ACS Applied Bio Materials
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2018
·
IF 0
Chunping Su,Huiping Zhao,Hao Yang,Rong Chen
In this work, we developed a facile approach for the fabrication of stearic acid-modified starch/chitosan composite sponge with asymmetric wettability and gradient wettability via mediating the amount of starch. The starch/chitosan composite sponge exhibited heterogeneous wetting properties on its two surfaces after stearic acid modification. The superhydrophobic top surface with a water contact angle of 150° could prevent water, blood, and bacterial permeation without losing the breathability of the sponge, whereas the superhydrophilic bottom surface possessed optimal water and blood absorption and clotting abilities. The asymmetric wettability of starch/chitosan composite sponge was attributed to the synergistic contribution of gradient distribution of starch, rough three-dimensional skeleton structure induced capillary effect and the nonuniform surface distribution of hydrophilic/hydrophobic groups. Furthermore, the sponge also possessed good biodegradability and noncytotoxicity to the human normal hepatocyte. The results indicated that the stearic acid-modified starch/chitosan composite sponge with ideal liquid absorption, vapor transmission rate, self-cleaning and stain-repellent ability could be used as a promising candidate for wound dressing.
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CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Yongjun Sun,Wenquan Sun,Kinjal J. Shah,Pen-Chi Chiang,Huaili Zheng
In this work, carboxylated chitosan modified flocculant (CC-g-PCD) was prepared by graft copolymerization technique to enhance the charge-attracting and adhesion of bridges and net-sweeping capacity of flocculants. The dimethyldiallylammonium chloride (DMDAAC), carboxylated chitosan (CMCS), and 3-chloro-2-chloropropyltrimethylammonium chloride (CTA) were utilized for synthesis of CC-g-PCD via photopolymerization techniques. The synthesized CC-g-PCD was characterized by 1 H NMR, SEM, XRD, and FTIR, and the characteristic groups on the main chain and surface morphological structure of CC-g-PCD were investigated. The obtained results indicated that CTA and DMDAAC were successfully grafted into the CPCTS. In ordered to evaluate the flocculation performance of CC-g-PCD at various dosages, stirring intensity (G value), and pH value by detecting Chl a, COD, and turbidity, the actual lake water that contains algae was used for flocculation assessment tests. The experimental results of the water sample with flocculation showed that the maximum flocculation efficiency of turbidity (91.1%), Chl a (97.2%), and COD (97.0%) can be achieved by CC-g-PCD at pH 7, G value 200 s −1 , and 4.0 mg/L. The comparison results demonstrated that CC-g-PCD had better flocculation efficiency than commercial flocculants. Finally, based on the analysis of algae removal in combination with Zeta potential measurements, the flocculation mechanisms in actual lake water at various dosages and pH values were adsorption bridging and electrical neutralization.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Yuefei Song,Qihua Hu,Tiemei Li,Yueke Sun,Xinxin Chen,Jing Fan
Phosphorylated chitosan (PCS) with tailored amount of phosphate groups was synthesized, and novel composite nanofiltration membranes (NFMs) with tunable surface charges were prepared by coating PCS onto polyacrylonitrile (PAN) supporting layer and subsequently cross-linked by glutaraldehyde (GA). Chemical structures and compositions of PCS and NFMs, along with morphologies, surface charges, and performance of NFMs were represented by using FTIR, TG, ATR-IR, SEM-EDX, AFM, streaming potential analyzer, and cross-flow flat permeation test, respectively. The effect of different phosphorous abundance of PCS precursors on the surface charge and permselectivity of NFMs was investigated systematically. It was illustrated that the incorporation of phosphate group with high-substitute degree did enhance the surface charge and selectivity of NFM, respectively, while retaining its permeability. The resultant membrane showed a zeta potential of −77.6 mV at 1 mol·m −3 KCl electrolyte solution and pH 7.0, significantly more superior than that of the commercial DL membrane. For the feedwater (Na 2 SO 4 + MgCl 2 , 1.0 g·L −1 ), the mass ratio of SO 4 2− /Cl − and Mg 2+ /Na + decreased from initial 0.5:1 in the feed to 1.58 × 10 −2 and 0.254 in the permeate after filtration by the optimal NF membrane. Anionic dyes removal tests also confirmed the existence of negative charge characteristics from the prepared membranes, and pivotal role of the Donnan exclusion in separating performance. In addition, NFM4 exhibits good chemical stability in the long-term operation.
