Journal of Materials Chemistry B
·
2018
·Vol. 7
·期 4
·548-555
·
IF 4.776
Chuan Zhang,Qiqing Li,Yue Zhao,Hou Liu,Shanliang Song,Yueqi Zhao,Quan Lin,Yulei Chang
Synergistic thermo-chemotherapy based multiple stimuli-responsive drug delivery systems have achieved significant improvement of cancer curative effects compared with single modality treatment. Nevertheless, the efficacy of thermo-chemotherapy is often reduced in drug-resistant tumors and the therapy method is unexpectedly associated with potential toxicity by utilizing poorly degradable materials. Here, we report a simple approach to encapsulate three drug payloads into multi-sensitive and degradable nanospheres (SDC@NS) to achieve anticancer effects. SDC@NS comprise a photothermal agent (cypate), an anticancer agent (doxorubicin), and a nitric oxide donor (SNAP) to achieve controllable drugs release in high concentration glutathione or under near-infrared light (NIR) irradiation. Hyperthermia from NIR-mediated cypate can accelerate cancer cell apoptosis in vitro and tumor tissue ablation in vivo. Furthermore, our results also confirmed that the nitric oxide-based SDC@NS showed significant cytotoxicity compared to the nitric oxide absent group (denoted as DC@NS) and an enhanced chemotherapy effect in vivo. The photothermal effect and payloads can synchronously realize cancer therapy and provide a new insight into the enhanced synergistic therapeutic effect.
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高影响因子
CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Feifei Sun,Hong Niu,Dongdong Wang,Yuanyuan Wu,Haibo Mu,Lili Ma,Jinyou Duan
Current studies have revealed the excellent moisture absorption-retention capacity of hyaluronan (HA); however, HA is easily degraded by hyaluronidase on the surface of skin. So, it is very necessary to develop an alternative derivative with low cytotoxicity and resistance to hyaluronidase. Herein, a HA decorated with photocaged groups was synthesized. The moisture absorption-retention capacity and hyaluronidase resistance of photocaged HA (HA-DMNB) and products of HA-DMNB irradiated by ultraviolet for different time (IHA-DMNB), were investigated. Results show that HA-DMNB is more resistant to hyaluronidase than HA, and HA-DMNB could release free carboxyl groups of HA upon ultraviolet to bond with H 2 O. More importantly, HA-DMNB was protective against UV light. In addition, HA-DMNB and IHA-DMNB were observed to be nontoxic to HaCat cells. This study indicates that HA-DMNB may be effectively used as a moisture-preserving reagent.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2023
·Vol. 37
·期 10
·e7231
·
IF 3.9
Xianjie Yin,Helin Wang,Lei Shen,Qingle Zeng
A three-component reaction of olefins, indoles, and diaryl diselenides catalyzed by copper chloride under irradiation of blue LED light is disclosed. Various diaryl diselenides including diheteroaryl diselenides are suitable for this bifunctionalization of olefins. This protocol provides 26 examples of β-(hetero)arylselenyl indoles in 60%–87% yields. The proposed mechanism involves activation of diaryl diselenides by coordination with copper chloride, generation of arylselenium cations by heterolysis of activated diaryl diselenides, electrophilic addition of arylselenium cations to styrenes, and then Friedel–Crafts-type alkylation at the 3-position of NH-indoles.
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CATALYSIS LETTERS
·
2023
·
IF 2.8
Du Juan,Bai Xinyue,Wang Simiao,Li Chunmei,Zhu Enwei,Liu Chunbo,Ma Chunhong,Guo Haiyong
The photocatalytic antibacterial method is one of the most effective and “green” methods for treating multidrug resistant (MDR) bacteria-caused infections. The most critical scientific question is how to improve the antibacterial efficiency of photosensitizers (PS). Herein, an organic-conjugated-polymer photocatalyst poly((E)-5-(2,5-dihydroxy-4-methylphenyl)-5′-(2-(5-methylthiophen-2-yl)vinyl)-[2,2'-bithiophene]-4-carboxylic acid) (PTH-COOH-(OH) 2 ) has been successfully synthesized. A new route for developing highly active organic-conjugated-polymer photocatalysts for environmental purification via the proper expansion of the backbone conjugate structure and the introduction of effective groups such as carboxyl and hydroxyl groups is proposed. The visible-light photocatalytic activities of PTH-COOH-(OH) 2 were evaluated against methicillin-resistant Staphylococcus aureus ( MRSA ), Staphylococcus epidermidis ( S. epidermidis ) and Escherichia coli ( E. coli ) under LED white light. A very high antimicrobial efficiency was achieved for optimized 0.3 mg mL −1 PTH-COOH-(OH) 2 under visible light illumination. Over 7 log of MRSA was killed in 3 h, 7 log of S. epidermidis was killed in 3 h, and 93.3% decomposition of E. coli was achieved in 3 h. These photoantimicrobial effectiveness values are among the most widely published for conjugated polymer photocatalysts. The findings of trapping studies and electron spin resonance (ESR) spectroscopic investigations indicated that during the photocatalytic antimicrobial process, ·OH, 1 O 2 , ·O 2 − , and e − are largely reactive oxygen species (ROS). Importantly, following recycling processes, the PTH-COOH-(OH) 2 photocatalyst demonstrated satisfactory stability and excellent photocatalytic activity. Graphical Abstract
The organic-conjugated-polymer photocatalysts poly((E)-5-(2,5-dihydroxy-4-methylphenyl)-5′-(2-(5-methylthiophen-2-yl)vinyl)-[2,2′-bithiophene]-4-carboxylic acid) (PTH-COOH-(OH) 2 ) is successfully synthesized using the Stille coupling reaction. PTH-COOH-(OH) 2 exhibits more outstanding photocatalytic antibacterial activity and stability, and has broad-spectrum antibacterial efficacy that can kill Gram-positive bacteria ( MRSA , Staphylococcus epidermidis ) and Gram-negative bacteria ( Escherichia coli) under visible light irradiationtreat. The highly photocatalytic antibacterial active is developed via the proper expansion of the backbone conjugate structure and the introduction of effective groups such as carboxyl and hydroxyl groups.
