RARE METALS
·
2025
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IF 11
Luo Qi-Zhi,Huang Jin-Shu,Liu Teng-Yu,Yuan Ji-Li,Belousov Artem S.,Li Sheng-Kun,Yang Song,Li Hu
Photocatalytic selective synthesis of lactic acid (LA) from biomass sugars with a single heterogeneous catalyst is promising but challenging due to the multiple reaction steps involved. Herein, a K-doped C-rich red polymerized carbon nitride (RPCN) photocatalyst with uniform K/C dual sites was constructed by a molten salt template method, which was highly efficient for cascade isomerization dehydration of glucose to LA with > 90% selectivity under visible light and gentle conditions. Control experiments and theoretical calculations expounded that the introduced K/C dual sites could improve the light capture ability and photogenerated charge separation efficiency, while the K species provided sufficient Lewis acid sites (adsorption sites) for the isomerization of glucose to fructose. Meanwhile, the introduced C sites that substitute N atoms could promote electrons to be captured by adsorbed oxygen for selective generation of superoxide radicals, which was highly efficient for the scission of the C3–C4 bond in fructose, exclusively furnishing LA. Importantly, the RPCN photocatalyst was also suitable for the photocatalytic upgrading of various biomass saccharides into LA with high yields of 81.3%–95.3% and could be recycled for five consecutive cycles. The tailored construction of dual sites by localization of space charge lightens an avenue for multi-step conversion of biomass with pronounced selectivity. Graphical abstract
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Food and Bioprocess Technology
·
2024
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IF 5.3
Yang Xiaoqing,Tan Zhifeng,Wang Zheming,Yu Xiliang,Wang Qi,Yu Chenxu,Dong Xiuping
The purpose of this study was to develop a soybean protein isolate (SPI)-based oleogel to enhance the quality of surimi products. In this study, SPI-based oleogel was formulated by mixing SPI and κ-carrageenan (κ-CG) using an emulsion-template approach optimized by adjusting the SPI/κ-CG ratio. The results demonstrated that the intramolecular and intermolecular hydrogen bonds between SPI and κ-CG reinforced the three-dimensional lattice structure of the oleogels. As the increase in κ-CG content, the oil droplets were more uniformly dispersed in the continuous SPI-κ-CG rigid network, which formed a dense network structure and enhanced the storage modules, loss modules, recovery rate, and gel strength of the resulting oleogels. Notably, when the SPI/κ-CG ratio was 9/1, the oleogel was dense and smooth with no oil leakage, and it exhibited the highest oil binding capacity (OBC, 94.52%) and thermal stability (412.91 °C). Cryo-scanning electron microscopy revealed that the oleo-surimi gel had a dense network structure, with oil droplets stably encapsulated within the surimi gel matrix by the polysaccharide-protein interfacial membrane. Compared with surimi gel made with the direct addition of liquid oil, the water-holding capacity and textural properties of oleo-surimi gel demonstrated improved. The surimi gel containing 10% oleogel exhibited the highest overall preference. This approach of making oleo-surimi gel could lead to innovation in the development of novel surimi products. Graphical Abstract
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npj Science of Food
·
2024
·Vol. 8
·期 1
·1-7
·
IF 6.3
Cai Shuangfeng,Xie Ningning,Zheng Ling,Li Quan,Zhang Siyu,Huang Qinghua,Luo Wei,Wu Mei,Wang Yidan,Du Yilun,Deng Shao-ping,Cai Lei
Sweet taste receptors found in oral and extra oral tissues play important roles in the regulation of many physiological functions. Studies have shown that urine volume increases during the lifetime exposure to artificial sweeteners. However, the detailed molecular mechanism and the general effects of different artificial sweeteners exposure on urine volume remain unclear. In this study, we investigated the relationship between urinary excretion and the sweet taste receptor expression in mice after three artificial sweeteners exposure in a higher or lower concentration via animal behavioral studies, western blotting, and real-time quantitative PCR experiment in rodent model. Our results showed that high dose of acesulfame potassium and saccharin can significantly enhance the urine output and there was a positive correlation between K + and urination volume. The acesulfame potassium administration assay of T1R3 knockout mice showed that artificial sweeteners may affect the urine output directly through the sweet taste signaling pathway. The expression of T1R3 encoding gene can be up-regulated specifically in bladder but not in kidney or other organs we tested. Through our study, the sweet taste receptors, distributing in many tissues as bladder, were indicated to function in the enhanced urine output. Different effects of long-term exposure to the three artificial sweeteners were shown and acesulfame potassium increased urine output even at a very low concentration.
