Bioengineered
·
2022
·
IF 6.832
Mingming Ma,Qiao Luo,Lijing Fan,Weilong Li,Qiang Li,Yu Meng,Chen Yun,Hongwei Wu,Yongping Lu,Shuang Cui,Fanna Liu,Bo Hu,Baozhang Guan,Huanhuan Liu,Shengling Huang,Wenxue Liang,Stanislao Morgera,Bernhard Krämer,Shaodong Luan,Lianghong Yin,Berthold Hocher
Acute kidney injury (AKI) is a susceptible factor for chronic kidney disease (CKD). There is still a lack of effective prevention methods in clinical practice. This study investigated the protective effect of the urinary exosomes from premature infants on cisplatin-induced acute kidney injury. Here we isolated exosomes from the fresh urine of premature infants. A C57BL/6 mice model of cisplatin-induced acute kidney injury was given 100 ug urinary exosomes 24 hours after model establishment. The kidneys were collected for pathological examination and the evaluation of renal tubular damage and apoptosis. In the in vitro experiment, human renal cortex/proximal tubular cells (HK-2) were induced by cisplatin to assess the effect of the urine exosomes from premature infants. Exosome microRNA (miRNA) sequencing technology was applied to investigate the miRNAs enriched in exosomes and the dual-luciferase gene reporter system to examine the targeting relationship of the miRNA with target genes. The results indicated that the urinary exosomes could decrease the serum creatinine level and the apoptosis of renal tubular cells, and reduce mice mortality. In addition, miR-30a-5p was the most abundant miRNA in the exosomes. It protected HK-2 cells from cisplatin-induced apoptosis by targeting and down-regulating the mitogen-activated protein kinase 8 (MAPK8). Together, our findings identified that the urinary exosomes derived from premature infants alleviated cisplatin-induced acute kidney injury and inhibited the apoptosis of HK-2 via miR-30a-5p, which could target MAPK8. These findings implied that urinary exosomes from premature infants riched in miR-30a-5p might become a potential treatment for AKI.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Xia Zhou,Xiaoling Lin,Haiqiu Huang,Ping Li,Jiamin Wu,Xueqin Huang,Huaihong Cai,Hai Han,Junxia Zheng,Haibo Zhou
Visual, highly selective, and sensitive detection of sulfur dioxide (SO 2 ) and its derivatives (SO 3 2- ) in vitro/in vivo is of great significance in maintaining cell homeostasis. A new Au@Ag@ZIF-8 optical sensor with o-phenylenediamine (OPD) internal coding surface-enhanced Raman scattering (SERS) tags based on the free radical reaction was synthesized for multi-mode detection of sulfite . First, Co 2+ is oxidized to Co 3+ . Second, the oxidoreduction between SO 3 2- and Co 3+ produces SO 4 -• and Co 2+ to complete the cycle. The resulting SO 4 -• is further reacted with the chromogenic substrate OPD to form the polymer. Due to the UV–vis absorbance of OPD polymer being stronger than that of OPD, but the fluorescence intensity is lower, and their Raman peaks are obviously different, this sensor can be used for the detection of SO 3 2- through colorimetric, fluorescence, and Raman multi-mode. The main advantages are as follows: (1) high selectivity; (2) achieve fast, visual, and highly sensitive detection of SO 3 2- , and the low limit of detection (LOD) is 1 nM; (3) improve the reliability of detection and expands the detection range (1 nM-800 μM); (4) demonstrate the applicability in recognizing SO 3 2- in HeLa cells to provide accurate information on the dynamic distribution of sulfur in cells.
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Journal of Water Process Engineering
·
2022
·
IF 7.34
Yu Zhang,Hong Zheng,Pengyi Zhang,Qi Zuo,Baichao Zhang,Xueying Ren
The deep purification of trace heavy metals in drinking water is of great significance and has received considerable attention worldwide. 2,5-dimercapto-1,3,4-thiadiazole (DMTD) functionalized magnetic ZIF-8 adsorbent (Fe 3 O 4 @ZIF-8-DMTD) using a novel one-pot post coordination modulation method at room temperature could effectively adsorb trace heavy metals from drinking water through cooperating with the abundant functional groups and surface charges. The negative surface charges promoted the rapid accumulation of trace heavy metals on the surface of the adsorbent, meanwhile, the abundant thiol/nitrogen sites contributed to their adsorption, thus the adsorption rate and adsorption capacity of trace heavy metals were greatly improved. For trace Pb(II) (150 ppb), the effluent concentration could meet the World Health Organization (WHO) standard (≤10 ppb) within 10 s after adsorption by Fe 3 O 4 @ZIF-8-DMTD, and the cumulative adsorption capacity that met WHO standard was 12.11 mg/g. Fe 3 O 4 @ZIF-8-DMTD also showed high stability in a broad pH range and excellent adsorption performance in a wide low concentration range. The effluent concentration still could meet the WHO standard when the initial Pb(II) concentration was 11.70 ppm, and the corresponding adsorption capacity reached 35.00 mg/g. Moreover, the capture experiments for multiple heavy metals that coexisted in tap water showed that the effluent concentrations of Hg(II), Pb(II), Cu(II), Cd(II), and Cr(III) could be lower than the allowable limits in a few minutes. The adsorbent could also be easily recovered using magnets and regenerated by thiourea solution, which showed great application potential for the purification of trace heavy metals in drinking water.
