NANOTECHNOLOGY
·
2020
·Vol. 31
·期 41
·415301
·
IF 3.551
Qian Zhao,Guangqiang Liu,Hongwen Zhang,Weiping Cai
A simple and cost-effective route to fabricating gold-coated glass nano-stings' arrays is presented for highly efficient surface enhanced Raman spectroscopy (SERS) chips via reactive ion etching of the glass slide covered with polystyrene (PS) colloidal monolayer and sputtering deposition of gold on it. The as-fabricated SERS chips consist of the nearly-hemispherical particles with submicron-size, which are hexagonally arranged into the ordered arrays. There are many short and long Au-coated glass nano-stings standing vertically on the hemispherical particles, showing high density tips (up to 7.0 × 103 μm−2). The formation of such gold-coated glass hierarchically structured array is attributed to the geometry of PS colloidal monolayer and the nanoscale roughness of glass slide's surface. Further, it has been demonstrated that such gold-coated glass array chip is highly SERS-active and can be utilized to detect trace organophosphorous toxicant with the limit below ppt level and good reproducibility in measurements. The intensity of the Raman peak shows the linear relation, in logarithmic scale, with the organophosphorous concentration from ppt to ppm level, exhibiting the possibility of quantitative detection in a large concentration range. This work has demonstrated the cost-effective method to fabricate the high performance SERS chips for trace detection of toxic molecules.
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Hao Lu,Yu Yang,Ruijue Chen,Wenyi Huang,Hao Cheng,Xueping Liu,Hongxing Kong,Lijun Li,Jun Feng
In this study, we synthesized gold nanoparticles (AuNPs) in situ on the surface of two-dimensional Cu-TCPP (meso-tetra(4-carboxyphenyl)porphine) metal– organic framework (MOF) nanosheets to produce AuNP@Cu-TCPP nanocomposites as surface-enhanced Raman scattering (SERS) substrates. The SERS signal was enhanced in two ways: aggregation of the AuNPs@Cu-TCPP near the SERS hotspot through the strong adsorption capacity of the MOF, and the synergistic effect between the charge-transfer enhancement of the Cu-TCPP MOF and the electromagnetic enhancement of plasmonic metal AuNPs. The SERS activity of AuNPs@Cu-TCPP was evaluated by the analysis of multiple model analytes; Rhodamine 6G (R6G) and benzidine were detected with detection limits below 10 –13 and 10 –12 mol·L –1 , respectively. We used AuNP@Cu-TCPP as a SERS substrate combined with an enzyme-linked immuno- sorbent assay (ELISA) to detect the tumor marker carboxylesterase 1 (hCE1) in human serum. The SERS signal of benzidine at 1609 cm −1 is linearly correlated with hCE1 in the concentration range of 0.1–120 ng·mL −1 . Owing to their high sensitivity and excellent SERS sensing capability, AuNPs@Cu-TCPP nanocomposites have potential applicability in the analysis of clinical samples.
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Microsystems & Nanoengineering
·
2024
·Vol. 10
·期 1
·1-16
·
IF 7.3
Yang Shuo,Li Kaiyue,Huang Ping,Liu Keyan,Li Wenhui,Zhuo Yuquan,Yang Ziwen,Han Donglai
This study introduces a multifunctional device based on Cu 2 O/g-C 3 N 4 monitoring and purification p–n heterojunctions (MPHs), seamlessly integrating surface-enhanced Raman scattering (SERS) detection with photocatalytic degradation capabilities. The SERS and photocatalytic performances of the Cu 2 O in various morphologies, g-C 3 N 4 nanosheets (NSs) and Cu 2 O/g-C 3 N 4 MPHs with different g-C 3 N 4 mass ratios were systematically evaluated, with a particular emphasis on the Cu 2 O/g-C 3 N 4 -0.2 MPH, where g-C 3 N 4 constituted 20% of the total mass. Multiple optical and electrochemical tests revealed that the Cu 2 O/g-C 3 N 4 -0.2 MPH effectively enhances charge separation and reduces charge transfer resistance. The Cu 2 O/g-C 3 N 4 -0.2 SERS sensor exhibited a relative standard deviation (RSD) below 15% and achieved an enhancement factor (EF) of 2.43 × 10 6 for 4-ATP detection, demonstrating its high sensitivity and consistency. Additionally, it demonstrated a 98.3% degradation efficiency for methyl orange (MO) under visible light within 90 min. Remarkably, even after 216 days, its photocatalytic efficiency remained at 93.7%, and it retained an 84.0% efficiency after four cycles. XRD and SEM analyses before and after cycling, as well as after 216 days, confirmed the structural and morphological stability of the composite, demonstrating its cyclic and long-term stability. The excellent performance of the Cu 2 O/g-C 3 N 4 MPH is attributed to its Z-type mechanism, as verified by radical trapping experiments. The evaluation of the self-cleaning performance of the Cu 2 O/g-C 3 N 4 -0.2 SERS sensor demonstrated that its Z-scheme structure not only provides excellent self-cleaning capability but also enables the detection of both individual and mixed pollutants, while significantly enhancing the SERS signal response through an effective charge transfer enhancement mechanism.