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PubMed
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JOURNAL OF MATERIALS SCIENCE
·
2025
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IF 3.9
Wang Yifan,Dong Wenjian,Yan Xuefeng,Li Xia,Yu Liangmin
Tin-free self-polishing antifouling coatings are prevalent today. However, its high Cu 2 O content endangers the marine environment. Leveraging the fluorescent properties of coating to prevent fouling is an environmentally friendly antifouling coating development. In this paper, four unreported fluorescent structural carbazole amide derivatives (FSCAD) were synthesized by Friedel–Crafts alkylation reaction. Their fluorescence, antibacterial, and algal inhibition properties were examined. The fluorescent properties test results showed that the four FSCAD exhibited high fluorescence properties. The results of antibacterial test and anti-algae growth test showed that the maximum bacterial inhibition rate can reach 90%, and the growth inhibition rate of three kinds of microalgae can reach more than 75%. It was added to the antifouling coating system as an antifouling agent instead of the traditional antifouling agent Cu 2 O. The abrasion rate, contact angle, surface morphology, and roughness of the coatings were determined by dynamic simulation experiments, and the antifouling properties of the coatings were evaluated by the anti-algae sedimentation test and marine environment antifouling experiments. The results of dynamic simulation experiments showed that adding FSCAD does not affect the wettability and surface state of the coating. Anti-algae sedimentation test exhibited that marine antifouling coatings with FSCAD showed excellent inhibition on the sedimentation of microalgae. The anti-fouling performance of the coating was tested in the marine environment antifouling experiments. The results showed that the coating exhibited excellent anti-fouling performance, with minimal biofouling was attached to the surface of the coating. Especially, the antifouling performance with compound A was better than that of chlorothalonil. Graphical abstract
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CHEMISTRY OF NATURAL COMPOUNDS
·
2025
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IF 0.9
Popov S. A.,Qi Z.,Yang G.,Wang C.,Semenova M. D.,Shpatov A. V.,Shults E. E.
New conjugates of lupane triterpenoids bound through a 1,2,3-triazole linker with gallate derivatives were prepared via Cu-catalyzed cycloaddition reactions of [3 β ,28-diacetoxy-20(29)-lupen-30-yl]azide and 3 β -acetoxylup-20(29)-en-30-azido-28-oic acid with gallate derivatives with propargyl substituents in various positions. Conjugate 4 based on betulin with a modified gallate substituent containing a dioxolane moiety possessed potent antioxidant properties and anti-inflammatory activity (suppression of NO hyperexpression).
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CELL RESEARCH
·
2025
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IF 25.9
Qin Rui,Zhang Yong,Shi Jiawei,Wu Peng,An Chenyi,Li Zhenhai,Liu Nuo,Wan Ziyan,Hua Ting,Li Xiaolong,Lou Jizhong,Yin Weiwei,Chen Wei
Naturally evolved T-cell receptors (TCRs) exhibit remarkably high specificity in discriminating non-self antigens from self-antigens under dynamic biomechanical modulation. In contrast, engineered high-affinity TCRs often lose this specificity, leading to cross-reactivity with self-antigens and off-target toxicity. The underlying mechanism for this difference remains unclear. Our study reveals that natural TCRs exploit mechanical force to form optimal catch bonds with their cognate antigens. This process relies on a mechanically flexible TCR–pMHC binding interface, which enables force-enhanced CD8 coreceptor binding to MHC-α 1 α 2 domains through sequential conformational changes induced by force in both the MHC and CD8. Conversely, engineered high-affinity TCRs create rigid, tightly bound interfaces with cognate pMHCs of their parental TCRs. This rigidity prevents the force-induced conformational changes necessary for optimal catch-bond formation. Paradoxically, these high-affinity TCRs can form moderate catch bonds with non-stimulatory pMHCs of their parental TCRs, leading to off-target cross-reactivity and reduced specificity. We have also developed comprehensive force-dependent TCR–pMHC kinetics-function maps capable of distinguishing functional and non-functional TCR–pMHC pairs and identifying toxic, cross-reactive TCRs. These findings elucidate the mechano-chemical basis of the specificity of natural TCRs and highlight the critical role of CD8 in targeting cognate antigens. This work provides valuable insights for engineering TCRs with enhanced specificity and potency against non-self antigens, particularly for applications in cancer immunotherapy and infectious disease treatment, while minimizing the risk of self-antigen cross-reactivity.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-16
