COMPOSITES COMMUNICATIONS
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2026
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IF 8.6
Bowen Sun,Ying Wang,Jaslyn Ru Ting Chen,Manli Guo,Emily Xi Tan,Lam Bang Thanh Nguyen,Wanzong Wang,Hao Feng,In Yee Phang,Yan Lv,Jianhua Li,Xing Yi Ling,Qi-Zhi Zhong
Surface-enhanced Raman scattering spectroscopy (SERS) enables ultrasensitive and multiplexed detection, but unstable interfacial chemistry limits its reliability in complex environments. We introduce metal-polyphenol networks (MPNs) as a universal coating for stabilizing diverse SERS substrates. In a one-step aqueous co-assembly, tannic acid, Fe 3+ ions, and Raman reporters rapidly (<1 min) form uniform MPN shells on plasmonic and semiconducting nanostructures without additional surface pretreatment. The coatings offer tunable nanogap, Raman intensity enhancement, and maintain signal stability under physiological conditions. Optimized thickness (∼8 nm) maximizes enhancement factors and reporter loading, supporting applications from sensing to therapy. The intrinsic photothermal properties of MPNs enable antibacterial therapy against methicillin-resistant Staphylococcus aureus . These results establish MPN coatings as a substrate-independent, bioactive, and multifunctional strategy for robust SERS nanocomposites sensing in complex biological environments.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Miao Miao,Qijie Jin,Yan Shao,Feng Zeng,Huanhao Chen
This study developed a ternary CuCoIn/Al 2 O 3 catalyst for the direct hydrogenation of CO 2 to ethanol. The incorporation of Co and In species created a synergistic effect that enhanced CO 2 interaction and activation. This synergy also modulated the electronic state of surface Cu atoms, increasing the proportion of Cu + species, which promoted the non-dissociative adsorption of CO and the formation of *HCOO intermediates. These changes significantly enhanced C C coupling, leading to the generation of key ethoxy intermediates. The optimized catalyst, with a Co/(Co + Cu) ratio of 0.08 and 1.5 wt% In loading, achieved over 90% ethanol selectivity among total alcohols at 260 °C, along with a relatively high ethanol production rate of 33.0 g EtOH kg cat −1 h −1 . This work presented an effective strategy for designing high-performance, non-precious metal catalysts for selective CO 2 -to-ethanol conversion.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Fangbing Wang,Qiwen Peng,Yongheng Zhang,Min Zhang,Guoyue Shi
Blood marker analysis technology is crucial for real-time monitoring of physiological health. However, traditional routine blood tests require prior plasma separation, consuming significant blood volume and time. This study introduces an innovative sensor platform that achieves simultaneous plasma separation and multi-marker detection in real-time, such as calcium ions (Ca 2+ ), magnesium ions (Mg 2+ ), chloride ions (Cl − ), creatinine (Cr), and urea nitrogen (BUN). The sensor consists of a dedicated separation unit and a detection unit. The separation unit employs a Janus membrane with asymmetric driving to enable spontaneous plasma separation and transmission. The sensing unit contains chromogenic agents specific to Ca 2+ , Mg 2+ , Cl − , Cr, and BUN, facilitating colorimetric reactions for visual analysis. The detection system primarily comprises a smartphone equipped with a custom application that captures RGB values and converts them into concentration data for marker detection. This novel Five-in-One Colorimetric Multiplexed Point-of-Care Testing system not only presents a new method for real-time blood testing but also pioneers new approaches and concepts in blood diagnostics.
