POLYMER SCIENCE SERIES A
·
2021
·Vol. 63
·期 3
·267-274
·
IF 1.206
Jun Shao,Tang Juan,Pu Shouzhi,Hou Haoqing
Abstract Blending of poly( L -lactic acid)/poly( D -lactic acid) (PLLA/PDLA) leads to the formation of poly(lactide) stereocomplexation (PLA SC), which exhibits higher melting temperature and faster crystallization rate. The crystallization behavior of PLA homochiral crystallization (HC) under the existence of PLA SC was also widely investigated. During the variable processing, the SC with different morphologies would produce, and these SC could exert different influences on the subsequent formation of HC. However, the effects of SC developed in various conditions on the formation of HC are not compared yet and are also not clear until now, and which is important for the application of PLLA/PDLA blends. In this paper, the PDLAs with different molecular weights were blended with PLLA at a weight ratio of PLLA/PDLA 90/10, and the crystallization behaviors of PLLA HC from different conditions were investigated by differential scanning calorimetry (DSC). Results indicated that, incorporating a small amount of PDLA accelerated the formation of PLLA HC significantly regardless of the SC developed from the solution evaporation or the melt. The higher crystallization rate of HC was received in the PLLA/PDLA specimens with lower molecular weight of PDLA. For the specimens crystallized from the partially melting (most of SC developed during solution evaporation), the crystallization rate was higher than that corresponding specimens crystallized from the completely melting state (the SC were produced from the melt). This discrepancy would be due to variable SC morphologies produced during diverse processing.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yuting Wang,Ying Xiong,Hui Tian,Shi Wang,Qianying Zhang,Mingjing Zhang,Hong Ding,Ye Gu,Anlin Peng
A novel disposable sensor modified with MWNTs/Al 2 O 3 /poly-L-lysine film was developed for detection of clinical 17β-estradiol (17β-E 2 ) urine samples in this study. The electrochemical behavior of 17β-E 2 was greatly increased due to the good electrocatalytic activity of MWNTs/Al 2 O 3 /poly-L-lysine nanocomposites. The optimum experimental conditions such as scan rate, pH, accumulation time were obtained, and the peak potentials of 17β-E2 was explored at about 530mV. The peak current of 17β-E 2 measured by CV displayed the good linear property with the increasing of the concentrations. Under optimized conditions, the disposable sensor displayed excellent analytical performance with linear ranges of 17β-E 2 from 0.5nM to 50nM. And a very low detection limit of 0.014 nM was attained. Furthermore, the MWNTs/Al 2 O 3 /poly-L-lysine SPE was used to the rapid and successful determination of the hormone in spiked synthetic and real clinical pregnant woman urine samples with wonderful selectivity and sensitivity.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Qing Yang,Hongbin Pu,Da-Wen Sun
The sensitive detection of quinalphos in food is crucial due to its improper use and the potential for serious harm. Surface-enhanced Raman spectroscopy (SERS) technology, provides a new way for rapid and ultra-sensitive detection. To exploit the molecular sieving effect of metal-organic frameworks (MOFs) in mitigating interference from food matrix components during pesticide residue detection, a novel chiral spiny L-Au@Ag@ZIF-8 (L-AAZ) three-layer core-shell composite was developed as an effective SERS substrate, with chiral L-AABPs providing abundant “hot spots” and spiny ZIF-8 shell provides excellent absorption properties, causing a five-fold increase in SERS intensity compared to traditional Au@Ag NPs. The experimental results revealed that L-AAZ achieved a high enhancement factor (EF) of 3.15 × 10 5 , a low limit of detection (LOD) of 6.56 × 10 −10 M, and a relative standard deviation (RSD) of 14.6 % for malachite green (MG), indicating its superior SERS sensitivity and consistency. Moreover, it demonstrated stable performance, maintaining good storage stability for up to 55 days. The substrate's suitability for the actual fruit sample (tangerine) was confirmed, showing an LOD of 10 ng/mL, demonstrating its capability for rapid and sensitive detection of trace amounts of pesticide residues in food.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Haoran Zhuang,Zhenxia Li,Menglin Wang,Bo Liu,Yiwen Chu,Ziyu Lin
