SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
·
2025
·
IF 3.8
Jiamin Li,Kezeng Pan,Changhong Zhang,Yuanyuan Xue,Shilei Zhong,Ye Tian,Junxian Lu
Heavy metal pollution threatens human health and ecosystems, and countries have established strict standards for heavy metal content in water bodies. This paper presents a new method based on microporous array sprayed on solid substrate enhanced laser-induced breakdown spectroscopy (MASSS-LIBS) technology and NELIBS, which enables high sensitivity and multi-element detection at the μg/L level. The method involves sequentially spraying metal nanomaterials, water samples, and surfactants onto a silicon substrate to form nanostructures that are conducive to LIBS analysis. Experimental research examined the impact of key parameters, including surfactant type and nanoparticle preparation, on signal quality. Results showed significant improvements in signal intensity and stability after forming nanostructures compared to using only Au nanoparticles. Different surfactants provided varying LIBS enhancements for heavy metals, with sodium dodecyl sulfate (SDS) demonstrating superior enhancement and stability for Pb, Cr, Cu, and Mn. Controlling nanoparticle density through spraying time for Au NPs helped manage nanostructure surface density and reduce Au nanoparticle loss, further enhancing LIBS signals. Under optimized parameters, the intensity of LIBS spectral peaks following nanostructure formation was approximately 10 times higher than that observed without nanostructures, with a stability of 6 %. The LoD for Mn reached sub-μg/L levels, while the LoD for Cu, Cr, and Pb was approximately several μg/L, demonstrating a one-order-of-magnitude improvement. In eleven quantitative inversion experiments in the low concentration range of tens of μg/L. Overall, this method shows potential as an alternative for qualitative and quantitative analyses in water quality testing.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2025
·
IF 4.1
Zhansong Zhu,Kaiqiang Sun,Linlin Han,Zhencui Wang
Kanamycin is an antibiotic commonly used for the prevention and treatment of infections. The monitoring of kanamycin is of vital significance for maintaining food safety and safeguarding public health. However, the sensitive and reliable detection of kanamycin under visible light irradiation still presents significant challenges. In this study, a self–supported electrode was fabricated from a titanium dioxide nanowire array modified with gold nanoparticles, utilizing a straightforward and controllable electrochemical deposition method. The synthesized photoanode exhibited enhanced photoelectrochemical performance under visible light, which can be attributed to the localized surface plasmon resonance effect of Au nanoparticles. Kanamycin aptamers served as recognition elements, immobilized on the TiO₂/Au nanowires through Au S bonds. The specific recognition and high affinity between the aptamers and kanamycin contributed to the excellent sensitivity of the photoelectrochemical aptasensor. The sensor demonstrated a linear range of 1–500 nM, with a limit of detection as low as 0.42 nM (S/N = 3). Furthermore, the sensor exhibited remarkable anti–interference capability in the presence of other contaminants and maintained excellent stability. It has been successfully applied for the analysis of kanamycin in real milk samples. The simple, efficient, highly sensitive, selective, and reproducible detection platform for kanamycin developed in this study offers significant potential for a wide range of applications.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 12
·847
·
IF 5.3
Ma Haibo,Ru Changhai,Zhang Fanghao,Hoettges Kai,Zhu Junhui,Song Pengfei
ZIF-8-core/Au-shell (ZIF-8@Au) nanoparticles were fabricated through a two-step strategy involving thiol-modification of ZIF-8 substrates and subsequent Au shell growth via seed-mediated approach, and the ZIF-8@Au nanoparticles were applied to the screening of clostridium difficile infection (CDI). Through regulating dosage of thiol-modifier, we established a surface functionalization protocol that introduced tunable thiol groups onto ZIF-8 particles while preserving their pristine morphology and crystallinity. Subsequent refinement of Au coating parameters enabled the construction of ZIF-8@Au core–shell nanostructures via seed-mediated growth. The resulting ZIF-8@Au nanoparticles were successfully applied to detect biomarkers of CDI, including toxin A, toxin B, and glutamate dehydrogenase (GDH), with sensitivities of 7 pg/mL, 115 pg/mL, and 27 pg/mL, respectively. These results demonstrate the promising potential of this nanoparticle-based platform for lateral flow assays. Graphical
