM811 cells assembled with the LSiPSClBrO electrolyte also demonstrated excellent cycling stability and rate performance, with a specific capacity of 123.0 mAh g −1 after 70 cycles at a rate of 0.2 C and 93.1 mAh g −1 after 150 cycles at a rate of 1 C. This study highlights the potential of Si, O, and Br co-doping in improving the air stability of sulfide electrolytes while maintaining high ionic conductivity, providing insights and guidance for the design and synthesis of multielement-doped materials.
✓ 已验证
产品关联
DOI
高影响因子
METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
·
2025
·Vol. 56
·期 3
·2541-2557
·
IF 3.1
Cao Jianqi,Feng Shanshan,Wang Wanlin,Huang Daoyuan,Sun Yongqi
Vanadium, an extremely important metal element, is dominantly produced from the roasting–leaching process of vanadium–bearing slags, with the roasting process involving a conversion of vanadium–containing phases including iron–vanadium spinels and liquid phase into soluble vanadate. It is difficult to extract vanadium from iron–vanadium spinels due to their ultrastabilities and complex compositions. The presence of minor elements affects the stability of iron–vanadium spinels upon roasting as well as the further leaching process. In this study, the roles of various minor elements on phase and composition evolutions of iron–vanadium spinels upon calcium roasting were investigated by both advanced experimental characterizations (EPMA, XRD and XPS) and thermodynamic calculation using FactSage 8.3. The results first showed that the iron–vanadium spinel underwent a phase transition to form two distinct phases, namely a V-enriched phase and a Fe 2 O 3 solid solution. The presence of Cr 2 O 3 , MnO and MgO did not produce a new phase, but affected the compositions of the two phases formed. However, new phases were generated in the presence of TiO 2 and Al 2 O 3 , namely a Fe 2 TiO 5 phase and an Al-enriched phase, respectively. Moreover, a higher roasting temperature enhanced the partitioning of TiO 2 , Al 2 O 3 and Cr 2 O 3 from the V-enriched phase to the Fe 2 O 3 solid solution, which promoted the enrichment of V 2 O 5 into the V-enriched phase. A lower roasting temperature promoted the formation of manganese vanadate and magnesium vanadate for further leaching process. These findings offer a guidance for optimizing the roasting conditions for maximum vanadium extraction from iron–vanadium spinels.
✓ 已验证
产品关联
DOI
高影响因子
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
·
2025
·
IF 1.7
Qiu Yu,Ruan Huijie,Ji Decai,Cao Na
Bladder cancer is a common malignancy in the genitourinary system with its incidence rate among the world's highest. Neuralized E3 ubiquitin protein ligase 1 (NEURL1) belongs to the RING E3 ubiquitin ligase family, and its role in bladder cancer has not been reported yet. We aimed to explore the expression and roles of NEURL1 in bladder cancer. The NEURL1 expression was determined in clinical samples of bladder cancer. We stably overexpressed NEURL1 and NEURL1 with the RING domain deletion in human bladder cancer cell lines 5637 and RT-112 to investigate its functions. NEURL1 was confirmed to be significantly down-regulated in clinical bladder tumor specimens. NEURL1 overexpression significantly inhibited the growth, colony formation, and Ki-67 protein expression in both bladder cancer cells. The overexpression of NEURL1 also increased the apoptosis rate and cleaved caspase-3 protein expression in 5637 and RT-112 cells. As expected, the RING-deleted NEURL1 had no such effect. Moreover, NEURL1 overexpression facilitated the apoptosis of 5637/RT-112 cells under cisplatin conditions. NEURL1 promotes ubiquitination and proteasomal degradation of PDE9A. PDE9A protein expression was notably increased in bladder tumors from clinical specimens. Overexpressed NEURL1 inhibited PDE9A protein expression in both cell lines, whereas NEURL1 with the RING domain deletion did not. The addition of proteasome inhibitors MG-132 reversed the decrease in PDE9A expression by NEURL1 overexpression. Cell viability was inhibited and apoptosis was increased in the 5637 and RT-112 cells with stable knockdown of PDE9A. NEURL1 may be involved in the bladder cancer progression by increasing apoptosis, thereby leading to tumor cell growth inhibition.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Qian Shao-Kang,Lv Hui,Qiao Wen-Huan,Hu Zhen-Yan,Shen Jin-Zhao,Cao Gui-Ping