Photosynthesis provides carbon sources and energy for crop growth and development , and the widespread presence of microplastics and plastic plasticisers in agricultural soils affects crop photosynthesis, but the mechanism of the effect is not clear. This study aims to investigate the effects of different microplastics and plasticizers on cucumber photosynthesis. Using polyvinyl chloride (PVC), polyethylene (PE), polystyrene (PS), and di- n -octyl phthalate (DOP) as representative microplastics and plasticizers, we assessed their impact on cucumber photosynthesis. Our results reveal significant alterations in key parameters: intercellular CO 2 concentration (Ci) and transpiration rate (Tr) increased across all treatments, whereas stomatal limit value (Ls) and water use efficiency (WUE) decreased. Notably, PS + DOP treatment led to a significant reduction in the maximum efficiency of photosystem II ( F v / F m ) and ATP accumulation. Furthermore, PE and PS + DOP treatments decreased lycopene and ɛ-carotene synthesis rates, as well as abscisic acid (ABA) accumulation. All treatments inhibited the conversion of β-carotene into strigolactone (SL) and decreased chlorophyll synthesis rates, with PS + DOP exhibiting the most severe impact. Regarding chlorophyll degradation pathways, PVC and PE treatments reduced chlorophyll decomposition rates, whereas DOP with PS promoted degradation. PE and PS treatments also impaired light energy capture, electron transport , and the structural stability of photosystems I and II, as well as photosynthetic capacity and NADPH and ATP synthesis rates. Our findings underscore the differential impacts of microplastics and plasticizers on cucumber photosynthesis, with PS + DOP having the most detrimental effect. These results shed light on the complex interactions between microplastics and plant physiology, highlighting the urgent need for mitigation strategies in agricultural practices to safeguard crop productivity and environmental sustainability.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2020
·
IF 2.69
Yasong Hu,Congcong Zhan,Anduo Zhou,Shanfeng Zhang,Juying Chen,Xia Huang
A novel amino acid-modified biomacromolecule was designed and synthesized as the quaternary ammonium salt chitosan grafted-tyrosine (CA-g-Tyr) suitable for biomedical applications. L-tyrosine was grafted onto the quaternary ammonium salt chitosan (CA) by N-(3-dimethylaminopropy)-N-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). The chemical structure of CA-g-Tyr was confirmed by Fourier transform infrared (FTIR) spectroscopy and 13C-NMR. The change in the crystalline structure after the graft was characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). The surface wettability and moisturizing performance of the CA-g-Tyr were also characterized. The CA-g-Tyr film possessed good hydrophilicity, and the mechanical tensile experiments showed that the introduction of tyrosine gave CA mechanical properties more suitable for blood vessel. Cell experiments showed that the endothelial cells can adhere and proliferate better on the surface of a CA-g-Tyr film than CA. The results confirm the favorable properties and biocompatibility of CA–g-Tyr with potential applications as scaffolds for tissue engineering.
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LANGMUIR
·
2018
·
IF 3.789
Lele Zhou,Qiongzheng Hu,Qi Kang,Ming Fang,Li Yu
The detection of l-phenylalanine (l-Phe) has become one of the most pressing issues concerning diagnosis and treatment of phenylketonuria in neonates; however, a simple and robust methodology is yet to be developed. Here, the application of novel liquid crystals (LCs)-sensing platform for sensitive, selective, and label-free detection of l-Phe was reported at the first time. We devised a strategy to fabricate the sodium monododecyl phosphate (SMP)-decorated LC sensing platform with the appearance of dark. Then, a dark to bright (D–B) optical images alteration of LCs was observed after transferring alkaline phosphatase (ALP) to the interface, owing to cleavage of SMP induced by ALP. LCs remained dark images after the SMP-decorated interface in contact with the pre-incubated ALP and l-Phe. Such optical appearance resulted from the inhibition of ALP by l-Phe, which was further verified by the isothermal titration calorimetry (ITC). The strategy was applied to sensing l-Phe, which have been proven to allow for sensitively and selectively differentiation of l-Phe from interfering compounds with similar aromatic groups, as well as seven other essential amino acids. More importantly, the detection limit of l-Phe reached 1 pg/mL in urine samples, further demonstrating its value in the practical applications. Results obtained in this study clearly demonstrated the superiority of LCs toward the l-Phe detection, which can pave a way for the development of high performance and robust probes for l-Phe detection in clinical applications.