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高影响因子
Journal of Materials Chemistry A
·
2025
·Vol. 13
·期 38
·32731-32740
·
IF 9.5
Ying Li,Dandan Song,Bing Liu,Xin Li,Jie Huang,Haiyan Zhu,Gang Shi
A surface-enhanced Raman spectroscopy sensor combined with the molecular imprinting technique (MIT-SERS) has the ability of high sensitivity and specific recognition, but its accurate quantitative analysis and high-stability reuse are poor. To solve the above problems, a novel MIT-SERS sensor with internal standard self-correction and spatially separated photocatalysis is designed. This MIT-SERS sensor is composed of a SERS substrate and a MIT recognizer. Photocatalyst TiO2, co-reductant catalyst Ag and co-oxidant catalyst Fe2O3 are the main materials of the SERS substrate. The occupying molecule C3H6S and the template molecule 4-ATP are adsorbed on the surface of Ag and Fe2O3 in turn. The molecularly imprinted layer is SiO2. It is worth noting that the space-confined assembly of C3H6S and 4-ATP ensures that C3H6S is protected and 4-ATP is completely degraded during the photocatalysis process, realizing the reusability of the MIT-SERS sensor. In addition, SiO2 is used as an internal standard to improve the accuracy of quantitative analysis of the sensor. For this MIT-SERS sensor, the detection limit (LOD) is as low as 2.24 × 10−11 M and the linear fit (R2) of quantitative analysis is as high as 0.9975. During repeated use, the relative standard deviation (RSD) of the corrected signals from the MIT-SERS sensor is as low as 1.27%.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Tianxing Fang,Qingyi Wei,Erwen Wu,Hongbin Pu
Malachite green (MG), with teratogenic and reproductive toxicity, is widely misused as an antimicrobial agent, posing a serious threat to animal and human health. Therefore, this study developed a novel recyclable Surface-enhanced Raman scattering (SERS) hydrogel substrate, TiO 2 /MXene/PAA-PAM@AuNPs (TMPA), by forming a dual hydrogen-bond network using a PAA-PAM hydrogel matrix with TiO 2 /MXene and embedding AuNPs, for detecting MG residues in aquatic products. This hydrogel exhibits high sensitivity, with a detection limit for MG of 8.13 × 10 −6 mg/L. Additionally, it can completely degrade surface-adsorbed MG within 60 min under light irradiation, achieving self-cleaning and enabling reuse for more than seven cycles, and can be stored for over 50 days while maintaining its SERS activity due to the support and preservation provided by the hydrogel network. Additionally, this substrate can rapidly detect MG residues on or within fish, offering a new strategy for monitoring MG residues in aquatic products.
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PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Tao Xu,Huan Liu,Jing Tang,Wenxi Wen,Chenjie Gu,Tao Jiang,Hongbin Xu
Surface enhanced Raman scattering (SERS) with high detection sensitivity has emerged as a fascinating protocol for monitoring trace amount of drugs in clinical serum sample. Herein, a simple and environmentally friendly photo-induced in-situ reduction strategy was proposed to synthesize RP@Ag composites with both SERS and photocatalytic activities. By carefully adjusting the concentration of the Ag source in the precursor solution, the amount and diameter of the decorated Ag nanoparticles were precisely tuned. The resulting optimal RP@Ag composites exhibited reliable SERS enhancement ability (enhancement factor: 1.76 × 10 7 ) and the highest degradation efficiency (degradation ratio: 95.04 %, irradiation time: 120 mins) in recyclable detection of Rhodamine B. After further confirming the reliable accuracy, sensitivity, homogeneity, and durability of the RP@Ag composites, they were used to monitor osimertinib and enabled an extremely low limit of detection as 1.63 × 10 −7 mg/mL. In particular, such a recyclable SERS platform achieved perfect recovery rates, the obtained deviations were all within 10 % in the monitoring of clinical samples from patients taking medicine for different durations.
