查找使用阿拉丁产品的科研文献

Co-Delivery of Morphologically Switchable Au Nanowire and Hemoglobin-Resveratrol Nanoparticles in the Microneedle for Diabetic Wound Healing Therapy

Peng Ye,Yuan Yang,Mengzhe Liu,Jiaqi Meng,Jingyang Zhao,Jiawei Zhao,Jinghui Wang,Qianyun Lu,Jing Liu,Luying Wang,Jiandu Lei,Changlong Wang

Diabetic wounds are a common complication of diabetes and pose a significant threat to human health. High glucose concentration in the wound remains a major obstacle, necessitating effective strategies to achieve sustained glucose consumption for synergistic diabetic wound therapy. In this study, an Au-based nanomaterial is developed that can adjust its morphology in different therapeutic processes. The prepared Au nanowire (ANW) can be converted into Au nanospheres (AS) under ultrasonic conditions by adjusting the amount of polyethylene glycol (PEG) on its surface for convenient delivery. Intriguingly, AS is depolymerized into ANW again in the wound area, prolonging the retention time, and ensuring continuous consumption of glucose. After constructing the morphologically switchable Au nanowire, a polyvinyl alcohol (PVA) is applied it to microneedle and co-delivered it with hemoglobin (Hb)-resveratrol (RES) nanoparticles for synergistic diabetic wound therapy. In a streptozotocin (STZ)-induced diabetic mouse model, the microneedle degraded gradually, and the Hb-RES nanoparticles synergistically ameliorated hypoxia, scavenged ROS, and inhibited macrophage differentiation into pro-inflammatory M1 phenotypes. During this process, ANW continuously catalyzed glucose through its inherent glucose oxidase activity. Thus, this study provides novel insights into the long-term management of glucose concentration during synergistic diabetic wound healing.

Direct detection of polystyrene microspheres by using easily fabricated Ag core embedded Au film SERS substrates with high sensitivity

Yansheng Liu,Zhenle Qin,Xiaobo Jia,Jin Zhou,Hongli Li,Xiaohong Wang,Guofu Wang

Plastics as very important materials have been extensively utilized, and they make people’s lives comparative and economic. However, recent studies find that the micro/nano-plastic particles degenerating from plastic materials especially for food containers may lead to some unknown diseases when they enter into the human lung or stomach. The methods of detecting micro/nano-plastic particles are urgently required, and conventional methods necessitate intricate pre-processing steps and specialized equipment. Hence, this paper introduces a highly sensitive and direct detection method based on Surface-Enhanced Raman Spectroscopy (SERS) in quantitatively and qualitatively analyzing polystyrene (PS) nanoplastics that are drop cast on substrate. The mechanism of SERS performance of the proposed Ag core embedded Au film (Ag@AuFilm) SERS substrate is studied by using the finite-different time-domain (FDTD) method. By optimizing the gap distance between the Ag core and the Au film, PS nanoplastics with three diameters were used to validate the effectiveness of the SERS substrate. The limits of detection (LOD) for PS nanoparticles with diameters of 50 nm, 70 nm, and 310 nm in DI water and real-river water were the same and the corresponding LODs were 50, 50, and 25 μg/mL, respectively. Thus, this study proposes an easily fabricated SERS substrate and provides a rapid, quantitative, and qualitative method for detecting PS nanoplastics. This new way of addressing the pervasive issue of nanoplastics pollution provided an accurate, efficient, and rapid detection of the nanoplastics.

A colorimetric assay method for Co2+ based on thioglycolic acid functionalized hexadecyl trimethyl ammonium bromide modified Au nanoparticles (NPs)

Fuqiang Zhang,Leyong Zeng,Yingxin Zhang,Haiyan Wang,Aiguo Wu

A simple, rapid and sensitive colorimetric assay method for detection of Co2+ through thioglycollic acid (TGA) functionalized hexadecyl trimethyl ammonium bromide (CTAB) modified Au NPs has been discovered in our work. TGA functionalized CTAB modified Au NPs can be aggregated quickly in the presence of Co2+ through a cooperative metal–ligand interaction. Transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDS), and UV-vis spectra were used to characterize the Au NPs aggregation. The presence of Co2+ is monitored by a colorimetric response of functionalized Au NPs, and had a detection limit of 3.0 × 10−7 M. Moreover, the selectivity of this method has been investigated by comparing with other metal ions (Hg2+, Na+, Cu2+, Cd2+, Ba2+, Pb2+, Mn2+, Ni2+, Zn2+, Fe2+ and Fe3+).

