Scientific Reports
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2024
·Vol. 14
·期 1
·1-13
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IF 3.8
Yao Fei,Yuan Qin,Yan Yichao,Liang Guoqiang,Zhou Liang,Xu Heng,Gao Shaomei,Zou Ting,Zhang Lurong
Yu-Ping-Feng-San (YPF) is a famous classical Chinese medicine formula known for its ability to boost immunity. YPF has been applied to enhance the immune status of tumor patients in clinical practice. However, there is still a lack of research on its immune regulatory effects and mechanisms in the tumor microenvironment. This study was designed to investigate the effects and mechanism of YPF on improving the immune suppression state of hepatocellular carcinoma (HCC) microenvironment. In an orthotopic mouse model of HCC, YPF improved the immune microenvironment of HCC immunosuppression, enhanced the maturation of dendritic cells (DCs), promoted the release of IL-12, and decreased the presence of JAK2, p-JAK2, STAT3, and p-STAT3 proteins in both tumor tissue and paracancerous tissues. YPF also could promote the maturation and reduce the activation of JAK2, p-JAK2, STAT3, and p-STAT3 proteins of mouse bone marrow-derived DCs induced by culture medium or tumor supernatant in vitro . Transient transfection of siRNA-STAT3 with DCs resulted in an increase in its maturation and its secretion of IL-12. On the whole, these combined effects of YPF served to ameliorate the HCC immune suppression microenvironment, which conducive to immune cells play the role of immune surveillance and killing liver cancer cells. The mechanisms of these combined effects were, at least in part, related to its inhibition of the activated JAK2-STAT3 signaling pathway in DCs within the HCC microenvironment.
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JOURNAL OF MATERIALS RESEARCH
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2025
·
IF 2.9
Ye Zhiqiu,Li Hao,Fang Jing
Lithium is vital for energy transformation, but traditional extraction methods from salt lakes face challenges due to magnesium ion interference. To overcome this, we developed HTO@ZIF, a hybrid nanomaterial that combines titanium hydroxide (HTO) with a zeolite imidazolate framework (ZIF), increasing lithium adsorption capacity by 2.5 times compared to pure HTO at pH 8.0. We also designed a solar microevaporator system that enhances lithium recovery while managing the water footprint of hypersaline brines. With 98% solar energy harvesting efficiency, the system raises local temperature, promoting Li + extraction and solar steam generation. The photothermal effect, enhanced water flux, and Li + enrichment in nanospaces lead to a double-enhanced lithium recovery, increasing from 10.95 to 20.29 mg·g −1 . The system also accelerates adsorption kinetics, reaching saturation in 4 h, twice as fast as at 295K, improving efficiency while reducing water and carbon consumption, contributing to carbon neutrality goals. Graphical abstract
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npj Parkinsons Disease
·
2025
·Vol. 11
·期 1
·1-10
·
IF 8.2
Lei Li,Chen Xiuli,Long Xincheng,Tu Qiuxia,Zhao Liping,Huang Dan,Song Lingli,Wang Jiaojiao,Zhai Suzhen,Chen Xiaozhong,Zhang Chunlin
Inspired by natural enzymes, artificial enzymes have garnered significant interest due to their simplicity of production, robustness under harsh conditions, and enhanced stability. This study introduces, for the first time, a novel Z/Ce@hemin composite enzyme, constructed by anchoring hemin onto zeolitic imidazolate framework-8 (ZIF-8)-encapsulated ceria (CeO 2 ) nanoparticles. This innovative design overcomes the challenges of hemin dimerization, enhances substrate affinity, and accelerates mass transport, leading to significantly improved peroxidase-like activity. The enzyme also demonstrates remarkable stability and resistance to environmental interference. Utilizing this Z/Ce@hemin composite, a sensitive and selective colorimetric detection system was developed for rapid and accurate quantification of hydrogen peroxide (H 2 O 2 ), a key oxidative stress marker. This approach was successfully applied in cellular models and Caenorhabditis elegans models of Parkinson’s disease, enabling precise monitoring of H 2 O 2 . The study provides a groundbreaking platform for oxidative stress modeling and expands possibilities in neurodegenerative disease research and therapeutic screening.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2024
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IF 2.3
Sun Xingjie,Zhang Wei-chao,Umar Ahmad,Wu Xiang
Bimetallic/polymetallic cobaltite possesses abundant redox reactions, high conductivity and theoretical capacity. This feature makes them a research focus of electrode materials for capacitor. In this study, we synthesize ZnCo 2 S 4 nanowires grown uniformly on Ni substrate through a controllable two-step hydrothermal strategy. The synthesized samples are used as cathode materials. The assembled supercapacitor delivers a specific capacitance of 81.66 C g −1 at a current density of 0.5 A g −1 . It keeps 73% of the initial capacitance after 15000 times cycling and an energy density of 85 Wh kg −1 at 2970 W kg −1 . These properties indicate their potential applications in future portable micro/nano and high-performance electrochemical devices. Graphical Abstract In this study, we synthesize ZnCo 2 S 4 nanowires grown uniformly on Ni substrate through a controllable two-step hydrothermal strategy. The assembled supercapacitor delivers a specific capacitance of 81.66 C g −1 at a current density of 0.5 A g −1 .