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VIBRATIONAL SPECTROSCOPY
·
2025
·
IF 3.1
Xubo Wang,Hongjun Yin,Jingwen Zhu,Yong Huang,Zhenguang Wang,Xinmei Zheng,Xiaowei Cao,Wei Wei
MicroRNA (miRNA) is a potential biomarker for tumor diagnosis. Therefore, it is important to investigate a method for accurate analysis of miRNA. In this study, we developed a novel and cost-effective surface-enhanced Raman scattering (SERS)-lateral flow assay(LFA) dual detection line test strip for quantitatively detecting miR-19a-3p and miR-4491, respectively. These two miRNAs are closely associated with the development of gastric cancer (GC) and their significant overexpression in patients gives them great potential as innovative tumor markers for GC detection. During the detection process, miR-19a-3p and miR-4491 would compete for binding to the corresponding SERS tags. The presence of concentrations of miR-19a-3p and miR-4491 in the sample solution reduces the binding of the SERS tags to the ssDNAs, thereby reducing the SERS intensity. The test strips were designed to be highly specific and reproducible, and the entire assay was completed in 15 minutes. The test strips we designed were simpler, more sensitive, and more efficient than other detection methods. The detection limit in serum were 21.14 fM for miR-19a-3p and 10.34 fM for miR-4491. In addition, the results of SERS-based LFA test strip and quantitative real-time polymerase chain reaction (qRT-PCR) were consistent for serum testing of healthy individuals, patients with mild intraepithelial neoplasia (IE), patients with severe IE, and patients with gastric cancer. Therefore, SERS-based LFA test strip has great potential for the clinical diagnosis of gastric cancer.
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MARINE POLLUTION BULLETIN
·
2025
·
IF 4.9
Tianshuo Lan,Yiping Du,Meichun Liu,Xinna Yu,Danyang Wang,Haotian Huang,Tianyuan Liu,Meizhen Huang
As a global environmental concern, real-time detection of marine nanoplastics (NPs) has gained increasing attention. However, current detection methods are still confronted with the challenge of detecting low concentration NPs in marine solution conditions, and it is imperative to establish a rapid detection method for directly detecting NPs in marine solution. In this study, a silver coated gold nanoparticle (Au@Ag) based real-time SERS detection strategies is proposed, with a particular focus of the enhancement mechanism of the particle diameter for SERS performance. Compared with common SERS enhancing particles, Au@Ag demonstrates remarkable SERS enhancement capability. For mechanism investigation, particle diameter is a critical factor significantly influenced the signal intensity of testing specimen. Among all diameter combinations, SERS performance reaches the maximum level when the particle diameter of Au@Ag is slightly smaller than polystyrene nanoparticles (PS NPs). Under these conditions, the lowest detection concentration of PS NPs in purified water without any extra pretreatments was determined to be approximately 0.1 μg/mL. By employing the same PS NPs and Au@Ag in artificial seawater solution, the lowest detection concentration of PS NPs reaches to 0.01 μg/mL. These results indicate that the efficacy of Au@Ag for real-time SERS detection of PS NPs in marine solution, and provide a valuable reference for future study of material selection and particle size optimization for NPs in-situ SERS detection for real marine condition.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Yupeng Sun,Kaihui Zhou,Yuxin Wang,Ye Lin,Weiran Wang,Xue Xiong,Xiangru Zhao,Huinan Cui,Min Liang,Qiao Wang,Shengnan Yang,Li Li
Rapid, low-cost, and in-situ detection of illegal residues on aquatic product surfaces remains a significant challenge. Herein, we developed a versatile surface-enhanced Raman scattering (SERS) sensor by integrating instant interfacial self-assembled silver nanostar film onto flexible polytetrafluoroethylene filter membrane (AgNS/PTFE) for sensitive detection of malachite green (MG) and crystal violet (CV) in crayfish. The entire process, from room-temperature substrate preparation to detection completion, takes less than 20 min. The AgNS/PTFE flexible substrate not only provides excellent hydrophobicity for signal enhancement with minimal sample volumes (2 μL) but also ensures good uniformity, resulting in a homogeneous and dense distribution of SERS-active hot spots with superior anti-interference properties and mechanical durability. By simple “drop/wipe” operations and data visualization treatment, this method achieved detection limits as low as 10 pg/mL for MG and 7 pg/mL for CV, with in-situ analysis in spiked and actual crayfish samples, demonstrating significant potential for food safety applications.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Ruixuan Han,Yixing Tian,Xinru Guo,Peilong Wang,Jie Cheng