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高影响因子
MRS Communications
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2018
·Vol. 8
·期 3
·1224-1229
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IF 3.008
Junlan Guo,Jianguo Tang,Jing Wang,Sui Mao,Haidong Li,Yao Wang,Jin Liu,Jing Wang,Yanxin Wang,Linjun Huang,Matt J. Kipper,Laurence A. Belfiore
This paper presents new water-soluble bio-polyelectrolyte-based nanoparticles, formed from lanthanide-induced polysaccharide aggregates (LIPAs). These new nano-aggregates are formed by coordinating a photoluminescent lanthanide–ligand complex to a single polyelectrolyte [i.e. polyanionic hyaluronic acid (HA)] or to two oppositely charged polyelectrolytes [i.e. HA and polycationic chitosan (CHI)]. We demonstrate that photoluminescent Eu3+–ligand complexes, which are dispersed homogeneously in aqueous solution by the association with water-soluble HA. The polysaccharide supermolecular assembly can be tuned to obtain nanoparticles of different sizes and surface charges. The preparation of stable and water-soluble lanthanide complexes via Eu3+–LIPAs opens opportunities for use of luminescent lanthanides in aqueous environments, for biosensing and bioimaging applications.
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Materials Science & Engineering C-Materials for Biological Applications
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2018
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IF 5.08
Ruixue Yin,Jing He,Meirong Bai,Cong Huang,Kemin Wang,Hongbo Zhang,Shih-Mo Yang,Wenjun Zhang
The closed-loop delivery of insulin in response to change of the blood glucose level and long-term supply of insulin are both important for diabetes patients. However, combination of these two goals in a chemically controlled implantable system is still challenging yet highly desirable. The purpose of the present study is to design a synthetic artificial pancreas by integration of chitosan hydrogels with insulin-loaded glucose-responsive microspheres to deliver insulin in a close-looped and long-term way for diabetes care. Glucose-responsive insulin-loaded microspheres were firstly fabricated via a high-speed shear-emulsion based crosslinking method and then embedded into chitosan hydrogels to make a scaffold-based synthetic artificial pancreas. In vitro experiments indicated the scaffold exhibited a longer insulin supply as well as a lower burst release compared with free microspheres, and could keep the glucose-responsive insulin release property inherited from the corresponding microspheres even after 12 day-release. The released insulin was proved to remain active, and the culture of HDF cells on the scaffold showed good cell proliferation during 7 days incubation. These results suggested the scaffold-based synthetic artificial pancreas have great promise in the application of insulin delivery.
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高影响因子
JOURNAL OF POLYMER RESEARCH
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2018
·Vol. 25
·期 10
·1-11
·
IF 1.434
Zhang Na,Yin Sheng-nan,Hou Zhao-sheng,Xu Wei-wei,Zhang Jun,Xiao Ming-hui,Zhang Qi-kun
In the paper, novel composites of biodegradable poly(ether-ester-urethane) (PEEU) and water-soluble chitosan oligosaccharide (CHO) were prepared using a simple physical mixing method and their potential application as biomaterials was assessed. The PEEU and CHO were dissolved in N,N -dimethylformamide to get a homogenous solution, then the composite films were obtained by the solvent evaporation method. The composites were characterized by FT-IR, and the influence of CHO content on the physicochemical properties of the composite films, including thermal properties, surface morphologies, mechanical properties, surface and bulk hydrophilicity, and in vitro biodegradability, were researched. The thermal stability studies indicated that the composite films had lower initial decomposition temperature and higher maximum decomposition temperature than PEEU film. Only one broad endothermic peak found in DSC curves demonstrated the high compatibility of CHO with PEEU. The ultimate stress and elongation at break of composite films decreased with the increment of CHO content, and the CHO content in the composites should be controlled no more than 25 wt % in order to maintain the mechanical properties (ultimate stress: 18.5 MPa; elongation at break: 890%) to meet the requirement of implant materials. The surface morphologies of composite films were observed by cold field emission scanning electron microscope (FE-SEM), and the results indicated that the homogeneous-dispersed composites could be obtained with CHO content being less than 20 wt %. The results of water contact angle and water absorption showed that the surface and bulk hydrophilicity were closely related with the water-solubility of CHO component. In vitro degradation studies showed that the degradation rate increased with the increasing content of CHO in composites, indicating that the degradation rate of composite films could be controlled by adjusting CHO content. The surface blood compatibility of the composite films was examined by bovine serum albumin adsorption and platelet adhesion tests. It was found that composite films had improved resistance to protein adsorption and possessed excellent resistance to platelet adhesion.