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Light-Science & Applications
·
2025
·Vol. 14
·期 1
·1-9
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IF 23.4
Chen Zhong,Man Zhongwei,Rao Shichao,Zhao Jinxing,Wang Shuaibing,Zhang Runtong,Teng Feng,Tang Aiwei
Recently, colloidal quantum dots (QDs) with high luminescent efficiency and tunable colors have become ideal materials for next-generation display devices. Direct photolithography is a powerful tool for patterning QD devices, but it faces the serious issue of degradation in the photophysical properties of the patterned QDs. Here, we use relatively rigid cyclopentane as a bridging group to design the crosslinker CPTA, achieving high-resolution direct photolithography of QDs with nearly nondestructive under ambient conditions. The key to the crosslinker design is the introduction of a rigid bridging group that elevates the LUMO level, providing a stronger energy barrier to prevent QD electrons from being trapped or undergoing non-radiative recombination, thus preserving their PL and EL properties. The efficient and high-resolution RGB line and dot arrays were fabricated with pixel sizes down to 1 μm and a resolution of up to 6350 PPI. The patterned RGB QD films, especially red QDs, maintained their optical and optoelectronic properties, with patterned red QLEDs achieving peak external quantum efficiency (EQE) of 21% and a maximum luminance ( L max ) of ~180,000 cd m⁻², matching pristine devices. These results highlight the importance of photo-crosslinker design for nondestructive QDs patterning, paving the way for advanced display applications in patterned QLED technology.
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Scientific Reports
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2025
·Vol. 15
·期 1
·1-14
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IF 3.9
Yu Ling,Luo Qianwen,Rao Xiaohui,Xiao Xiao,Wang Pinghan
Kawasaki disease (KD) is a severe pediatric vasculitis leading to coronary artery complications. Hydrogen sulfide (H 2 S), a recognized endogenous gasotransmitter with anti-inflammatory properties, offers potential as a novel treatment for KD through its cardiovascular benefits. However, the specific effects and underlying mechanisms remain unclear. The objective of present study is to investigate the anti-inflammatory and therapeutic effects of exogenous H 2 S in KD using network pharmacology and experimental validation. By online database searches, a total of 405 pharmacological targets for H 2 S, 826 KD-related targets, and 107 potential therapeutic targets of H 2 S for KD were identified. Through PPI analysis and Cytoscape screening, 9 hub genes were filtered, namely TNF, IL6, JUN, AKT1, IL1B, TP53, NFKB1, MAPK1, and RELA. KEGG pathway enrichment indicated that the TLR4/MyD88/NF-κB signaling pathway may play a crucial role in the therapeutic effects of H 2 S on KD. Additionally, in vivo experiments confirmed that the treatment of sodium hydrosulfide (NaHS), an H 2 S donor, markedly improved body weight, reduced inflammatory pathology in the coronary arteries, and downregulated levels of inflammatory cytokines TNF-α, IL-1β, and IL-6. Furthermore, WB analysis confirmed that NaHS inhibited the expression of TLR4, MyD88, NF-κB, and p-NF-κB. In brief, it is the first to reveal that exogenous H 2 S attenuates the inflammatory response in KD via the TLR4/MyD88/NF-κB pathway, highlighting its potential as a novel therapeutic approach for KD. These findings lay a foundation for further development of H 2 S-based therapies for KD management.
