JOURNAL OF POWER SOURCES
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2025
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IF 7.9
Jingjing Zhao,Danfeng Wang,Fengyin Zhou,Hongya Wang,Xin Qu,Yuqi Cai,Zhiyu Zheng,Dihua Wang,Huayi Yin
The recycling of spent lithium-ion batteries (LIBs) is pivotal for advancing industrial resource sustainability and economic viability. However, conventional recovery processes face significant challenges, including excessive energy consumption, reagent overuse, and inefficiencies in material separation. Herein, a slurry electrochemical assisted method is proposed for co-recycling spent LiCoO 2 (LCO) and LiFePO 4 (LFP) enabled by their redox reactions. The redox reaction of LCO and LFP allows the leaching efficiency of Li to reach 99.4 % and Co to achieve 98.1 % at the conditions of 1 mol L −1 H 2 SO 4 and under a constant cell voltage of 3 V. Over the process, the dissolved Fe 2+ from LFP in the beginning plays a critical reduction role in destructing the stable structure of LCO. And the additional applied electricity reinforces the circulate of proton, thus enhancing the utilization rate of acid close to ∼99 %. More importantly, over 90 % of Fe 3+ is directly precipitated to FePO 4 ·2H 2 O without the precipitant additive. What's more, the relatively high solid-liquid ratio of 132.5 g L −1 simplifies the separation step and reduces process energy consumption. This study optimizes metal recovery efficiency through advanced electrochemical assisted co-leach and selective separation strategies, aiming to reconcile industrial scalability with circular economy goals.
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高影响因子
Desalination and Water Treatment
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2024
·
IF 1
Hong-yan Wu,Wen-kai Wu,Bo Chen,Qiao-ping Kong,Jian-jun Lian
The gradual increase of antibiotics and heavy metals in aquatic environments poses a serious threat to human health and ecosystems, and finding effective methods for simultaneous removal of antibiotics and heavy metals has attracted increasing concern. In this study, a novel porous structure of thiourea-modified sodium alginate microspheres (UA-Ca) was synthesized by modification with thiourea, epichlorohydrin, and calcium chloride, and was applied for the simultaneous removal of tetracycline (TC) and Cu(II) from water. The results indicated that the UA-Ca material with 1:2 mass ratio of thiourea and sodium alginate showed the highest removal of TC and Cu(II) under the reaction condition of pH= 7. The removal process of both TC and Cu(II) follows the pseudo-second-order adsorption model and Langmuir isotherm model. UA-Ca had a high adsorption capacity toward TC and Cu(II) with the maximum value of 1.099 mmol/g and 2.793 mmol/g based on the Langmuir model at 298 K, respectively. Thermodynamical parameters revealed that TC and Cu(II) adsorption is spontaneous with endothermic nature. Competing ionic cations (Ca 2+ 、Mg 2+ 、NH 4 + ) and organics (sulfamethoxazole, hygromycin) had a certain inhibitory effect on the removal of TC and Cu(II) by UA-Ca, whereas the anionic ions (CO 3 2- 、PO 4 3- 、SO 4 2- ) all had little effect on its removal. Fourier transform infrared spectra and X-ray photoelectron spectroscopy analyses showed that the removal of TC and Cu(II) by UA-Ca was mainly due to electrostatic adsorption and surface complexation. This work provides a promising UA-Ca material for the effective removal of TC and Cu(II) in contaminated water.