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Journal of Materials Chemistry B
·
2014
·Vol. 3
·期 4
·629-634
·
IF 0
Xinhong Xiong,Zhaoqiang Wu,Jingjing Pan,Lulu Xue,Yajun Xu,Hong Chen
Tailoring the surface properties of poly(dimethylsiloxane) (PDMS) is essential for the advancement of its applications. However, the modification process is usually complicated and limited due to the chemical inertness of the surfaces of PDMS. Here, we report for the first time, a facile and versatile method for the functional surface modification of PDMS via visible light-induced grafting polymerization at room temperature. This modification is readily achieved in two steps: (1) covalently integrating alkyl bromine into the PDMS networks using a simple mixing procedure and (2) visible light-induced surface grafting polymerization using Mn2(CO)10. We have demonstrated that the PDMS surface can be functionalized with a wide variety of polymers via covalent grafting, such as poly(trifluoroethyl methacrylate) (PTFEMA), poly(N-isopropylacrylamide) (PNIPAAm), poly(acrylic acid) (PAA) and poly(vinyl acetate) (PVAc). As an example, after the grafted PVAc was transformed into its hydrophilic analogue poly(vinyl alcohol) (PVA), anti-biofouling functionalization of PDMS was obtained. The anti-biofouling properties of the functionalized PDMS were demonstrated using cell adhesion and bacterial adhesion tests. Moreover, the grafting kinetics of PVAc showed that this process was fast and efficient.
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TALANTA
·
2013
·
IF 3.498
Lin Zhang,Lu Tian,Zhiqiang Ye,Bo Song,Jingli Yuan
By using a visible-light-excited ternary Eu 3+ complex, BHHBCB-Eu 3+ -BPT (BHHBCB: 1,2-bis[4′-(1“,1“,1“,2“,2“,3“,3“-heptafluoro-4″,6″-hexanedion-6″-yl)-benzyl]-4-chlorosulfobenzene; BPT: 2-( N , N -diethylanilin-4-yl)-4,6-bis(pyrazol-1-yl)-1,3,5-triazine), as a luminophore, two kinds of novel visible-light-excited europium materials, the silica-encapsulated BHHBCB-Eu 3+ -BPT (Eu@SiO 2 ) nanoparticles and BHHBCB-Eu 3+ -BPT-conjugated bovine serum albumin (BSA–BHHBCB-Eu 3+ -BPT), were prepared for biolabeling and time-resolved luminescence cell imaging applications. The Eu@SiO 2 nanoparticles, prepared by the copolymerization of 3-aminopropyl(triethoxy)silane–BHHBCB-Eu 3+ -BPT conjugate, free 3-aminopropyl(triethoxy) silane and tetraethyl orthosilicate in a water-in-oil reverse microemulsion , are monodispersed, spherical and uniform in size, and strongly luminescent with an excitation peak at ∼400 nm and a long luminescence lifetime of 346 μs. The BSA–BHHBCB-Eu 3+ -BPT, prepared by covalent binding of BHHBCB-Eu 3+ -BPT to BSA, shows also strong visible-light-excited luminescence with a excitation peak at ∼400 nm and a long luminescence lifetime of 402 μs. The two materials were used for labeling transferrin and folic acid . Using the time-resolved luminescence imaging of living HeLa cells, the cell-surface receptors of transferrin and folic acid were successfully visualized by the prepared biolabels based on the ligand–receptor affinity binding interaction. The results demonstrated the feasibility of the new materials as visible-light-excited biolabels for the time-resolved luminescence cell imaging.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2017
·
IF 3.887
Yuhua Chen,Huiming Lin,Ruihan Tong,Na An,Fengyu Qu
Recently, incorporating multiple components into one nanoplatform for anticancer theranostics has attracted most attention. Herein, a rattle-structured nanocomposite by using UCNPs (NaYF 4 :Yb,Tm@NaYF 4 ) as core coated with hollow mesoporous TiO 2 (UCNPs@mHTiO 2 ) was constructed as the nanocarrier. First, UCNPs@SiO 2 @TiO 2 was prepared, by a selective etching method to remove SiO 2 shell, to make sure the hollow mesoporous structure and high surface area (347 m 2 g −1 ) of UCNPs@mHTiO 2 . Under near-infrared (NIR) light irradiation, the UV emission can excite TiO 2 to produce ROS and to realize photodynamic therapy (PDT). In addition, the hollow structure offers space to store antitumor drug molecules (doxorubicin, DOX) and this nanocomposite also exhibits the improved DOX release in mildly acidic environment, which could greatly promote chemotherapy efficiency. Moreover, the luminescence resonance energy transfer (LRET) from UCNPs to DOX, owing to the effective distance restricted by the cavity, can be used to monitor the intercellular drug release kinetics. HeLa cells were used as the model cancer cells and the detailed cell experiments show the enhanced cytotoxicity, ascribing to the synergistic effect of chemotherapy and PDT. Therefore, the novel multifunctional nanocomposite, combining with chemotherapy, PDT, and imaging, should be a potential candidate in anticancer field.
