Food Analytical Methods
·
2025
·
IF 3
Yue Jia-Hui,Zhou Jie-Fang,Zhu Feng-Mei,Li Rong-Di,Liu Xiao-Jing
With the rapid development of nanomaterials, carbon quantum dots (CQDs) with diverse and superior physicochemical characteristics have garnered considerable attention. In this work, we report a sustainable and green synthetic strategy for fabricating novel blue-emissive, water-dispersible CQDs utilizing grape pomace (a winemaking waste) as a renewable carbon precursor, achieving a quantum yield of 32% without requiring additional surface modification. This approach not only promotes waste valorization but also aligns with principles of environmental sustainability. The as-prepared CQDs demonstrate remarkable selectivity toward tetracycline (TC), inducing significant fluorescence quenching via the inner filter effect (IFE). Conversely, enrofloxacin (ENR) triggers notable fluorescence enhancement, predominantly governed by the surface passivation (SP) mechanism. A linear response range of 0–100 µM for TC was established and 0–100 µM for ENR, with a remarkably low detection limit (LOD) of 0.48 µM and 0.94 µM. Furthermore, the CQDs demonstrated robust performance in the quantification of TC and ENR in real-world samples, with stable analytical responses achieved within 1–60 min. Collectively, these findings underscore the potential of the CQDs as a cost-effective, facile, and highly sensitive fluorescence-based sensing platform for monitoring veterinary drug residues.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 10
·1-11
·
IF 5.3
Wang Haiping,Luo Li,Han Feifei,Peng Sibei,Wang Li,Shu Xiji,Sun Binlian,Liu Yuchen,Zhang Song,Yu Yao
Non-alcoholic fatty liver disease (NAFLD) is a global health concern, but early diagnosis remains challenging due to the limitations of current methods, which are often invasive or lack sensitivity. To address this, we developed UIO-YB, a dual-responsive fluorescence probe combining water-soluble UIO carriers with a polarity-sensitive dye (YB) for precise NAFLD detection. UIO-YB exhibits dual fluorescence emission (red for YB, blue for UIO), enabling simultaneous detection of lipid accumulation (via YB’s polarity response) and oxidative stress markers (via UIO’s RNS reactivity). In vitro, UIO-YB detected lipid droplets in HepG2 cells within 2 h, surpassing Oil Red O in speed and simplicity. In vivo, it accurately visualized Hepatic steatosis in mice after 6 weeks of a high-fat diet, demonstrating high specificity and sensitivity. Unlike conventional dyes, UIO-YB operates without organic solvents, simplifying protocols while reducing background noise. UIO-YB’s water solubility and dual-response design overcome key limitations of existing probes, offering a rapid, scalable tool for early NAFLD detection. Its performance in cellular and preclinical models highlights its potential to advance NAFLD research and clinical diagnostics. This innovation paves the way for non-invasive, high-sensitivity imaging to improve disease monitoring and intervention. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IRANIAN POLYMER JOURNAL
·
2025
·
IF 2.8
Ban Jianfeng,Yang Zilong,Pan Lulu,Liao Junqiu,Shi Bo
This work was designed to investigate the complex shape memory phenomena and explore the potential for bidirectional reversibility within polymer matrices, focusing particularly on dual-response capabilities. A series of shape memory azobenzene liquid crystal elastomers (Dp-LCEs) were synthesized with azobenzene-4,4'-dicarboxylic acid, polycaprolactone, and hexamethylene diisocyanate as the primary raw materials, and triethanolamine was utilized to establish cross-linking points. The structural and thermal properties of these Dp-LCEs were meticulously characterized through Fourier-transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and X-ray diffraction techniques. According to the structural and thermal properties test results, they afforded a deep understanding of the material's composition and thermal behavior, essential for optimizing its performance in practical applications. Furthermore, the stretchability, photo-thermal responsiveness, and reversible deformation capabilities of the Dp-LCEs were assessed via stretching tests and by subjecting them to ultraviolet radiation. The findings revealed that the Dp-LCEs demonstrated distinctive photo-thermo-synergy response shape memory features and exhibited outstanding bidirectional reversible shape memory behavior. This research work provided a solid theoretical basis for customization of the advanced multifunctional shape memory materials, potentially paving the way for innovative applications in various fields such as smart textiles, biomedical devices, and adaptive structures. These advancements suggested significant potential for future developments in smart material technologies, particularly in areas requiring precise environmental responsiveness and high-performance adaptability. Graphical
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2024
·
IF 1.5
Chen Yuxin,Zhang Yu,Liu Zihao,Guan Haohai,Huang Cong,Su Xuebin,Hua Rong