·
IF 10.6
Guo Yiming,Wu Jicheng,Chen Lefan,Liu Lujie,Bi Tianxiang,Pan Yuanwei,Meng Qian-Fang,Wang Chaoliang,Rao Lang,Li Qi
Androgen deprivation therapy (ADT) is a crucial and effective strategy for prostate cancer, while systemic administration may cause profound side effects on normal tissues. More importantly, the ADT can easily lead to resistance by involving the activation of NF-κB signaling pathway and high infiltration of M2 macrophages in tumor microenvironment (TME). Herein, we developed a biomimetic nanotherapeutic platform by deriving cell membrane nanovesicles from cancer cells and probiotics to yield the hybrid cellular nanovesicles (hNVs), loading flutamide (Flu) into the resulting hNVs, and finally modifying the hNVs@Flu with Epigallocatechin-3-gallate (EGCG). In this nanotherapeutic platform, the hNVs significantly improved the accumulation of hNVs@Flu-EGCG in tumor sites and reprogramed immunosuppressive M2 macrophages into antitumorigenic M1 macrophages, the Flu acted on androgen receptors and inhibited tumor proliferation, and the EGCG promoted apoptosis of prostate cancer cells by inhibiting the NF-κB pathway, thus synergistically stimulating the antitumor immunity and reducing the side effects and resistance of ADT. In a prostate cancer mouse model, the hNVs@Flu-EGCG significantly extended the lifespan of mice with tumors and led to an 81.78% reduction in tumor growth compared with the untreated group. Overall, the hNVs@Flu-EGCG are safe, modifiable, and effective, thus offering a promising platform for effective therapeutics of prostate cancer. Graphical Abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Peng Junjiang,Li Wenguo,Yao Deqiang,Xia Ying,Wang Qian,Cai Yan,Li Shaobai,Cao Mi,Shen Yafeng,Ma Peixiang,Liao Rijing,Zhao Jie,Qin An,Cao Yu
The proper assembly and maturation of collagens necessitate the orchestrated hydroxylation and glycosylation of multiple lysyl residues in procollagen chains. Dysfunctions in this multistep modification process can lead to severe collagen-associated diseases. To elucidate the coordination of lysyl processing activities, we determine the cryo-EM structures of the enzyme complex formed by LH3/PLOD3 and GLT25D1/ColGalT1, designated as the KOGG complex. Our structural analysis reveals a tetrameric complex comprising dimeric LH3/PLOD3s and GLT25D1/ColGalT1s, assembled with interactions involving the N-terminal loop of GLT25D1/ColGalT1 bridging another GLT25D1/ColGalT1 and LH3/PLOD3. We further elucidate the spatial configuration of the hydroxylase, galactosyltransferase, and glucosyltransferase sites within the KOGG complex, along with the key residues involved in substrate binding at these enzymatic sites. Intriguingly, we identify a high-order oligomeric pattern characterized by the formation of a fiber-like KOGG polymer assembled through the repetitive incorporation of KOGG tetramers as the biological unit.
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高影响因子
Journal of Food Measurement and Characterization
·
2024
·
IF 2.9
Xue Jiao,Wang Yifei,Qi Xiaofen,Zeng Weimin,Zhang Yanlong,Lei Hong
Auricularia auricula melanin has a variety of biological activities, but its application is limited because melanin is not easily soluble in water and most organic solvents. In this study, Auricularia auricula melanin was modified using arginine and analyzed for its structure, physicochemical properties, as well as antioxidant and antibacterial activities. It was found that the water solubility of melanin modified by arginine was 11.6 mg/mL. Arg-melanin is stable under cold dark conditions. Structural analysis by UV, IR and NMR revealed that Auricularia auricula melanin was mainly eumelanin. Arg-melanin exhibited scavenging activities of 75.4%, 76.7%, and 77.6% against DPPH radicals, OH radicals, and O 2 − , respectively, which were 9.6%, 42.2%, and 31.2% higher than those of melanin. The MICs of melanin and Arg-melanin were 2.5 mg/mL and 1.5 mg/mL against S. aureus , and 3 mg/mL against E. coli . The MIC and MBC values were identical. As the concentration of melanin increased, the strain exhibited greater growth inhibition and more nucleic acid leakage. Arginine modification of melanin can improve its water solubility, and can enhance the antioxidant and bacteriostatic activity of melanin, which provides a theoretical basis for the application of melanin in the field of food and medicine.
