Energy Storage Materials
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2018
·
IF 0
Hui Li,Feng Wang,Chongrong Zhang,Weixiao Ji,Jiangfeng Qian,Yuliang Cao,Hanxi Yang,Xinping Ai
The thermal runaway is now recognized to be a main cause for the unsafety of Li-ion batteries, which poses a serious concern for large scale electric vehicles and energy storage applications . To address this issue, we propose in this work a new positive-temperature-coefficient (PTC) material, poly(3-Octylpyrrole):poly(styrenesulfonate) (P3OPy:PSS)/carbon composite, and use it as conductive matrix of cathode to enhance thermal stability of Li-ion batteries. The electrochemical and safety evaluations reveal that the such-fabricated graphite/LiCoO 2 full pouch cells exhibit not only improved electrochemical performances compared to the conventional cells at ambient temperature conditions, but also a reliable thermal-switching function at an elevated temperature of ≥ 120 °C, demonstrating a strong tolerance to overcharge, thermal impact and short-circuiting. Such a thermal stable mechanism originates from the PTC effect of the cathode matrix , which turns the conductive network into an insulating state under thermally abusive conditions and therefore terminates the charge/discharge reactions, thus protecting the cell from thermal runaway. This work provides a new strategy and electrode design for constructing safer LIBs. In addition, the materials and fabrication technique of the thermal stable cathode is facile and also fully compatible with the present industrial manufacture process, making it convenient for use in practical LIBs.
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Asian Journal of Pharmaceutical Sciences
·
2018
·
IF 4.56
Shilei Yang,Zhihao Liu,Changyuan Wang,Shijie Wen,Qiang Meng,Xiaokui Huo,Huijun Sun,Xiaodong Ma,Jinyong Peng,Zhonggui He,Kexin Liu
To assess the mechanism of the pharmacokinetic interaction between piperacillin and tazobactam , renal excretion and pharmacokinetic studies of piperacillin/tazobactam were investigated in normal and bacteremia rats. A bacteremia model was established to investigate the pharmacokinetic properties of piperacillin and tazobactam under different conditions. Renal slices were taken to examine the uptake of piperacillin and tazobactam. Pharmacokinetic studies of β-lactamase in rats were performed to study the contribution of rOat1/3 to the inhibition of tazobactam on β-lactamase. The AUC (from 2.93 ± 0.58 to 6.52 ± 1.44 mg·min/ml) and the plasma clearance ( CL P ) (from 2.41 ± 1.20 to 0.961 ± 0.212 ml/min/kg) of tazobactam were both altered after the intravenous coadministration of piperacillin and tazobactam in the bacteremia rats. The renal clearance ( CL R ) of tazobactam decreased from 1.30 ± 0.50 to 0.361 ± 0.043 ml/min/kg. In summary, there was a beneficial interaction between piperacillin and tazobactam mediated by rOat1 and rOat3. Piperacillin enhances the inhibitory effect of tazobactam on β-lactamase through the inhibition of rOat1 and rOat3 in rats. The contribution rate of rOat1/3 for the synergistic effect was 20% when the two drugs were coadministered.
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PubMed
高影响因子
Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 47
·12879-12887
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IF 5.976
Zhuang Li,Fei Liang,Yangwu Guo,Zheshuai Lin,Jiyong Yao,Guochun Zhang,Wenlong Yin,Yicheng Wu,Chuangtian Chen
Demands for UV birefringent materials are growing dramatically owing to the rapid development of ultraviolet technology. Here, a new family of UV birefringent materials, Ba2Mg(C3N3O3)2 (BMCY) and Ba2Ca(C3N3O3)2 (BCCY), have been successfully discovered. It is the first time that the excellent birefringent properties of cyanurates have been studied. These materials exhibit an extremely large birefringence (Δn = 0.728–0.351 and 0.771–0.346 from 230 nm to 800 nm for BMCY and BCCY, respectively), much larger than that of the commercial UV birefringent crystal α-BaB2O4 (α-BBO) (Δn = 0.12@532 nm). Our study indicates that the impressive optical properties of BMCY and BCCY stem from the strengthened optical anisotropy of the planar (C3N3O3)3− group compared with the isoelectronic (B3O6)3− group. Besides, its congruent-melting properties make it feasible to grow a bulk crystal by the Bridgman–Stockbarger technique. The extraordinary properties of BMCY and BCCY may shed light on a new path to explore birefringent materials for practical application.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
·
IF 3.412
Wei Dong,Ke Shi,Miao Liu,Caihong Shen,Anjun Li,Xiaotao Sun,Mouming Zhao,Jinyuan Sun,Hehe Li,Fuping Zheng,Mingquan Huang
The “mud”-like off-odor, which is an odor reminiscent of musty and strong animal fecal odors, affects the quality classification of the strong-aroma types of baijiu (SAB), but little is known about which compounds are responsible for this aroma, except for certain phenolic compounds. However, not all mud-like off-odor expressions in SAB can be attributed to those phenolic compounds. In this work, volatile compounds in pit mud and SAB samples were isolated by headspace solid-phase microextraction and liquid–liquid extraction. An odoriferous zone was detected by GC–MS/olfactometer and GC–MS and was attributed to 3-methylindole rather than ethyl oleate on the basis of their odor characteristics, MS data, and retention indices. Combined with the detection threshold of 3-methylindole determined by a three-alternative forced-choice (6.09 μg/L) procedure, odor activity values in the tested base SAB were from 1 to 23. Sensory studies and the prepared heat map highlighted the contribution of this compound to the odor characteristics for the first time.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2015