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高影响因子
POLYMER TESTING
·
2022
·
IF 4.931
Yiyu Wang,Wenlong Yu,Chunqing Niu,Guiting Yu,Xin Huang,Jian Shi,Da Ma,Xuezheng Lin,Kai Zhao
Microspheres produced from biodegradable poly (D, L-lactic-co-glycolic acid) (PLGA) have been studied widely as drug delivery carriers for therapeutics. This study aimed to develop a near-infrared (NIR) light-activated PLGA microsphere loaded with two kinds of drugs with different molecular weights respectively or simultaneously by the double emulsion method (bovine serum albumin (BSA) and tetracycline hydrochloride (TH) as the drug model agents, indocyanine green (ICG) as the NIR responsive component). To optimize the incorporation of drugs and particle size for PLGA microspheres loaded single drug, the effect of three processing parameters, including the amount of polymer, initial ICG content, and initial BSA or TH content on the drug entrapment efficiency (EE), drug loading and the particle size were investigated. The PLGA microspheres were spherical and ranged from 5 to 10 μm in diameter. The EE of ICG and BSA in PLGA@ICG-BSA was 78.41 ± 0.71% and 69.88 ± 5.14%, respectively. The EE of ICG and TH in PLGA@ICG-TH was 71.52 ± 5.07% and 28.39 ± 3.39%. The PLGA microspheres exhibited desirable biodegradability and low cytotoxicity. Based on the optimized processing of single drug-loaded microspheres, dual-drug-loaded microspheres containing both large and small molecule drugs were further prepared. The EE of ICG, BSA, and TH was 83.37 ± 0.59%, 52.65 ± 3.48%, and 12.88 ± 2.53%; the particle size was ∼7.21 μm. All the NIR-responsive PLGA microspheres exhibited an efficient photothermal property and enhanced photothermal stability under multiple NIR irradiation cycles. The drugs from the different PLGA microspheres were released continuously over 18 days, mainly determined by Fick's diffusion. Furthermore, the drugs can be controlled released through a NIR light trigger, resulting in a dosage increase at a specific time point.
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RSC Advances
·
2020
·Vol. 10
·期 44
·26059-26066
·
IF 3.119
Shuwei Liu,Lu Wang,Bin Zhao,Ze Wang,Yinyu Wang,Bin Sun,Yi Liu
In clinical tumor therapy, traditional treatments such as surgery, radiotherapy and chemotherapy all have their own limitations. With the development of nanotechnology, new therapeutic methods based on nanomaterials such as photothermal therapy (PTT) have also emerged. PTT takes advantage of the poor thermal tolerance of tumor cells and uses the heat generated by photothermal reagents to kill tumor cells. A transition metal sulfide represented as Cu2S is an ideal photothermal reagent because of its easy preparation, high extinction coefficient and photothermal conversion efficiency. Surface modification of nanoparticles (NPs) is also necessary, which not only can reduce toxicity and improve colloidal stability, but also can provide the possibility of further chemotherapeutic drug loading. In this work, we report the fabrication of Tween-20 (Tw20)-modified and doxorubicin (Dox)-loaded Cu2S NPs (Cu2S/Dox@Tw20 NPs), which significantly improves the performance in tumor therapy. Apart from the enhancement of colloidal stability and biocompatibility, the drug loading rate of Dox in Tw20 reaches 11.3%. Because of the loading of Dox, Cu2S/Dox@Tw20 NPs exhibit chemotherapeutic behaviors and the tumor inhibition rate is 76.2%. Further combined with a near-infrared laser, the high temperature directly leads to the apoptosis of a large number of tumor cells, while the release of chemotherapeutic drugs under heat can not only continue to kill residual tumor cells, but also inhibit tumor recurrence. Therefore, with the combination of PTT and chemotherapy, the tumor was completely eliminated. Both hematological analysis and histopathological analysis proved that our experiments are safe.
