MACROMOLECULAR BIOSCIENCE
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2024
·
IF 4.4
Xuanrong Sun,Yubei Gong,Ting Xie,Zixi Fu,Dongze Lu,Bin Wei,Yue Cai,Wenlong Yao,Jie Shen
Irinotecan hydrochloride (CPT-11) is one of the first-line drugs used in the clinical treatment of colorectal cancer (CRC). However, the concomitant adverse effect of delayed diarrhea has hindered its clinical use. CPT-11 combined with Thalidomide (THA) therapy is considered a palliative strategy. To optimize the synergistic treatment of CPT-11 and THA, co-loaded liposomes are constructed using cholesterol, lecithin, and 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol) (DSPE-PEG) as the “immune and gut microbiota regulator.” The co-loaded liposomes, which possess good stability, are prepared by the solvent injection method. After the treatment with the co-loaded liposomes, tumor growth in CRC-bearing mice is significantly inhibited. In particular, the co-loaded liposomes demonstrate favorable diarrhea-relieving effects through the modulation of inflammatory cytokines and gut microbiota. These findings suggest that the co-loaded liposomes have great potential as a combined drug-delivery platform for CRC therapy.
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PubMed
高影响因子
RARE METALS
·
2024
·
IF 9.6
Zeng Jin-Quan,Qi Jun-Lei,Yang Yue-Yang,Zhang Min-Hao,Lin Yuan-Hua
The practical application of CaSmAlO 4 microwave dielectric ceramics is limited by its low quality factor ( Q × f ) value and non-zero temperature coefficient resonant frequency ( τ f ) value. In this study, we introduced Mg 2+ –Ti 4+ ionic pairs into CaSmAlO 4 , along with an excess of 9% Sm 2 O 3 . The Mg 2+ –Ti 4+ ionic pairs substituted Al 3+ , and two phases simultaneously coexisted in the ceramics: CaSmAlO 4 and Sm 2 O 3 . As the doping concentration of Mg 2+ –Ti 4+ ionic pairs increased, the relative permittivity exhibited an upward trend, while the quality factor and resonant frequency temperature coefficient first rose and then descended. Remarkably, 0.09Sm 2 O 3 –0.91CaSmAl 0.7 Mg 0.15 –Ti 0.15 O 4 sintered at 1450 °C yielded excellent dielectric properties: ε r = 19.72, Q × f = 72,936 GHz, and τ f = –0.044 ppm·°C − 1 . The factors influencing the microwave dielectric properties of 0.09Sm 2 O 3 –0.91CaSmAlO 4 ceramics were further examined by considering the crystal structure, grain size, Lichtenecker logarithmic rule, tolerance factor and packing fraction. Graphic abstract
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高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Xia Lu,Qinyi Gao,Liqing Xu,Yanxin Ren,Fenfen Tong,Yuxin Wang,Linfan Wang,Na Ge,Wupeng Ge
This study successfully synthesized high performance blue emissive carbon dots (ZrN-CDs) using citric acid, zirconium chloride, and ethylenediamine as precursors through a hydrothermal method. The resulting ZrN-CDs exhibit excitation-independent emission characteristics, along with good water solubility, salt resistance, and photobleaching resistance. The fluorescence resonance energy transfer (FRET) mechanisms allow for the selective attenuation of ZrN-CD fluorescence by tetracyclines (TCs). Building on this effect, a dual-emission ratiometric fluorescent sensor was developed by integrating europium ions (Eu 3+ ), featuring an inverse fluorescence signal response to enhance detection accuracy through self-calibration. The fluorescence emission behavior of ZrN-CDs (F 440 ) showed selective quenching in response to TCs, while the characteristic emission of Eu 3+ (F 615 ) exhibited fluorescence enhancement due to the antenna effect (AE). Quantification of common TCs antibiotics, including tetracycline (TET) and oxytetracycline (OTC), was achieved by recording the fluorescence intensity ratio (F 615 /F 440 ). The limits of detection (LOD) for TET and OTC reached 0.029 μM and 0.016 μM, respectively. This method was successfully applied to the detection of TET in bovine, goat, and camel milk, with recovery rates ranging from 83.65% to 106.60%, thereby confirming the reliability and effectiveness of the sensor in practical applications.