It is very important to properly treat uranium-containing wastewater scattered in the environment. In this study, we used the hydrothermal method to synthesize carbon-coated magnetic Fe 3 O 4 nanoparticles and then modified by sodium hydroxide to yield magnetic carbon nanomaterials (Fe 3 O 4 @HTC-NaOH). The microstructure and chemistry of the material were characterized by TEM and FTIR. We investigated the adsorption behavior of materials for uranium (VI) under different conditions, including pH, contact time, initial uranium concentration, and temperature. The results indicated that this material adsorbs uranium quickly, achieving equilibrium in static adsorption after approximately 225 min. The adsorption behavior was strongly dependent on pH, and the maximum adsorption capacity (457.83 mg/g) was reached at pH 5.5. The initial concentration also had a role in the adsorption behavior. With the gradual increase of the initial concentration of uranium (VI), the adsorption capacity showed an increasing trend and reached saturation at 100 mg/g. Adsorption isotherm could be well fitted by the Langmuir model and the pseudo-second-order kinetic model. And the results indicated it is a heat-absorbing reaction. Owing to the introduction of Fe 3 O 4 , the material is magnetic and the solid-liquid separation can be rapidly completed by the pairing of magnets. The new material could be regenerated using HNO 3 , and the adsorption rate could maintain above 75% after five adsorption/regeneration cycles, which illustrated its certain practical application value.
✓ 已验证
产品关联
DOI
高影响因子
RARE METALS
·
2024
·
IF 9.6
He Jin-Di,Wang Han-Du,Zhang Xu-Ming,Huang Li,Li Yun,Xia Lu,Pi Chao-Ran,Li Jian-Ping,Zheng Yang,Gao Biao,Huo Kai-Fu
The development of cost-effective, highly efficient and stable catalysts is critical to promote the industrial alkaline hydrogen evolution reaction (HER). However, single-component catalysts often cannot handle the multiple kinetic steps during hydrogen production. To address this challenge, a heterogeneous catalyst comprising metal Co, CoO and carbon-doped Mo 2 N (Co–CoO–C/Mo 2 N/CC) was synthesized by heat treatment of carbon cloth-supported CoMoO 4 microrods in a mixed reduction atmosphere. The resulting catalyst has rich interfaces, exhibiting excellent initial HER activity with an overpotential of 27 mV at 10 mA·cm −2 and a Tafel slope of 37 mV·dec −1 . Further studies show that the activity and stability of the catalyst can be tailored by the dynamic surface reconfiguration and doping effects. The carbon doping and high crystallinity in Mo 2 N help to reduce the dissolution of Mo and the surface metal Co is preferentially converted into stable Co(OH) 2 , thus stabilizing the structure of the catalyst and coordinating various reaction kinetics. In an electrolyzer comprising a heterogeneous Co–CoO–C/Mo 2 N cathode and NiFe layered double hydroxides (LDH) anode, only 1.58 V is required to achieve a current density of 50 mA·cm −2 , outperforming Pt/RuO catalysts. After continuous electrolysis for 100 h, the potential increases by merely 19 mV from the initial 1.58 V, indicating excellent stability. This study presents a novel strategy for developing highly active and stable heterogeneous catalysts, offering insights into the dynamic evolution of catalyst structures and laying the groundwork for designing efficient and stable composite catalysts for energy conversion applications. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS AND STRUCTURES
·
2024
·Vol. 57
·期 6
·1-14
·
IF 3.4
Liu Qing,Li Yunjian,Wang Qiao,Wang Miaomiao,Li Zongjin,Geng Guoqing
The inherent brittleness of cement hydrates poses a major issue to the mechanical and durable performances of concrete. To conquer this issue, we constructed an organic–inorganic network within the cement matrix by utilizing the synergy of in situ polymerization of monomers and cement hydration, which significantly enhances its flexural strength and toughness while maintaining a comparable compressive strength with ordinary Portland cement (OPC). By tuning the proportions of acrylic acid (AA), methacrylic acid (MAA), and acrylamide (AM), the cement paste experienced an 86% increase in flexural strength with a similar compressive strength to OPC. The in situ formed organic–inorganic (polymer-cement) network provided both flexibility and stiffness, playing a pivotal role in the increased mechanical strength. Cement hydration was retarded with the incorporation of the AMA copolymer, which was supported by the offset of the maximum hydration temperature. In contrast, in situ polymerization of monomers proved more effective than directly adding polymer in improving the fluidity and mechanical strength. We hope this strategy provides a new way to increase the crack resistance of cementitious materials and thereby contributes to their overall durability.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2024
·
IF 3.1
Xu Dejun,He Liu,Zeng Fudong,Liu Bo,Ma Jinli,Han Dongmei,Yang Qingbiao,Du Jianshi
Polyvinylpyrrolidone-iodine (PVP-I) complexes are widely used in the medical and health field due to its strong antimicrobial properties and good biocompatibility, but their water solubility negates the possibility to be used as a wound dressing. In this work, the problem of PVP dissolving in water was solved by the method of thermally crosslinking, and it was found that the thermally crosslinked PVP nanofiber heated at 170 °C for 6 h had good liquid absorption capacity, stability and good fiber morphology. In addition, the thermally crosslinked PVP nanofiber is complexed with I 2 to endow it with excellent antibacterial properties. It has been demonstrated to have good biocompatibility through cytotoxicity and hemolysis experiments, which provides the possibility for it to be a dressing for the treatment of infectious wounds.