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Journal of Materials Chemistry A
·
2024
·Vol. 12
·期 8
·4893-4902
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IF 10.7
Zhao Sun,Yunhan Gong,Dongfang Cheng,Zhiqiang Sun
Catalytic methane decomposition shows the prominent superiority of generating hydrogen in one step with almost no carbon oxide production; however, it suffers from catalyst deactivation and low by-product carbon quality. Herein, a series of H2-reduced NixCr2Ox+3 (abbreviated as reduced NixCr2) catalysts were designed and synthesised for highly efficient methane decomposition and carbon nanotube production. A maximum methane conversion of 87.1% and hydrogen concentration of 91.8 vol% were achieved at 750 °C without deactivation. The results from XPS, XAS, and Raman reveal that the reduced NixCr2 catalysts have significant activity and stability. On the one hand, they form the Cr–O–Ni structure, thus possessing strong Ni–Cr2O3 interaction. On the other hand, the lattice oxygen of the reduced NixCr2 catalysts induces methane activation, thus accelerating methane activation, as demonstrated by the generation of a little amount of CO. In addition, the relationship between the types of carbon deposited and Ni/Cr ratio, decomposition temperature, and time was also revealed to guide carbon nanotube synthesis. Density functional theory calculation confirms the lowest dehydrogenation barrier of Ni(111)/Cr2O3(012), demonstrating the superiority of the Cr–O–Ni catalyzed methane decomposition. These findings provide innovative ideas for the construction of functionalized materials, which will substantially promote the development of methane decomposition.
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BIOMATERIALS
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2015
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IF 8.557
Bing-Feng Zhang,Lei Xing,Peng-Fei Cui,Feng-Zhen Wang,Rong-Lin Xie,Jia-Liang Zhang,Mei Zhang,Yu-Jing He,Jin-Yuan Lyu,Jian-Bin Qiao,Bao-An Chen,Hu-Lin Jiang
The mitochondria-mediated apoptosis pathway is an effective option for cancer therapy due to the presence of cell-suicide weapons in mitochondria. However, anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as Bcl-2 protein, could allow the cancer cells to evade apoptosis, greatly reducing the efficacy of this type of chemotherapy. Here, we constructed a hierarchical targeted delivery system that can deliver siRNA and chemotherapeutic agents sequentially to tumor cells and mitochondria. In detail, the copolymer TPP-CP-LND (TCPL) was synthesized by the mitochondria-targeting ligand triphenylphosphine (TPP) and therapeutic drug lonidamine (LND) conjugated to the polyethyleneimine in chitosan- graft -PEI (CP), and then complexed with siRNA. Followed, the complexes were coated with poly(acrylic acid)-polyethylene glycol-folic acid (PPF) copolymer to form a hierarchical targeted co-delivery system (TCPL/siRNA/PPF NPs). The TCPL/siRNA/PPF NPs had a neutral surface charge, were stable in plasma and exhibited pH-responsive shell separation. Remarkably, the TCPL/siRNA/PPF NPs simultaneously released siBcl-2 into the cytoplasm and delivered LND to mitochondria in the same cancer cell after FA-directed internalization, and even synergistically activated mitochondria apoptosis pathway. This work demonstrated the potential of RNA-interference and mitochondria-targeted chemotherapeutics to collaboratively stimulate the mitochondria apoptosis pathway for cancer therapy.
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PubMed
高影响因子
Oncotarget
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2017
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IF 5.168
Muhammad Sarfraz,Attia Afzal,Shahid Masood Raza,Sajid Bashir,Asadullah Madni,Muhammad Waseem Khan,Xiang Ma,Guangya Xiang
Doxorubicin in combination with other cytotoxic drugs has clinical advantages. However, doxorubicin-induced cardiotoxicity negatively impacts clinical utility and outcomes. Cardiotoxicity can result from increased oxidative stress or from a local cytochrome P450 mediated increase in 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE). Oleanolic acid (OA) is a natural pentacyclic triterpenoid with free radical scavenging, cardioprotective, and P450-mediated cyclooxygenase-upregulating properties. We investigated co-delivery of liposomal OA and doxorubicin in a HepG2 model of hepatocellular carcinoma (HCC). OA attenuated the cardiotoxicity induced by doxorubicin without compromising its anticancer activity. Apoptosis assays revealed that co-delivery of DOX and OA produced a synergistic anticancer effect. However, the drugs had antagonistic effects on cardiomyocytes. Female BALB/c nude mice treated with OA- and DOX-loaded liposomes (ODLs) exhibited reduced tumor growth, stable body weight, and stable organ indices. Reduced 20-HETE production suggested ODLs had limited cardiotoxicity. No changes in biochemical or histopathological markers were observed in mice treated with ODLs. Tailored co-delivery of OA and DOX may thus be an effective therapeutic strategy for treating HCC.