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Science China-Materials
·
2024
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IF 6.8
Gong Jiaqi,Ji Shilei,Li Jintian,Wei Hudie,Mao Weiwei,Hu Jing,Huang Wen,He Xuemin,Li Xing’ao,Chu Liang
Memristors have great potential in neural network computation. Perovskite memristors exhibit excellent resistive-switching (RS) properties between high resistance state (HRS) and low resistance state (LRS) state under applied voltage due to the extraordinary ion migration and superior charge transfer. However, the stability issue of traditional three-dimensional (3D) perovskites is still challenging. Here, one-dimensional (1D) (CH 3 ) 3 SPbI 3 perovskite passivation layer was in-situ formed on 3D perovskite film, which was further applied in stable synaptic memristor. The memristor was provided with three resistance states due to the heterojunction electric field coupled with ion migration. The on/off ratio of memristors was obviously improved from 10 to over 60. The RS characteristics of 3D/1D perovskite memristor remained unchanged after 10 3 s read and 300 switching cycles. The 3D/1D perovskite memristor effectively exhibited versatile synaptic plasticity behaviors including long-term potentiation, long-term depression and paired-pulse facilitation by controlling the input voltages. Notably, the novel device provides a new candidate for next-generation neuromorphic computing.
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CABI Agriculture & Bioscience
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2024
·Vol. 5
·期 1
·1-9
·
IF 2.8
Kou Jing,Zhu Zheng-Yang,Wang Su,Zhang Yu,Wang Jie,Jaworski Coline C.,Harwood James D.,Jing Lan,Desneux Nicolas,Di Ning
The heavy metal cadmium (Cd) leads to significant bottom-up effects on food chains of plants, herbivores, and predators in agroecosystems. Through the transfer and accumulation of Cd. In addition to the indirect effects of this cascading effects, predators Orius sauteri fed with artificial diets containing Cd also have a direct effect. We found that O. sauteri fed with sucrose solutions containing Cd at high concentrations of 125 mg/L and 625 mg/L significantly decreased the survival of the 3rd and 5th instar, female, and male adults (except 125 mg/L) of O . sauteri . However, the survival of O. sauteri nymphs was significantly increased when they fed with low concentrations of 1 mg/L, 5 mg/L and 25 mg/L Cd sucrose solutions. Cd stress has differing effects on the LC 50 of each age of O. sauteri , the lowest LC 50 for male adults (153 mg/L), followed by 3rd instar nymphs (192 mg/L), 5th instar nymphs (289 mg/L) and female adults (383 mg/L). It is interesting that 1 mg/L, 5 mg/L, and 25 mg/L of sucrose solutions containing Cd significantly improved the predation capacity of the nymphs of O. sauteri to the B emisia tabaci pupa. The predation ability of the male adults of O . sauteri on B . tabaci pupa were significantly improved, but significantly decreased in the female adults when they fed with 125 mg/L and 625 mg/L sucrose solutions containing Cd. This difference needs to be studied in depth in the future, controlling Cd contamination and protecting natural enemies to enhance the biological control of pests. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Guo Danman,Wang Wen,Zhang Kaimin,Chen Jinzheng,Wang Yuyuan,Wang Tianyi,Hou Wangmeng,Zhang Zhen,Huang Huahua,Chi Zhenguo,Yang Zhiyong
Organic room temperature phosphorescence (RTP) has significant potential in various applications of information storage, anti-counterfeiting, and bio-imaging. However, achieving robust organic RTP emission of the single-component system is challenging to overcome the restriction of the crystalline state or other rigid environments with cautious treatment. Herein, we report a single-component system with robust persistent RTP emission in various aggregated forms, such as crystal, fine powder, and even amorphous states. Our experimental data reveal that the vigorous RTP emissions rely on their tight dimers based on strong and large-overlap π - π interactions between polycyclic aromatic hydrocarbon (PAH) groups. The dimer structure can offer not only excitons in low energy levels for visible-light excited red long-lived RTP but also suppression of the nonradiative decays even in an amorphous state for good resistance of RTP to heat (up to 70 °C) or water. Furthermore, we demonstrate the water-dispersible nanoparticle with persistent RTP over 600 nm and a lifetime of 0.22 s for visible-light excited cellular and in-vivo imaging, prepared through the common microemulsion approach without overcaution for nanocrystal formation.