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Zixuan Yuan,Yiting Zhu,Leying Xue,Danhua Ge,Shuo Xue,Ying Xie,Wei Zhang,Xiaojun Chen
Overuse of the anti-tuberculosis drug isoniazid (INH) would cause serious damage to human health. Currently, commonly used analytical methods such as high-performance liquid chromatography, liquid chromatography/mass spectrometry, etc. often rely on large instruments and are difficult to achieve rapid INH detection. Herein, we established an efficient colorimetric method for detecting INH in human serum based on a novel Au-doped hollow double-shell Prussian blue analogue (Mn-PBA-DSNB@Au), which could be prepared through a series of simple co-precipitation, etching, and in-stiu reduction procedures. Due to the high specific surface area and multiple active sites of the hollow structure, the obtained Mn-PBA-DSNB@Au exhibits enhanced peroxidase-like activity, realizing the rapid oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to blue oxTMB in the presence of hydrogen peroxide, producing a strong absorption at 652 nm. Based on the inhibitory effect of the reducing hydrazide group in INH upon the TMB colorimetric reaction, we constructed a sensitive colorimetric sensing platform for the determination of INH around Mn-PBA-DSNB@Au nanozymes. The developed INH sensor exhibited a linear range of 2–40 μM with a low detection limit of 0.835 μM. Furthermore, it could be extended to the actual detection of real human blood samples, achieving a recovery rate of 101.2 %–102.2 % with <2.6 % RSD.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hongchao Geng,Rongfu Peng,Junning Wang,Yuting Dong,Yuzhang Yan,Jiahui Dong,Linlang Xu,Haiyan Kang,Xu Yan,Xia Zhang,Chaopeng Wang,Yanli Mao
The development of high-performance near-infrared (NIR) photocatalysts with long-term stability broaden the range of light absorption and improve the utilization rate of solar energy have not been explored sufficiently. Herein, a novel hybrid material of upconversion nanoparticle (NPs) CaF 2 : Yb, Er, Tm decorated with TiO 2 and Au NPs has been synthesized by a simple and robust solvothermal route for NIR light active photocatalysis. It has been found that effective energy transfer occurred from CaF 2 : Yb, Er, Tm to TiO 2 and Au NPs by a nonradiative luminescence resonance energy transfer process. The enhanced activity is attributed to the nanostructured architecture that favors the efficient charge transfer and the localized surface plasmon resonance effects of Au NPs. Thus, the heterojunction showed the synergetic effects of both upconversion and localized surface plasmon resonance features, which could broaden the absorption spectrum to the NIR. Our work demonstrates that CaF 2 :Yb,Er,Tm@TiO 2 -Au could be potential candidates for NIR active photocatalysts for environmental applications.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Mingyuan Dong,Fangfang Ding,Yanan Jin,Chi Li,Xiang Lin,Shuang Lin
Self-assembly of nanocrystals into a macroscopic 3D superlattice has emerged as a promising nanostructure due to its collective optical and electrical properties. In this work, a macroscale supercrystal was constructed under constant temperature and humidity with an ultrasmooth Au nanosphere (NS) as a building block synthesized by a facile route. In particular, a reproducible and facile strategy was developed to fabricate highly spherical Au NSs with nanoscale size tenability. Importantly, this method does not require a syringe pump and breaks the limitation of instrumentation for the synthesis of Au NS, significantly contributing to the promotion and popularization of Au NSs. Meanwhile, an operable and cost-effective droplet slow evaporation self-assembly approach was applied to form a homogeneous 3D superlattice array against coffee rings with an enhancement factor as high as 1.37 × 108 verified by FDTD simulation results. Furthermore, integrating a convolutional neural network (CNN) model with the ultrasensitive 3D superlattice SERS platform, the precise and wide-range concentration prediction of the pesticide thiram in soil was successfully demonstrated, breaking the limitation of high-concentration saturation in the conventional concentration–intensity fitting curve. Consequently, this innovative Au NS 3D supercrystal facilitates the fabrication of novel nanoassemblies with ideal plasmonic functions for extensive applications in the fields of food safety, environment, medicine, and biology.