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高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Jie Lu,Qi Kang,Jianhong Xiao,Tao Wang,Ming Fang,Li Yu
Fabrications and applications of luminescent films have been an interesting and important challenge within the realm of academia and industry. Herein, a novel fluorescence-based strategy for the H 2 O 2 detection has been developed by fabrication of stabilized, thin, transparent, and luminescent films composed of europium-containing polyoxometalates (Eu-POM) and environmentally friendly chitosan (CS) via a facile solution casting approach. In comparison with pure Eu-POM, enhanced fluorescent properties are obtained from the as-prepared Eu-POM/CS films in terms of prolonged fluorescence lifetime and a remarkable fluorescent quenching effect in the presence of hydrogen peroxide (H 2 O 2 ). The fluorescence intensity of Eu-POM/CS films exhibits a linear correlation in response to the H 2 O 2 concentration over a wide range of 1.1–66 μM, with a detection limit of 0.11 μM. Furthermore, the fluorescent films display a high detection selectivity which are capable of differentiating hydrogen peroxide (H 2 O 2 ) from the interfering species, such as sugars, l -amino acids, and other metabolites. All these advances towards the development of Eu-POM/CS films open up new applications for luminescent films, but most importantly, they can help in the far-reaching technological implementations of a simple, cost-effective method for the detection of H 2 O 2 in many fields.
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高影响因子
FOOD HYDROCOLLOIDS
·
2018
·
IF 5.089
Fei Zhou,Tao Xu,Yajing Zhao,Huaxin Song,Liuquan Zhang,Xiaodan Wu,Baiyi Lu
The stability and bioavailability of acteoside were improved by encapsulating it with liposomes and chitosan. The liposomes were characterized through transmission electron microscopy , differential scanning calorimetry and Fourier transform infrared spectroscopy , and their particle size, zeta potential , encapsulation efficiency ( EE ), in vitro release, storage stability and oral bioavailability were tested. Results showed that the particles were nanosized and spherical. The average diameter, zeta potential, EE and relative bioavailability ( F rel ) of the acteoside liposome (Ac-Lip) were 78.49 ± 1.44 nm, −4.93 ± 0.79 mV, 81.06 ± 3.48% and 217.62%, respectively. These parameters increased to 92.77 ± 2.99 nm, +19.65 ± 0.90 mV, 88.10 ± 5.36% and 442.84%, respectively, after the surface of Ac-Lip was coated with 2 mg/mL of chitosan (CS-Ac-Lip). In contrast to Ac-Lip, the CS-Ac-Lip showed a reduced in vivo release rate and enhanced storage stability. The chitosan coating increased the diameter, zeta potential, EE , in vivo release time, stability and bioavailability of the Ac-Lip, and the chitosan–liposome is a promising delivery system for transporting acteoside or other bioactive components.
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高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 10
·1-9
·
IF 5.705
Jiao Zhe,Li Jingwen,Mo Liangji,Liang Jinming,Fan Hongbo
A molecularly imprinted polymer (MIP) was fabricated for selective recognition of the highly persistent pollutant perfluorooctane sulfonate (PFOS). The MIP was prepared from chitosan and doped with fluorescent carbon quantum dots (CQDs). It was characterized by fluorescence spectrophotometry, scanning electron microscopy, and Fourier transform infrared spectroscopy. The fluorescence of the CQDs, best measured at excitation/emission wavelengths of 350/460 nm, is enhanced by PFOS, and the effect is much stronger for the MIP than for the nonimprinted polymer (NIP). The imprinting factor is 2.75. The method has good specificity over sodium dodecyl sulfate (SDS), perfluorooctanoic acid (PFOA), sodium dodecyl sulfonate (SDS’), sodium dodecyl benzene sulfonate (SDBS), perfluorooctanesulfonyl fluoride (POSF), perfluorobutane sulfonate (PFBS) and 1-octanesulfonic acid sodium (OSA). Fluorescence increases linearly in the 20–200 pg·L −1 POSF concentration range in aqueous solution. The method was applied to the determination of PFOS in spiked serum and urine samples. The limits of detection are 66 and 85 pg·L −1 for serum and urine samples respectively. The recoveries ranged from to 81–98%, with relative standard deviations in the range of 1.8–8.2%. Compared with LC-MS/MS, this assay is more convenient since the material can be prepared flexibly and the method can be applied on-site.