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PubMed
高影响因子
Annals of Translational Medicine
·
2022
·Vol. 10
·期 18
·971-971
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IF 3.616
Shuqi Zhao,Meifeng Chen,Zhu Yu,Thi Thai Hoa Pham,Shutian Mo,Yongfei He,Tianyi Liang,Wenlong Cao,Chuangye Han
BackgroundBreast cancer (BC) is the most common type of cancer affecting females. It is also a leading cause of cancer-related death in women worldwide.MethodsSonodynamic therapy (SDT) is an emerging therapeutic strategy for cancer treatment. SDT ensures non-invasive penetration of deep tumors and results in activation of non-toxic sonosensitizers administered in deep tumor sites to become cytotoxic. It has been reported that 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) has a significant anti-tumor effect against various cancer types including BC. However, DMDD is hydrophobic. Therefore, a one-step encapsulation method was used in the current study to construct zeolitic imidazole frameworks-8 (ZIF-8) loaded with DMDD and sonosensitizer chlorin e6 (Ce6). ZIF-8 was further modified by coating it with a biomimetic cell membrane to improve targeted delivery.ResultsIn vitro and in vivo results indicated that the nanomedicines had great biocompatibility properties and targeting ability. The nanocomposite exhibited a higher release rate under an acidic tumor microenvironment. The tumor killing effect of reactive oxygen species (ROS) generated from Ce6 and inhibition of tumor growth was enhanced after ultrasound (US) treatment, which might be caused by the increase in apoptosis rate.ConclusionsThese findings show that the combination of nanomedicine and SDT provides a potential therapeutic method for BC.Keywords: Breast cancer (BC), 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), metal-organic framework, sonodynamic therapy, ZIF-8 nanoparticles
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PubMed
高影响因子
Biomaterials Science
·
2022
·Vol. 10
·期 5
·1292-1303
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IF 7.59
Zian Wang,Xuan Wang,Hua Yu,Meiwan Chen
Camptothecin (CPT) is a potent broad-spectrum antitumor agent with efficient therapeutic effect for various cancers. However, its application in glioma therapy has been impeded by the tumor immunosuppressive environment and blood–brain barrier (BBB)-associated drug delivery challenges. Herein, neurotransmitter analogs-modified liposomes (NTs-LIP) were prepared by doping lipidized tryptamine (Tryp) to co-deliver CPT and curcumin (CUR) for improved chemo-immunotherapy in glioma. The introduction of Tryp promotes the delivery efficiency of CPT and CUR across the BBB. CPT inhibits cell proliferation after cellular uptake of NTs-LIP, the combination of which with CUR downregulates the elevated expression of the programmed cell death 1 ligand 1 (PD-L1) caused by CPT to prevent the inactivation of T-cells and synergistically enhance chemo-immunotherapy efficacy. Furthermore, both Tryp and CUR interfere with the indoleamine 2,3-dioxygenase (IDO) pathway to reduce regulatory T cell (Treg)-mediated immunosuppression, exhibiting the potential to combine with PD-L1 inhibition for synergistic antitumor immunity. Taken together, this platform contributes towards targeted delivery and alleviation of the immunosuppressive environment in glioma therapy.