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BIORESOURCE TECHNOLOGY
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2026
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IF 8.2
Xin Li,Haoyu Chai,Zhifan Yang,Cuiluan Ma,Yu-Cai He
Syringyl alcohol is an important lignin-derived aromatic alcohol with potential utility in the fragrance and pharmaceutical research. In this study, it was biologically synthesized from syringaldehyde. The recombinant Escherichia coli C165F-V231D expressing alcohol dehydrogenase K p ADH from Kluyveromyces polyspora enabled the effective biotransformation of syringaldehyde. Based on structural analysis and previous work for mutation of 165C to 165F and 231 V to 231D in K p ADH. This variant was created, demonstrating a markedly increased catalytic activity under low dimethyl sulfoxide (DMSO) concentrations. C165F-V231D activity could be improvemed significantly in DMSO-H 2 O (5:95, V/V). Eventually, C165F-V231D cells transformed syringaldehyde (25 mM) to syringyl alcohol in 99.7% analytical yield. This work provides a sustainable biocatalytic strategy for the synthesis of syringyl alcohol from lignin-derived aldehydes, deserves the further development lignin valorization and the green synthesis of bio-derived aromatic alcohols.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·121737
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IF 7.5
Xixi Di,Xia Zeng,Shujun Meng,Tian Tang,Wei Wang,Hanghang Zhao,Xiaohui Ji,Lingxia Jin,Chao Duan,Xianzhao Shao
s Iron-based heterogenous catalysts play an important role in Fenton-like reactions, but their practical application is hindered by complex synthetic procedures and limited comprehension of reaction mechanisms. A straightforward impregnation and pyrolysis method was devised to synthesize a zero-valent iron (ZVI) modified carbon-based catalyst which significantly boosts PMS activation to degradation of tetracycline hydrochloride (TCH), more importantly, it elucidated the correlation between the electronic structure and the production of non-radical reactive oxygen species (ROS). The optimized catalyst demonstrates exceptional performance, achieving 97 % removal of TCH within 30 min, with a remarkable apparent rate constant ( k obs ) of 0.1962 min −1 , outperforming the pristine carbon catalyst by 11-fold. Mechanistic investigations reveal that the incorporation of ZVI facilitates redox cycling with PMS, thereby boosting the generation of diverse ROS. Theoretical calculations reveal that both radical and non-radical pathways synergistically enhance catalytic activity. This work presents a cost-effective and scalable approach to designing high-performance carbon-based catalysts for PMS activation, providing valuable insights into the development of sustainable water purification technologies for emerging contaminants.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Jiayao Gan,Wenyu Jiang,Wei Liao,Huan Liu,Jielun Hu
The purpose of this research was to investigate the application of azobenzene modified polysaccharide on the single probiotic encapsulation by carbodiimide-mediated amidation and evaluate its targeted delivery potential in colon. Yeast β-glucan (YBG) was first modified by azobenzene groups via esterification (AA-YBG), which was then conjugated to the amino groups on the Escherichia coli Nissle 1917 (EcN) surface membrane through carbodiimide-mediated amidation, resulting in the successful fabrication of single probiotic microcapsules (EcN@AA-YBG). SEM and TEM showed that AA-YBG formed a nano-sacle intact thin film on the surface of EcN through covalent coupling between amino groups on the EcN membrane and the carboxyl groups in AA-YBG molecular chains as evidenced by FT-IR, and the biocompatibility analysis showed that AA-YBG coupled nanolayer has no significant effect on the proliferation of probiotics. In vitro gastrointestinal digestion showed that compared to the free EcN which suffered structural disintegration and lost all the viability within 0.5 h of gastric acid digestion, the EcN@AA-YBG maintained robust structural integrity with viability above 77% after the entire 6 h of digestion. Colonic targeted release analysis revealed that EcN@AA-YBG not only susceptible to enzymatic cleavage by colonic azo reductase and hypoxic colonic condition, triggering the rapid release of probiotics in colon, the adhesion of EcN@AA-YBG to colon mucosa was significantly improved as well. Furthermore, due to the compact and intact surface nanocoating of AA-YBG, the resistance of EcN@AA-YBG to high temperature, antibiotics and reactive oxygen species conditions were all improved significantly.