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CHEMOSPHERE
·
2021
·
IF 7.086
Lingshuai Zeng,Danqi Cheng,Zhenxing Mao,Yikai Zhou,Tao Jing
Novel halogenated flame retardants (HFRs) have attracted much attention due to their environmental hazard and adverse effects on human health. In this study, a sensitive and simultaneous method for the determination of six novel HFRs was developed, including tetrabromobisphenol A (TBBPA), tetrachlorobisphenolA, TBBPA bis(2-hydroxyethyl ether), TBBPA bis(allyl ether), TBBPA bis(2,3-dibromopropyl ether) and 2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine. ZIF-8 modified nitrogen-doped reduced graphene oxide (ZIF-8@N-rGO) was synthesized and coated onto a syringe filter to prepare a thin film microextraction (TFME) device. The adsorption capacities of ZIF-8@N-rGO for novel HFRs ranged from 50.98 to 112.84 mg g −1 , exhibiting good extraction efficiency through a combination of π-π, hydrophobic, and hydrogen bonding interactions. The TFME device was coupled to a high-performance liquid chromatography-ultraviolet detection system to simultaneously determine target HFRs in crayfish-aquaculture water systems. Under the optimal extraction parameters, the linearities ranged from 0.1 to 100 ng mL −1 . The method detection limits ranged from 0.030 to 0.14 ng mL −1 and relative recoveries ranged from 88.6 to 106.2%. We found that novel HFRs were detected in water and crayfish samples and were primarily distributed in the viscera and head shell of the crayfish. The bioconcentration factors ranged from 0.25 to 19.20 L kg −1 , indicating non-bioaccumulation in the crayfish. This study provides valuable technology and information for potential health risks of exposure to novel HFRs from consuming crayfish.
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Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 40
·14408-14420
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IF 7.393
Shuangxi Yuan,Sining Yun,Yongwei Zhang,Jiaoe Dang,Menglong Sun,Changwei Dang,Yingying Deng
Constructing cost-effective and robust counter electrodes (CEs) without noble metals remains a challenge for the commercialization of current dye-sensitized solar cells (DSSCs). In this study, we focus on the built-in zinc element into the zeolitic imidazolate framework (ZIF-8) to construct a composite of dual-phase zinc selenide (ZnSe) encapsulated by the size-reduced ZIF-derived Se/N-doped carbon (PS N-CSR) using a post-selenization procedure. Benefitting from the enhanced synergy and charge transfer between the small-sized doped carbon skeleton and well-dispersed dual-phase ZnSe active sites, the resultant PS N-CSR exhibited superior catalytic activity and durability to the triiodide reduction reaction (IRR). The devices that utilize PS N-CSR CE achieved a high power conversion efficiency of 8.48%, surpassing that of Pt (7.20%). It is expected that this work will provide an extensible pathway for designing efficient hybrid electrocatalysts with beneficial structures containing transition metal compounds based on ZIF analogs.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2021
·Vol. 32
·期 8
·3194-3204
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IF 3.665
Hong-yan Niu,Li-qin Cao,Xu-le Yang,Kai-nan Liu,Lu Liu,Ji-de Wang
Here, the ZnO/polyacrylamide (ZnO/PAM) macroporous composite monolith was first prepared through the radical polymerization of acrylamide in ZnO-costabilized CO 2 -in-water Pickering high internal phase emulsions (HIPEs). An efficient and green synthesis method was used to prepare the ZnO/PAM porous precursor materials, and ZnO nanoparticles (NPs) were used as a metal ion source to grow the metal organic frameworks (MOF) phase through secondary recrystallization, thereby synthesizing the target MOF/PAM porous monolith. The effects of the contents of ZnO NPs on the formation of HIPEs and properties of the target MOF/PAM composites for the photocatalytic degradation of cationic dye were studied. As the content of ZnO NPs increased to 3.75 wt%, the composite monolith had high mechanical stress (0.24 MPa) at 80% strain and recovered their shape. The as-synthesized ZIF-8/PAM composites were characterized using X-ray diffraction, scanning electron microscope (SEM), Brunauer Emmett Teller (BET), energy dispersive X-ray spectrometer (EDS) mapping, and TG methods. SEM images showed that the hybrid materials were interconnected, and the sizes of the open macropore and interconnected pore throats were 30–125 and about 2–20 μm, respectively. In addition, the ZIF-8/PAM material could be used as a high-efficiency photocatalyst to remove the cationic dye at a fast rate (88.6%).