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MICROCHIMICA ACTA
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2024
·Vol. 191
·期 12
·1-10
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IF 5.3
Wang Linhai,Hu Xiao,Yao Guoqing,Chen Qinhua,Wang Sicen
A visual aptasensor based on the combination of graphitic carbon nitride loaded with platinum nanoparticles (PtNPs/g-C 3 N 4 ) and deoxyribonuclease I (DNase I) was developed for detecting acetamiprid. The prepared PtNPs/g-C 3 N 4 exhibited excellent peroxidase (POD)-like activity, demonstrating the capacity to oxidize the colourless o-phenylenediamine (OPD) to produce the coloured product diaminophenazine (DAP) in the presence of hydrogen peroxide (H 2 O 2 ). The DNA aptamer of acetamiprid can adsorb onto the surface of PtNPs/g-C 3 N 4 , thereby inhibiting its POD activity. The binding of acetamiprid to its aptamer results in the aptamer desorbing from the surface of PtNPs/g-C 3 N 4 and subsequent digestion by DNase I. Ascribed to the synergistic effect of these factors, the aptasensor can achieve the rapid on-site detection of acetamiprid based on the acetamiprid-induced the colour change of the solution just with the smartphone. Furthermore, due to the remarkable fluorescence signal of DAP at 570 nm, the aptasensor under fluorescence mode enables highly sensitive and quantitative detection of acetamiprid with a linear range of 1 ng/mL to 4 µg/mL and a detection limit as low as 0.31 ng/mL. The aptasensor has successfully realized the detection of acetamiprid in river water and cucumber samples, offering a novel perspective for the rapid assessment of environmental pollution and food safety risks associated with acetamiprid residues. Graphical abstract
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Microsystems & Nanoengineering
·
2024
·Vol. 10
·期 1
·1-10
·
IF 7.3
Zhao Yunlong,Sun Qingxia,Mei Shixuan,Gao Libo,Zhang Xikuan,Yang Zekun,Nan Xueli,Zhang Haiyan,Xue Chenyang,Li Junyang
With the modernization of traditional Chinese medicine (TCM), creating devices to digitalize aspects of pulse diagnosis has proved to be challenging. The currently available pulse detection devices usually rely on external pressure devices, which are either bulky or poorly integrated, hindering their practical application. In this work, we propose an innovative wearable active pressure three-channel pulse monitoring device based on TCM pulse diagnosis methods. It combines a flexible pressure sensor array, flexible airbag array, active pressure control unit, advanced machine learning approach, and a companion mobile application for human–computer interaction. Due to the high sensitivity (460.1 kPa −1 ), high linearity ( R 2 > 0.999) and flexibility of the flexible pressure sensors, the device can accurately simulate finger pressure to collect pulse waves (Cun, Guan, and Chi) at different external pressures on the wrist. In addition, by measuring the change in pulse wave amplitude at different pressures, an individual’s blood pressure status can be successfully predicted. This enables truly wearable, actively pressurized, continuous wireless dynamic monitoring of wrist pulse health. The innovative and integrated design of this pulse monitoring platform could provide a new paradigm for digitizing aspects of TCM and other smart healthcare systems.
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npj Flexible Electronics
·
2025
·Vol. 9
·期 1
·1-10
·
IF 15.5
Pang Jinglin,Duan Tianpeng,Liao Min,Jiang Limei,Zhou Yichun,Yang Qiong,Liao Jiajia,Jiang Jie
As the core component of ferroelectric memories, HfO 2 -based ferroelectric thin films play a crucial role in achieving their excellent storage performance. Here, we improved the ferroelectric properties and domain switching properties through in situ stress loading during annealing. The thin films are annealed under different bending states by applying different stress actions, and it is observed that, within a certain range of stress bending, the optimization of the ferroelectric properties of the annealed thin films can reach an extreme value. Specifically, under the influence of a small electric field, the 2 P r values of thin films annealed at +10 and −10 mm increased by 87.1% and 71.1%, respectively, compared with the unbent films. Additionally, these thin films exhibit extremely high domain wall mobility and excellent domain switching capabilities. Once the ferroelectric phase is formed through in situ stress modulation, it remains stable even under multiple service environments.
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