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高影响因子
Small
·
2021
·Vol. 18
·期 9
·2104120
·
IF 13.281
Ziyu Wu,Rui Wu,Xiaoyun Li,Xingwen Wang,Xueting Tang,Kaiyuan Tan,Mimi Wan,Chun Mao,Xingquan Xu,Huiming Jiang,Jiawei Li,Min Zhou,Dongquan Shi
Most of the current non-pharmacological treatment strategies for atherosclerosis (AS) suffer from poor penetration into the plaque and only aim at a certain factor in its formation process, resulting in limited therapeutic effect. Herein, a kind of nanomotor with dual-mode propulsion is constructed, which is sensitive to higher reactive oxygen species (ROS) at the AS site and near-infrared (NIR) laser by the covalent binding and self-assembly of β-cyclodextrin (β-CD) and L-arginine (LA) with immobilization of Au nanoparticles. NIR laser irradiation can be used as a driving force and to ablate inflammatory macrophages through the photothermal effect. The nitric oxide (NO) released by the nanomotors can be used as another driving force and a therapeutic agent to promote endothelial repair in the plaque site. LA can eliminate ROS in the inflammatory site, and β-CD can promote the removal of cholesterol from foam cells. In particular, the two driving modes of nanomotors synergistically promote their aggregation and penetration in the plaque. This kind of nanomotor can regulate the microenvironment of AS in multiple ways, including combination therapy for endothelial repair, lipid clearance, and reducing ROS, which is expected to become a potential non-pharmacological strategy in the treatment of AS.
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高影响因子
MICROCHEMICAL JOURNAL
·
2019
·
IF 3.206
Yuxiao Yang,Min Jiang,Kaihang Cao,Mei Wu,Chulei Zhao,Hongling Li,Chenglin Hong
An electrochemical immunosensor for quantitation of carcinoembryonic antigen (CEA) based on Au-Ag/ [email protected] nanocomposites for dual signal amplification strategy was designed. Polydopamine-coated Ag/graphene hybrids were synthesized by one-step reduction and functionalization, and the dopamine was introduced to replace some reducing agents that are harmful to organisms. Silver nanoparticles modified on the electrodes produced sensitive electrochemical redox peaks. When different amounts of protein (antigen, antibody, bovine serum protein, etc.) were adsorbed on the surface of nano-silver, the surface of nano-silver was covered. The electrochemical redox peak of silver particles decreased due to the change of the effective area of bare silver particles which could react with electrodes. In addition, CEA-antibody (anti-CEA) was immobilized into a biocompatible nanocomposite of Au nanoparticles as a conductive matrix, and CEA-antibody (anti-CEA) was combined with Ag/ [email protected] to form a dual signal amplifying element. Under optimal condition, the linear relationship was obtained from 0.001 ng mL −1 to 80 ng mL −1 between current signal and CEA concentration with a detection limit of 0.286 pg mL −1 (signal-to-noise ratio is 3). The label-free electrochemical immunosensor has been successfully applied to human serum detection due to good selectivity , stability and reproducibility.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Cong Peng,Lihua Jiang,Chen Qu,Jinhua Liu,Peng Zhao,Yifan Ren,Chuandong Wu,Jiemin Liu
The development of sensing materials capable of detecting H 2 S with ultrasensitivity and practicability is essential. To address this need, an Au and Sc co-modification strategy was proposed to boost the gas-sensing sensitivity of In 2 O 3 to H 2 S. In 2 O 3 and a sequence of binary (Au-In 2 O 3 and Sc x In (2-x) O 3 ) and ternary (Au-Sc x In (2-x) O 3 ) nanofibers (NFs) with different compositions were fabricated by electrospinning-calcination. Morphology characteristics revealed that the doping of Sc led to a reduction in the grain size, whereas the modification of Au induced an increase in the surface roughness of the NFs. Notably, after evolving pristine In 2 O 3 to the co-modified composites, the sensors exhibited an appreciable increase in sensitivity to H 2 S (from 0.51/ppm to 4.41/ppm), and ultralow detection limit of 5 ppb (measured) and 0.82 ppb (calculated). Moreover, the optimal Au-Sc x In (2-x) O 3 sensor exhibited preferable practicability, including selectivity (selectivity coefficient > 7), repeatability (RSD < 0.95 %, n = 7), stability (response decreased 4.3 % over 30 days), and moisture resistance (decreased 15 % at 88 % RH). Ultraviolet photo-electron spectroscopy and UV–vis spectroscopy analysis revealed that the enhanced performance was attributed to the formation of Au-Sc x In (2-x) O 3 heterojunctions, the electronic and chemical sensitization effect of Au, and the synergistic effect between Sc and Au.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xingkang Diao,GuoHua Qi,Yu Tian,Jing Li,Yongdong Jin