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Chemical and Biological Technologies in Agriculture
·
2024
·Vol. 11
·期 1
·1-17
·
IF 5.2
Zhang Hongbao,Cai Liuti,Yuan Kai,Liu Zhongwei,Ran Maoyang,Chen Siang,Cai Wu,Rao Cheng,Cai Lin,Zhou Dong
Background As a vital soil-borne pathogenic bacterium, Ralstonia solanacearum can cause wilt disease in multiple Solanaceae plants. Several phages, such as ϕPB2, could infect R . solanacearum acting as a potential biological control agent in soil. In addition, some nanoparticles, especially copper preparation, also showed high toxicity on R. solanacearum with low toxicity on plant. However, whether they can be administered in combination and how effective they are in inhibiting the plant disease caused by R . solanacearum is known very little. Results In this work, the characterization of CuONPs using scanning electron microscope, transmission electron microscope, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction ascertained the presence of CuONPs which were nanometer particle of 83 nm. Then it was found that combined application of CuONPs with phage (ϕPB2) was superior to that of ϕPB2 or CuONPs alone in controlling tobacco bacterial wilt, with the CuONPs (250 mg/mL) and phage (10 6 PFU/mL) ratio being the best, at 79.1%. The combination of CuONPs and ϕPB2 also showed no obvious toxicity on tobacco growth than control like single application of CuONPs or ϕPB2. Furthermore, the transcriptome changes of R . solanacearum analysis indicated that the combination application and single allocation of CuONPs could inhibit “biofilm formation”, molecular function, biological processes, cellular components, metabolic process, and so on. In addition, the combination application showed higher inhibition of motility and biofilm, and better enhancement of cell membrane permeability, protein leakage, MDA concentration, and enzyme activity of their respiratory chain dehydrogenase than single application of CuONPs or phage (ϕPB2). Transcriptomes analysis also supported that the addition of ϕPB2 enhanced the toxicity of CuONPs by influencing the ABC transporters and quorum sensing, metabolic processes, and cellular biosynthetic processes of R. solanacearum . Conclusion In total, our work not only proposed a novel way to increase the bactericidal effect of nanomaterials by adding phage, but also discovered the influence, synergistic effects, and mechanisms, which is useful to design novel way to combat phytopathogenic bacteria in the complicated environment. Graphical abstract
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Advanced Fiber Materials
·
2025
·
IF 21.3
Dong Jingwen,Lin Kang,Zhao Weijun,Su Fengmei,Zhou Bing,Feng Yuezhan,Liu Xianhu,Liu Chuntai
Passive radiative cooling fabrics with high solar reflectance and mid-IR emissivity hold great promise for personal cooling applications. Nevertheless, most current passive radiative cooling fabrics overlook their inherent thermal conductivity, resulting in ineffective heat transfer from human skin to the environment. Herein, by constructing highly anisotropic thermal conductive thermoplastic polyurethane/boron nitride nanosheet (TPU/BNNS) fabrics via one-step electrospinning, thermal conductive cooling mechanism was introduced into passive radiative cooling fabrics. The stacked TPU/BNNS nanofibers with aligned BNNS along the fiber direction and the porous fiber network with high contact thermal resistance resulted in high thermal conductivity along the in-plane direction but low thermal conductivity along the out-of-plane direction. This high anisotropy enables rapid heat transfer along the in-plane direction to dissipate heat while blocking external heat penetration along the out-of-plane direction, thus achieving an effective conductive cooling effect. Moreover, the incorporation of BNNS increased the scattering sites for solar radiation, further improving the fabric’s solar reflectivity to 95%. Combined with the high emissivity (92.9%) provided by the intrinsic groups of TPU and BNNS, the fabric demonstrates excellent radiative cooling ability. Therefore, under the dual action of passive radiative cooling and conductive cooling, the TPU/BNNS fabric achieved a sub-environmental cooling of 12.4 °C and a personal cooling of 10.7 °C. Along with excellent breathability, stretchability, and waterproof properties, the TPU/BNNS fabric exhibits outstanding potential for outdoor personal thermal management applications. Graphical
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WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 8
·1-16
·
IF 3.8
Deng Wenchao,Wang Guanghui,Wang Bing,Deng Nansheng
The contamination of soil with cadmium (Cd) poses a significant risk to both food safety and human health. It is crucial to urgently identify an effective technology for remediating Cd-contaminated soil. In the present study, a novel sulfur modified biochar supported ferrous sulfide (FeS@SBC) composite was fabricated by calcination and hydrothermal method. Indoor culture, column leaching, and pot experiments were employed to examine the immobilization effect of FeS@SBC on Cd in contaminated soil. The outcomes illustrated a significant immobilization effect on the Cd-contaminated soil with the application of FeS@SBC. After incubating the soil with the stabilizer for 28 d, the Cd that was previously highly mobile underwent a transformation into an immobilized state. In the experiment on leaching using simulated acid rain, the treatment with FeS@SBC showed a noteworthy decrease in the cumulative loss and leaching efficiency of Cd when compared to the control experiment. It achieved reductions of 70.9% and 71.6%, respectively. The adsorption and immobilization mechanisms resulted from co-precipitation, ion exchange and surface complexation. In the outdoor pot experiment, after 28 d of growth, the water spinach in contaminated soil treated with FeS@SBC has a better growth compared to the control group, with a biomass increase of 134.95%. Additionally, the values of BCF and TF of Cd decreased by 62.25% and 40.39%, respectively, and the available concentration of Cd in the soil decreased by 23.87%. The FeS@SBC composite shows promise as an effective stabilizer for remediating Cd-contaminated soil.
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