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高影响因子
Journal of Materials Chemistry C
·
2024
·
IF 5.7
Shuai Li,Chunrong Zhu,Jinjiang Wang,Zheling Zhang,Dongjie Wang,Yiwen Chen,Doudou Zhang,Jing Wang,Jian Zhang
The broad-band self-trapped exciton (STE) emission feature of lead-free halide double perovskites makes it challenging to realize emission with various wavelengths in a single material. Cs2NaInCl6:Sb3+ crystals with blue emission (440 nm) were synthesized by rationally introducing the Sb3+ ion into Cs2NaInCl6 with a photoluminescence quantum yield (PLQY) up to 99.35%. The Ln3+ (Tb3+ and Ho3+) ions were doped into Cs2NaInCl6:Sb3+ to achieve spectrally tunable emission from blue to green and pink emission owing to the energy transfer from the host STE to Ln3+ ions, with PLQY values of 90.68% and 61.87%, respectively. By carefully adjusting the doping level of Ln3+ ions, white light emission with a PLQY of 68.87% was achieved in the Tb3+ and Ho3+ co-doped Cs2NaInCl6:Sb3+ system. LED devices based on Sb3+/Ln3+ co-doped Cs2NaInCl6 with multicolor and white light emissions were fabricated based on these phosphors, which exhibit excellent spectral and environmental stability. The results show that double perovskite luminescence materials have potential for application in solid-state lighting and multi-color displays.
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高影响因子
Nature Catalysis
·
2023
·
IF 37.8
Sun Kai,Dong Juncai,Sun Hao,Wang Xingdong,Fang Jinjie,Zhuang Zhongbin,Tian Shubo,Sun Xiaoming
Metal-nitrogen-doped carbon (M-N-C) catalysts are promising platinum group metals alternatives for fuel cell cathodes; however, their randomly formed, unpredictable coordinations complicate any structure–property investigation and lead to low active site density. Here we achieve dense and well-defined cobalt sites on the surfaces of Co(CN) 3 microcrystals, which are identified by single-crystal X-ray diffraction and X-ray absorption spectroscopy. In situ infrared spectroscopy and density functional theory calculations elucidate that the high oxygen reduction reaction performance (half-wave potential is 0.90 V versus RHE) of the cubic Co(CN) 3 is due to its tailored coordination environment that optimizes *OH desorption. The cyanide linkage with minimized spacing between cobalt atoms maximizes active sites’ spatial density, which boosts the anion-exchange membrane fuel cell peak power density to 1.67 W cm −2 . The microcrystals with well-defined coordination structures can be used as Co-N-C analogues for their structure–property relationship investigations.
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高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Anquan Zhu,Heng Liu,Lulu Qiao,Bin Liu,Kunlun Liu,Chuhao Luan,Kai Liu,Yin Zhou,Dewu Lin,Guoqiang Gan,Jiapei Li,Guo Hong,Wenjun Zhang
The electrochemical nitrate reduction reaction (eNO 3 RR) is widely recognized as a promising strategy for sustainable ammonia production and supporting the nitrogen cycle. However, its advancement is impeded by complex behavior of reaction intermediates and the inevitable reconstruction of precatalysts. To address these challenges, the generation and utilization of active hydrogen (*H) are strategically managed by tailoring the RuO 2 /Co 3 O 4 precatalyst and optimizing the electrolyte composition (OH − and NO 3 − concentration), thereby selectively enhancing ammonia formation. Consequently, the in situ reconstructed RuO 2 /Co(OH) 2 catalyst achieves an impressive ammonia yield of 35.9 ± 0.9 mg h −1 cm −2 and a Faradaic efficiency (FE) of 98.1 ± 2.6% at −0.3 V versus RHE. Furthermore, the catalyst shows significant potential for applications in nitrate-rich wastewater treatment and rechargeable Zn-NO 3 − batteries, maintaining stable operation for over 260 hours at 1 mA cm −2 with only a 6 mV increase in the potential window. Mechanistic studies reveal that electron-rich RuO 2 facilitates *H generation through water dissociation, which subsequently migrates to Co(OH) 2 to hydrogenate nitrogenous intermediates, selectively producing ammonia. This study highlights the importance of designing efficient catalytic systems that address both precatalyst reconstruction and the complexities of reactant and intermediate conversion in electrolytes, which are essential for managing the intricate electron and proton transfer processes involved in eNO 3 RR.