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PubMed
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 19
·3723-3733
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IF 7.571
Qing Hao,Jinghong Wang,Jie Shen,Rong Gu,Yu Rao,Jian Feng,Huanhuan Wang,John L. Brash,Hong Chen
In analogy with adsorbed protein films, we have fabricated a family of 2D nanofilms composed of poly(N-vinyl caprolactam-co-vinylimidazole) (PNVCL) nanogels. NVCL was copolymerized with 1-vinylimidazole (VIM), and then cross-linked with α,ω-dibromoalkanes with 2 to 8 carbons via quaternization to form the nanogels. The swelling ratio of the gels was precisely controlled by regulating the inter-chain spacing of the polymers at the level of the carbon atom chain length of the cross-linker. The short-chain alkanes used are relatively rigid and their dimensions provide an accurate estimate of the chain spacing in the nanogels. It was shown that small differences in the carbon atom number of the cross-linking agent led to significant differences in the mechanical properties of the nanogels, in particular in the softness, deformability, and contact area (in film form), all of which increased with increasing carbon number. Films of the softer gels not only showed good adhesion to a number of substrates, but were also mechanically robust. In addition, the films showed excellent light transmission and nontoxicity to L929 cells. Nanogels of intermediate softness were shown to inhibit the adhesion of bacteria and human umbilical vein smooth muscle cells (HUVSMCs), and to be resistant to the adsorption of the plasma protein fibrinogen, indicating strong anti-biofouling properties. Gels that were either too stiff or too soft showed somewhat weaker anti-fouling activity in terms both of HUVSMCs adhesion and protein adsorption.
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PubMed
高影响因子
ChemSusChem
·
2025
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IF 6.6
Jiawei Zhan,Qinyi Zhang,Huazhong Wang,Shuyu Zhang,Minglin Zhang,Ying Zhang,Tingna Fan,Pengyun Zhang,Huizhen Ke
The interfacial properties of the hole transport layer (HTL) are absolutely critical for perovskite solar cells (PSCs) nowadays. [4-(3,6-Dimethyl-9H-carbazol-9-yl)butyl]phosphonic acid (Me-4PACz) is widely used HTL within the class of self-assembled materials. However, during its self-assembly process, Me-4PACz tends to form molecular clusters and micelles on indium tin oxide (ITO), leading to insufficient coverage. Therefore, we propose a co-assembled monolayer (Co-SAM) strategy via co-depositing phenylphosphonic acid (PPA) or its derivatives as co-dopants with Me-4PACz, the intermolecular steric hindrance between phenyl and carbazole groups effectively suppresses Me-4PACz aggregation. Simultaneously, the phosphonic acid groups of both molecules form a synergistic dual-anchoring effect, significantly enhancing HTL uniformity and coverage. Furthermore, active substituents (-OH, -NH 2 , -Br) in the dopants can passivate uncoordinated Pb 2+ ions and iodine vacancies at the perovskite interface, thereby optimizing the HTL/perovskite contact and improving carrier extraction ability. Results show that inverted devices based on Me-4PACz+BrPPA Co-SAM achieve a power conversion efficiency (PCE) of 23.73%, representing a substantial increase from 21.39% while maintaining excellent stability. This strategy provides a new direction for developing high-performance Co-SAM and advancing the industrialization of PSCs. Graphical In this contribution, a novel Co-SAM strategy is employed by introducing phenylphosphonic acid and its derivatives into Me-4PACz solution to suppress its molecular clustering, thereby optimizing the FAPbI 3 perovskite layer. The resulting device achieve a PCE of 23.73% and demonstrate exceptional long-term stability.