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
Ye Jian,Shi Chenyang,Lan Jian,Chen Qingqing,Si Qin,Xu Panpan,Zhang Xijiang,Zheng Cheng
Rapid and safe hemostasis is crucial for the survival of bleeding patients in prehospital care. It is urgent to develop high performance hemostatic material to control the massive hemorrhage in the military field and accidental trauma. In this work, an efficient protein hemostat of thrombin was immobilized onto commercial gauze, which was mediated by self-polymerization and anchoring of tannic acid (TA). Through TA treatment, the efficient immobilization of thrombin was achieved, preserving both the biological activity of thrombin and the physical properties of the dressing, including absorbency, breathability, and mechanical performance. Moreover, in the presence of TA coating and thrombin, Gau@TA/Thr could obviously shortened clotting time and enriched blood components such as plasma proteins, platelets, and red blood cells, thereby exhibiting an enhanced in vitro coagulation effect. In SD rat liver volume defect and artery transection hemorrhage models, Gau@TA/Thr still had outstanding hemostatic performance. Besides, the Gau@TA/Thr gauze had inherent antibacterial property and demonstrated excellent biocompatibility. All results suggested that Gau@TA/Thr would be a potential candidate for treating uncontrollable hemorrhage in prehospital care.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-17
·
IF 14.7
Zheng Botuo,Zhong Liling,Wang Xiaoxiao,Lin Peiyao,Yang Zezhou,Bai Tianwen,Shen Hang,Zhang Huagui
Inverse vulcanization exploits S 8 to synthesize polysulfides. However, evolution of products and its mechanism during inverse vulcanization remains elusive. Herein, inverse vulcanization curves are obtained to describe the inverse vulcanization process in terms of three stages: induction, curing and over-cure. The typical curves exhibit a moduli increment before declining or plateauing, reflecting the process of polysulfide network formation and loosing depending on monomers. For aromatic alkenes, in the over-cure, the crosslinked polysulfide evolves significantly into a sparse network with accelerated relaxation, due to the degradation of alkenyl moieties into thiocarbonyls. The inverse vulcanization product of olefins degrades slowly with fluctuated relaxation time and modulus because of the generation of thiophene moieties, while the inverse vulcanization curve of dicyclopentadiene has a plateau following curing stage. Confirmed by calculations, the mechanisms reveal the alkenyl groups react spontaneously into thiocarbonyls or thiophenes via similar sulfur-substituted alkenyl intermediates but with different energy barriers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 11
·1-13
·
IF 2.8
Wu Yunjian,Cai Fujin,Xu Kaidong,Liu Ying,Zhang Xiaoxing
The power grounding grid is a critical apparatus for ensuring the safe operation of electrical networks. However, the long-term burial of grounding grids underground makes them susceptible to soil corrosion, undermining their grounding effectiveness and posing threats to personnel and equipment safety. This paper developed silicone rubber with excellent mechanical properties, outstanding corrosion resistance, and high electrical conductivity to mitigate the corrosion rate of grounding electrodes and extend the lifespan of grounding grids. The effects of graphite and carbon nanotubes mixed conductive fillers on silicone rubber’s electrical, thermal, mechanical, and corrosion resistance were investigated. The results show that when the addition amount of carbon nanotubes and graphite mixed conductive filler is less than 4%, the content of conductive filler increases with the increase of the content of conductive filler. The electrical conductivity, tensile strength, thermal conductivity, and thermal stability of conductive silicone rubber gradually increase, and its corrosion resistance and adhesion are unaffected. With a filler loading of only 4 wt%, the silicone rubber achieves an electrical conductivity of 0.41 s/cm, a tensile strength of 4.08 MPa, and a fracture elongation of 113%. These results confirm that the corrosion resistance, heat resistance, and adhesion meet the requirements of grounding electrodes. The outcomes of this research provide robust support for the advancement of green electrical equipment.