Tetramethyl bisphenol A (TMBPA) is a crucial industrial precursor synthesized through acid catalysis. Solid acid catalysts are preferred due to their ease of separation and environmental compatibility. However, the limited understanding of their catalytic mechanisms constrains their application. In this study, sulfonic acid (–SO 3 H) and sulfhydryl groups (–SH) were employed to modify MCM-41 mesoporous molecular sieves to prepare solid acid catalysts. The solid acid catalysts were subjected to catalytic experimental evaluation and structural characterization. The results indicate that the dual-functional mesoporous catalysts exhibit exceptional catalytic activity, achieving a yield of 72.4%. A comprehensive catalytic pathway was proposed through theoretical calculations: The sulfonic acid group (–SO 3 H) facilitates the protonation of acetone; the protonated acetone reacts with the sulfhydryl group (–SH) to form an isopropyl cation through dehydration; the isopropyl cation reacts with 2,6-dimethylphenol to form a 4-isopropyl-2,6-dimethylphenol cation; and this cation combines with another 2,6-dimethylphenol, releasing a hydrogen proton to produce TMBPA. The activation mechanism of the intermediate reveals that the sulfonic acid group (–SO 3 H) induces a 0.011 electron transfer in the acetone molecule, thereby activating the molecule. The sulfhydryl group (–SH) activates the protonated acetone by transferring 0.359 electrons to the protonated species. 2,6-dimethylphenol undergoes a 0.183 electron transfer under the influence of the isopropyl cation, including 0.075 electrons at the solid–liquid interface and 0.108 electrons intramolecularly. The elucidation of the molecular-level catalytic pathway and the electronic-level activation mechanism provides a theoretical basis for the design of solid acid catalysts. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 12
·1-21
·
IF 2.8
Chen Yu,Yi Changnan,Wu Yurong,Yang Fan,Xu Longshan,Hu Yanling,Wang Xiaoshuai,Chen Yuanyi,Qiu Wenqian
Nanosheets self-assembled WO 3 microsphere with hollow and special core–shell structures was successfully synthesized using hydrothermal, acid etching, and heat treatment methods. The special core–shell WO 3 samples with oxygen vacancies (WN-O) have higher carrier concentration and specific capacitance. The symmetrical supercapacitors (SCs) assembled by WN-O show excellent potential in PVA/KOH gel electrolyte and 3 M KOH aqueous solution. The aqueous symmetric WN-O SCs demonstrated great capacitance (22 mAh g −1 , 1 A g −1 ), extraordinary stability in cycling (118% of the retained capacity after 20 000 cycles, 5 A g −1 ), and a huge energy storage capacity (8.8 Wh Kg −1 of energy density, 400 W Kg −1 of power density). Additionally, the all solid-state symmetric WN-O SCs displayed 52.2% retained capacitance even when the current density increases five times, to 5 A g −1 , and an outstanding capacity of 18.7 mAh g −1 at 1 A g −1 . The distinct core–shell structure and plenty of oxygen vacancies of the WN-O electrode are responsible for its exceptional electrochemical performance. The oxygen vacancies and loose core–shell structure provide more active sites, while the unique cavity structure on the core–shell provides channels for charge transfer and successfully prevents collapse caused by contraction and expansion during charge and discharge processes. The mechanism discovered in this study will contribute to the design of better performing WO 3 energy storage devices in the future.
✓ 已验证
产品关联
DOI
高影响因子
RARE METALS
·
2025
·
IF 11
Yue Hong-Lei,Liu Zhi-Chao,Yan Zi-Yu,Liu Guan-Qi,Chen Liang-Wei,Zhu Jian-Hua,Han Jian-Min
Magnesium (Mg)-based biometals are promising candidates for next-generation biodegradable implants in bone regeneration. However, their rapid biocorrosion in physiological environments necessitates protective coatings to enhance corrosion resistance and osteogenesis. Conventional hydrophobic modifications, while effective in mitigating corrosion, often impair biological responses, hindering tissue integration and bone regeneration. Inspired by the architecture of cell membranes, we developed a novel layered octacalcium phosphate (OCP) coating intercalated with a hydrophobic alkyl-phosphate-surfactant bilayer, imparting Mg biometals with enhanced bioactivity and resistance to biocorrosion. Additionally, an MgF 2 transition layer with a mechanically interlocking architecture is fabricated via an in situ growth approach, ensuring the long-term structural integrity and interface stability of the hybrid coating. Compared with conventional coatings, the resulting intercalated organic/inorganic hybrid coatings exhibit exceptional mechanical robustness, remarkable corrosion resistance, and bioactivities conducive to cellular adhesion and proliferation . In vivo implantation tests further revealed a significantly reduced corrosion depth (~ 1.1 μm), minimal inflammatory response, and reduced fibrous encapsulation (~ 65.2 μm), demonstrating its clinical potential. This work pioneers a bioinspired strategy for multifunctional inorganic/organic hybrid coatings, advancing the clinical application of Mg-based implants in osteogenesis. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）