Fabricated hydrogel SERS patches with controllable dehydration-triggered analyte enrichment. • Dynamic modulation of plasmon coupling and analyte accumulation synergistically boosts SERS sensitivity. • The flexible sensing platform achieves on-site detection of multiple pesticide residues on fresh agricultural products. On-site surface-enhanced Raman scattering (SERS) detection of trace pesticide residues on fresh agricultural products is essential for food safety assurance, which limited by poor conformal contact, severe biomolecular interference, and insufficient in-situ analyte enrichment of conventional substrates. Herein, a flexible sodium alginate hydrogel patch embedded with branched gold nanoflowers (AuNFs-SA) was designed for on-site quantitative detection of agricultural pesticide residues. The dendritic gold nanoflowers generate dense plasmonic hotspots, while Ca 2+ crosslinking improves conformal adhesion and molecular sieving within the hydrogel, thereby minimizing matrix interference from fruit and vegetable surfaces. A controllable dehydration-induced enrichment strategy was then introduced to dynamically regulate plasmonic coupling and analyte accumulation. Under optimal detection conditions, the AuNFs-SA patch enables reliable quantitative detection of four representative pesticides, with a linear range of 10–2500 ng·cm −2 (R 2 ≥ 0.98) and surface-based limits of detection as low as 1.10–6.85 ng·cm −2 . It exhibits excellent intra- and inter-batch signal reproducibility, with relative standard deviation values below 6.81%, and outstanding long-term stability, retaining over 88.87% of initial SERS intensity after 49 days of ambient storage. Combined with principal component analysis, accurate discrimination among four representative pesticide residues on the surfaces of fresh agricultural products was realized. This work proposes a feasible and portable hydrogel SERS platform for efficient on-site pesticide monitoring, providing a promising tool for practical food safety supervision. Download: Download high-res image (169KB) Download: Download full-size image
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ANALYTICAL LETTERS
·
2025
·
IF 1.8
Xuemei Wang,Xue Zhang,Yunsheng Shang,Guohai Yang,Xin Zhang,Lu-Lu Qu,Yingqiu Gu
Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for the rapid, real-time monitoring of trace aquatic pollutants. However, a major challenge persists in the development of SERS substrates capable of simultaneously determining and degrading pollutants. Herein, a highly sensitive Au/TiO2/Au sandwich-structured substrate was fabricated that exhibited excellent SERS performance with an enhancement factor (EF) of 1.05 × 107. Limits of detection (LODs) as low as 1.42 × 10−7 M for ofloxacin (OFL) and 1.26 × 10−9 M for trimethoprim (TMP) were achieved. Notably, the substrate retained stable SERS activity even after five consecutive detect-degrade cycles. By integrating plasmonic enhancement (for SERS detection) with photocatalytic degradation (for pollutant removal), this dual-functional platform demonstrated high reproducibility, with a relative standard deviation (RSD) below 6%, and long-term stability, retaining 60% of its initial SERS intensity after 60 days of storage. The strategy reported herein provides a practical approach for the simultaneous determination and degradation of antibiotics in aqueous matrices.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 2
·81
·
IF 5.3
Zhang Haili,Peng Man,Lu Anjiang,Peng Xishun,Wang Cunwei,Zu Caizhen,Bai Zhongchen
A surface-enhanced Raman scattering (SERS) sensor of Au/Ag nanoparticles (NPs) grown on ZnO/polypyrrole@Poly(3,4-ethylene dioxythiophene)-poly(styrene sulfonate) (PPy@PEDOT:PSS) film for detecting norfloxacin (NFX) residues in milk is presented. The ZnO/PPy@PEDOT:PSS film was prepared by the electrochemical deposition method. Subsequently, Ag NPs and Au NPs were deposited on the surface of ZnO/PPy@PEDOT:PSS film to form a Au/Ag/ZnO/PPy@PEDOT:PSS film by an electrochemical deposition process and the magnetron sputtering process, respectively. Owing to the charge transfer between the SERS substrate and the NFX molecules, this SERS sensor could effectively identify low-concentration NFX molecules with a limit of detection (LOD) of 0.84 nM. Moreover, it could also recognize NFX residues in milk with recoveries of 91.2% to 108.4%. The SERS sensor of Au/Ag/ZnO/PPy@PEDOT:PSS film had a high sensitivity, excellent long-term stability, and significant potential in food safety monitoring applications. Graphical abstract
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高影响因子
危险品化学品经营许可证（带存储）