·Vol. 50
·期 20
·6567-6577
·
IF 2.371
Hu Caibiao,Zhao Guodong,Xia Qiang,Sun Rui
The present study investigated a self-double-emulsifying drug delivery system (SDEDDS) loaded with epigallocatechin-3-gallate (EGCG) and α-lipoic acid to improve EGCG photostability and possess a sustained release behavior. The long chain solid lipids (cetostearyl alcohol) and macadamia oil were utilized as a carrier to co-deliver the two bioactive ingredients. The prepared EA-SDEDDS for topical application was formulated using modified two-step method and characterized by confocal microscopy, in vitro release, and antioxidant effects. EA-SDEDDS was found to be stable under simulated sunlight for 1 month (at room temperature). In vitro cell culture studies, EA-SDEDDS provided protection for 3t3 fibroblasts that underwent H 2 O 2 oxidative stress due to sustained release property. Cellular antioxidant activity assay indicated that EA-SDEDDS showed anti-oxidative capacity with the same efficacy compared to EGCG-α-lipoic acid solution.
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高影响因子
Analytical Methods
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2015
·Vol. 7
·期 5
·1745-1750
·
IF 1.821
Guolin Yuan,Junlin He,Yuan Li,Wailan Xu,Liuliu Gao,Chao Yu
In this work, a novel, ultrasensitive electrochemical immunosensor has been fabricated for the determination of gypican-3 (GPC3) in human serum. A disposable indium tin oxide (ITO) glass array was used as the working electrode on which pyrrole-α-carboxylic acid (Py-α-COOH) was electropolymerised. This approach provided a high content of surface-confined carboxyl groups suitable for the direct covalent binding of GPC3 antibody. In the immunosensor system, the “fluorescence microscopy” technique was first used for the characterisation of carboxyl groups. Meanwhile, the electrode was characterised by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). Using GPC3 as a model analyte, the immunoassay exhibited high sensitivity, acceptable stability and reproducibility with a wide linear range from 0.9 pg mL−1 to 9 ng mL−1 and an ultra-low detection limit of 0.3 pg mL−1 (S/N = 3). The results for real sample analysis in human serum demonstrated that the newly constructed immunosensor array provided a rapid, simple and cost-efficient immunoassay with high throughput and sufficiently low detection limits for clinical applications.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2012
·
IF 3.898
Yi Huang,Lijuan Bu,Wen Wang,Xiaoli Qin,Zou Li,Zhao Huang,Yingchun Fu,Xiaoli Su,Qingji Xie,Shouzhuo Yao
Chemical oxidation of glycoprotein-bound thiophene-3-boronic acid (TBA) monomer by relatively mild oxidant chloroplatinate in neutral aqueous solution containing uricase yielded uricase–PTBA–Pt nano bionanocomposite with high enzymatic specific activity on a platinized (Pt plate ) Au electrode, which was then covered by an outer-layer chitosan (CS) film to fabricate a CS/uricase–PTBA–Pt nano /Pt plate /Au electrode. This electrode exhibited a linear amperometric response to uric acid concentration from 5 μM to 1.2 mM with a sensitivity of 134 μA mM −1 cm −2 , a limit of detection ( S / N = 3) of 1 μM, and excellent operation/storage stability, which also worked well in serum samples.
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高影响因子
ONCOLOGY REPORTS
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2015
·Vol. 34
·期 6
·3147-3155
·
IF 2.301
Lili Zhang,Jie Zhang,Li Chen,Jianli Wang
Autophagy is an intracellular multi-step catabolic degradation process that involves the degradation and recycling of cellular proteins and cytoplasmic damaged organelles to maintain cellular homeostasis and reduction of metabolic stress. Numerous studies have indicated the importance of autophagy in cancer, but the role of autophagy in human skin squamous cell carcinoma (SSCC) development and response to therapy it is still unclear. In the present study, we investigated the role of autophagy in SSCC and the relationship with chemotherapy sensitivity. The present study demonstrated that autophagy related gene the microtubule-associated protein 1 light chain 3 (LC3) expression was low in SSCC. The negative correlation with Bcl2 and survivin, and the chemotherapy drug 5-FU increased the level of autophagy and the autophagy inhibitor 3-MA inhibited this effect in SSCC cells, time- and dose-dependently. When SSCC cells were treated first with 3-MA and then with 5-FU, the inhibition of proliferation, migration, invasion and apoptosis of SSCC cells was enhanced. Our results suggested the possibility of autophagy as a potential target in SSCC therapy and 3-MA and 5-FU combination treatment may be an effective SSCC therapy via autophagy modulating.