Au-loaded ZIF-8 derived porous carbon with improved photothermal catalysis ability from interfacial heating instead of hot-electrons

Hanhan Lv,Daniel K. Macharia,Zixiao Liu,Lisha Zhang,Chiyan Yu,Chihao Lu,Huansheng Liu,Yumei Zhang,Zhigang Chen

Photothermal catalysis has attracted increasing attention due to the efficient utilization of sustainable solar energy and high catalytic activity. However, its practical application is still limited due to the complex synthesis and low surface area of photothermal materials, as well as the challenges of distinguishing the effects of hot electrons and localized heating. To solve these issues, ZIF-8 derived porous carbon (ZPC) nanocrystals were constructed as high surface area photothermal materials and then decorated with Au nanoparticles as the catalytic components. Au/ZPC nanocomposites are prepared by the assembly of ZIF-8, the pyrolysis and in-situ Au reduction process. They are composed of rhombic dodecahedron-shaped ZPC with an average diameter of ∼120 nm, where Au nanoparticles (2–8 nm) are dispersed well on the surface or within the pore structure of ZPC . Besides, Au/ZPC exhibits a wide range of light absorption between 200 and 1100 nm and high photothermal efficiency of 45 %. With 4-nitrophenol (4-NP) reduction reaction as a model system, Au/ZPC catalyst exhibits a 2-fold increase in the rate of 4-NP reduction when exposed to an 808 nm laser irradiation, in comparison to thermocatalysis at the same temperature. Furthermore, the activation energy for the reduction of 4-NP via photothermal catalysis was much lower than that of thermocatalysis (74.16 vs. 104.26 kJ mol −1 ). By excluding hot electrons effects by transient absorption (TA) spectra, we can establish that the increase of photothermal catalysis rate should result from the localized heating which can decrease the energy barriers for the reduction of 4-NP. Additionally, Au/ZPC displays high stability and maintains remarkable activity even after five cycles. This study may provide some new perspectives for the design and development of efficient photothermal catalysts.

Au nanoparticles decorated SrTiO3−x hollow structure for plasmatic enhanced hydrogen production in UV–visible and near-infrared region

Meng Liu,Xiangyu Xu,Wanying Xiao,Yipeng Liu,Yongbo Cui,Haojie Zhang,Amin Ju,Bo Feng,Lijing Wang,Weilong Shi

Designing photocatalysts with a broad reaction to sunlight is crucial for efficient clean energy conversion. However, most catalysts reported so far can only respond to UV and visible light for photocatalysis, neglecting the utilization of near-infrared light, which accounts for almost 50 % of sunlight. In this study, we obtained Au nanoparticles (NPs) decorated porous hollow SrTiO 3 material rich in oxygen defects using an acid etching-assisted hydrothermal method. The formation of a Schottky heterojunction between Au and SrTiO 3−x with matched Fermi levels enhances the electron transfer ability of SrTiO 3−x . Additionally, Au NPs exhibit two types of surface plasma resonance (SPR) effects at 480 nm (transverse SPR) and 800 nm (longitudinal SPR in the near-infrared region) by absorbing specific photons emitted by SrTiO 3−x . The "hot" electrons of the photoexcited SPR state can be further injected into the CB of SrTiO 3−x . Furthermore, the local electromagnetic field around the SPR-enhanced Au NPs effectively promotes the excitation and transfer kinetics of photoelectrons, allowing more "hot" electrons to participate in the photocatalytic reaction. Besides, the unique hollow porous structure of the catalyst ensures multiple reflections of sunlight within SrTiO 3−x . As a result, the hydrogen production efficiency of Au-SrTiO 3−x under near-infrared (NIR) and UV–vis-NIR light irradiation reaches 850 and 3206 μmol h −1 g −1 , with apparent quantum efficiency of 6.4 % and 7.2 % at 820 nm and 420 nm, respectively. The possible photocatalytic mechanism was proposed based on thorough systematic experimental analysis and theoretical calculations.