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Journal of Advanced Research
·
2020
·
IF 6.992
Tengfei Li,Meng Lu,Yuhang Gao,Xiaodong Huang,Guangyang Liu,Donghui Xu
In this study, a novel metal-organic framework (M-ZIF-8@ZIF-67) was successfully prepared using the single layer Fe 3 O 4 -ZIF-8 as magnetic core and wrapped a layer of ZIF-67 outer. This M-ZIF-8@ZIF-67 was employed as an adsorbent for the adsorption and removal of fipronil and its metabolites from environmental water and cucumber samples. The characterization results suggested that M-ZIF-8@ZIF-67 has the double layer structure a polyhedral structure with uniform pores, while ZIF-67 was successfully coated on the surface of Fe 3 O 4 -ZIF-8. The unique structure endowed M-ZIF-8@ZIF-67 a high surface area (219 m 2 /g) and high adsorption capacity for fipronil, fipronil desulfinyl, fipronil sulfide and fipronil sulfone. To our knowledge, this is the first report detailing the adsorption properties of M-ZIF-8@ZIF-67 with double layer structure relating to the adsorption and removal of pesticides. Furthermore, the adsorption model analysis demonstrated that the static adsorption data fitted the Freundlich bimolecular layer adsorption model better than the Langmuir monolayer adsorption model. This study indicates that M-ZIF-8@ZIF-67 has significant potential in the adsorption and removal of fipronil and its metabolites in water and vegetable samples.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Jie Yue,Meng Yuan,Xuan Zhang,Guochang Wen,Guina Ren,Bo Ge,Limin Zhao,Xin Shao
Due to its porous structure, hydrophobic modified three dimensional melamine sponge (MS) was commonly used for high efficiency oil/water separation. Nevertheless, it does nothing to water-soluble pollutants. In order to deal with residual pollutants, the direct Z-scheme BiOI/CdS composites was constructed and loaded onto the melamine sponge which easily achieved efficient degradation and selective deoiling. Furthermore, traditional hydrophobic methods (such as grafting mercaptan, silanes and so on) had several drawbacks, hence a novel metal organic frame material ZIF-8 was adopted in order to attain the purpose of superhydrophobic . In this work, it has shown that the cyclic photodegradation efficiency of superhydrophobic BiOI/CdS/ZIF-8 melamine sponge (BCZ MS) could still achieve 92% after performing 4 cycles of degradation and the results indicated that BCZ MS has preeminent stability. Besides, it was verified by the capture experiment that the main active species was O 2 − .
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MOLECULES
·
2020
·Vol. 25
·期 8
·1957
·
IF 3.267
Ying Li,Chunyan Zhu
Microspheres containing absorption enhancer (sodiumN-[8-(2-hydroxybenzoyl)amino]caprylate, SNAC) were developed to enhance the oral bioavailability of berberine hydrochloride (BER) with poor intestinal membrane permeability. Microspheres were prepared and characterized by particle size measurements, scanning electron microscopy, differential scanning calorimetry, BER payload and release, Caco-2 cell monolayer transport, and rat pharmacokinetics. The microspheres were spherical and had uniform size, high encapsulation efficiency and high loading capacity. In vitro release studies showed that BER-loaded microspheres had good sustained release characteristics. The Caco-2 cell monolayer transport study proved that SNAC could significantly enhance permeability of BER 2–3-fold. Pharmacokinetic studies demonstrated a 9.87-fold increase in area under the curve (AUC) of BER mixed with SNAC and a 14.14-fold increase in AUC of microspheres compared with BER alone. These findings indicate that SNAC is a promising absorption enhancer for oral delivery of BER in the form of both solution and microspheres.Keywords:sodiumN-[8-(2-hydroxybenzoyl)amino]caprylate;permeation enhancement;berberine hydrochloride;microspheres;oral bioavailability
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 43
·16819-16828
·
IF 3.069
Guiling Luo,Ying Deng,Xiaoping Zhang,Ruyi Zou,Wei Sun,Binghang Li,Bi Sun,Yubao Wang,Guangjiu Li
A voltammetric sensor was developed using a nitrogen-doped porous carbon and nitrogen-doped graphene nanocomposite modified glassy carbon electrode for the simultaneous determination of dopamine (DA), uric acid (UA) and ascorbic acid (AA). Detailed characteristics of the nanocomposites were investigated by SEM, TEM, XPS, XRD and FT-IR. Experimental conditions such as accumulation time, accumulation potential and buffer solution pH were optimized. The sensor demonstrated a linear plot of 0.01–15.0 mmol L−1 for AA, 0.08–350.0 μmol L−1 for DA, and 0.5–100.0 μmol L−1 for UA, with detection limits of 1.99 μmol L−1, 0.011 μmol L−1 and 0.088 μmol L−1, respectively. The established method exhibited excellent reproducibility, anti-interference and stability, and it was applied to DA, UA and AA determination in real urine samples with recoveries between 100.2% and 102.0%.