Schematic of the fabrication of a molecularly imprinted chitosan hydrogel doped with CQDs for selective fluorometric determination of PFOS. a. The photo of chitosan hydrogel. b, c, d, e represents the hydrogel observed under UV lamp. b’, c’, d’, e’ represents the inner structure of hydrogel bead.
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高影响因子
RSC Advances
·
2018
·Vol. 8
·期 57
·32740-32746
·
IF 2.936
Ya-feng Jin,Chuang-ye Ge,Xiao-bo Li,Miao Zhang,Guang-ri Xu,Dong-hao Li
Herein, we fabricated a sensitive rutin electrochemical sensor via modifying glassy carbon electrode (GCE) with zeolitic imidazolate framework-8 (ZIF-8) and acetylene black (AB) in the presence of chitosan (CS). The electrochemical activity and experimental parameters of the ZIF-8-AB-CS/GCE sensor were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Under the optimal conditions, the sensor presented a reasonable linear response in the range of 0.1–10 μM with a limit of detection (LOD) as low as 0.004 μM (S/N = 3). The sensor possessed good reproducibility and high stability, and was successfully applied to detect rutin tablet samples with satisfactory results, which was attributed to the synergistic effect between ZIF-8 and AB. Meanwhile, the sensor displayed a potential application for detection of other analytes in real samples. Furthermore, a probable interaction mechanism was proposed to account for the interaction between rutin and the nanocomposite electrode, which was not discussed in previous reports.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2019
·Vol. 35
·期 3
·463-470
·
IF 1.071
Zhang Di,Li Ning,Cao Shuai,Liu Xi,Qiao Mingwu,Zhang Pingan,Zhao Qiuyan,Song Lianjun,Huang Xianqing
Along with the growing severity of environment problem and energy crisis, it is inevitable to develop novel materials, which are contributed to the removal of hazardous pollutants from contaminated water. Herein, we reported a facile method for the preparation of free-standing chitosan/graphene oxide(CS/GO) composite sponges with low density, where CS/GO mixtures were first synthesized by the homogeneous reaction of chitosan and graphene oxide in aqueous acetic acid solution; then CS/GO sponges were obtained by lyophilizing the suspension, which were prefrozen at −20 °C and in liquid nitrogen successively. The obtained layered sponge showed good water-driven shape memory effect and was a good adsorbent of Co 2+ and Ni 2+ with a large adsorption capacity of 224.8 and 423.7 mg/g, respectively. Importantly, the successive adsorption-desorption studies employing CS/GO sponge indicated that the composite could be regenerated by HCl solution and reused in more than five cycles with regeneration efficiency beyond 80%. Also, the resultant sponge was explored as an exceptionally adsorbent for the removal of organic dye ( e.g. , methylene blue, MB).
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Fang Wang,Qian Zhang,Xinxia Li,Kexin Huang,Wei Shao,Dawei Yao,Chaobo Huang
A simple method to fabricate redox-responsive composite hydrogel films via incorporating chitosan (CS) microspheres into carboxymethyl cellulose (CMC) hydrogel using a di-sulphide cross-linker cystamine dihydrochloride (CYS) have done in this paper. Dual drugs, an anticancer, 5-Fluorouracil (5-FU) and an antibiotic, Tetracycline Hydrochloride (TH) were used as model drugs. The prepared composite hydrogel films were characterized using FTIR, SEM, rheology measurement, mechanical and swelling tests. Our results showed that the well dispersed spherical CS microspheres endowed hydrogel film increased mechanical properties and swellability. In vitro drug release displayed an accelerated release under weak acidic or reducing media. The in vitro cytotoxicity and cell apoptosis studies showed the drug-loaded composite film caused enhanced inhibition to HepG2 cells in presence of glutathione (GSH). Moreover, the film has exhibited excellent antimicrobial efficacy against E.coli and Staphylococcus aureus . Therefore, our simple and effective dual drug-loaded system has the potential to be used for cancer therapy in the future.
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高影响因子
危险品化学品经营许可证（带存储）