Advancing Protein Detection and Analysis Based on Ag/Au PHCN for Enhanced SERS Sensitivity and Specificity in Biomolecular Diagnostics

Jing Wu,Ying Zhang,Jiuchuan Wang,Zhuangzhuang Ling,Xuanhua Yan,Xiaoming Lyu,Jinghuai Fang,Mingfei Cheng,Min Zhao,Tao Ban,Yu Liu,Yang Li

In the realm of disease diagnostics, particularly for conditions such as proteinuria and hemoglobinuria, the quest for a method that combines accurate, label-free detection of protein compositions and their conformational changes remains a formidable challenge. In this study, we introduce an innovative Ag/Au plasmonic hybrid coupling nanoarray (Ag/Au PHCN) architecture marked by sub-10 nm interparticle gaps. These nanoarrays, leveraging plasmonic hybrid coupling and synergistic enhancement mechanisms, create a plethora of uniform surface-enhanced Raman spectroscopy (SERS) hotspots. The Ag/Au PHCN substrates demonstrated unparalleled sensitivity in the unmarked detection of hemoglobin (HGB), bovine serum albumin (BSA), and cytochrome C (Cyt.C) in bodily fluids, incorporating the advantages of high sensitivity, high reproducibility, durability, recyclability, and biocompatibility. Notably, the detection limits for BSA and HGB are unprecedented at 0.5 and 5 ng/mL, respectively. This achievement sets a new benchmark for label-free protein detection using two-dimensional nanostructures. Crucially, the Ag/Au PHCNs possess the novel capability to discern protein conformational changes post denaturation, underscoring their potential in probing protein functionalities. Most importantly, these nanoarrays can differentiate between normal and proteinuria-affected urine samples and monitor protein content variations over time, heralding a new era in clinical diagnostics with particular relevance to proteinuria and hemoglobinuria detection.

Advanced quasi-2D amorphous TiOx-Au photocatalyst: Harnessing defects and carriers transport to boost visible-light organic pollutants degradation

Jingting Su,Junyi Xia,Huijun Liang,Jun Xiao,Ruohu Zhang,Shuhong Xu,Li Zhu

Amorphous materials have recently garnered significant interest due to their low-cost fabrication methods, extensive surface area and plentiful surface defects , which offer numerous active sites for catalytic reactions . However, carriers self-trapping and recombination caused by bulk defects limit the employment of amorphous materials as photocatalysts . As such, it is essential to adjust the structure and defects to improve carriers utilization for creating high-performance amorphous photocatalysts. In this study, we developed a novel and facile strategy to fabricate a quasi-2D amorphous crepe-like TiO x -Au (cTiO x -Au) photocatalyst, in which the cTiO x was synthesized simply through one-step hydrolysis method at room temperature by constructing discrete reaction system with mass-confinement of the precursor to guide the morphology of the cTiO x . The removal efficiencies of the cTiO x -Au to antibiotic tetracycline (TC) and gaseous pollutant formaldehyde (HCHO) under visible light were 84.43 % and 95.92 %, respectively, which greatly surpassed those of its counterparts, normal amorphous TiO x (amTiO x )-Au (54.32 % and 73.67 %) and crystalline catalyst TiO 2 -P25-Au (49.29 % and 54.03 %). The remarkable visible-light photocatalytic capacity of cTiO x -Au can be attributed to the unique quasi-2D morphology of cTiO x . The ultrathin nanostructure not only maximizes surface defects and minimizes bulk defects, but also effectively shortens the carriers transport time and reduces recombination probability, on the other hand, it provides ample adsorption sites and accessible binding sites for plasmonic Au nanoparticles to amplify the effect of surface plasmon resonance enhancement. The excellent photocatalytic performances of cTiO x -Au for removing both aqueous and atmospheric pollutants endow it great potential in real environmental remediation applications.

Uricase-Based Highly Sensitive and Selective Spectrophotometric Determination of Uric Acid Using BSA-Stabilized Au Nanoclusters as Artificial Enzyme

Huihui Zhao,Zhonghui Wang,Xue Jiao,Lichun Zhang,Yi Lv

A Multifunctional Mesoporous Silica-Coated UCNP/Au Nanoplatform for Near-Infrared Light-Triggered Photothermal Conversion/Photoluminescence and Drug Delivery

Zheng Zhang,Dan Sui,Man Xu,Lingling Yang,Chuan Lai,Yuanhui Ji,Kangjun Wang

The combination of near-infrared (NIR) light-triggered photoluminescence, photothermal conversion, and drug delivery in a single multifunctional nanoplatform has attracted a great deal of attention. In this work, a novel multifunctional nanoplatform (UCNP/Au@SiO2 NPs) was developed to construct a multifunctional drug nanocarrier by incorporating Au-doped upconversion nanoparticles (UCNP/Au NPs) and mesoporous SiO2. In our design, UCNP/Au NPs can provide dual photoluminescence and photothermal conversion. After that, the prepared UCNP/Au NPs were further coated with a mesoporous SiO2 shell. The UCNP/Au@SiO2 NPs were investigated by using different characterization methods. As a multifunctional nanoplatform, the photothermal conversion and photoluminescence properties were evaluated in detail. The results showed that UCNP/Au@SiO2 NPs had good photothermal conversion ability in both the NIR-I and NIR-II regions. Additionally, UCNP/Au@SiO2 NPs showed an effective photoluminescence performance under 808 nm laser excitation. Benefiting from mesoporous SiO2, the UCNP/Au@SiO2 NPs proved to be an effective nanocarrier for drug loading and controlled release. Overall, this study described a novel NIR light-triggered nanoplatform for intelligent photoluminescence, photothermal conversion, drug delivery, etc.