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PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2019
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IF 3.218
Huang Chen,Peng Sun,Meijia Qiu,Min Jiang,Jie Zhao,Dongxue Han,Li Niu,Guofeng Cui
In response to the challenges posed by diabetes, portable glucose sensors with enzyme-free catalytic materials have received great attention in recent years. Herein, a facile strategy for fabricating inexpensive and efficient electrochemical sensors is proposed. Flexible copper clad laminate (FCCL) can be firstly decorated with nanoporous copper (NP Cu) through electrodepositing Cu-Sn alloy and dealloying the Sn element. Then Co-P is further electrodeposited onto the NP Cu/FCCL and the final Co-P/NP Cu/FCCL composite electrode exhibits high catalytic activity for glucose. The great performance of the Co-P/NP Cu/FCCL mainly derives from the enlarged surface area of the NP Cu and the high electrocatalytic activity of Co-P. This electrode exhibits a high sensitivity of 1818 μA cm −2 mM −1 , low limit of detection of 378 nM (S/N = 3), fast response time of 4 s, a wide linear dynamic range of 0.5 μM to 10.0 mM, good anti-interference performance, excellent repeatability and considerable stability for glucose detection. The well-designed structure for catalyzing glucose in high efficiency enable the Co-P/NP Cu/FCCL a potential candidate for future flexible electrochemical sensors.
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高影响因子
ACS Catalysis
·
2025
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IF 13.1
Zhuo Li,Huimin Yang,Rui Gao,Peng He,Xingchen Liu,Ruilin Liu,Xiaomin Dai,Yunhua Xu,Yong Qin,Bin Zhang
The hydroformylation of high-carbon α-olefins is a pivotal industrial process. Still, heterogeneous Co-based catalysts suffer from low activity and Co leaching due to strong coordination of CO to Co atoms. Herein, we address the dynamic evolution and active structure of Co species by interacting Co nanoparticles or ultrahigh-dispersed clusters with β-Mo2C nanoparticles (Co-30Mo2Cparticle/CNF) and nanofilms (Co-100Mo2Cfilm/CNF) on carbon nanofibers. The specific activity in the formation of heptanal from 1-hexene hydroformylation increased by 10.7 times on Co-30Mo2Cparticle/CNF (21.4 molheptanal/molCo/h) and 2.4 times on Co-100Mo2Cfilm/CNF (4.7 molheptanal/molCo/h) compared with Co/CNF (2.0 molheptanal/molCo/h). Moreover, Co-100Mo2Cfilm/CNF exhibits enhanced stability with only 1.7% Co leaching. The Mo2C nanoparticles interact with Co nanoparticles, oxidizing them to form highly active Co-MoOx sites with a lower CO insertion barrier. The reaction environment influences the structural evolution of the Co-MoOx interaction. In contrast, Mo2C nanofilms form robust Co–C and Co–Mo bonds at the Co–Mo2C interface, stabilizing atomically distributed Co clusters against leaching. This work establishes a morphology-driven strategy to control the dynamic interaction of Co and additives, thereby decoupling activity and stability in heterogeneous catalysis for hydroformylation.
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高影响因子
POWDER TECHNOLOGY
·
2025
·
IF 4.6
Yuting Shang,Mingan Zou,Zhihong Zhao,Zhiyan Lai,Tao Liu
This study established a top-down methodology for nano-amorphous rutin production, with systematic evaluation of amorphous state effects (polymer-based vs. small molecule-based) on both manufacturing processes and microneedle formulations. Experimental data coupled with molecular dynamics simulations confirmed that strategic selection of small-molecule co-formers with optimized ratios could generate smaller nanoparticles (288 nm) exhibiting superior physical stability compared to polymer-based nano-amorphous systems. Radial distribution function analysis of the amino acid-rutin system detected robust intermolecular interactions (708.8103 kcal/mol), where the formed hydrogen-bonding network effectively suppressed rutin recrystallization. The dual strategy combining nanotechnology with amorphization technology achieved remarkable dissolution enhancement (85 % drug release), substantially exceeding the performance of microparticulate systems. This effect was further amplified through lyophilization using a ternary excipient system (hyaluronic acid-povidone-polyvinyl alcohol), which improved mechanical resilience. The nano-co-amorphous powder demonstrated 69.87 μg/mL transdermal flux, representing significant advancement over nanocrystalline formulations (49.86 μg/mL). The developed rutin-lysine nano-co-amorphous microneedles exhibited clinically relevant wound healing efficacy, validating their therapeutic potential.
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