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高影响因子
ANALYTICAL CHEMISTRY
·
2015
·
IF 5.636
Yingzi Liu,Meina Li,Fan Zhang,Anwei Zhu,Guoyue Shi
A Au disk nanoelectrode down to 3 nm in radius was developed by a facile and reliable method and successfully applied for monitoring dopamine release from single living vesicles. A fine etched Au wire was coated with cathodic electrophoretic paint followed by polyimide, which retracted from the tip end during curing to expose the Au nanotip. By cyclic voltammetric scanning the above tip in 0.5 M KCl, the transformation of a core-shaped apex into a geometrically well-defined Au disk nanoelectrode with different dimensions can be controllably and reproducibly achieved. Scanning electron microscopy, transmission electron microscopy, and steady-state voltammetry were used to determine the size of nanoelectrodes. The results showed that the specific etching and insulation method not only avoids the use of toxic etching solution and the uncontrollable treatment to expose the tip but also makes possible the controllable and reproducible fabrication of Au disk nanoelectrode down to 3 nm in radius. The nanoelectrodes with well-demonstrated analytical performance were further applied for amperometrically monitoring dopamine release from single rat pheochromacytoma cells with high spatial resolution.
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高影响因子
TALANTA
·
2014
·
IF 3.511
Dangqin Jin,Qin Xu,Yanjuan Wang,Xiaoya Hu
Nonelectroactive acetochlor can be indirectly determined through the photocatalytical degradation of acetochlor. A derivative visible light photoelectrochemical sensor for indirect detection of the herbicide acetochlor using TiO 2 –poly(3-hexylthiophene)–ionic liquid nanocomposite is constructed. Poly(3-hexylthiophene) (P3HT) was synthesized via chemical oxidative polymerization with anhydrous FeCl 3 as oxidant, 3-hexylthiophene as monomer , chloroform as solvent, and the functional TiO 2 nanoparticles were facilely prepared by blending TiO 2 nanoparticles and P3HT at room temperature ionic liquid , 1-Butyl-3-methylimidazolium hexafluorophosphate solution. Operational parameters, including the photolysis time, ratios of TiO 2 to P3HT, bias voltage and pH of buffer solution have been optimized. Under optimal conditions, the proposed photoelectrochemical method could detect acetochlor ranging from 0.5 to 20 μmol L −1 with a detection limit of 0.2 nmol L −1 at a signal-to-noise ratio of 3. The assay results of acetochlor in water samples with the proposed method were in acceptable agreement with those of the gas chromatograph–mass spectrometer (GC–MS) method. The promising sensor opens a new opportunity for fast, portable, and sensitive analysis of acetochlor in environmental samples.
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高影响因子
TheScientificWorldJOURNAL
·
2013
·
IF 1.73
Wei Lin Li,Shuan Bao Tian,Feng Zhu
A simple and efficient synthetic protocol has been developed for the synthesis of 3-substituted-2H-1,4-benzothiazines by using a novel sulfonic acid functionalized nano-γ-Al2O3 catalyst, devoid of corrosive acidic, and basic reagents. The developed method has the advantages of good to excellent yields, short reaction times, operational simplicity, and a recyclable catalyst. The catalyst can be prepared by a simple procedure from inexpensive and readily available nano-γ-Al2O3 and has been shown to be recoverable and reusable up to six cycles without any loss of activity.
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高影响因子
ELECTROCHIMICA ACTA
·
2013
·
IF 3.777
Ping He,Bohong Chen,Yuhao Wang,Zhengwei Xie,Faqin Dong
Organophilic vermiculite was prepared by ionic exchange reaction between vermiculite and cetyltrimethylammonium bromide, and it was then used as filler to prepare a series of composite gel polymer electrolytes containing poly(methyl methacrylate) and room temperature ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate. Surface morphology and structural nature of the composite electrolytes were examined by scanning electron microscopy and Fourier transform infrared spectroscopy, respectively. X-ray diffraction analysis confirmed that organophilic vermiculite decreased the crystallinity of polymer and formed intercalated polymer/layered silicate composite. On the other hand, the dispersion of organophilic vermiculite increased the thermal property of polymer electrolytes. Furthermore, the ionic conductivity and electrochemical window of composite gel polymer electrolyte reached up to the value of 4.01 × 10 −3 S cm −1 and 3.8 V at the adding content of 8 wt.% organophilic vermiculite, respectively.
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