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高影响因子
POLYMER DEGRADATION AND STABILITY
·
2022
·
IF 5.204
Qi Liu,Dong Feng,Wenbo Zhao,Delong Xie,Yi Mei
It is a challenge to prepare flame-retardant composites via addition of low content of fire retardant all the time. In this contribution, a compounding method based on combining long-chain phosphaphenanthrene (DPP) flame retardant and two dimensional (2D) black phosphorene (BP) is used to achieve molecule-scale dispersion of a Si-P flame retardant in poly(ethylene-co-vinyl acetate) (EVA) matrix (donated as EVA/DBP) by the interaction of intermolecular hydrogen bonds. By this way of doing, EVA/DBP composites with various flame retardant contents were investigated. Cone calorimeter, vertical combustion, thermo-gravimetric analysis, scanning electron microscope, Raman Spectrum, and Fourier transform infrared spectroscopy are used to evaluate the flame retardance and analyze the corresponding mechanisms. The results show that the DBP can effectively improve the flame retardant properties and thermal stability of EVA with slight influence on its mechanical performance. Compared with pure EVA resin, EVA/DBP composite with 5 wt% dosage of DBP achieves UL94-V0 rating, 9.6% increased in limiting oxygen index (LOI), 16.1% and 47.5% reduction in total heat release (THR) and peak heat release rate (PHRR), respectively. Moreover, the tensile yield stress and elongation at break are only reduced by 8.1% and 6.2%, respectively. It shows that the interaction between DBP and EVA effectively promote gas phase fire resistance.
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高影响因子
Polymers
·
2019
·Vol. 11
·期 5
·826
·
IF 3.164
Chengguo Liu,Qiong Wu,Rongrong An,Qianqian Shang,Guodong Feng,Yun Hu,Puyou Jia,Yonghong Zhou,Wen Lei
New tung oil (TO)-based, unsaturated, co-ester (Co-UE) macromonomers bearing steric hindrance were synthesized by modifying a TO-based maleate (TOPERMA) monomer with an anhydride structure with hydroxyethyl methacrylate (HEMA) and methallyl alcohol (MAA), respectively. The obtained Co-UE monomers (TOPERMA-HEMA and TOPERMA-MAA) were then characterized by1H NMR and gel permeation chromatography (GPC). For comparison, hydroxyethyl acrylate (HEA)-modified TOPERMA (TOPERMA-HEA) was also synthesized and characterized. Subsequently, the obtained Co-UEs were thermally cured with styrene, and the ultimate properties of the resulting materials were studied. It was found that by introducing the structure of steric hindrance into the TO-based Co-UE monomer, the tensile strength and Young’s modulus of the resulting materials were improved. Furthermore, by reducing the length of the flexible chain in the Co-UE monomer, the tensile strength, Young’s modulus, and glass transition temperature (Tg) of the resultant materials were also improved. The TOPERMA-MAA resin gave the best performance in these TO-based Co-UE resins, which showed a tensile strength of 32.2 MPa, Young’s modulus of 2.38 GPa, andTgof 130.3 °C. The developed ecofriendly materials show promise in structural plastic applications.Keywords:tung oil;unsaturated polyester resins;thermosetting polymers;structure–property relationship;structural plastics
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高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 19
·3723-3733
·
IF 7.571
Qing Hao,Jinghong Wang,Jie Shen,Rong Gu,Yu Rao,Jian Feng,Huanhuan Wang,John L. Brash,Hong Chen
In analogy with adsorbed protein films, we have fabricated a family of 2D nanofilms composed of poly(N-vinyl caprolactam-co-vinylimidazole) (PNVCL) nanogels. NVCL was copolymerized with 1-vinylimidazole (VIM), and then cross-linked with α,ω-dibromoalkanes with 2 to 8 carbons via quaternization to form the nanogels. The swelling ratio of the gels was precisely controlled by regulating the inter-chain spacing of the polymers at the level of the carbon atom chain length of the cross-linker. The short-chain alkanes used are relatively rigid and their dimensions provide an accurate estimate of the chain spacing in the nanogels. It was shown that small differences in the carbon atom number of the cross-linking agent led to significant differences in the mechanical properties of the nanogels, in particular in the softness, deformability, and contact area (in film form), all of which increased with increasing carbon number. Films of the softer gels not only showed good adhesion to a number of substrates, but were also mechanically robust. In addition, the films showed excellent light transmission and nontoxicity to L929 cells. Nanogels of intermediate softness were shown to inhibit the adhesion of bacteria and human umbilical vein smooth muscle cells (HUVSMCs), and to be resistant to the adsorption of the plasma protein fibrinogen, indicating strong anti-biofouling properties. Gels that were either too stiff or too soft showed somewhat weaker anti-fouling activity in terms both of HUVSMCs adhesion and protein adsorption.