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Materials Today Bio
·
2026
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IF 11
Saadullah Khattak,Salim Ullah,Muhammad Tufail Yousaf,Jianliang Shen,Xiaoqun Xu,Hong-Tao Xu
Bacterial infection and severe inflammatory responses are major barriers to successful wound healing. Drug delivery systems have shown promise in precision medicine by enhancing the targeting and protection of therapeutic agents. However, their use is limited by challenges such as biocompatibility issues, structurally complex, high manufacturing costs, suboptimal drug loading, unstable release, and premature immune clearance. Although targeted delivery aims to improve efficacy, it may increase the risk of toxicity. Consequently, conventional non-carrier drugs often remain more practical and effective. Emerging vehicle-free systems with multifunctional capabilities show promise for precise targeting, controlled release, reduced toxicity, and simplified manufacturing. Here, we rationally designed and established a vehicle-free perfluoroalkyl material (PFAS)–gallium composites (PFASs@Ga) through introducing gallium (Ga) in PFASs, taking advantage of the collective merits of Ga’s antibacterial and pro-healing properties and PFAS’s well-recognized oxygen absorption, carrying of oxygen, chemical inertness, and tunable physicochemical properties. Extensive characterization showed well-defined morphology, elemental configuration, and distinct profiles of gallium ion release. The PFUnA@Ga composite improves gallium integration, Ga release, and O 2 delivery. This allowed it to demonstrate potent broad-spectrum antibacterial activity against bacteria, including MRSA and E. coli , which are known to be resistant. In a MRSA -infected wound model, PFUnA@Ga enhances wound closure and reduces bacterial load, thereby promoting regeneration and angiogenesis. The downregulation of pro-inflammatory M1 macrophages and the upregulation of anti-inflammatory M2 macrophages and CD31 + endothelial cells, representing immunomodulatory effects that facilitate inflammation resolution and vascularization. Results confirmed the composites’ antibacterial activity and accelerated wound-healing efficacy. This multifunctional composite offers a novel approach for advanced wound management. More specifically, the synergistic approach combines metal–ion mediated bacterial inactivation with sustained oxygenation to support infection control and tissue repair.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Zizhao Wang,Yang Yang,Hongxin Sun,Peng Fan,Xiaoqing Jia,Liang Zhang,Ting Wang,Jiulong Zhao,Qian Chen,Shige Wang
Endoscopic submucosal dissection (ESD), a minimally invasive procedure, is constrained by the rapid dissipation of conventional submucosal cushions and the absence of sustained postoperative therapeutic support. Herein, we develop a multifunctional hydrogel integrating mucosal elevating, sustained local analgesia, wound protection, antibacterial and antioxidant capabilities for perioperative management of ESD. The hydrogel is formed via Schiff base reactions between carboxymethyl chitosan and oxidized dextran, incorporates methylene blue for intraoperative visualization, and integrates mesoporous silica nanoparticles loaded with Bupivacaine (BUP@MSNs) to enable local sustained-release analgesia. Targeting critical limitations of conventional mucosal elevating agents, the hydrogel rapidly forms a stable submucosal cushion through in situ gelation, enhancing ESD procedural efficiency and safety while enabling immediate wound sealing and protection. Under physiological conditions, the hydrogel exhibits excellent injectability, self-healing capacity, and tissue adhesion at the lesion site. It also exerts potent antioxidant and antibacterial activities, fulfilling requirements for perioperative microenvironment modulation. Furthermore, the hydrogel delivers early postoperative analgesia that persists for over 48 h, effectively covering the peak pain phase post-ESD. Comprehensive in vitro and in vivo safety evaluations confirm its favorable biocompatibility and tolerability. Collectively, the hydrogel represents an integrated, clinically operable, and cost-effective candidate for gastrointestinal endoscopic minimally invasive therapies.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Xurui Zhao,Xiufeng Wang,Yijie Sheng,Shuizhi Lin,Shuping Xu,Zhixiang Hu,Xueping Ling,Cuixue Chen,Mingfeng Cao,Haiyang Cui,Yinghua Lu
Phosphatidylserine (PS), a major brain phospholipid, supports the central nervous system’s health and may alleviate cognitive decline, including in Alzheimer’s disease. A key challenge in green enzymatic PS synthesis is the suppression of hydrolysis while enhancing PLD-catalyzed transphosphatidylation. Here, we developed a mechanism-guided engineering strategy for Streptomyces antibioticus phospholipase D (SaPLD). The substitution of W187I increased the PS yield to 58.3%, while V380W improved thermostability. Combining beneficial mutations generated SaPLD-R7 (W187I/V380W/G381A), which overcame the activity–stability trade-off and achieved up to 95.8% PS yield using the enzyme produced by 5 L scale fermentation. Molecular dynamics simulations showed that SaPLD-R7 enhanced substrate binding and catalysis by shortening the key active site distances and reducing local flexibility. Solvent contact and energy analyses further indicated improved stability. This work establishes a structure–mechanism–function framework for enhancing PLD transphosphatidylation and provides a robust enzymatic route for high-efficiency PS production as a valuable functional food ingredient.