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LANGMUIR
·
2022
·
IF 4.331
Xiao-Jun Feng,Ning Yan,Yanqun Wang,Ping Mei,Wu Chen,Lilin Lu,Lu Lai
Twelve kinds of 8-hydroxyquinoline derivatives were synthesized and characterized. The weight loss method was used to evaluate their inhibition efficiencies (IEs) in a 1.0 M HCl solution at 333 K. The results showed that the alkyl chain length, heteroatoms (S, N, and O), and number of benzene rings significantly affect the IE. Herein, the IE of 5-[(dodecylthio)methyl]-8-quinolinol reached 98.71%. Meanwhile, the potentiodynamic polarization results indicated that all 8-hydroxyquinoline derivatives were mixed-type inhibitors. Electrochemical impedance spectroscopy results revealed that 8-hydroxyquinoline derivatives can increase polarization resistance, supporting their adsorption on the N80 steel surface. Moreover, according to density functional theory (DFT), the frontier orbital distribution and quantum chemical parameters (EHOMO, ELUMO, dipole moment μ, etc.) were calculated, and the results confirmed that the substituents of protonated 8-hydroxyquinoline derivatives significantly influenced the frontier orbital distribution. Molecular dynamics simulation illustrated that all protonated 8-hydroxyquinoline derivatives were adsorbed parallel to the Fe(110) surface, and the interaction energy (Eint) evidenced that the molecular size would affect their strength of adsorption on the Fe(110) surface. The linear and nonlinear quantitative structure–activity relationship models were established by linear regression (LR) methods and BP neural networks (NN), respectively. The LR model was established by using Eint and μ, and the coefficient of determination (R2) was 0.934. In addition, the nonlinear NN model was obtained according to IE and all parameters (DFT parameters and Eint). Then, the two calculation inhibition efficiencies (IEcal) were obtained from the LR and NN models, and the R2 values of the linear correlation between the IEcal and the experimental IE were 0.940 and 0.951, respectively. In addition, the IE of the tested inhibitor was 51.86% and the IEcal values predicted by the LR and NN models were 52.68% and 53.06%, respectively. Our results demonstrate that both the LR and NN models have good fits and predictive ability.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Yang Yu,Rong Zhang,Lurong Hao,Yanni Li,Baoling Wang,Dandan Ge
In this work, a new type of magnetic ZIF-8 based on ferrofluids (FFs) and supramolecular solvents (SUPRASs) was prepared and applied as an extraction phase in vortex-assisted liquid–liquid microextraction of cationic dyes (chrysoidin, auramine O and rhodamine B) in beverage and river water samples. The FFs comprised sodium dodecyl sulfate (SDS) - coupled titanium dioxide - coated MZIF-8 and hexafluorobutanol-geraniol SUPRAS (MZIF-8/SDS-TiO 2 @HFB-Ger). The prepared extraction phase exhibited high extraction recoveries of these cationic dyes owing to strong interaction mechanisms, including hydrogen-bonding, hydrophobic, π-π and electrostatic attractions, between the FFs and the analytes. The optimum extraction conditions of cationic dyes were as follows: Ger content was 4 %, HFB content was 6 %, MZIF-8/TiO 2 -SDS was 25 mg, vortex time was 3 min, solution pH was 6–8, salt concentration was 5 % (m/v), elution solvent was ethanol and elution solvent volume was 500 μL. Under the optimized conditions, cationic dyes were linear in 5–1000 ng mL −1 with determination coefficients higher than 0.9957. The limits of detection ranged from 1 to 1.5 ng mL −1 , and the limits of quantification were between 3.5 and 5 ng mL −1 . Finally, the developed method was applied to determine the target analytes in beverage and river water samples, achieving extraction recoveries ranging from 93.1 % to 104.3 %, with relative standard deviations between 1.1 % and 8.1 %. Compared with MZIF - 8, MZIF-8/SDS - TiO 2 @HFB - Ger exhibited higher extraction efficiency for cationic dyes. Therefore, the developed method has great potential in extracting various analytes from various food and water samples.
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