✓ 已验证
产品关联
DOI
高影响因子
Parasites & Vectors
·
2024
·Vol. 17
·期 1
·1-11
·
IF 3
Li Xin,Jiang Ning,Li Qilong,Zheng Kexin,Zhang Yiwei,Sang Xiaoyu,Feng Ying,Chen Ran,Chen Qijun
Background Artemisinin (ART) is a frontline drug for the treatment of malaria; however, the emergence of ART-resistant Plasmodium strains necessitates increasing ART sensitivity. Given that taurine (TAU) has been shown to have immunomodulatory activity, we investigated the effects of TAU as an adjunct therapy to ART in mice infected with Plasmodium berghei . Methods Mice infected with P. berghei ANKA strain ( P. berghei ANKA) were treated with TAU alone, ART alone or a combination of TAU and ART (TAU + ART), and their survival time and parasitaemia were recorded. The cytotoxic effects of TAU and ART were subsequently assessed. The expression levels of inflammasome-related genes and inflammatory factors in mice infected with P. berghei ANKA were analysed in relation to those in mice treated with TAU alone, ART alone or the TAU + ART combination. The therapeutic effects were further evaluated by histological analysis and measurement of the spleen index. Results Compared with the control mice, P. berghei ANKA-infected mice treated with ART in combination with TAU presented significantly lower parasitaemia and prolonged survival. The combined treatment resulted in significant reductions in the expression levels of inflammasome-related genes in the spleen, including absent in melanoma 2 ( AIM2 ), caspase-1, NOD-, LRR- and pyrin domain-containing protein 3 ( Nlrp3 ), Nlrp1b , Nlrp1b , NLR family CARD domain containing 4 ( Nlrc4 ), Nlrp6 , nucleotide binding oligomerization domain containing 1 ( NOD1 ) and NOD2 , and decreases in the levels of inflammatory cytokines in the serum, including interleukin (IL)-12p70, tumour necrosis factor-alpha, monocyte chemoattractant protein-1, IL-10 and IL-6. Histopathological analysis confirmed that TAU + ART combination treatment reduced spleen pathology caused by P. berghei ANKA infection. Conclusions The findings indicate that TAU potentiates ART efficacy by modulating the immune response in P. berghei -infected mice. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PSYCHOPHARMACOLOGY
·
2024
·
IF 3.5
Liu Xin,Jin Yongzeng,Cheng Xinyi,Song Qinghua,Wang Yanan,He Ling,Chen Tong
Rationale The plasma ceramide levels in Alzheimer’s disease (AD) patients are found abnormally elevated, which is related to cognitive decline. Objectives This research was aimed to investigate the mechanisms of aberrant elevated ceramides in the pathogenesis of AD. Results The ICR mice intracerebroventricularly injected with Aβ 1-42 and APP/PS1 transgenic mice were employed as AD mice. The cognitive deficiency, impaired episodic and spatial memory were observed without altered spontaneous ability. The serum levels of p-tau and ceramide were evidently elevated. The modified expressions and activities of glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2A (PP2A) influenced the serum content of p-tau. The levels of ceramide synthesis-related genes including sptlc1, sptlc2, cers2, and cers6 in the liver of AD mice were increased, while the ceramide degradation-related gene asah2 did not significantly change. The regulations of these genes were conducted by activated nuclear factor kappa-B (NF-κB) signaling. NF-κB, promoted by free fatty acid (FFA), also increased the hepatic concentrations of proinflammatory cytokines. The FFA amount was modulated by fatty acid synthesis-related genes acc1 and srebp-1c. Besides, the decreased levels of pre-proopiomelanocortin (pomc) mRNA and increased agouti-related protein (agrp) mRNA were found in the hypothalamus without significant alteration of melanocortin receptor 4 (MC4R) mRNA. The bioinformatic analyses proved the results using GEO datasets and AlzData. Conclusions Ceramide was positively related to the increased p-tau and impaired cognitive function. The increased generation of ceramide and endoplasmic reticulum stress in the hypothalamus was positively related to fatty acid synthesis and NF-κB signaling via brain–liver axis.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）