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Arabian Journal of Chemistry
·
2024
·
IF 5.3
Yuyi Liu,Xuan Hu,Enhui Li,Yajing Fang,Hui Xue,Jiachao Zhang,Rajesh Jha,Ruimin Wang
Paederia foetida L. leaf (PFL) is recognized for its uric acid-lowering. However, the key compounds and their mechanisms of countering hyperuricemia remain unclear. In this study, bioaffinity ultrafiltration in combination with UPLC-ESI-QTrap-MS/MS was used to screen and identify potential xanthine oxidase (XO) inhibitors in the purified PFL extract, and the possible mechanisms of their interaction were investigated by molecular docking. The experimental results showed that the purified PFL extract exhibited excellent antioxidant and anti-XO effect. Further the results of enzyme inhibition experiments in vitro showed that luteolin-7- O -glucoside (IC 50 = 61.41 μg/mL), astragalin (IC 50 = 114.89 μg/mL), quercitrin (IC 50 = 124.50 μg/mL), dihydromyricetin (IC 50 = 296.32 μg/mL), cyanidin-3- O -rutinoside (IC 50 = 373.82 μg/mL), kaempferol-3- O -rutinoside (IC 50 = 450.10 μg/mL) and (-)-epigallocatechin (IC 50 = 610.48 μg/mL) in purified PFL extract were the major contributors to the XO inhibitory activity, and confirmed this finding. Molecular docking revealed these inhibitors interact with critical XO residues through hydrogen bonding, hydrophobic, and electrostatic interactions, highlighting flavonoids in purified PFL extract as potent XO inhibitors. This work provides insight into flavonoids in the purified PFL extract as potent XO inhibitors.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Ting Zhuo,Jun-ru Qi,Jin-song Liao,Hui-ying Wei,Rong Xiao
Konjac glucomannan (KGM) is a natural functional polysaccharide, and deacetylation (removing acetyl groups) impacts its physicochemical and gel properties. In order to study KGM's gel properties and explore new deacetylation modifiers, three deacetylated konjac glucomannan (DKGM) with different deacetylation degrees (DD, 17.51 %, 35.41 %, and 54.52 %) were prepared using L-arginine. Results showed that L-arginine deacetylated and retained the main structure and high molecular weight of KGM. Solubility decreased from 85.38 % to 81.17 %, transparency decreased from 38.52 % to 35.73 %, water absorbing and swelling slowed down, and molecular morphology changed from chain structures to micelle-like aggregates after deacetylation. Dynamic viscoelastic analysis showed that deacetylation facilitated the formation of the entangled network structure of KGM. The strength of konjac glucomannan and κ-carrageenan mixed gels increased after deacetylation, and this enhancement was mainly through hydrogen bonds and hydrophobic interactions. These findings will provide theoretical guidance for the application of KGM.
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TALANTA
·
2025
·
IF 6.1
Shuojiang Liu,Ying Chen,Xingliang Cheng,Gongke Li,Yuling Hu
Surface-enhanced Raman scattering (SERS) in conjunction with nanozymes has emerged as a powerful technique for bioanalysis due to their signal conversion and amplification effect. However, clinical applications continue to encounter challenges such as inadequate selectivity. Herein, we proposed a novel approach for the selective SERS detection of L-DOPA in human serum with dual enzyme-mimicking MOF-919(Fe–Cu). This material exhibits both catechol oxidase-like and peroxidase-like activities, enabling it to catalyze catecholic compounds to o -quinones and subsequently oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) molecules into SERS-active ox-TMB. Ultrasonic-assisted synthesis ensures uniform and dense loading of AgNPs within MOF-919(Fe–Cu), thereby enhancing SERS activity. A sensitive and selective method for SERS detection of L-DOPA was developed. The catechol oxidase-like activity of MOF-919(Fe–Cu) provides ideal selectivity and anti-interference to L-DOPA, while the cascade catalytic system transforms weak SERS signals of L-DOPA into amplified SERS signals of ox-TMB. The mechanism of dual enzyme-mimicking activity was further discussed. The detection process was optimized to achieve high sensitivity towards L-DOPA with a linear range 0.5–100 μmol/L and low limit of detection (LOD) of 0.16 μmol/L. Furthermore, it has been applied in serum sample of Parkinson's patients, demonstrating excellent recovery and low relative error compared to HPLC-UV. This approach offers an economical, efficient and accurate strategy for the detection of L-DOPA and provides valuable insights for the integration of selective multifunctional nanozyme and sensitive SERS detection method.