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PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 71
·40598-40610
·
IF 2.936
Yanxin Liu,Baolin Huang,Jiaoyang Zhu,Kailin Feng,Yuan Yuan,Changsheng Liu
Although multi-drug synergetic therapy is increasingly important in clinical application, sophisticated delivery systems with the ability to deliver multiple drugs and realize sequential release with independently tunable kinetics at different stages are highly desirable. In this study, a dual-generation mesoporous silica nanoparticle (DAMSN) with three-dimensional dendrimer-like structure as an adaptable dual drug delivery system is developed. The DAMSN was synthesized via a heterogeneous interfacial reaction and was of uniformly spherical morphology (150–170 nm) with dendritic structures and hierarchical pores (inner pore, 3.5 nm; outer pore, 8.3 nm). And the inner generation of DAMSN was modified with 3-aminopropyltriethoxysilane (APTMS). The IBU and BSA as model drugs were loaded into the inner generation via covalent conjugation and the outer generation by electrostatic adsorption, respectively. Intriguingly, DAMSN underwent a rapid bio-degradation for about 4 days, partly due to its center-radial dendritic channel structure. The release results showed that IBU was of a typical two-phase release profile with almost zero release in the first 12 h and more sustained release for the following 88 h, while BSA was sustained over a long period of 100 h. Notably, the release behaviors of both drugs can be independently tailored by changing the intrinsic properties of the DAMSN. In addition, DAMSN exhibited good bio-compatibility. These results indicated that the dual-generation, dendrimer-like MSN structure could spatiotemporally present different drugs to realize sequential drug release, and has potential use in the field of tissue engineering and regenerative medicine.
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高影响因子
Foods
·
2022
·Vol. 11
·期 19
·3136
·
IF 5.561
Xiaohu Zhou,Chaohua Zhang,Liangzhong Zhao,Wenhong Cao,Chunxia Zhou,Xin Xie,YuLian Chen
Isoelectric solubilisation/co-precipitation (ISP) has been proven to be a better method than blending for preparing plant–animal dual-proteins, which can achieve synergies in the functional properties of heterologous proteins. This paper aims to investigate the effect of extraction pH on the functional properties of co-precipitated dual-protein. The basic composition, subunit composition, solubility, surface hydrophobicity, emulsification and gel properties of co-precipitated dual-protein (Co) prepared from pea and grass carp with pH (2.0, 3.0, 9.0, 10.0 and 11.0) were analysed in this study using ISP. The results showed that the functional properties of Co (Co9, Co10, Co11) prepared by alkali extraction were generally better than those prepared by acid extraction (Co2, Co3). Among them, Co10 has the highest vicilin/legumin α + β value and solubility, while having the lowest surface hydrophobicity, making its emulsification and gel properties superior to other extraction pH values. This study provides an important method reference for preparing plant-animal Co with exceptional functional properties.Keywords:pea;co-precipitated dual-protein;blended dual-protein;plant protein;grass carp;surface hydrophobicity;emulsifying properties;gel properties;mixed protein
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PubMed
高影响因子
SEPARATION SCIENCE AND TECHNOLOGY
·
2020
·
IF 1.718
Zhen Jiao,Ningjie Ruan,Weifang Wang,Mengyang Guo,Sai Han,Jiangrui Cheng
The perilla oil rich in polyphenols was obtained by the co-extraction of perilla seeds and perilla leaves using supercritical carbon dioxide. The effects of the operating conditions on the properties of the obtained oil were investigated by single-factor analysis and response surface methodology. Under the optimum conditions, the values of the oil yield, the DPPH scavenging activity, and the alpha-linolenic acid yield were 7.43 ± 0.15 g/60 g sample, 69.41 ± 1.17%, and 49.14 ± 1.38%, respectively, which were in good agreement with the predicted values. Additional, the co-extraction product was observed high total polyphenol content and good oxidation stability.
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高影响因子
危险品化学品经营许可证（带存储）