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APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Jianmei Pan,Wei Shen,Yahai Zhang,Hua Tang,Haoyu Sun,Wenqiang Zhong,Xuehua Yan
Photocatalytic water splitting to product hydrogen (H 2 ) is a desired route to utilize solar energy into chemical energy. At present, most photocatalysts for H 2 generation contains metallic elements with high-cost, confined reserves, and environmentally unfriendly. The exploitation of metal-free and efficient photocatalysts becomes particularly important. Herein, a new metal-free g-C 3 N 4 -based heterojunction composites were facilely produced via the ultrasonic assisted deposition and subsequent calcination from g-C 3 N 4 layers embedded with SiOC with prominent conductivity and large surface area. Systematic investigates suggested that the SiOC/g-C 3 N 4 heterojunctions exhibited eminently meliorated photocatalytic H 2 production efficiency. The optimum H 2 production rate (1020 μmol h −1 g −1 ) of the SiOC/g-C 3 N 4 photocatalyst is 3.2 and 25.5 folds that of g-C 3 N 4 and SiOC , respectively. The boosted photocatalytic activity primarily originates from the increased absorptivity of light, the markedly expedited charge migration and the impeded recombination of charge carriers. This study offers a new perspective for the scientific contrive and fabrication of high-quality heterojunction photocatalysts for solar energy utilization.
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MATERIALS CHEMISTRY AND PHYSICS
·
2019
·
IF 2.781
Jianli Tao,Meng Zhang,Xiang Gao,Hao Zhao,Zhenpeng Ren,Donghui Li,Jiaojiao Li,Ruiqin Zhang,Yonggang Liu,Yunpu Zhai
Co 3 O 4 /red phosphorus (Co 3 O 4 /RP) photocatalysts were synthesized via facile hydrothermal and mechanically grinding approach. The catalysts were characterized via XRD , TEM , XPS , N 2 sorption , photoelectro chemical measurements and UV–vis DRS . The results showed that the Co 3 O 4 nanocrystals were assembled on the surface of the RP. The loading of Co 3 O 4 on RP was beneficial to enhance the light absorption compared with pure RP. Under visible light , 94.5% of malachite green (MG) can be photodegraded within 20 min over 10% Co 3 O 4 /RP composite, while only 17.3% and 59.9% of MG can be photodegraded over pure Co 3 O 4 and RP. The reaction rate constant k obtained over 10% Co 3 O 4 /RP heterojunction (0.1464 min −1 ) is approximately 3.2 times that of pure RP (0.0457 min −1 ), and 15.3 times that of bare Co 3 O 4 (0.0096 min −1 ). The cycle experiments showed that the catalyst had high photocatalytic stability. Co 3 O 4 nanocrystals inhibit the photoelectron-hole pair recombination of red phosphorus semiconductor, and exhibit improved visible light absorption . Consequently, the catalytic performance of Co 3 O 4 /RP has been enhanced under visible light .
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POLYMER DEGRADATION AND STABILITY
·
2018
·
IF 3.193
Ke Huang,Hongyan Wu,Fan Jiang,Guozhu Shen,Lu Wang
Smart near-infrared (NIR) light-responsive poly N-isopropylacrylamide (PNIPAM) nanocomposite hydrogels were prepared by incorporating sparse chemical cross-linking of small molecules. The thermo-sensitive, NIR light-responsive, toughness and strength of the pure PNIPAM, PNIPAM-Graphene oxide(GO) and PNIPAM-GO-Zirconia(ZrO 2 ) hydrogels were invesitgated. The introduction of GO induced PNIPAM the transformation from the thermosensitive to NIR light-responsive, and the oxidized groups of GO nanosheets could physically cross-link the PNIPAM chains to increase the toughness of the hydrogel networks. The loading capability and penetration resistance of PNIPAM-GO-ZrO 2 composite hydrogel was obviously improved due to that the ZrO 2 powder stabilize the hydrogel networks and strengthen the hydrogen bond interaction with the amide groups of PNIPAM chains compared with that of the pure PNIPAM and PNIPAM-GO, respectively.
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