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Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Xiuli Cheng,Xiangyu Zhou,Wenping Wang,Jing Chen,Yikun Cao,Jia Wen,Jin Hu
Sophora alopecuroides L. empyreumatic oil (SoA oil) exhibits therapeutic potential for psoriasis and eczema but suffers from poor skin permeability and formulation challenges. To overcome these limitations, a nanoemulsion (NE) gel was developed. The NE was optimized using pseudo-ternary phase diagrams and characterized for droplet size, polydispersity index (PDI), zeta potential, and rheological properties. Skin permeability and retention were assessed in vitro using Franz diffusion cells, with oxymatrine quantified by HPLC. In vivo skin irritation was tested on rabbit dorsal skin, and anti-biofilm activity was evaluated against Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA). A final concentration of 5% SoA oil in the NE formulation was used for subsequent studies. The optimized SoA oil NE (the NE) had a mean droplet size of 53.27 nm, PDI of 0.236, and zeta potential of −38.13 mV. Adding 2% carbomer 940 (CP940) to the gel enhanced viscoelasticity. The NE showed superior skin permeability and higher cutaneous retention of oxymatrine. SoA oil caused moderate irritation to the skin of rabbits, while the other two formulations did not. The NE demonstrated enhanced biofilm inhibition against S. aureus at 0.09766 mg/mL, with an 8.9% rate surpassing SoA oil (2.0%) and SoA oil NE gel (the gel, 4.0%). At 12.50 mg/mL, the NE and the gel achieved slightly higher inhibition rates (81.7% and 82.1%, respectively) than SoA oil (78.3%). Notably, the NE showed significantly greater anti-biofilm effects against MRSA within the concentration range from 0.09766 to 3.12 mg/mL (P < 0.001). In mature biofilm clearance against S. aureus, the NE demonstrated a clearance rate of 4.9% at 0.09766 mg/mL, while SoA oil and the NE gel achieved clearance rates of 2.3% and 0.8%, respectively. At a higher concentration of 12.50 mg/mL, the clearance rate for the NE increased to 38.1%, significantly outperforming SoA oil (29.1%) and the NE gel (36.4%). Against MRSA, the NE and the gel displayed significantly improved clearance at 12.50 mg/mL (42.7% and 43.9%, respectively) compared to SoA oil (31.9%) (P < 0.0001). These findings highlight the potential of nanotechnology-driven delivery systems to improve the clinical application of herbal extracts for treating biofilm-associated dermatological infections.
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CRYSTENGCOMM
·
2022
·Vol. 24
·期 36
·6400-6407
·
IF 3.756
Anzhou Yang,Qiuzi Huang,Ziqi Wei,Zehan Yu,Meifeng Cui,Wu Lei,Yawen Tang,Xiaoyu Qiu
Designing cost-effective, highly active, and durable noble-metal-free electrocatalysts as alternative electrode materials for the methanol oxidation reaction (MOR) is of significant importance for practical applications. Herein, we report a facile one-pot synthetic route to construct Cu@Ni core–satellite nanoassemblies (CS-NAs) with the assistance of eco-friendly L-lysine, which involves the spontaneous process of preferential formation of the Cu core followed by self-assembly growth of Ni satellites. The selection of the Cu core is beneficial for enhancing the charge transfer and tuning the electronic structure of Ni satellites, as well as serving as a self-skeleton to enhance the structural stability for catalysis. Meanwhile, the tiny Ni satellites could be fully exposed, which not only produce a larger number of valid active sites, but also provide a short electron and ion transport distance. As a result, the Cu@Ni CS-NAs are qualified as superior and durable electrocatalysts for the MOR, affording 29.6 mA cm−2 at 1.6 V with long-term chronoamperometric stability.
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Asian Pacific Journal of Cancer Prevention
·
2011
·
IF 1.24
Feng L,Jia X,Zhu M,Chen Y,Shi F
Chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lung cancer (NSCLC). The present study aimed to explore the mechanisms of chemoprevention of NSCLC by Prunella vulgaris L. (PV) using a PV extract of 60% ethanol (P-60). In an A/J mouse model benzo[a]pyrene induction of lung tumors was significantly reduced difference by P-60 group. In addition, P-60 was found to have the ability to regulate cell cycle and induce apoptosis in SPC-A-1 cells. Therefore, we propose that P-60 has potential as a lung cancer chemopreventive agent.
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