Hydrogen peroxide (H2O2) is a key reactive oxygen species (ROS) that regulates redox signals in organisms by reversibly oxidizing target proteins. However, it causes oxidative damage at supraphysiological concentrations, leading to various diseases. Therefore, accurate and sensitive detection of H2O2 in organisms, especially in cells, is essential for reliable pathological diagnosis. Herein, a sensitive and reproducible surface-enhanced Raman spectroscopy (SERS) platform was developed for in situ profiling detection of H2O2 released from cells utilizing a uniform and dense plasmonic Ag@Au core/shell nanoparticle nanomembrane (Ag@AuNPs-NM) as the SERS substrate. In the designed substrate configuration, the Ag@Au core/shell nanostructure combines the strong electromagnetic field enhancement of AgNPs with the stability of AuNPs, which could enhance the sensitivity of SERS detection. Meanwhile, the dense and uniform distribution of “hot spots” in the Ag@AuNPs-NM endows the platform with excellent detection reproducibility. In the presence of H2O2, the ratiometric I1073/I998 SERS signal of the Raman reporter 4-mercaptophenylboronic acid (4-MPBA) is changed due to the oxidation of the boronate group of 4-MPBA to the phenolic hydroxyl group of 4-hydroxythiophenol (4-HTP). The developed SERS sensing platform possesses a good linear relationship between the ratiometric I1073/I998 signal of 4-MPBA and the concentration of H2O2 in the range from 1 to 500 μM, with a limit of detection of 0.26 μM. As a proof of concept, we applied this platform to in situ monitoring of drug-stimulated H2O2 released from cells that were cultured on the SERS chips. This work provides a practical method for the in situ profiling detection of cellular H2O2 with satisfactory results, holding promise for the diagnosis of H2O2-associated diseases.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2014
·Vol. 38
·期 10
·4931-4937
·
IF 3.159
Wei Xu,Yu Wang,Su Liu,Jinghua Yu,Hongzhi Wang,Jiadong Huang
In this work, we report a novel sandwich-type electrochemical aptasensor for sensitive and selective detection of antibiotic kanamycin. This aptasensor was constructed by assembling graphene–polyaniline (GR–PANI) and polyamidoamine dendrimer–Au nanoparticle (PAMAM–Au) nanocomposites on the surfaces of a glass carbon electrode, which as electrode materials exhibited excellent charge-transport property and loading capacity of biomolecules. Followed by the sandwich-type specific identification, kanamycin detection was realized by outputting a redox current from electro-reduction reaction of H2O2 catalyzed by HRP. It was demonstrated that the developed strategy had a wide linear response range from 5 × 10−6 to 4 × 10−2 μg mL−1 and a low detection limit of 4.6 × 10−6 μg mL−1. Additionally, this aptasensor had the advantages in its low cost, high sensitivity, and superb specificity. Thus, it might provide a useful tool for kanamycin determination and related food safety analysis and clinical diagnosis.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Yanna Lin,Xueying Wang,Yuanling Sun,Yuxue Dai,Weiyan Sun,Xiaodong Zhu,Hao Liu,Rui Han,Dandan Gao,Chuannan Luo
In this work, target-responsive DNA hydrogel with high loading and good biocompatibility was used to construct chemiluminescent biosensor for specific detection of adenosine. Acrydite-modified adenosine aptamer (Acry-A-Apt), acrydite-modified single-strand DNA (Acry-ssDNA) and hemin aptamer (H-Apt) were used to prepared the DNA hydrogel, and the three single-strand DNA were partially complementary to each other. Thus, the DNA hydrogel only dissolved when adenosine and hemin were present simultaneously. HKUST-1 is a Cu-based MOFs with peroxidase-like activity. Au NPs were coated into cavities of HKUST-1 to obtain [email protected] , and the [email protected] had a stronger peroxidase-like activity than HKUST-1. [email protected] was coated in the DNA hydrogel. When only hemin was present, hemin bound to the H-Apt to form the G-quadruplex/hemin and the DNA hydrogel remained in the gel state. Therefore, the G-quadruplex/hemin was formed in the hydrogel and the excess hemin can be removed, avoiding background signal interference. Adenosine was then added and the preferential interaction between adenosine and adenosine aptamer resulted in complete dissolution of the DNA hydrogel. Subsequently, G-quadruplex/hemin and [email protected] were released simultaneously, enabling dual signal amplification of chemiluminescent biosensor, yielding a “signal on” readout. As a result, the biosensor could quantify adenosine from 4 × 10 −13 – 1.5 × 10 -10 mol/L with a detection limit as low as 1.04 × 10 −13 mol/L. The DNA hydrogel system provides a simple, sensitive and biocompatible method for the detection of adenosine which is useful in the field of biotechnology.
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