Photocatalytic degradation of four organophosphorus pesticides in aqueous solution using D-cys/Au NPs modified TiO2 by natural sunlight

Mengtian Cui,He Wang,Xia Fan,Jianhao Zhang,Changrui Xing,Wenjing Yan

The widespread use of organophosphorus pesticides (OPPs) in foods, poses a serious threat to human and environmental health, it is crucial to develop methods that can efficiently degrade residual OPPs . Herein, a chiral TiO 2 photocatalyst was developed by modification TiO 2 with D-cys/Au NPs (DAT) for the simultaneous degradation of four OPPs (chlorpyrifos, chlorpyrifos-methyl, malathion, and parathion) by natural light. The influence of D-Au NPs concentration on the degradation process was optimized, along with the initial pesticide concentration. Under optimal conditions, the photocatalytic degradation efficiencies of DAT for four OPPs were 96.7 %, 56.9 %, 42.6 %, and 49.2 %, respectively, after 12 h of natural light exposure. 12 degradation products of OPPs were identified, among which three products were identified for the first time. The degradation pathway revealed that the degradation of OPPs by DAT involves the oxidation of the P═S bond and the cleavage of the P-O bond and C-O bond. This study establishes a theoretical foundation for applying chiral TiO 2 nanomaterials for the photocatalytic degradation of OPPs in foods.

SPR sensor based on sapphire prism coupling with dual-Au-layer sandwiched GaN structure for enhanced sensitivity and FOM

Zhuo-Yu Jin,Chu Cao,Nuerguli Kari,Dian-Yun Zhang,Qi Wang

Surface plasmon resonance (SPR) sensors are currently applied in various fields, driving the development of precise detection technologies. However, few designs effectively balance ease of fabrication, high detection performance, and structural stability. To address this challenge, we developed an SPR sensor with a sapphire prism-Au/Gallium Nitride (GaN)/Au composite film structure. The GaN thin film enhances sensitivity, while the coupling between the dual Au layers and sapphire reduces the full width at half maximum (FWHM) and improves sensor stability. Simulation results indicate a significant increase in the electric field intensity at the sensor surface. Experimental results demonstrate that the structure exhibits excellent long-term stability. Compared with conventional Au film sapphire prism SPR sensors, this design achieves a 3.14-fold increase in sensitivity and a 5.43-fold improvement in the figure of merit (FOM). This study presents a novel approach to further enhancing SPR sensor performance and highlights the potential applications of this structure in detection technologies.

The Efficient and Sensitive Detection of Serum Dopamine Based on a MOF-199/Ag@Au Composite SERS Sensing Structure

Yuyu Peng,Chunyan Wang,Gen Li,Jianguo Cui,Yina Jiang,Xiwang Li,Zhengjie Wang,Xiaofeng Zhou

In this study, a MOF-199/Ag@Au SERS sensing structure was successfully synthesized by combining metal–organic frameworks (MOFs) with surface-enhanced Raman scattering (SERS) technology for the efficient detection of dopamine (DA), a biomarker for neurological diseases, in serum. Using electrochemical methods, a copper-based MOF (MOF-199) was synthesized in situ on copper substrates and further deposited with silver nanoparticles (AgNPs). Subsequently, gold nanoshells were encapsulated around these silver cores by in situ chemical deposition. This preparation process is simple, controllable, and inexpensive. Furthermore, a novel Azo reaction-based DA SERS method was proposed to detect 1 pM DA, which represents an improvement in sensitivity by two orders of magnitude compared to previous unlabeled SERS detection methods and by four orders of magnitude compared to another SERS approach proposed in this work. There was an excellent linear relationship (R2= 0.976) between the SERS signal at 1140 cm−1and the DA concentration (0.001 M~1 pM). The results indicate that the MOF-199/Ag@Au sensor structure can successfully achieve both the qualitative and quantitative detection of DA in serum, thus providing a robust technical basis for the application of SERS technology in the field of clinical neurological disease screening.