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MACROMOLECULES
·
2026
·
IF 5.7
Shijing Yan,Yingying Han,Meng Wu,Zhiwei Yang,Hui You,Weihua Xu,Jun Du,Cailiu Yin
The development of sustainable electronics demands materials that combine high performance with designed degradability, yet achieving this balance remains a challenge. Here, we demonstrate that systematically engineering the soft-segment molecular weight in fully degradable, biobased polyurethanes (PUs) unlocks a suite of tunable properties for high-performance pressure sensing. By varying poly(butylene adipate) (PBA) diol molecular weight in networks containing isosorbide and acid-cleavable hexahydrotriazine, we establish that longer PBA chains enhance soft-segment crystallinity and elongation (up to 978%), while an optimal intermediate molecular weight (2000 g/mol) yields the highest tensile strength (25.7 MPa) and excellent biocompatibility. This optimized PU exhibits robust shape-memory behavior (Rf > 98%) and undergoes controlled dual degradation: enzymatic (up to 50% mass loss in 6 weeks) and complete acid-triggered dissolution, enabling quantitative recovery of conductive carbon black filler. A microstructured composite sensor fabricated from this material achieves high sensitivity (15.32 kPa–1) with fast response/recovery and successfully monitors human motion. This work establishes molecular design rules for degradable PUs and provides a viable pathway toward sustainable, high-performance flexible electronics.
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CHEMISTRY OF MATERIALS
·
2026
·
IF 7.1
Chao Zeng,Haoliang Liu,Shangyong Wu,Huaxuan He,Guodong Meng,Le Shi,Kai Wu,Yonghong Cheng,Bing Xiao
The synthesis of phase-pure out-of-plane ordered MAX phases (o-MAX) Cr2VAlC2 and Cr2V2AlC3 is notoriously challenging and often hindered by parasitic reactions inherent to conventional elemental powder routes. This work combines thermodynamic calculations with experimental synthesis to validate the proposed solid-state reaction pathways employing Cr2AlC and VC as starting compositions to prepare high-purity o-Cr2VAlC2 and o-Cr2V2AlC3 MAX phases in the Cr–V–Al-C system. The thermodynamic formability of 312 and 413 MAX phases is evaluated by calculating the formation enthalpies and Gibbs free energies for both fully ordered o-MAX phases and their corresponding solid solutions, confirming the high thermodynamic stability of o-MAX compounds in comparison to solid solution forms from both typical elemental powder metallurgy and solid-state reaction synthesis. Combining the linear programming optimization algorithm for reaction thermodynamics and the systematic experimental verifications of phase formation kinetics, high yields of o-Cr2VAlC2 (82.0 wt %) and o-Cr2V2AlC3 (88.7 wt %) MAX phases are obtained with starting compositions as Cr2AlC/VC = 1:1.2 and 1:1.9 at the sintering temperature of 1500 °C. Using the JMAK equation, the apparent activation energies for phase nucleation and growth of o-Cr2VAlC2 and o-Cr2V2AlC3 phases are found to be 313.6 and 98.4 kJ mol–1, respectively. The calculated electronic density of states and bond orders for solid solutions and fully ordered MAX phases confirm that the stabilization of higher-order o-MAX phases in the Cr–V–Al-C system is mainly attributed to the significant reduction of Cr–C and V–C bond orders for those antisite atoms in disordered structures. This work elucidates a new pragmatic strategy to precisely tailor both reaction thermodynamics and kinetics for the synthesis of o-MAX phases in general.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Leilei Zhang,Haoheng Bai,Weiqi Sun,Luqi Wang,Minyan Duan,Qianying Liu,Chao Zhou,Xueyang Fang,Tao Zhang
Triple-negative breast cancer (TNBC) treatment with traditional phototherapeutics generally suffers from short light penetration depth and limitations of the hypoxic tumor microenvironment. Developing effective therapeutic modalities tailored to TNBC’s features remains highly desirable yet challenging. Herein, we propose a near-infrared dual windows (NIR-II) photoacoustic (PA) cavitation-based strategy to amplify oxidative stress and induce metabolic disruption in TNBC cells, achieving effective tumor suppression. With a fabricated nanoagent (DTG), we integrated the oxygen-independent therapeutic effects of photomechanical damage, cavitation-promoted oxidative damage and glucose oxidase (GOx)-mediated glucose depletion. Specifically, under NIR-II pulsed laser (PL) irradiation, PA cavitation generates collapsing bubbles and shock waves, causing mechanical injury to tumor cells. Meanwhile, GOx depletes intratumoral glucose, blocking glycolysis, reducing adenosine triphosphate (ATP) production, and generating hydrogen peroxide (H2O2) that would be further converted into more toxic hydroxyl radicals (•OH) by the photocavitation to suppress the tumors effectively. In addition, the strong NIR-II PA signal produced from the DTG facilitates high-resolution deep-tissue imaging to provide precise therapeutic guidance. Thus, these findings establish the multimodal strategy as a potent candidate for TNBC management.
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